当前位置： SCI文献检索 > Molecular Cancer期刊下所有文献 > Oncolytic viruses as therapeutic cancer vaccines.

Oncolytic viruses as therapeutic cancer vaccines.

Abstract：

:Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells via tumor vasculature targeting and bystander effect. Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. With this favorable immune backdrop, genetic engineering of OVs and rational combinations further potentiate OVs as cancer vaccines. OVs armed with GM-CSF (such as T-VEC and Pexa-Vec) or other immunostimulatory genes, induce potent anti-tumor immunity in both animal models and human patients. Combination with other immunotherapy regimens improve overall therapeutic efficacy. Coadministration with a HDAC inhibitor inhibits innate immunity transiently to promote infection and spread of OVs, and significantly enhances anti-tumor immunity and improves the therapeutic index. Local administration or OV mediated-expression of ligands for Toll-like receptors can rescue the function of tumor-infiltrating CD8+ T cells inhibited by the immunosuppressive tumor microenvironment and thus enhances the antitumor effect. Combination with cyclophosphamide further induces ICD, depletes Treg, and thus potentiates antitumor immunity. In summary, OVs properly armed or in rational combinations are potent therapeutic cancer vaccines.

journal_name

Mol Cancer

journal_title

Molecular cancer

authors

Bartlett DL,Liu Z,Sathaiah M,Ravindranathan R,Guo Z,He Y,Guo ZS

doi

10.1186/1476-4598-12-103

subject

Has Abstract

pub_date

2013-09-11 00:00:00

pages

103

issue

1

issn

1476-4598

pii

1476-4598-12-103

journal_volume

12

pub_type

杂志文章,评审

相关文献

Molecular Cancer文献大全
  • Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells.

    abstract：BACKGROUND:Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal, therefore the search for novel therapies against such tumors is warranted. Curcumin is a phytochemi...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-137

    authors： Pisano M,Pagnan G,Dettori MA,Cossu S,Caffa I,Sassu I,Emionite L,Fabbri D,Cilli M,Pastorino F,Palmieri G,Delogu G,Ponzoni M,Rozzo C

    更新日期：2010-06-03 00:00:00

  • Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer.

    abstract：BACKGROUND:We have previously reported that expression of the Wnt antagonist genes SFRP1 and SFRP5 is frequently silenced by promoter hypermethylation in breast cancer. SFRP2 is a further Wnt inhibitor whose expression was recently found being downregulated in various malignancies. Here we investigated whether SFRP2 is...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-7-83

    authors： Veeck J,Noetzel E,Bektas N,Jost E,Hartmann A,Knüchel R,Dahl E

    更新日期：2008-11-06 00:00:00

  • Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression.

    abstract：:Cancer precursor/progenitor cells may initiate and sustain the growth of tumors, but evidence for their existence in human disease is indirect, relying on their in vitro properties and animal models. More directly, specific elimination of these rare cells from cancer patients should produce a delayed but progressive d...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-8-106

    authors： Foster AE,Okur FV,Biagi E,Lu A,Dotti G,Yvon E,Savoldo B,Carrum G,Andreeff M,Goodell MA,Heslop HE,Brenner MK

    更新日期：2009-11-18 00:00:00

  • Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma.

    abstract：BACKGROUND:Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with significant morbidity. METHODS:To identify new molecular targets, we performed an integrated genomic analy...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-13-72

    authors： Harris PS,Venkataraman S,Alimova I,Birks DK,Balakrishnan I,Cristiano B,Donson AM,Dubuc AM,Taylor MD,Foreman NK,Reigan P,Vibhakar R

    更新日期：2014-03-24 00:00:00

  • METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer.

    abstract：BACKGROUND:As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing, and translation. Recently, the regulatory role of m6A in tumorigenesis has been increasingly recognized. However, dysregulation of m6A and its fu...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-019-1065-4

    authors： Yue B,Song C,Yang L,Cui R,Cheng X,Zhang Z,Zhao G

    更新日期：2019-10-13 00:00:00

  • Role of long non-coding RNAs in glucose metabolism in cancer.

    abstract：:Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their action is highly complex. Mounting evidence shows that lncRNAs can regulate cancer onset and progression in a va...

    journal_title：Molecular cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12943-017-0699-3

    authors： Fan C,Tang Y,Wang J,Xiong F,Guo C,Wang Y,Zhang S,Gong Z,Wei F,Yang L,He Y,Zhou M,Li X,Li G,Xiong W,Zeng Z

    更新日期：2017-07-24 00:00:00

  • Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice.

    abstract：BACKGROUND:Many human cancer cells express filamin A (FLNA), an actin-binding structural protein that interacts with a diverse set of cell signaling proteins, but little is known about the biological importance of FLNA in tumor development. FLNA is also expressed in endothelial cells, which may be important for tumor a...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-11-50

    authors： Nallapalli RK,Ibrahim MX,Zhou AX,Bandaru S,Sunkara SN,Redfors B,Pazooki D,Zhang Y,Borén J,Cao Y,Bergo MO,Akyürek LM

    更新日期：2012-08-02 00:00:00

  • Tyrosine-kinase inhibition results in EGFR clustering at focal adhesions and consequent exocytosis in uPAR down-regulated cells of head and neck cancers.

    abstract：BACKGROUND:Antisense (AS) induced down-regulation of uPAR in ACCS adenoid-cyctic carcinoma cells decreased the cellular adhesion and invasion on various extracellular matrices. Additionally, ACCS-AS cells showed an increased EGFR expression and other behavioral similarities to NA-SCC, a typical highly proliferative but...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-7-47

    authors： Abu-Ali S,Fotovati A,Shirasuna K

    更新日期：2008-06-03 00:00:00

  • Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1.

    abstract：BACKGROUND:N6-methyladenosine (m6A) emerges as one of the most important modification of RNA. Bladder cancer is a common cancer type in developed countries, and hundreds of thousands of bladder cancer patients die every year. MATERIALS AND METHODS:There are various cells in bladder tumor bulk, and a small population c...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-019-1084-1

    authors： Gu C,Wang Z,Zhou N,Li G,Kou Y,Luo Y,Wang Y,Yang J,Tian F

    更新日期：2019-11-25 00:00:00

  • Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy.

    abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy affecting children. Despite significant progress and success in the treatment of ALL, a significant number of children continue to relapse and for them, outcome remains poor. Therefore, the search for novel therapeutic approaches ...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-6-46

    authors： Sengupta TK,Leclerc GM,Hsieh-Kinser TT,Leclerc GJ,Singh I,Barredo JC

    更新日期：2007-07-10 00:00:00

  • Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion.

    abstract：BACKGROUND:ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMT...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-12-2

    authors： Freitas VM,do Amaral JB,Silva TA,Santos ES,Mangone FR,Pinheiro Jde J,Jaeger RG,Nagai MA,Machado-Santelli GM

    更新日期：2013-01-05 00:00:00

  • Asymmetric segregation of template DNA strands in basal-like human breast cancer cell lines.

    abstract：BACKGROUND AND METHODS:Stem or progenitor cells from healthy tissues have the capacity to co-segregate their template DNA strands during mitosis. Here, we set out to test whether breast cancer cell lines also possess the ability to asymmetrically segregate their template DNA strands via non-random chromosome co-segrega...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-12-139

    authors： Liu W,Jeganathan G,Amiri S,Morgan KM,Ryan BM,Pine SR

    更新日期：2013-11-15 00:00:00

  • Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression.

    abstract：BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-020-01152-2

    authors： Liang G,Ling Y,Mehrpour M,Saw PE,Liu Z,Tan W,Tian Z,Zhong W,Lin W,Luo Q,Lin Q,Li Q,Zhou Y,Hamai A,Codogno P,Li J,Song E,Gong C

    更新日期：2020-03-25 00:00:00

  • Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells.

    abstract：BACKGROUND:Truncated dopamine and cyclic-AMP-regulated phosphoprotein (t-DARPP) is frequently overexpressed in gastrointestinal malignancies. In this study, we examined the role of t-DARPP in regulating β-catenin. RESULTS:The pTopFlash construct that contains multiple TCF/LEF-binding sites was used as a measure of β-c...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-10-32

    authors： Vangamudi B,Zhu S,Soutto M,Belkhiri A,El-Rifai W

    更新日期：2011-03-29 00:00:00

  • Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca2+-permeable Cationic Channel in lung carcinoma cells.

    abstract：BACKGROUND:Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biological roles of PLPP4 in lung carcinoma. METHODS:PLPP4 expression was examined in 8 paired lung carcino...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-017-0717-5

    authors： Zhang X,Zhang L,Lin B,Chai X,Li R,Liao Y,Deng X,Liu Q,Yang W,Cai Y,Zhou W,Lin Z,Huang W,Zhong M,Lei F,Wu J,Yu S,Li X,Li S,Li Y,Zeng J,Long W,Ren D,Huang Y

    更新日期：2017-08-29 00:00:00

  • Retraction Note: HGF and TGFβ1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells.

    abstract：:This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1186/s12943-015-0389-y. ...

    journal_title：Molecular cancer

    pub_type： 杂志文章,撤回出版物

    doi：10.1186/s12943-020-01242-1

    authors： Bendinelli P,Maroni P,Matteucci E,Desiderio MA

    更新日期：2020-08-15 00:00:00

  • Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1.

    abstract：BACKGROUND:In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae; small Omega-shaped invaginations within the plasma membrane. Caveolae are involved in signal trans...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-4-21

    authors： Lin M,DiVito MM,Merajver SD,Boyanapalli M,van Golen KL

    更新日期：2005-06-21 00:00:00

  • Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells.

    abstract：BACKGROUND:Reovirus type 3 Dearing strain (ReoT3D) has an inherent propensity to preferentially infect and destroy cancer cells. The oncolytic activity of ReoT3D as a single agent has been demonstrated in vitro and in vivo against various cancers, including colon, pancreatic, ovarian and breast cancers. Its human safet...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-8-47

    authors： Sei S,Mussio JK,Yang QE,Nagashima K,Parchment RE,Coffey MC,Shoemaker RH,Tomaszewski JE

    更新日期：2009-07-14 00:00:00

  • Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis.

    abstract：BACKGROUND:Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emerge to indicate that they also provide function(s) in the oncogenic programme. Human TEX19 is a recen...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-017-0653-4

    authors： Planells-Palop V,Hazazi A,Feichtinger J,Jezkova J,Thallinger G,Alsiwiehri NO,Almutairi M,Parry L,Wakeman JA,McFarlane RJ

    更新日期：2017-04-26 00:00:00

  • Serum microRNA profiling in patients with glioblastoma: a survival analysis.

    abstract：:Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with outcome in glioblastoma patients. To do this, we performed global miRNA profiling in serum samples from 106 prima...

    journal_title：Molecular cancer

    pub_type： 信件

    doi：10.1186/s12943-017-0628-5

    authors： Zhao H,Shen J,Hodges TR,Song R,Fuller GN,Heimberger AB

    更新日期：2017-03-11 00:00:00

  • Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis.

    abstract：BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) have significant regulatory roles in cancer development and progression; however, the expression patterns and biological functions of circRNAs in renal cell carcinoma (RCC) remain largely elusive. METHOD:Bioinformatics methods were applied to screen...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-021-01314-w

    authors： Cen J,Liang Y,Huang Y,Pan Y,Shu G,Zheng Z,Liao X,Zhou M,Chen D,Fang Y,Chen W,Luo J,Zhang J

    更新日期：2021-01-20 00:00:00

  • Potent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivo.

    abstract：BACKGROUND:Oncolytic virotherapy is an attractive drug platform of cancer gene therapy, but efficacy and specificity are important prerequisites for success of such strategies. Previous studies determined that Apoptin is a p53 independent, bcl-2 insensitive apoptotic protein with the ability to specifically induce apop...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-10

    authors： Li X,Liu Y,Wen Z,Li C,Lu H,Tian M,Jin K,Sun L,Gao P,Yang E,Xu X,Kan S,Wang Z,Wang Y,Jin N

    更新日期：2010-01-20 00:00:00

  • Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.

    abstract：BACKGROUND:Transforming Growth Factor beta (TGF-beta) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-beta antagonists in a human metastatic basal-like breast cancer model. We examined the effects of two types of the TGF-beta pathway antagonists (...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-9-122

    authors： Ganapathy V,Ge R,Grazioli A,Xie W,Banach-Petrosky W,Kang Y,Lonning S,McPherson J,Yingling JM,Biswas S,Mundy GR,Reiss M

    更新日期：2010-05-26 00:00:00

  • Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer.

    abstract：BACKGROUND:The disruption of normal gene regulation due to microRNA dysfunction is a common event in cancer pathogenesis. MicroRNA-27b is an example of an oncogenic miRNA, and it is frequently upregulated in breast cancer. MicroRNAs have been found to deregulate tumor metabolism, which typically manifests as heightened...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-018-0851-8

    authors： Eastlack SC,Dong S,Ivan C,Alahari SK

    更新日期：2018-07-16 00:00:00

  • SLC/CCL21-mediated anti-tumor responses require IFNgamma, MIG/CXCL9 and IP-10/CXCL10.

    abstract：BACKGROUND:SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated anti-tumor responses are accompanied by significant induction of IFNgamma and the CXC chemokines, monok...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-2-22

    authors： Sharma S,Yang SC,Hillinger S,Zhu LX,Huang M,Batra RK,Lin JF,Burdick MD,Strieter RM,Dubinett SM

    更新日期：2003-04-15 00:00:00

  • Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity.

    abstract：BACKGROUND:Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed that glycogen branching enzyme (GBE1) is downstream of the HIF1 pathway in hypoxia-conditioned lung ...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-019-1027-x

    authors： Li L,Yang L,Cheng S,Fan Z,Shen Z,Xue W,Zheng Y,Li F,Wang D,Zhang K,Lian J,Wang D,Zhu Z,Zhao J,Zhang Y

    更新日期：2019-06-20 00:00:00

  • DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival.

    abstract：BACKGROUND:The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investigated the underlying mechanism of Akt Ser-473 phosphorylation by UVB radiation. RESULTS:We found tha...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-12-172

    authors： Tu Y,Ji C,Yang B,Yang Z,Gu H,Lu CC,Wang R,Su ZL,Chen B,Sun WL,Xia JP,Bi ZG,He L

    更新日期：2013-12-24 00:00:00

  • circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway.

    abstract：BACKGROUND:Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy and circular RNAs (circRNAs) play critical roles in cancer progression and chemoresistance. However, the function and mechanism of circRNA in autophagy regulation of LSCC remain unclear. METHODS:Th...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/s12943-020-01279-2

    authors： Gao W,Guo H,Niu M,Zheng X,Zhang Y,Xue X,Bo Y,Guan X,Li Z,Guo Y,He L,Zhang Y,Li L,Cao J,Wu Y

    更新日期：2020-11-24 00:00:00

  • Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis.

    abstract：:seRNA is a noncoding RNA (ncRNA) transcribed from active super-enhancer (SE), through which SE exerts biological functions and participates in various physiological and pathological processes. seRNA recruits cofactor, RNA polymerase II and mediator to constitute and stabilize chromatin loop SE and promoter region, whi...

    journal_title：Molecular cancer

    pub_type： 杂志文章,评审

    doi：10.1186/s12943-020-01195-5

    authors： Tan Y,Li Y,Tang F

    更新日期：2020-04-11 00:00:00

  • microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer.

    abstract：BACKGROUND:miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer (CRC). METHODS:The biological function of miR-139-5p was examined by cell growth, cell cycle and a...

    journal_title：Molecular cancer

    pub_type： 杂志文章

    doi：10.1186/1476-4598-13-124

    authors： Zhang L,Dong Y,Zhu N,Tsoi H,Zhao Z,Wu CW,Wang K,Zheng S,Ng SS,Chan FK,Sung JJ,Yu J

    更新日期：2014-05-26 00:00:00