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Nano-based delivery of RNAi in cancer therapy.

Abstract：

BACKGROUND:RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticles, which have distinctive size effects along with facile modification strategies and are capable of mediating effective RNAi with targeting potential, are attracting extensive interest. OBJECTIVE:This review presents an overview of the mechanisms of RNAi molecules in gene therapy and the different nanoparticles used to deliver RNAi molecules; briefly describes the current uses of RNAi in cancer therapy along with the nano-based delivery of RNA molecules in previous studies; and highlights some other carriers that have been applied in clinical settings. Finally, we discuss the nano-based delivery of RNAi therapeutics in preclinical development, including the current status and limitations of anti-cancer treatment. CONCLUSION:With the growing number of RNAi therapeutics entering the clinical phase, various nanocarriers are expected to play important roles in the delivery of RNAi molecules for cancer therapeutics.

journal_name

Mol Cancer

journal_title

Molecular cancer

authors

Xin Y,Huang M,Guo WW,Huang Q,Zhang LZ,Jiang G

doi

10.1186/s12943-017-0683-y

subject

Has Abstract

pub_date

2017-07-28 00:00:00

pages

134

issue

1

issn

1476-4598

pii

10.1186/s12943-017-0683-y

journal_volume

16

pub_type

杂志文章,评审

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