Small nucleolar RNA signatures of lung tumor-initiating cells.

abstract：BACKGROUND:CD44 is considered as 'a' metastasis associated gene, despite the fact that it is an umbrella term for a group of molecules produced from a single gene by alternative splicing. However, little consideration is given to the above in the literature of colorectal carcinomas as well as other tumour types, leadin...

journal_title：Molecular cancer

authors： Bánky B,Rásó-Barnett L,Barbai T,Tímár J,Becságh P,Rásó E

更新日期：2012-11-14 00:00:00

abstract：:Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by ...

journal_title：Molecular cancer

authors： Bian X,Xiao YT,Wu T,Yao M,Du L,Ren S,Wang J

更新日期：2019-03-30 00:00:00

abstract：BACKGROUND:Certain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern of the Eag1 channel in a large range of normal and tumour tissues from different collections utilising molecular biological a...

journal_title：Molecular cancer

authors： Hemmerlein B,Weseloh RM,Mello de Queiroz F,Knötgen H,Sánchez A,Rubio ME,Martin S,Schliephacke T,Jenke M,Heinz-Joachim-Radzun,Stühmer W,Pardo LA

更新日期：2006-10-05 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive type of primary brain tumours. Anti-angiogenic therapies (AAT), such as bevacizumab, have been developed to target the tumour blood supply. However, GBM presents mechanisms of escape from AAT activity, including a speculated direct effect of AAT on GBM cells. Furthermore, beva...

journal_title：Molecular cancer

authors： Simon T,Pinioti S,Schellenberger P,Rajeeve V,Wendler F,Cutillas PR,King A,Stebbing J,Giamas G

更新日期：2018-08-31 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) have been identified as important epigenetic regulators that play critical roles in human cancers. However, the regulatory functions of lncRNAs in tumorigenesis remains to be elucidated. Here, we aimed to investigate the molecular mechanisms and potential clinical application o...

journal_title：Molecular cancer

authors： He X,Chai P,Li F,Zhang L,Zhou C,Yuan X,Li Y,Yang J,Luo Y,Ge S,Zhang H,Jia R,Fan X

更新日期：2020-07-15 00:00:00

abstract：:Cancer is a leading cause of death worldwide, particularly because of its high mortality rate in patients who are diagnosed at late stages. Conventional biomarkers originating from blood are widely used for cancer diagnosis, but their low sensitivity and specificity limit their widespread application in cancer screeni...

journal_title：Molecular cancer

authors： Wang S,Zhang K,Tan S,Xin J,Yuan Q,Xu H,Xu X,Liang Q,Christiani DC,Wang M,Liu L,Du M

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:Though esophageal cancer is three to four times more common among males than females worldwide, this type of cancer still ranks in the top incidence among women, even more than the female specific cancer types. The occurrence is currently attributed to extrinsic factors, including tobacco use and alcohol con...

journal_title：Molecular cancer

authors： Li W,Zhang L,Guo B,Deng J,Wu S,Li F,Wang Y,Lu J,Zhou Y

更新日期：2019-02-08 00:00:00

abstract：BACKGROUND:SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN pro...

journal_title：Molecular cancer

authors： Javelaud D,van Kempen L,Alexaki VI,Le Scolan E,Luo K,Mauviel A

更新日期：2011-01-06 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) have been documented as playing important roles in cancer development. In this study, we investigated the role of miR-124 in breast cancer and clarified the regulation of flotillin-1 (FLOT1) by miR-124. METHODS:The expression levels of miR-124 were examined in breast cancer cell lines and...

journal_title：Molecular cancer

authors： Li L,Luo J,Wang B,Wang D,Xie X,Yuan L,Guo J,Xi S,Gao J,Lin X,Kong Y,Xu X,Tang H,Xie X,Liu M

更新日期：2013-12-13 00:00:00

abstract：BACKGROUND:Recent advances have revealed a significant contribution of chemokines and their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis. The CXC chemokine receptor-7 (CXCR7) is the latest chemokine receptor implicated in cancer. Although over expressed in breast cancer cell lin...

journal_title：Molecular cancer

authors： Salazar N,Muñoz D,Kallifatidis G,Singh RK,Jordà M,Lokeshwar BL

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMT...

journal_title：Molecular cancer

authors： Freitas VM,do Amaral JB,Silva TA,Santos ES,Mangone FR,Pinheiro Jde J,Jaeger RG,Nagai MA,Machado-Santelli GM

更新日期：2013-01-05 00:00:00

abstract：BACKGROUND:In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanis...

journal_title：Molecular cancer

authors： Yang R,Xing L,Zheng X,Sun Y,Wang X,Chen J

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Fusion of the MOZ and TIF2 genes by an inv (8) (p11q13) translocation has been identified in patients with acute mixed-lineage leukemia. Characterization of the molecular structure of the MOZ-TIF2 fusion protein suggested that the fusion protein would effect on nuclear receptor signaling. RESULTS:A series o...

journal_title：Molecular cancer

authors： Yin H,Glass J,Blanchard KL

更新日期：2007-08-13 00:00:00

abstract：BACKGROUND:High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied in chondrosarcomas. We examined the importance of P-glycoprot...

journal_title：Molecular cancer

authors： Kim DW,Kim KO,Shin MJ,Ha JH,Seo SW,Yang J,Lee FY

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:Human or animals lacking either JAK3 or the common gamma chain (gammac) expression display severe combined immunodeficiency disease, indicating the crucial role of JAK3 in T-cell development and the homeostasis of the immune system. JAK3 has also been suggested to contribute to the pathogenesis of tumorigene...

journal_title：Molecular cancer

authors： Kim BH,Jee JG,Yin CH,Sandoval C,Jayabose S,Kitamura D,Bach EA,Baeg GH

更新日期：2010-02-11 00:00:00

abstract：BACKGROUND:Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to induce apoptosis and augment standard chemotherapy. RESULTS:The binding affini...

journal_title：Molecular cancer

authors： Hornick JR,Xu J,Vangveravong S,Tu Z,Mitchem JB,Spitzer D,Goedegebuure P,Mach RH,Hawkins WG

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:The cyclin D1 proto-oncogene is an important regulator of G1 to S-phase transition and an important cofactor for several transcription factors in numerous cell types. Studies on neonatal cardiomyocytes and postmitotic neurons indicate that the activity of cyclin D1 may be regulated through its cytoplasmic se...

journal_title：Molecular cancer

authors： Alao JP,Gamble SC,Stavropoulou AV,Pomeranz KM,Lam EW,Coombes RC,Vigushin DM

更新日期：2006-02-17 00:00:00

abstract：:Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cl...

journal_title：Molecular cancer

authors： Moossavi M,Parsamanesh N,Bahrami A,Atkin SL,Sahebkar A

更新日期：2018-11-17 00:00:00

abstract：BACKGROUND:The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell c...

journal_title：Molecular cancer

authors： Teh MT,Gemenetzidis E,Chaplin T,Young BD,Philpott MP

更新日期：2010-02-26 00:00:00

abstract：BACKGROUND:Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biological roles of PLPP4 in lung carcinoma. METHODS:PLPP4 expression was examined in 8 paired lung carcino...

journal_title：Molecular cancer

authors： Zhang X,Zhang L,Lin B,Chai X,Li R,Liao Y,Deng X,Liu Q,Yang W,Cai Y,Zhou W,Lin Z,Huang W,Zhong M,Lei F,Wu J,Yu S,Li X,Li S,Li Y,Zeng J,Long W,Ren D,Huang Y

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Abnormal amplification/expression of HER-2/neu oncogene has been causally linked with tumorigenesis and metastasis in breast cancer and associated with shortened overall survival of patients. Recently, heat shock protein 27 (Hsp27) was reported to be highly expressed in HER-2/neu positive tumors and cell lin...

journal_title：Molecular cancer

authors： Zhang D,Wong LL,Koay ES

更新日期：2007-08-14 00:00:00

abstract：BACKGROUND:The human genome encodes thousands of unique long non-coding RNAs (lncRNAs), and these transcripts are emerging as critical regulators of gene expression and cell fate. However, the transcriptional regulation of their expression is not fully understood. The pivotal transcription factor E2F1 which can induce ...

journal_title：Molecular cancer

authors： Feldstein O,Nizri T,Doniger T,Jacob J,Rechavi G,Ginsberg D

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 and Wnt signaling pathways, a clear genetic association or unique mutational link to the disease is still missing. Recent...

journal_title：Molecular cancer

authors： Korah R,Healy JM,Kunstman JW,Fonseca AL,Ameri AH,Prasad ML,Carling T

更新日期：2013-08-05 00:00:00

abstract：BACKGROUND:The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investigated the underlying mechanism of Akt Ser-473 phosphorylation by UVB radiation. RESULTS:We found tha...

journal_title：Molecular cancer

authors： Tu Y,Ji C,Yang B,Yang Z,Gu H,Lu CC,Wang R,Su ZL,Chen B,Sun WL,Xia JP,Bi ZG,He L

更新日期：2013-12-24 00:00:00

abstract：:Gene fusions occur in up to 17% of solid tumours. Oncogenic kinases are often involved in such fusions. In lung cancer, almost 30% of patients carrying an activated oncogene show the fusion of a tyrosine kinase to an heterologous gene. Several genes are partner in the fusion with the three kinases ALK, ROS1 and RET in...

journal_title：Molecular cancer

authors： Cerrato A,Visconti R,Celetti A

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND:Kinases downstream of growth factor receptors have been implicated in radioresistance and are, therefore, attractive targets to improve radiotherapy outcome in head and neck squamous cell carcinoma (HNSCC) patients. METHODS:An antibody-based array was used to quantify the expression levels of multiple phosp...

journal_title：Molecular cancer

authors： Stegeman H,Kaanders JH,Verheijen MM,Peeters WJ,Wheeler DL,Iida M,Grénman R,van der Kogel AJ,Span PN,Bussink J

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:Reactive oxygen species contribute to normal thyroid function. The NRF2 oxidative response pathway is frequently and constitutively activated in multiple tumor types, including papillary thyroid carcinoma (PTC). Genetic mechanisms underlying NRF2 pathway activation in PTC are not fully understood. Thus, we a...

journal_title：Molecular cancer

authors： Martinez VD,Vucic EA,Pikor LA,Thu KL,Hubaux R,Lam WL

更新日期：2013-10-20 00:00:00

abstract：:Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established cell lines. Therefore, the proper use of in vitro models is crucial to enhance our understanding of cancer. Ther...

journal_title：Molecular cancer

authors： Brodaczewska KK,Szczylik C,Fiedorowicz M,Porta C,Czarnecka AM

更新日期：2016-12-19 00:00:00

abstract：BACKGROUND:Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emerge to indicate that they also provide function(s) in the oncogenic programme. Human TEX19 is a recen...

journal_title：Molecular cancer

authors： Planells-Palop V,Hazazi A,Feichtinger J,Jezkova J,Thallinger G,Alsiwiehri NO,Almutairi M,Parry L,Wakeman JA,McFarlane RJ

更新日期：2017-04-26 00:00:00

abstract：:Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their action is highly complex. Mounting evidence shows that lncRNAs can regulate cancer onset and progression in a va...

journal_title：Molecular cancer

authors： Fan C,Tang Y,Wang J,Xiong F,Guo C,Wang Y,Zhang S,Gong Z,Wei F,Yang L,He Y,Zhou M,Li X,Li G,Xiong W,Zeng Z

更新日期：2017-07-24 00:00:00