Phosphorylation of Ser78 of Hsp27 correlated with HER-2/neu status and lymph node positivity in breast cancer.

abstract：BACKGROUND:Although the prognosis of gastric cancer patients have a favorable progression, there are some patients with unusual patterns of locoregional and systemic recurrence. Therefore, a better understanding of early molecular events of the disease is needed. Current evidences demonstrate that long noncoding RNAs (...

journal_title：Molecular cancer

authors： Liu YW,Xia R,Lu K,Xie M,Yang F,Sun M,De W,Wang C,Ji G

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:Truncated dopamine and cyclic-AMP-regulated phosphoprotein (t-DARPP) is frequently overexpressed in gastrointestinal malignancies. In this study, we examined the role of t-DARPP in regulating β-catenin. RESULTS:The pTopFlash construct that contains multiple TCF/LEF-binding sites was used as a measure of β-c...

journal_title：Molecular cancer

authors： Vangamudi B,Zhu S,Soutto M,Belkhiri A,El-Rifai W

更新日期：2011-03-29 00:00:00

abstract：BACKGROUND:Fusion of the MOZ and TIF2 genes by an inv (8) (p11q13) translocation has been identified in patients with acute mixed-lineage leukemia. Characterization of the molecular structure of the MOZ-TIF2 fusion protein suggested that the fusion protein would effect on nuclear receptor signaling. RESULTS:A series o...

journal_title：Molecular cancer

authors： Yin H,Glass J,Blanchard KL

更新日期：2007-08-13 00:00:00

abstract：BACKGROUND:To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation. METHODS:To quantify non-tumor and tumor DNA and RNA in the plasma of tumor-bearing rats and to correlate such levels with tumor ...

journal_title：Molecular cancer

authors： García-Olmo DC,Picazo MG,Toboso I,Asensio AI,García-Olmo D

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication. This stu...

journal_title：Molecular cancer

authors： Lin Q,Chen X,Meng F,Ogawa K,Li M,Song R,Zhang S,Zhang Z,Kong X,Xu Q,He F,Bai X,Sun B,Hung MC,Liu L,Wands J,Dong X

更新日期：2019-11-07 00:00:00

abstract：:Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or suppress tumor development, so it is a "double-edged sword" in tumors that depends on the cell and tissue typ...

journal_title：Molecular cancer

authors： Chen HT,Liu H,Mao MJ,Tan Y,Mo XQ,Meng XJ,Cao MT,Zhong CY,Liu Y,Shan H,Jiang GM

更新日期：2019-05-24 00:00:00

abstract：BACKGROUND:Increasing evidence supports the role of small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs) as master gene regulators at the epigenetic modification level. However, the underlying mechanism of these functional ncRNAs in colorectal cancer (CRC) has not been well investigated. METHODS:The dysre...

journal_title：Molecular cancer

authors： Wu H,Qin W,Lu S,Wang X,Zhang J,Sun T,Hu X,Li Y,Chen Q,Wang Y,Zhao H,Piao H,Zhang R,Wei M

更新日期：2020-05-22 00:00:00

abstract：:The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERalpha) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR). In fact, 4ICD has recently emerged as an important regulator and predictor of tamoxifen response, a role pr...

journal_title：Molecular cancer

authors： Rokicki J,Das PM,Giltnane JM,Wansbury O,Rimm DL,Howard BA,Jones FE

更新日期：2010-06-15 00:00:00

abstract：:A vast array of tumor-derived genetic, proteomic and cellular components are constantly released into the circulation of cancer patients. These molecules including circulating tumor DNA and RNA, proteins, tumor and immune cells are emerging as convenient and accurate liquid biomarkers of cancer. Circulating cancer bio...

journal_title：Molecular cancer

authors： Lim SY,Lee JH,Diefenbach RJ,Kefford RF,Rizos H

更新日期：2018-01-17 00:00:00

abstract：BACKGROUND:Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biological roles of PLPP4 in lung carcinoma. METHODS:PLPP4 expression was examined in 8 paired lung carcino...

journal_title：Molecular cancer

authors： Zhang X,Zhang L,Lin B,Chai X,Li R,Liao Y,Deng X,Liu Q,Yang W,Cai Y,Zhou W,Lin Z,Huang W,Zhong M,Lei F,Wu J,Yu S,Li X,Li S,Li Y,Zeng J,Long W,Ren D,Huang Y

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Alterations of chromosome 8 and hypomethylation of LINE-1 retrotransposons are common alterations in advanced prostate carcinoma. In a former study including many metastatic cases, they strongly correlated with each other. To elucidate a possible interaction between the two alterations, we investigated their...

journal_title：Molecular cancer

authors： Schulz WA,Alexa A,Jung V,Hader C,Hoffmann MJ,Yamanaka M,Fritzsche S,Wlazlinski A,Müller M,Lengauer T,Engers R,Florl AR,Wullich B,Rahnenführer J

更新日期：2007-02-05 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR), a well-known oncogenic driver, contributes to the initiation and progression of a wide range of cancer types. Aberrant lipid metabolism including highly produced monounsaturated fatty acids (MUFA) is recognized as a hallmark of cancer. However, how EGFR regulates MUFA...

journal_title：Molecular cancer

authors： Zhang J,Song F,Zhao X,Jiang H,Wu X,Wang B,Zhou M,Tian M,Shi B,Wang H,Jia Y,Wang H,Pan X,Li Z

更新日期：2017-07-19 00:00:00

abstract：:Live animal imaging is becoming an increasingly common technique for accurate and quantitative assessment of tumor burden over time. Bioluminescence imaging systems rely on a bioluminescent signal from tumor cells, typically generated from expression of the firefly luciferase gene. However, previous reports have sugge...

journal_title：Molecular cancer

authors： Tiffen JC,Bailey CG,Ng C,Rasko JE,Holst J

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:In our previous studies, we have demonstrated that insulin-like growth factor binding protein-related protein1 (IGFBP-rP1) played its potential tumor suppressor role in colon cancer cells through apoptosis and senescence induction. In this study, we will further uncover the role of IGFBP-rP1 in colon cancer ...

journal_title：Molecular cancer

authors： Ruan W,Zhu S,Wang H,Xu F,Deng H,Ma Y,Lai M

更新日期：2010-10-26 00:00:00

abstract：BACKGROUND:Human or animals lacking either JAK3 or the common gamma chain (gammac) expression display severe combined immunodeficiency disease, indicating the crucial role of JAK3 in T-cell development and the homeostasis of the immune system. JAK3 has also been suggested to contribute to the pathogenesis of tumorigene...

journal_title：Molecular cancer

authors： Kim BH,Jee JG,Yin CH,Sandoval C,Jayabose S,Kitamura D,Bach EA,Baeg GH

更新日期：2010-02-11 00:00:00

abstract：BACKGROUND:Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects chemotherapeutic effects by regulating targets involved in drug metabolism and transportation, but t...

journal_title：Molecular cancer

authors： Dong Y,Wang Z,Xie GF,Li C,Zuo WW,Meng G,Xu CP,Li JJ

更新日期：2017-03-29 00:00:00

abstract：:Chimeric antigen receptor T (CAR-T) cell therapy is an emerging and effective cancer immunotherapy. Especially in hematological malignancies, CAR-T cells have achieved exciting results. Two Anti-CD19 CAR-T therapies have been approved for the treatment of CD19-positive leukemia or lymphoma. However, the application of...

journal_title：Molecular cancer

authors： Yu S,Yi M,Qin S,Wu K

更新日期：2019-08-20 00:00:00

abstract：:Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its physiologic roles in the immune and nervous systems have been extensively explored. However, the roles of Sema4D have extended beyond these traditionally studied territories. Via interaction with its high affinity receptor Plexin-B1, Sema4...

journal_title：Molecular cancer

authors： Ch'ng ES,Kumanogoh A

更新日期：2010-09-21 00:00:00

abstract：BACKGROUND:Relapse due to chemoresistant residual disease is a major cause of death in acute myelogenous leukemia (AML). The present study was undertaken to elucidate the molecular mechanisms of chemoresistance by comparing differential gene expression in blasts from patients with resistant relapsing AML and chemosensi...

journal_title：Molecular cancer

authors： Huang TS,Myklebust LM,Kjarland E,Gjertsen BT,Pendino F,Bruserud Ø,Døskeland SO,Lillehaug JR

更新日期：2007-04-23 00:00:00

abstract：BACKGROUND:Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal, therefore the search for novel therapies against such tumors is warranted. Curcumin is a phytochemi...

journal_title：Molecular cancer

authors： Pisano M,Pagnan G,Dettori MA,Cossu S,Caffa I,Sassu I,Emionite L,Fabbri D,Cilli M,Pastorino F,Palmieri G,Delogu G,Ponzoni M,Rozzo C

更新日期：2010-06-03 00:00:00

abstract：BACKGROUND:Nilotinib is a tyrosine kinase inhibitor with high target specificity. Here, we characterized the effects of nilotinib for the first time on CD4+CD25+ regulatory T cells (Tregs) which regulate anti-tumor/leukemia immune responses. DESIGN AND METHODS:Carboxyfluorescein diacetate succinimidyl ester (CFSE) and...

journal_title：Molecular cancer

authors： Fei F,Yu Y,Schmitt A,Rojewski MT,Chen B,Greiner J,Götz M,Bunjes D,Schmitt M

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:The role of TNF-alpha in affecting the fate of tumors is controversial, while some studies have reported apoptotic or necrotic effects of TNF-alpha, others provide evidence that endogenous TNF-alpha promotes growth and development of tumors. Understanding the mechanism(s) of TNF-alpha mediated growth arrest ...

journal_title：Molecular cancer

authors： Kumar PS,Shiras A,Das G,Jagtap JC,Prasad V,Shastry P

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:Glycochenodeoxycholate (GCDA) is one of the major human bile salts. Bile salts stimulate cell survival and proliferation through the mitogen-activated protein kinase, but the downstream signaling mechanism(s) remains enigmatic. Mcl-1 is an antiapoptotic molecule of the Bcl2 family that is extensively overexp...

journal_title：Molecular cancer

authors： Liao M,Zhao J,Wang T,Duan J,Zhang Y,Deng X

更新日期：2011-04-20 00:00:00

abstract：:Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthesis in normoxia. In hypoxia, the rate of the canonical protein synthesis pathw...

journal_title：Molecular cancer

authors： Chee NT,Lohse I,Brothers SP

更新日期：2019-03-30 00:00:00

abstract：BACKGROUND:Metabolic plasticity has been increasingly thought to be a determinant of tumor growth and metastasis. MACC1, a transcriptional regulator of MET, was recognized as an oncogene in gastric cancer (GC); however, its transcriptional or post-translational regulation was not clear. We previously reported the metab...

journal_title：Molecular cancer

authors： Zhao Y,Liu Y,Lin L,Huang Q,He W,Zhang S,Dong S,Wen Z,Rao J,Liao W,Shi M

更新日期：2018-03-06 00:00:00

abstract：BACKGROUND:Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous disorder and it is associated with an elevated risk for malignant tumors of tissues derived from neural crest cells. The NF1 gene is considered a tumor suppressor gene and inactivation of both copies can be found in NF1-associated be...

journal_title：Molecular cancer

authors： Rübben A,Bausch B,Nikkels A

更新日期：2006-09-10 00:00:00

abstract：BACKGROUND:An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate me...

journal_title：Molecular cancer

authors： Bredholt T,Dimba EA,Hagland HR,Wergeland L,Skavland J,Fossan KO,Tronstad KJ,Johannessen AC,Vintermyr OK,Gjertsen BT

更新日期：2009-11-13 00:00:00

abstract：BACKGROUND:In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae; small Omega-shaped invaginations within the plasma membrane. Caveolae are involved in signal trans...

journal_title：Molecular cancer

authors： Lin M,DiVito MM,Merajver SD,Boyanapalli M,van Golen KL

更新日期：2005-06-21 00:00:00

abstract：:Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body's immune surveillance. Because of their metabolic reprogramming characteristics, tumors can modify the physicochemical properties of the microenvironment, which in turn affects t...

journal_title：Molecular cancer

authors： Wang YA,Li XL,Mo YZ,Fan CM,Tang L,Xiong F,Guo C,Xiang B,Zhou M,Ma J,Huang X,Wu X,Li Y,Li GY,Zeng ZY,Xiong W

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticles, which have distinctive size effects along with facile modification strategies and are capable of ...

journal_title：Molecular cancer

authors： Xin Y,Huang M,Guo WW,Huang Q,Zhang LZ,Jiang G

更新日期：2017-07-28 00:00:00