Abstract:
BACKGROUND:The economic burden of ulcerative colitis (UC), specifically related to indirect costs, is not extensively documented. Understanding and quantifying it is required by health care decision makers. AIM:To assess the impact of indirect costs of UC in observation studies. METHOD:A systematic literature search was conducted in MEDLINE®, Embase® and Cochrane Library to capture all relevant publications reporting outcomes on absenteeism, presenteeism and productivity losses in moderate to severe UC. Eligibility criteria for inclusion into the review were established using a predefined PICOS scheme. All costs were adjusted to 2017 currency values (USD dollars, $). RESULTS:In total, 18 studies reporting data on indirect costs were included in the analysis. Absenteeism costs were classified into three categories: sick leave, short-term and long-term disability. Most of the studies captured absenteeism costs related specifically to sick leave, which was experienced on average by 10 to 24% patients with UC. Only three studies captured presenteeism costs, as these are difficult to measure, however costs ranged from 1602 $ to 2947 $ per patient year. The proportion of indirect costs accounted for 35% of total UC costs (Total UC costs were defined as the sum of healthcare costs, productivity costs and out-of-pocket costs). DISCUSSION:A limited number of studies were identified describing the indirect costs in patients with moderate to severe UC. Insufficient data on different components of costs allowed a limited analysis on the impact of indirect costs in patients with UC. Further studies are needed to gain an understanding of the influence of UC on patients' functional abilities.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Constantin J,Atanasov P,Wirth D,Borsi Adoi
10.1186/s12876-019-1095-9subject
Has Abstractpub_date
2019-11-09 00:00:00pages
179issue
1issn
1471-230Xpii
10.1186/s12876-019-1095-9journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Polyethylene glycol is commonly used to manage constipation and is available with or without electrolytes. The addition of electrolytes dates back to its initial development as lavage solutions in preparation for gastrointestinal interventions. The clinical utility of the addition of electrolytes to polyethy...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12876-016-0457-9
更新日期:2016-03-31 00:00:00
abstract:BACKGROUND:Liver fibrosis is the result of continuous liver injury stemming from different etiological factors. Bile duct injury induces an altered expression of TGF-beta, which has an important role in liver fibrosis because this cytokine induces the expression of target genes such as collagens, PAI-1, TIMPs, and othe...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-9-81
更新日期:2009-10-31 00:00:00
abstract:BACKGROUND:The search for better non-invasive biomarkers for gastric cancer remains ongoing. We investigated the predictive power of serum trefoil factor (TFF) levels as biomarkers for gastric cancer in comparison with the pepsinogen (PG) test. METHODS:Patients with gastric cancer, chronic atrophic gastritis (CAG) or ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-74
更新日期:2014-04-11 00:00:00
abstract:BACKGROUND:Gastric cancer can progress from a chronic inflammation of the gastric mucosa resulting from Helicobacter pylori infection that activates the inflammatory response of the host. Therefore, polymorphisms in genes involved in the inflammatory response, such as inducible nitric oxide synthase (NOS2), have been i...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-64
更新日期:2010-06-17 00:00:00
abstract:BACKGROUND:CMUSE is a rare disease whose diagnosis remains difficult because the lesion is confined to the small bowel. CASE PRESENTATION:Here, we present a case of 43-year-old female patient suffered chronic abdominal pain for 20 years, and finally diagnosed with CMUSE. Capsule endoscopy was performed when general en...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-0962-8
更新日期:2019-04-03 00:00:00
abstract:BACKGROUND:Cystic artery pseudoaneurysm is a rare complication following cholecystitis. Its presentation with upper gastrointestinal hemorrhage (UGIH) is even rarer. Thirteen patients with cystic artery pseudoaneurysm have been reported in the literature but only 2 of them presented with UGIH alone. CASE PRESENTATION:...
journal_title:BMC gastroenterology
pub_type: 杂志文章,评审
doi:10.1186/1471-230X-7-12
更新日期:2007-03-26 00:00:00
abstract:BACKGROUND:Endothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various animal models. The present study was conducted to investigate the influence of exogenously and endog...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-16
更新日期:2004-08-06 00:00:00
abstract:BACKGROUND:As anorexia and hypermetabolism are common in cirrhosis, leptin levels may be increased in this disease. In this study, we investigated the relation between the severity of disease and serum leptin levels in post-hepatitis cirrhosis and the role of body composition, gender and viral aetiology of cirrhosis in...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-4-23
更新日期:2004-09-23 00:00:00
abstract:BACKGROUND:To observe and compare the short term results and functional recovery of laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis (LSCACRA) in the treatment of Adult slow transit constipation (STC) with two different reservoir length: short colonic reservoir and long colonic reservoir. ME...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0257-7
更新日期:2015-03-18 00:00:00
abstract:BACKGROUND:The normal physiology of the gastrointestinal tract has been only cursorily examined. Consequently, the pathophysiology of disturbances of the gastrointestinal functions is poorly known. Recurrent vomiting is one of many functional conditions for which it is difficult to find an explanation and to treat. In ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-6-28
更新日期:2006-10-21 00:00:00
abstract:BACKGROUND:Coeliac disease is characterised by villous atrophy, which usually normalises after gluten withdrawal. Sometimes the revaluation of duodenal histology is required during follow-up, even if the methodology for comparing duodenal histology before and after introducing a gluten-free diet is not yet established....
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0361-8
更新日期:2015-10-14 00:00:00
abstract:BACKGROUND:Tumor-to-tumor metastasis is a rare event. Rectal cancer to primary thyroid neoplasm metastasis is extremely rare. Herein, we reported a case of metastatic rectal adenocarcinoma to a papillary thyroid carcinoma. The incidence and clinicopathological characteristics of metastatic colorectal cancer to a thyroi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01286-z
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:Erdheim-Chester disease (ECD) is a rare multisystem non-Langerhans cell histiocytosis that is characterized histologically by xanthogranulomatous infiltrates and radiologically by symmetrical sclerosis of long bones. The xanthomatous process is characterized by prominent foamy histiocytes staining positive f...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-77
更新日期:2011-06-22 00:00:00
abstract:BACKGROUND:Symptoms suggestive of functional dyspepsia (FD) and irritable bowel syndrome (IBS) frequently overlap with those of gastroesophageal reflux disease. Despite the high prevalence of symptomatic overlap, the underlying etiology remains poorly defined. We assessed the correlation of symptomatic relief and healt...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-230X-13-145
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:The natural course and treatment strategies for asymptomatic or oligosymptomatic pancreatic necrosis are still poorly defined. The aim of this retrospective study was to establish criteria for the need of intervention in patients with pancreatic necrosis. METHODS:A total of 31 consecutive patients (18 male,...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-48
更新日期:2012-05-14 00:00:00
abstract:BACKGROUND:Acute pancreatitis is an inflammatory disease characterized by local tissue injury and systemic inflammatory response leading to massive nitric oxide (NO) production and haemodynamic disturbances. Therefore, the aim of this work was to evaluate the vascular reactivity of pulmonary and mesenteric artery rings...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-8-19
更新日期:2008-05-29 00:00:00
abstract:BACKGROUND:Perianal fistula surgery can damage the anal sphincters which may cause faecal incontinence. By measuring regional pressures, 3D-HRAM potentially provides better guidance for surgical strategy in patients with perianal fistulas. The aim was to measure regional anal pressures with 3D-HRAM and to compare these...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0770-6
更新日期:2018-04-04 00:00:00
abstract:BACKGROUND:MCAD-deficiency is the most common inborn error of fatty acid oxidation now included in many newborn screening programms using MS/MS. During prolonged catabolic episodes, patients may suffer from metabolic decompensation with dysfunction of liver, skeletal- and heart muscle as well as brain. In anabolism, ne...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-119
更新日期:2012-08-30 00:00:00
abstract:BACKGROUND:The majority of colonic obstructions result from colorectal cancer. However, malignancies of extra-colonic origin can also disrupt colorectal patency, and the efficacy of self-expanding metal stents (SEMS) insertion as a bridge to surgery in these patients are still in debate. The aim of this study is to eva...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01273-4
更新日期:2020-04-19 00:00:00
abstract:BACKGROUND:Many studies suggest that in chronic hepatitis B virus (HBV) infection regulate T (Treg) cells and interlukin-17-producing T help cells (Th17) are mutually antagonistic in the immune response. This study is aimed to reveal the cell differentiation environment and the significance of Treg and Th17 balance in ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-43
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Efforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells. In the present study, we described the first procedure of via hepatic artery transplantation of human fetal...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-014-0204-z
更新日期:2014-12-04 00:00:00
abstract:BACKGROUND:Desmoid tumors are a group of benign, invasive, solid tumors that are relatively rare in the general population, but can occur in up to 21 % of patients with Familial Adenomatous Polyposis (FAP). They can be difficult to treat and have high rates of recurrence even after resection. Our goal with this study w...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1186/s12876-015-0306-2
更新日期:2015-07-16 00:00:00
abstract:BACKGROUND:Animal models of non-alcoholic steatohepatitis (NASH) are important tools in preclinical research and drug discovery. Gubra-Amylin NASH (GAN) diet-induced obese (DIO) mice represent a model of fibrosing NASH. The present study directly assessed the clinical translatability of the model by head-to-head compar...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01356-2
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:Transarterial chemoembolization (TACE) and sorafenib are the therapeutic standard for intermediate and advanced stage hepatocellular carcinoma (HCC) patients respectively. High costs with adverse events (AE) of sorafenib might limit sorafenib dosage, further affecting therapeutic response. To attain greatest...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0464-x
更新日期:2016-04-27 00:00:00
abstract:BACKGROUND:Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity. METHODS:Thirty-seven UC ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-29
更新日期:2011-03-31 00:00:00
abstract:BACKGROUND:Stercoral colitis is a rare inflammatory process involving the colonic wall secondary to fecal impaction with high morbidity and mortality; especially if complicated with ischemic colitis, stercoral ulcer formation and subsequent perforation. There are several case reports published on abdominal perforation ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0686-6
更新日期:2017-11-28 00:00:00
abstract:BACKGROUND:Vitamin K deficiency results in serious coagulation dysfunction, but hemorrhagic shock is rare. Herein, we describe a case of vitamin K deficiency and abnormality in the path of the intercostal artery, the combination of which led to hemorrhagic shock. CASE PRESENTATION:An 83-year-old woman was hospitalized...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-0978-0
更新日期:2019-04-18 00:00:00
abstract:BACKGROUND:Occurrence of metastatic cancer to the stomach is rare, particularly in patients with prostate cancer. Gastric metastasis generally presents as a solitary and submucosal lesion with a central depression. CASE PRESENTATION:We describe a case of gastric metastasis arising from prostate cancer, which is almost...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0655-0
更新日期:2017-08-07 00:00:00
abstract:BACKGROUND:Gas-related symptoms represent very common complaints in children. The reduction of gas production can be considered as a valuable target in controlling symptoms. α-galactosidase has been shown to reduce gas production and related symptoms in adults. To evaluate the efficacy and tolerability of α-galactosida...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-230X-13-142
更新日期:2013-09-24 00:00:00
abstract:BACKGROUND:Haemolytic uraemic syndrome is a rarely seen in adults often leading to critical illness. This case highlights how difficult it can be to establish a diagnosis and treat when a patient presents with bloody diarrhoea. CASE PRESENTATION:A 17-year-old Iraqi man presented to the emergency department with abdomi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1071-4
更新日期:2019-08-28 00:00:00