Abstract:
BACKGROUND:The search for better non-invasive biomarkers for gastric cancer remains ongoing. We investigated the predictive power of serum trefoil factor (TFF) levels as biomarkers for gastric cancer in comparison with the pepsinogen (PG) test. METHODS:Patients with gastric cancer, chronic atrophic gastritis (CAG) or chronic non-atrophic gastritis (CNAG), and healthy people were recruited. Serum concentrations of TFFs, PG I, and PG II, as well as the presence of antibodies against Helicobacter pylori, were measured by enzyme-linked immunosorbent assays (ELISA). Receiver operating characteristics (ROC) were used to compare the predictive powers of the selected factors. RESULTS:The serum concentrations of TFF1, TFF2, and TFF3 in the control groups were significantly lower than those in the gastric cancer group with the exception of TFF2 which was elevated in CAG. The area under the ROC curve for TFF3 was greater than that for the PG I/II ratio (0.81 vs 0.78). TFF3 also had a significantly higher predictive power for distinguishing gastric cancer than the PG test (odds ratio: 10.33 vs 2.57). Moreover, combining the serum TFF3 and PG tests for gastric cancer had better predictive power than either alone. CONCLUSIONS:Serum TFF3 may be a better predictor of gastric cancer than the PG test, while the combined testing of serum PG and TFF3 could further improve the efficacy of gastric cancer screening.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Huang Z,Zhang X,Lu H,Wu L,Wang D,Zhang Q,Ding Hdoi
10.1186/1471-230X-14-74subject
Has Abstractpub_date
2014-04-11 00:00:00pages
74issn
1471-230Xpii
1471-230X-14-74journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Advances in intensive care support such as therapeutic hypothermia or new liver assist devices have been the mainstay of treatment attempting to bridge the gap from acute liver failure to liver transplantation, but the efficacy of the available devices in reducing mortality has been questioned. To address th...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-79
更新日期:2011-07-14 00:00:00
abstract:BACKGROUND:Non-adherence to drug therapy is common in Inflammatory Bowel Disease (IBD). Patients' beliefs about treatment have an important influence on adherence. An in-depth understanding of this area is, therefore, important for patient-centred care. The aim of the study was to assess patients' perspectives and beli...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-7-20
更新日期:2007-06-08 00:00:00
abstract:BACKGROUNDS:Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in Asians. However, data on prevalence and factors associated with NAFLD in Asians are lacking. The aim of this study is to investigate the prevalence of NAFLD in Shanghai employees to assess the relationship between N...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-123
更新日期:2012-09-14 00:00:00
abstract:BACKGROUND:This study investigated a possible role of Escherichia coli in propagation and perpetuation of the chronic inflammation in ulcerative colitis (UC). The lesions of UC are located superficially on the rectal and/or colonic mucosa. It is suggested that the commensal bacteria of the digestive tract may play a ro...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-61
更新日期:2013-04-08 00:00:00
abstract:BACKGROUND:Adult lactase non-persistence (LNP) is due to low lactase expression, resulting in lactose malabsorption (LM). LNP is a genetic trait, but is typically determined by LM markers including breath H2, blood glucose, and urinary galactose after a lactose tolerance test. Known validity of these markers using milk...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01352-6
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:Little is known about the prognostic impact of cirrhosis on long-term survival of patients with combined hepatocellular-cholangiocarcinoma (cHCC-CC) after hepatic resection. The aim of this study was to elucidate the long-term outcome of hepatectomy in cHCC-CC patients with cirrhosis. METHODS:A total of 144...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0584-y
更新日期:2017-02-10 00:00:00
abstract:BACKGROUND:The value of abdominal echography in primary care is great because it is innocuous, inexpensive, easy to perform and provides a great deal of information making this the first examination to be requested in cases of probable abdominal disease. However, too many abdominal echographies are probably requested o...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-10-101
更新日期:2010-09-06 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection is commonly associated with a disturbance of glucose metabolism. However, there have been conflicting reports on whether the clearance of the HCV may be followed by changes of serum blood glucose and insulin resistance. The aim of the present study was to evaluate the impact...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1003-3
更新日期:2019-06-13 00:00:00
abstract:BACKGROUND:Wireless capsule pH-metry (WC) is better tolerated than standard nasal pH catheter (SC), but endoscopic placement is expensive. AIMS:to confirm that non-endoscopic peroral manometric placement of WC is as effective and better tolerated than SC and to perform a cost analysis of the available esophageal pH-me...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-230X-12-58
更新日期:2012-05-31 00:00:00
abstract:BACKGROUND:Patients with liver cirrhosis typically exhibit abnormal coagulation parameters in conventional coagulation tests (CCTs). Rotational thromboelastometry (ROTEM) is a holistic blood coagulation assay. This method provides an insight into the global hemostatic capabilities and has been suggested to provide a be...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01413-w
更新日期:2020-08-17 00:00:00
abstract:BACKGROUND:Self-expandable metallic stents (SEMSs) are widely used for palliation of malignant gastric outlet obstruction (GOO). There are two types of SEMS, covered and uncovered, each with its own advantages and disadvantages. We aimed to compare the efficacy and safety between uncovered and covered SEMSs in the pall...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-230X-14-170
更新日期:2014-09-30 00:00:00
abstract:BACKGROUND:Endothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various animal models. The present study was conducted to investigate the influence of exogenously and endog...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-16
更新日期:2004-08-06 00:00:00
abstract:BACKGROUND AND AIM:Carbohydrate deficient transferrin (CDT) is the most specific serum biomarker of heavy alcohol consumption, defined as ≥ 350-420 g alcohol/week. Despite introduction of a standardized reference measurement technique, widespread use of CDT remains limited due to low sensitivity. The aim of this study ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-97
更新日期:2014-05-22 00:00:00
abstract:BACKGROUND:Microcirculatory disturbance is an important factor in the pathogenesis of Inflammatory Bowel Disease (IBD) but there have been few studies in this field. Confocal Laser Endomicroscopy (CLE) has been used over the last 10 years and has made it possible to explore the changes in microcirculation of the coloni...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1037-6
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:A gluten-free diet (GFD) is the only effective treatment for celiac patients and assessing adherence to this diet is important. Celiac disease Adherence Test (CDAT) is a valid English-language questionnaire that is used for assessing the adherence to the GFD. In the present study, we aimed to translate the C...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01396-8
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Amebiasis is a rare condition in developed countries but epidemiologically growing. Clinical manifestation may range from asymptomatic to invasive disease, amoebic liver abscess being the most common manifestation. We report a peculiar case of left hepatic amoebic liver abscess in a patient without a well-kn...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01440-7
更新日期:2020-09-11 00:00:00
abstract:BACKGROUND:Foreign body ingestion complicated by perforation of the digestive tract is a well-known occurrence. Contrary to this, perforation by fishbones has most often been described in South East Asian populations, and has the unusual characteristic of often being paucisymptomatic until secondary complications occur...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-167
更新日期:2014-09-27 00:00:00
abstract:BACKGROUND:Compared with biofluids, target tissues and organs more directly reflect the pathophysiological state of a disease process. In this study, a D-galactosamine (GalN) / lipopolysaccharide (LPS)-induced mouse model was constructed to investigate metabonomics of liver tissue and directly characterize metabolic ch...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-73
更新日期:2013-04-29 00:00:00
abstract:BACKGROUND:To investigate the effect of albumin infusion on cirrhotic patients admitted for acute gastrointestinal bleeding. METHODS:Medical records of cirrhotic patients who admitted due to acute gastrointestinal bleeding through January 2009 to December 2018 were reviewed. Clinical data and the total amount of album...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01337-5
更新日期:2020-06-23 00:00:00
abstract:BACKGROUND:It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-light endoscopy (HD-WLE) in detecting serrated lesions in patients with prior serrated lesions > 5 mm not completely fulfilling serrated polyposis syndrome (SPS) criteria. METHODS:We conducted a randomized, cr...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12876-020-01257-4
更新日期:2020-04-16 00:00:00
abstract:BACKGROUND:Saturated fatty acids are thought to be of relevance for the development of non-alcoholic fatty liver disease and obesity. However, the underlying mechanisms are poorly understood. In previous studies we found that food-derived carbohydrates such as fructose alter the intestinal serotonergic system while ind...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-169
更新日期:2013-12-09 00:00:00
abstract:BACKGROUND:Pegylated interferon (PEG-IFN) alfa-2b is recommended for chronic hepatitis B (CHB). We aimed to investigate the sustainability of off-treatment responses among Chinese HBeAg-positive CHB patients treated with PEG-IFN alfa-2b from a randomized trial. METHODS:Eligible Chinese patients (n = 322) were followed...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12876-019-0981-5
更新日期:2019-05-02 00:00:00
abstract:BACKGROUND:Autoimmune hepatitis causes chronic hepatitis and often leads to cirrhosis and death without treatment. We wanted to see if having access to primary care or insurance prior to diagnosis is associated with better outcomes for patients in an urban, public hospital with mostly socioeconomically disadvantaged Hi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0318-y
更新日期:2015-07-28 00:00:00
abstract:BACKGROUND:Helicobacter pylori (H. pylori) infection and excessive salt intake are known as important risk factors for stomach cancer in humans. However, interactions of these two factors with gene expression profiles during gastric carcinogenesis remain unclear. In the present study, we investigated the global gene ex...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-122
更新日期:2013-07-30 00:00:00
abstract:BACKGROUND:In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several non-hepatological conditions but for PBC and PSC no data are available. This study aimed to identify...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-5-11
更新日期:2005-03-24 00:00:00
abstract:BACKGROUND:Idiopathic portal hypertension (IPH) is a disorder of unknown etiology and is characterized clinically by portal hypertension, splenomegaly, and hypersplenism accompanied by pancytopenia. This study evaluates the pathogenic concept of the disease by a systematic review of the literature and illustrates novel...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-122
更新日期:2010-10-20 00:00:00
abstract:BACKGROUND:It is believed that inflammatory bowel diseases (IBD) result from an imbalance in the intestinal immune response towards the luminal microbiome. Dectin-1 is a widely expressed pattern recognition receptor that recognizes fungi and upon recognition it mediates cytokine responses and skewing of the adaptive im...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-33
更新日期:2012-04-16 00:00:00
abstract:BACKGROUND:Rebamipide is a gastroprotective agent with promising results against gastric damage induced by non-steroidal anti-inflammatory drugs. The present study evaluated if rebamipide protects against naproxen-induced gastric damage in healthy volunteers. Changes in gastric PGE2 tissue concentration were also evalu...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12876-016-0472-x
更新日期:2016-06-04 00:00:00
abstract:BACKGROUND:Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity. METHODS:Thirty-seven UC ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-29
更新日期:2011-03-31 00:00:00
abstract:BACKGROUND:Pancreatic cancer has significant morbidity and mortality worldwide. Good prognosis relies on an early diagnosis. The purpose of this study was to develop techniques for identifying cancer biomarkers in the serum of patients with pancreatic cancer. METHODS:Serum samples from five individuals with pancreatic...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-68
更新日期:2010-06-29 00:00:00