Abstract:
BACKGROUND:Erdheim-Chester disease (ECD) is a rare multisystem non-Langerhans cell histiocytosis that is characterized histologically by xanthogranulomatous infiltrates and radiologically by symmetrical sclerosis of long bones. The xanthomatous process is characterized by prominent foamy histiocytes staining positive for CD68, occasionally for PS100 and negative for S100 and CD1a. Gastroenterological involvement is exceedingly rare. CASE PRESENTATION:This case report describes the case of a 69-year-old man who presented otherwise well to the gastroenterology department with unspecific abdominal symptoms, nausea, vomiting and weight loss. ECD involving the gastrointestinal tract was confirmed clinically, radiologically and histologically. CONCLUSION:Gastroenterological manifestation of ECD is rare but should be considered in the differential diagnosis in patients presenting with evidence of multi-organ disease and typical radiological features of Erdheim-Chester disease elsewhere.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Pan A,Doyle T,Schlup M,Lubcke R,Schultz Mdoi
10.1186/1471-230X-11-77subject
Has Abstractpub_date
2011-06-22 00:00:00pages
77issn
1471-230Xpii
1471-230X-11-77journal_volume
11pub_type
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