Abstract:
BACKGROUND:Calprotectin is a stable neutrophil protein, which can be measured in faecal samples. The faecal level of calprotectin increases during disease activity in ulcerative colitis (UC). Nonetheless, the relevance of faecal calprotectin (FC) measurement during granulomonocytapheresis (GMA) for UC has not yet been fully evaluated. This prospective study was to investigate the value of FC for assessing disease activity and predicting clinical course in UC patients undergoing GMA therapy. METHODS:One hundred and eighty-four patients with moderately active UC with endoscopic activity (Mayo endoscopic subscore [MES] = 2 or 3) received Adacolumn GMA therapy (10 apheresis sessions over consecutive 5 weeks). Patients who achieved clinical remission were subsequently given maintenance medications for 12 months. FC levels were measured at entry and after treatment. RESULTS:After GMA, 80 of the 184 patients (43%) achieved clinical remission, and 51 (28%) achieved mucosal healing (MH; MES = 0 or 1). The median FC level significantly decreased in patients who achieved MH (P = 0.02), but not in those without MH. Thirty-four patients (43%) relapsed during the 12-month follow-up. The median FC level at the end of GMA therapy was significantly higher in patients who subsequently relapsed than in those who maintained remission (149.5 vs 45.5 μg/g, P < 0.001). A cut off value of 114 μg/g had a sensitivity of 76% and a specificity of 85% to predict future relapse. CONCLUSIONS:Our findings indicate that FC is a relevant biomarker, which is convenient to measure for assessing endoscopic activity and predicting relapse in patients who achieve remission following a course of GMA therapy.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Shimoyama T,Yamamoto T,Umegae S,Matsumoto Kdoi
10.1186/s12876-018-0853-4subject
Has Abstractpub_date
2018-08-01 00:00:00pages
120issue
1issn
1471-230Xpii
10.1186/s12876-018-0853-4journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Infliximab (IFX) has proven to be an effective addition to the therapeutic arsenal for refractory, fistulizing, and steroid dependent Crohn's disease (CD), with efficacy in the induction and maintenance of clinical remission of CD. Our objective in this study is to report the nationwide, multicenter experien...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-9-66
更新日期:2009-09-10 00:00:00
abstract:BACKGROUND:Low 25-Hydroxy-vitamin-D; "25(OH)-D3" serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In this study, we aimed to evaluate changes in liver NK cells cytotoxicity due to modulations in VDR in C...
journal_title:BMC gastroenterology
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journal_title:BMC gastroenterology
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journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-10-101
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abstract:BACKGROUND:The oral multi-kinase inhibitor sunitinib malate improves the survival of patients with gastrointestinal stromal tumors (GIST) after the disease progresses or intolerance to imatinib mesylate develops. Urinary fistulae arising during treatment with sunitinib for GIST have not been described. CASE PRESENTATI...
journal_title:BMC gastroenterology
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journal_title:BMC gastroenterology
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journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析
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journal_title:BMC gastroenterology
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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abstract:BACKGROUND:As anorexia and hypermetabolism are common in cirrhosis, leptin levels may be increased in this disease. In this study, we investigated the relation between the severity of disease and serum leptin levels in post-hepatitis cirrhosis and the role of body composition, gender and viral aetiology of cirrhosis in...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
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更新日期:2004-09-23 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2021-01-06 00:00:00
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pub_type: 杂志文章
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更新日期:2013-04-29 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-04-16 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0533-1
更新日期:2016-10-06 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2019-02-11 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-06-04 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-06 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-08 00:00:00
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pub_type: 杂志文章
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更新日期:2012-11-16 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-12-17 00:00:00
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更新日期:2009-10-13 00:00:00
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pub_type: 杂志文章
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更新日期:2019-12-30 00:00:00
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:BMC gastroenterology
pub_type: 信件
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更新日期:2009-12-14 00:00:00