Faecal calprotectin level for assessing endoscopic activity and predicting future clinical course in patients with moderately active ulcerative colitis undergoing granulomonocytapheresis: a prospective cohort study.

Abstract:

BACKGROUND:Calprotectin is a stable neutrophil protein, which can be measured in faecal samples. The faecal level of calprotectin increases during disease activity in ulcerative colitis (UC). Nonetheless, the relevance of faecal calprotectin (FC) measurement during granulomonocytapheresis (GMA) for UC has not yet been fully evaluated. This prospective study was to investigate the value of FC for assessing disease activity and predicting clinical course in UC patients undergoing GMA therapy. METHODS:One hundred and eighty-four patients with moderately active UC with endoscopic activity (Mayo endoscopic subscore [MES] = 2 or 3) received Adacolumn GMA therapy (10 apheresis sessions over consecutive 5 weeks). Patients who achieved clinical remission were subsequently given maintenance medications for 12 months. FC levels were measured at entry and after treatment. RESULTS:After GMA, 80 of the 184 patients (43%) achieved clinical remission, and 51 (28%) achieved mucosal healing (MH; MES = 0 or 1). The median FC level significantly decreased in patients who achieved MH (P = 0.02), but not in those without MH. Thirty-four patients (43%) relapsed during the 12-month follow-up. The median FC level at the end of GMA therapy was significantly higher in patients who subsequently relapsed than in those who maintained remission (149.5 vs 45.5 μg/g, P < 0.001). A cut off value of 114 μg/g had a sensitivity of 76% and a specificity of 85% to predict future relapse. CONCLUSIONS:Our findings indicate that FC is a relevant biomarker, which is convenient to measure for assessing endoscopic activity and predicting relapse in patients who achieve remission following a course of GMA therapy.

journal_name

BMC Gastroenterol

journal_title

BMC gastroenterology

authors

Shimoyama T,Yamamoto T,Umegae S,Matsumoto K

doi

10.1186/s12876-018-0853-4

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

120

issue

1

issn

1471-230X

pii

10.1186/s12876-018-0853-4

journal_volume

18

pub_type

杂志文章
  • Efficacy and safety of infliximab induction therapy in Crohn's Disease in Central Europe--a Hungarian nationwide observational study.

    abstract:BACKGROUND:Infliximab (IFX) has proven to be an effective addition to the therapeutic arsenal for refractory, fistulizing, and steroid dependent Crohn's disease (CD), with efficacy in the induction and maintenance of clinical remission of CD. Our objective in this study is to report the nationwide, multicenter experien...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-230X-9-66

    authors: Miheller P,Lakatos PL,Horváth G,Molnár T,Szamosi T,Czeglédi Z,Salamon A,Czimmer J,Rumi G,Palatka K,Papp M,Jakab Z,Szabó A,Gelley A,Lakatos L,Barta Z,Balázs C,Rácz I,Zeher M,Döbrönte Z,Altorjay I,Hunyady B,Simo

    更新日期:2009-09-10 00:00:00

  • 25(OH) D3 alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model of BALB/c mice due to modulations in vitamin D receptor.

    abstract:BACKGROUND:Low 25-Hydroxy-vitamin-D; "25(OH)-D3" serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In this study, we aimed to evaluate changes in liver NK cells cytotoxicity due to modulations in VDR in C...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01248-5

    authors: Salhab A,Amer J,Yinying L,Safadi R

    更新日期:2020-04-10 00:00:00

  • Efficacy of capillary pattern type IIIA/IIIB by magnifying narrow band imaging for estimating depth of invasion of early colorectal neoplasms.

    abstract:BACKGROUND:Capillary patterns (CP) observed by magnifying Narrow Band Imaging (NBI) are useful for differentiating non-adenomatous from adenomatous colorectal polyps. However, there are few studies concerning the effectiveness of magnifying NBI for determining the depth of invasion in early colorectal neoplasms. We aim...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-33

    authors: Ikematsu H,Matsuda T,Emura F,Saito Y,Uraoka T,Fu KI,Kaneko K,Ochiai A,Fujimori T,Sano Y

    更新日期:2010-03-27 00:00:00

  • Adequacy and quality of abdominal echographies requested by primary care professionals.

    abstract:BACKGROUND:The value of abdominal echography in primary care is great because it is innocuous, inexpensive, easy to perform and provides a great deal of information making this the first examination to be requested in cases of probable abdominal disease. However, too many abdominal echographies are probably requested o...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-230X-10-101

    authors: Auladell MA,Caballeria L,Pera G,Rodríguez L,Casas JD,Aznar J,Miranda D,Sánchez C,Negrete A,Castellví JM,Bernad J,Canut S,Aubà J,Aizpurua MM,Torán P

    更新日期:2010-09-06 00:00:00

  • Vesicocutaneous fistula formation during treatment with sunitinib malate: Case report.

    abstract:BACKGROUND:The oral multi-kinase inhibitor sunitinib malate improves the survival of patients with gastrointestinal stromal tumors (GIST) after the disease progresses or intolerance to imatinib mesylate develops. Urinary fistulae arising during treatment with sunitinib for GIST have not been described. CASE PRESENTATI...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-128

    authors: Watanabe K,Otsu S,Morinaga R,Kawano S,Hirashima Y,Sakashita H,Shirao K

    更新日期:2010-11-01 00:00:00

  • Long intestinal tube splinting prevents postoperative adhesive small-bowel obstruction in sclerosing encapsulating peritonitis.

    abstract:BACKGROUND:Sclerosing encapsulating peritonitis (SEP) is a rare cause of small-bowel obstruction. The optimal treatment for this condition remains controversial. METHODS:In this study, we performed a retrospective analysis of the data of 44 patients who underwent surgery for SEP between December 2001 and 2008 at our h...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-180

    authors: Li M,Zhu W,Li Y,Jiang J,Li J,Li N

    更新日期:2014-11-25 00:00:00

  • Gastric cancer is associated with NOS2 -954G/C polymorphism and environmental factors in a Brazilian population.

    abstract:BACKGROUND:Gastric cancer can progress from a chronic inflammation of the gastric mucosa resulting from Helicobacter pylori infection that activates the inflammatory response of the host. Therefore, polymorphisms in genes involved in the inflammatory response, such as inducible nitric oxide synthase (NOS2), have been i...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-64

    authors: Jorge YC,Duarte MC,Silva AE

    更新日期:2010-06-17 00:00:00

  • Effect of antecolic or retrocolic reconstruction of the gastro/duodenojejunostomy on delayed gastric emptying after pancreaticoduodenectomy: a meta-analysis.

    abstract:BACKGROUND:Delayed gastric emptying (DGE) is one of the most frequent complications after pancreaticoduodenectomy (PD). This meta-analysis aimed to evaluate the effect of antecolic versus retrocolic reconstruction of gastro/duodenojejunostomy on DGE after PD. METHODS:Randomized controlled trials (RCTs) comparing antec...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12876-015-0300-8

    authors: Zhou Y,Lin J,Wu L,Li B,Li H

    更新日期:2015-06-16 00:00:00

  • Changes of Treg and Th17 cells balance in the development of acute and chronic hepatitis B virus infection.

    abstract:BACKGROUND:Many studies suggest that in chronic hepatitis B virus (HBV) infection regulate T (Treg) cells and interlukin-17-producing T help cells (Th17) are mutually antagonistic in the immune response. This study is aimed to reveal the cell differentiation environment and the significance of Treg and Th17 balance in ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-43

    authors: Xue-Song L,Cheng-Zhong L,Ying Z,Mo-Bin W

    更新日期:2012-05-01 00:00:00

  • Unsedated peroral wireless pH capsule placement vs. standard pH testing: a randomized study and cost analysis.

    abstract:BACKGROUND:Wireless capsule pH-metry (WC) is better tolerated than standard nasal pH catheter (SC), but endoscopic placement is expensive. AIMS:to confirm that non-endoscopic peroral manometric placement of WC is as effective and better tolerated than SC and to perform a cost analysis of the available esophageal pH-me...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-230X-12-58

    authors: Andrews CN,Sadowski DC,Lazarescu A,Williams C,Neshev E,Storr M,Au F,Heitman SJ

    更新日期:2012-05-31 00:00:00

  • Clinical predictors of incident gallstone disease in a Chinese population in Taipei, Taiwan.

    abstract:BACKGROUND:Gallstone disease (GSD) is a common gastrointestinal disorder throughout the world. The authors explored the incidence of GSD in Taiwan and its condition-associated predictive factors. METHODS:The initial study cohort comprised 2386 healthy adult participants, who were voluntarily admitted to a teaching hos...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-83

    authors: Chen JY,Hsu CT,Liu JH,Tung TH

    更新日期:2014-04-28 00:00:00

  • Child-Pugh classification dependent alterations in serum leptin levels among cirrhotic patients: a case controlled study.

    abstract:BACKGROUND:As anorexia and hypermetabolism are common in cirrhosis, leptin levels may be increased in this disease. In this study, we investigated the relation between the severity of disease and serum leptin levels in post-hepatitis cirrhosis and the role of body composition, gender and viral aetiology of cirrhosis in...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-230X-4-23

    authors: Bolukbas FF,Bolukbas C,Horoz M,Gumus M,Erdogan M,Zeyrek F,Yayla A,Ovunc O

    更新日期:2004-09-23 00:00:00

  • Chronic active EBV infection in refractory enteritis with longitudinal ulcers with a cobblestone appearance: an autopsied case report.

    abstract:BACKGROUND:Chronic active Epstein-Barr virus infection (CAEBV) is defined as Epstein-Barr virus (EBV)-positive T/NK cell-related neoplasia, and its major clinical symptom is systemic inflammation presenting as infectious mononucleocytosis, whereas enteritis and diarrhea are minor clinical symptoms. The complex mixture ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01589-1

    authors: Aihara Y,Moriya K,Shimozato N,Nagamatsu S,Kobayashi S,Uejima M,Matsuo H,Ishida E,Yagi H,Nakatani T,Yoshiji H,Kikuchi E

    更新日期:2021-01-06 00:00:00

  • Metabonomic analysis of liver tissue from BALB/c mice with D-galactosamine/lipopolysaccharide-induced acute hepatic failure.

    abstract:BACKGROUND:Compared with biofluids, target tissues and organs more directly reflect the pathophysiological state of a disease process. In this study, a D-galactosamine (GalN) / lipopolysaccharide (LPS)-induced mouse model was constructed to investigate metabonomics of liver tissue and directly characterize metabolic ch...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-13-73

    authors: Feng B,Wu S,Liu F,Gao Y,Dong F,Wei L

    更新日期:2013-04-29 00:00:00

  • Effects of pectin liquid on gastroesophageal reflux disease in children with cerebral palsy.

    abstract:BACKGROUND:The use of thickeners is a standard therapy for decreasing episodes of regurgitation or vomiting in infants. However, it remains to be investigated whether thickener is effective for vomiting and/or chronic respiratory symptoms in children with cerebral palsy. METHODS:We enrolled 18 neurologically impaired ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-230X-8-11

    authors: Miyazawa R,Tomomasa T,Kaneko H,Arakawa H,Shimizu N,Morikawa A

    更新日期:2008-04-16 00:00:00

  • Collagenous colitis presenting as spontaneous perforation in an 80 year old woman: Report of a Case.

    abstract:BACKGROUND:Perforation of the colon occurring during or shortly following colonoscopy or barium enema is a rare complication of collagenous colitis (CC). "Spontaneous" perforation in CC, in which no instigating factor is identified, is even less common, with only five cases reported to date. We report herein an additio...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-016-0533-1

    authors: Mitchell A,Dugas A

    更新日期:2016-10-06 00:00:00

  • Clinical and molecular characterization of a patient with mitochondrial Neurogastrointestinal Encephalomyopathy.

    abstract:BACKGROUND:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP). MNGIE mainly presents with gastrointestinal symptoms and is mostly misdiagnosed in many patients as malabsorption syndrome, inf...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01280-5

    authors: Habibzadeh P,Silawi M,Dastsooz H,Bahramjahan S,Ezzatzadegan Jahromi S,Ostovan VR,Yavarian M,Mofatteh M,Faghihi MA

    更新日期:2020-05-08 00:00:00

  • Chlamydia trachomatis antigens in enteroendocrine cells and macrophages of the small bowel in patients with severe irritable bowel syndrome.

    abstract:BACKGROUND:Inflammation and immune activation have repeatedly been suggested as pathogentic factors in irritable bowel syndrome (IBS). The driving force for immune activation in IBS remains unknown. The aim of our study was to find out if the obligate intracellular pathogen Chlamydia could be involved in the pathogenes...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-19

    authors: Dlugosz A,Törnblom H,Mohammadian G,Morgan G,Veress B,Edvinsson B,Sandström G,Lindberg G

    更新日期:2010-02-16 00:00:00

  • Reactive lymphoid hyperplasia of the liver in a patient with colon cancer: report of two cases.

    abstract:BACKGROUND:Reactive lymphoid hyperplasia (RLH) of the liver is very rarely reported, and we encountered two cases of RLH of the liver in a patient with colon cancer. CASE PRESENTATION:In the first case, a 77-year-old woman was admitted for the surgical removal of a ascending colon cancer. A hepatic tumor in the left l...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-6-25

    authors: Takahashi H,Sawai H,Matsuo Y,Funahashi H,Satoh M,Okada Y,Inagaki H,Takeyama H,Manabe T

    更新日期:2006-09-12 00:00:00

  • Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase.

    abstract:BACKGROUND:Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated. METHODS:Wistar rats were used (6 in each group)--Groups: (1) sham, (2) ischemia...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230x-2-22

    authors: Serracino-Inglott F,Virlos IT,Habib NA,Williamson RC,Mathie RT

    更新日期:2002-09-20 00:00:00

  • Hepatic sonic hedgehog protein expression measured by computer assisted morphometry significantly correlates with features of non-alcoholic steatohepatitis.

    abstract:BACKGROUND:Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnosis of NASH. This pilot study was designed to confirm that staining for SHH is useful in NASH diagnos...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-0951-y

    authors: Estep M,Mehta R,Bratthauer G,Alaparthi L,Monge F,Ali S,Abdelatif D,Younoszai Z,Stepanova M,Goodman ZD,Younossi ZM

    更新日期:2019-02-11 00:00:00

  • A rapid, simple questionnaire to assess gastrointestinal symptoms after oral ferrous sulphate supplementation.

    abstract:BACKGROUND:Oral iron supplementation is often associated with rapid onset of gastrointestinal side-effects. The aim of this study was to develop and trial a short, simple questionnaire to capture these early side-effects and to determine which symptoms are more discriminating. METHODS:The study was a double-blind plac...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-230X-14-103

    authors: Pereira DI,Couto Irving SS,Lomer MC,Powell JJ

    更新日期:2014-06-04 00:00:00

  • Case report: an aortic aneurysm as cause of pseudoachalasia.

    abstract:BACKGROUND:Pseudoachalasia is a rare disorder which has clinical, radiographic, and manometric findings that are often indistinguishable from primary achalasia. It is usually associated with malignancy. Few reports describe vascular compression as a cause of pseudoachalasia. CASE PRESENTATION:Here we present a case of...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01198-y

    authors: Dejaeger M,Lormans M,Dejaeger E,Fagard K

    更新日期:2020-03-06 00:00:00

  • Real-world clinical effectiveness and safety of vedolizumab and anti-tumor necrosis factor alpha treatment in ulcerative colitis and Crohn's disease patients: a German retrospective chart review.

    abstract:BACKGROUND:Real-world comparisons of biologic treatment outcomes for ulcerative colitis (UC) or Crohn's disease (CD) patients are limited. We sought to evaluate the real-world effectiveness of vedolizumab (VDZ) and anti-tumor necrosis factor alpha (anti-TNFα) in UC and CD patients in Germany. METHODS:A retrospective c...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01332-w

    authors: Helwig U,Mross M,Schubert S,Hartmann H,Brandes A,Stein D,Kempf C,Knop J,Campbell-Hill S,Ehehalt R

    更新日期:2020-07-08 00:00:00

  • Rumination syndrome in children and adolescents: a school survey assessing prevalence and symptomatology.

    abstract:BACKGROUND:Rumination syndrome (RS) is a functional gastrointestinal disorder (FGD) increasingly recognized in children and adolescents. The epidemiology of this condition in school aged children is poorly understood. The main objective of this study was to assess the prevalence of rumination and other related associat...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-163

    authors: Rajindrajith S,Devanarayana NM,Crispus Perera BJ

    更新日期:2012-11-16 00:00:00

  • Plastic or metal stents for benign extrahepatic biliary strictures: a systematic review.

    abstract:BACKGROUND:Benign biliary strictures may be a consequence of surgical procedures, chronic pancreatitis or iatrogenic injuries to the ampulla. Stents are increasingly being used for this indication, however it is not completely clear which stent type should be preferred. METHODS:A systematic review on stent placement f...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1186/1471-230X-9-96

    authors: van Boeckel PG,Vleggaar FP,Siersema PD

    更新日期:2009-12-17 00:00:00

  • Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.

    abstract:BACKGROUND:Intestinal metaplasia (IM) is an important precursor lesion in the development of gastric cancer (GC). The aim of this study was to investigate genetic factors previously linked to GC risk for their possible association with IM. A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-9-76

    authors: Zhu F,Loh M,Hill J,Lee S,Koh KX,Lai KW,Salto-Tellez M,Iacopetta B,Yeoh KG,Soong R,Singapore Gastric Cancer Consortium.

    更新日期:2009-10-13 00:00:00

  • "Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study".

    abstract:BACKGROUND:A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Jap...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-1152-4

    authors: Mardian Y,Yano Y,Ratnasari N,Choridah L,Wasityastuti W,Setyawan NH,Hayashi Y

    更新日期:2019-12-30 00:00:00

  • TNF-alpha induced endothelial MAdCAM-1 expression is regulated by exogenous, not endogenous nitric oxide.

    abstract:BACKGROUND:MAdCAM-1 is an adhesion molecule expressed in Peyer's patches and lymphoid tissues which is mobilized by cytokines like TNF-alpha and is a major determinant of lymphocyte trafficking to the gut in human inflammatory bowel disease (IBD). It has been suggested that both reactive oxygen and nitrogen metabolites...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230x-1-5

    authors: Oshima T,Jordan P,Grisham MB,Alexander JS,Jennings M,Sasaki M,Manas K

    更新日期:2001-01-01 00:00:00

  • A proposal for a new clinical classification of chronic pancreatitis.

    abstract:BACKGROUND:The clinical course of chronic pancreatitis is still unpredictable, which relates to the lack of the availability of a clinical classification. Therefore, patient populations cannot be compared, the course and the outcome of the disease remain undetermined in the individual patient, and treatment is not stan...

    journal_title:BMC gastroenterology

    pub_type: 信件

    doi:10.1186/1471-230X-9-93

    authors: Büchler MW,Martignoni ME,Friess H,Malfertheiner P

    更新日期:2009-12-14 00:00:00