Abstract:
BACKGROUND:The current clinical practice on chronic hepatitis B (CHB) requires better on-treatment monitoring of viral persistence. Quantified assays for hepatitis B surface antigen (HBsAg) and core-related antigen (HBcrAg) hold promise for further optimization of therapy. Here, we aimed to characterize HBcrAg during the natural course of CHB. METHODS:Four-hundred and forty four treatment naïve CHB patients, who all underwent liver histology examination, were enrolled in this cross-sectional study. Their HBV DNA, HBsAg, HBeAg and HBcrAg titres were quantified and analyzed in the context of four distinct clinical phases. Correlation of HBcrAg and HBsAg with other markers were performed. The relationship between liver and serum antigen levels were also assessed. RESULTS:HBcrAg, like HBsAg, exhibited high degree of correlation with HBV DNA. However, a more significant linear relationship was found between HBcrAg and HBeAg titre in immune tolerant (IT) and immune clearance (IC) phases, while in HBeAg negative hepatitis (ENH) group, HBV DNA is a major determinant of HBcrAg. Significant difference was observed in liver HBcAg score and HBcrAg level in both IT and IC phases whereas barely significant positive correlations between liver HBsAg score and HBsAg titre was documented. CONCLUSION:HBcrAg titre exhibited distinct correlative profile in a phase-specific manner. In addition, its level is well-related to the intrahepatic expression of core antigen. It has a considerable utility in monitoring and refining antiviral therapy.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Zhang ZQ,Zhang XN,Lu W,Wang YB,Weng QC,Feng YLdoi
10.1186/s12876-017-0703-9subject
Has Abstractpub_date
2017-12-04 00:00:00pages
140issue
1issn
1471-230Xpii
10.1186/s12876-017-0703-9journal_volume
17pub_type
杂志文章abstract:BACKGROUND:The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening markers for the presence of EV are of interest. Here, we aim to investigate whether non-inflammatory gall...
journal_title:BMC gastroenterology
pub_type: 杂志文章
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journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1186/s12876-015-0300-8
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journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1186/s12876-020-01435-4
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0850-7
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pub_type: 杂志文章
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