Hypophosphataemia after ferric carboxymaltose is unrelated to symptoms, intestinal inflammation or vitamin D status.

Abstract:

BACKGROUND:Intravenous iron replacement is recommended for iron-deficient patients with inflammatory bowel disease (IBD), but may be associated with hypophosphataemia, predisposing to osteomalacia and fractures. This study aimed to evaluate the incidence and risk factors for hypophosphataemia following intravenous ferric carboxymaltose (FCM) in patients with IBD. METHODS:This prospective observational study of patients with and without IBD evaluated serum phosphate for 28 days following intravenous FCM, and assessed associations with symptoms, markers of inflammation and vitamin D status. RESULTS:Twenty-four patients with IBD (11 with Crohn's disease [CD], 13 with ulcerative colitis [UC], mean age 45 years [range 19-90], 7 female), and 20 patients without IBD (mean age 56 [22-88] y, 11 female), were included. Overall, serum phosphate declined by a mean of 36% at Day 7, with a mean fall of 42% (SD 19%) at some time point over 28 days (p <  0.001). Twenty-four of 44 (55%) patients developed moderate to severe hypophosphataemia (serum phosphate < 0.6 mmol/L). No differences between patients with and without IBD were seen, but patients with CD had greater decline in phosphate than those with UC. There was no association between hypophosphataemia and symptomatic adverse events, faecal calprotectin, C-reactive protein, albumin, platelet count, 25(OH) vitamin D, or 1,25(di-OH) vitamin D. Serum phosphate < 1.05 mmol/L on Day 2 predicted susceptibility to moderate-severe hypophosphataemia (OR 7.0). CONCLUSIONS:Hypophosphataemia following FCM is common, unrelated to symptomatic adverse events, baseline intestinal or systemic inflammation, or vitamin D status.

journal_name

BMC Gastroenterol

journal_title

BMC gastroenterology

authors

Fang W,Kenny R,Rizvi QU,McMahon LP,Garg M

doi

10.1186/s12876-020-01298-9

subject

Has Abstract

pub_date

2020-06-10 00:00:00

pages

183

issue

1

issn

1471-230X

pii

10.1186/s12876-020-01298-9

journal_volume

20

pub_type

杂志文章
  • Over-The-Scope-Clip pre-mounted onto a double balloon enteroscope for fast and successful closure of post-EMR jejunal perforation: case report.

    abstract:BACKGROUND:Familial adenomatous polyposis (FAP) is a rare, autosomal dominant disease clinically characterized by the early onset of many adenomatous polyps throughout the colon, which turn into colon cancer, if left untreated. In FAP patients, polyps can also occur in the upper gastrointestinal (GI) tract, especially ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-017-0718-2

    authors: Purchiaroni F,Nakajima T,Sakamoto T,Abe S,Saito Y

    更新日期:2017-12-08 00:00:00

  • Gynecomastia during imatinib mesylate treatment for gastrointestinal stromal tumor: a rare adverse event.

    abstract:BACKGROUND:Imatinib mesylate has been the standard therapeutic treatment for chronic myeloid leukemia, advanced and metastatic gastrointestinal stromal tumor (GIST). It is well tolerated with mild adverse effects. Gynecomastia development during the course of treatment has been rarely reported. METHODS:Ninety-eight pa...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-116

    authors: Liu H,Liao G,Yan Z

    更新日期:2011-11-02 00:00:00

  • Inter-observer agreement in the assessment of endoscopic findings in ulcerative colitis.

    abstract:BACKGROUND:Endoscopic findings are essential in evaluating the disease activity in ulcerative colitis. The aim of this study was to evaluate how endoscopists assess individual endoscopic features of mucosal inflammation in ulcerative colitis, the inter-observer agreement, and the importance of the observers' experience...

    journal_title:BMC gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-230X-4-9

    authors: de Lange T,Larsen S,Aabakken L

    更新日期:2004-05-18 00:00:00

  • Efficacy and safety of infliximab induction therapy in Crohn's Disease in Central Europe--a Hungarian nationwide observational study.

    abstract:BACKGROUND:Infliximab (IFX) has proven to be an effective addition to the therapeutic arsenal for refractory, fistulizing, and steroid dependent Crohn's disease (CD), with efficacy in the induction and maintenance of clinical remission of CD. Our objective in this study is to report the nationwide, multicenter experien...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-230X-9-66

    authors: Miheller P,Lakatos PL,Horváth G,Molnár T,Szamosi T,Czeglédi Z,Salamon A,Czimmer J,Rumi G,Palatka K,Papp M,Jakab Z,Szabó A,Gelley A,Lakatos L,Barta Z,Balázs C,Rácz I,Zeher M,Döbrönte Z,Altorjay I,Hunyady B,Simo

    更新日期:2009-09-10 00:00:00

  • Lymphatic marker podoplanin/D2-40 in human advanced cirrhotic liver--re-evaluations of microlymphatic abnormalities.

    abstract:BACKGROUND:From the morphological appearance, it was impossible to distinguish terminal portal venules from small lymphatic vessels in the portal tract even using histochemical microscopic techniques. Recently, D2-40 was found to be expressed at a high level in lymphatic endothelial cells (LECs). This study was underta...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-230X-10-131

    authors: Yokomori H,Oda M,Kaneko F,Kawachi S,Tanabe M,Yoshimura K,Kitagawa Y,Hibi T

    更新日期:2010-11-08 00:00:00

  • Laparoscopic versus conventional appendectomy--a meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Although laparoscopic surgery has been available for a long time and laparoscopic cholecystectomy has been performed universally, it is still not clear whether open appendectomy (OA) or laparoscopic appendectomy (LA) is the most appropriate surgical approach to acute appendicitis. The purpose of this work is...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/1471-230X-10-129

    authors: Li X,Zhang J,Sang L,Zhang W,Chu Z,Li X,Liu Y

    更新日期:2010-11-03 00:00:00

  • A novel collagen area fraction index to quantitatively assess bowel fibrosis in patients with Crohn's disease.

    abstract:BACKGROUND:A validated histopathological tool to precisely evaluate bowel fibrosis in patients with Crohn's disease is lacking. We attempted to establish a new index to quantify the severity of bowel fibrosis in patients with Crohn's disease-associated fibrostenosis. METHODS:We analyzed the histopathological data of 3...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-1100-3

    authors: Li XH,Fang ZN,Guan TM,Lin JJ,Sun CH,Huang SY,Mao R,Lu BL,Cao QH,Feng ST,Li ZP

    更新日期:2019-11-11 00:00:00

  • Serum trefoil factor 3 is a promising non-invasive biomarker for gastric cancer screening: a monocentric cohort study in China.

    abstract:BACKGROUND:The search for better non-invasive biomarkers for gastric cancer remains ongoing. We investigated the predictive power of serum trefoil factor (TFF) levels as biomarkers for gastric cancer in comparison with the pepsinogen (PG) test. METHODS:Patients with gastric cancer, chronic atrophic gastritis (CAG) or ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-74

    authors: Huang Z,Zhang X,Lu H,Wu L,Wang D,Zhang Q,Ding H

    更新日期:2014-04-11 00:00:00

  • Development of the Pediatric Quality of Life Inventory™ Eosinophilic Esophagitis module items: qualitative methods.

    abstract:BACKGROUND:Currently there is no disease-specific outcome measure to assess the health-related quality of life (HRQOL) of pediatric patients with Eosinophilic Esophagitis (EoE). Therefore, the objective of this qualitative study was to further develop and finalize the items and support the content validity for the new ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-135

    authors: Franciosi JP,Hommel KA,Greenberg AB,DeBrosse CW,Greenler AJ,Abonia JP,Rothenberg ME,Varni JW

    更新日期:2012-09-25 00:00:00

  • Comparison of sequential therapy and amoxicillin/tetracycline containing bismuth quadruple therapy for the first-line eradication of Helicobacter pylori: a prospective, multi-center, randomized clinical trial.

    abstract:BACKGROUND:The <80 % Helicobacter pylori eradication rate with sequential therapy is unsatisfactory. Modified bismuth quadruple therapy, replacing metronidazole with amoxicillin, could be promising because H. pylori resistance to tetracycline or to amoxicillin is relatively low. A 14-day modified bismuth quadruple prot...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12876-016-0490-8

    authors: Lee JY,Kim N,Park KS,Kim HJ,Park SM,Baik GH,Shim KN,Oh JH,Choi SC,Kim SE,Kim WH,Park SY,Kim GH,Lee BE,Jo Y,Hong SJ

    更新日期:2016-07-26 00:00:00

  • The characteristics of nivolumab-induced colitis: an evaluation of three cases and a literature review.

    abstract:BACKGROUND:The use of immune-checkpoint inhibitors in cancer treatment has become increasingly common, resulting in an increase in the incidence of related side effects. Diarrhoea and colitis have been previously documented as gastrointestinal tract-related side effects of immune-checkpoint inhibitors. Although PD-1/PD...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1186/s12876-018-0864-1

    authors: Yamauchi R,Araki T,Mitsuyama K,Tokito T,Ishii H,Yoshioka S,Kuwaki K,Mori A,Yoshimura T,Tsuruta O,Torimura T

    更新日期:2018-08-31 00:00:00

  • Gastric bacterial Flora in patients Harbouring Helicobacter pylori with or without chronic dyspepsia: analysis with matrix-assisted laser desorption ionization time-of-flight mass spectroscopy.

    abstract:BACKGROUND:The gastric microbiota has recently been implicated in the causation of organic/structural gastroduodenal diseases (gastric and duodenal ulcers, gastric cancer) in patients with Helicobacter pylori (H. pylori) infection. We aimed to ascertain, in patients harbouring H. pylori, the role of the gastric microbi...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0744-8

    authors: Pereira V,Abraham P,Nallapeta S,Shetty A

    更新日期:2018-01-26 00:00:00

  • Clinical characteristics of hepatic Arterioportal shunts associated with hepatocellular carcinoma.

    abstract:BACKGROUND:Hepatic arterioportal shunt (A-P shunt) is defined as the direct blood flow established between hepatic artery and portal venous system; it is frequently observed in patients with hepatocellular carcinoma (HCC). Clinically, it is important to diagnose HCC associated A-P shunts, as it may impact the treatment...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0899-3

    authors: Wu H,Zhao W,Zhang J,Han J,Liu S

    更新日期:2018-11-12 00:00:00

  • Effect of antecolic or retrocolic reconstruction of the gastro/duodenojejunostomy on delayed gastric emptying after pancreaticoduodenectomy: a meta-analysis.

    abstract:BACKGROUND:Delayed gastric emptying (DGE) is one of the most frequent complications after pancreaticoduodenectomy (PD). This meta-analysis aimed to evaluate the effect of antecolic versus retrocolic reconstruction of gastro/duodenojejunostomy on DGE after PD. METHODS:Randomized controlled trials (RCTs) comparing antec...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12876-015-0300-8

    authors: Zhou Y,Lin J,Wu L,Li B,Li H

    更新日期:2015-06-16 00:00:00

  • Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis.

    abstract:BACKGROUND:This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure stiffness, and a radio frequency (RF) vascular quantitative ultrasound technique to measure changes ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0910-z

    authors: Li JH,Zhu N,Min YB,Shi XZ,Duan YY,Yang YL

    更新日期:2018-12-05 00:00:00

  • The overmethylated genes in Helicobacter pylori-infected gastric mucosa are demethylated in gastric cancers.

    abstract:BACKGROUND:The transitional-CpG sites between weakly methylated genes and densely methylated retroelements are overmethylated in the gastric mucosa infected with Helicobacter pylori (H. pylori) and they are undermethylated in the gastric cancers depending on the level of loss of heterozygosity (LOH) events. This study ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-137

    authors: Hong SJ,Oh JH,Jeon EJ,Min KO,Kang MI,Choi SW,Rhyu MG

    更新日期:2010-11-20 00:00:00

  • "Fast track" rehabilitation after gastric cancer resection: experience with 80 consecutive cases.

    abstract:BACKGROUND:To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. METHODS:Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic an...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-147

    authors: Song JX,Tu XH,Wang B,Lin C,Zhang ZZ,Lin LY,Wang L

    更新日期:2014-08-18 00:00:00

  • Histological improvement in chronic hepatitis B patients treated with bicyclol: real world experience.

    abstract:BACKGROUND:Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes after bicyclol treatment in these patients are scarce. Therefore, this study has been conducted to fin...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-1005-1

    authors: Chi X,Xiao H,Shi M,Cai G,Xie Y,Jiang J,Tian G,Wu S,Zhang C,Zhao P,Chen J

    更新日期:2019-06-13 00:00:00

  • Rectal forceps biopsy procedure in cystic fibrosis: technical aspects and patients perspective for clinical trials feasibility.

    abstract:BACKGROUND:Measurements of CFTR function in rectal biopsies ex vivo have been used for diagnosis and prognosis of Cystic Fibrosis (CF) disease. Here, we aimed to evaluate this procedure regarding: i) viability of the rectal specimens obtained by biopsy forceps for ex vivo bioelectrical and biochemical laboratory analys...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-13-91

    authors: Servidoni MF,Sousa M,Vinagre AM,Cardoso SR,Ribeiro MA,Meirelles LR,de Carvalho RB,Kunzelmann K,Ribeiro AF,Ribeiro JD,Amaral MD

    更新日期:2013-05-20 00:00:00

  • The prevalence, incidence and natural history of primary sclerosing cholangitis in an ethnically diverse population.

    abstract:BACKGROUND:Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease often associated with inflammatory bowel diseases (IBD). Current epidemiological data are limited to studies of predominantly Caucasian populations. Our aim was to define the epidemiology of PSC in a large, ethnically diverse US...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-83

    authors: Toy E,Balasubramanian S,Selmi C,Li CS,Bowlus CL

    更新日期:2011-07-18 00:00:00

  • Folate levels in hepatocellular carcinoma patients with portal vein thrombosis.

    abstract:BACKGROUND:Portal vein thrombosis (PVT) occurs frequently in hepatocellular carcinoma (HCC) and is often diagnosed in the course of a routine patient evaluation and surveillance for liver cancer. The purpose of this study is to investigate the relationship between folate status and portal vein thrombosis. METHODS:HCC ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01525-3

    authors: Malaguarnera G,Catania VE,Latteri S,Borzì AM,Bertino G,Madeddu R,Drago F,Malaguarnera M

    更新日期:2020-11-10 00:00:00

  • Tracking the foreign body, a rare cause of hepatic abscess.

    abstract:BACKGROUND:Foreign body ingestion complicated by perforation of the digestive tract is a well-known occurrence. Contrary to this, perforation by fishbones has most often been described in South East Asian populations, and has the unusual characteristic of often being paucisymptomatic until secondary complications occur...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-167

    authors: Dangoisse C,Laterre PF

    更新日期:2014-09-27 00:00:00

  • Pre-study protocol MagPEP: a multicentre randomized controlled trial of magnesium sulphate in the prevention of post-ERCP pancreatitis.

    abstract:BACKGROUND:Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effectively reducing the incidence of ERCP-induced pancreatitis has found its way into clinical practise. ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-230X-13-11

    authors: Fluhr G,Mayerle J,Weber E,Aghdassi A,Simon P,Gress T,Seufferlein T,Mössner J,Stallmach A,Rösch T,Müller M,Siegmund B,Büchner-Steudel P,Zuber-Jerger I,Kantowski M,Hoffmeister A,Rosendahl J,Linhart T,Maul J,Czakó L,

    更新日期:2013-01-15 00:00:00

  • Sensitivity is not an intrinsic property of a diagnostic test: empirical evidence from histological diagnosis of Helicobacter pylori infection.

    abstract:BACKGROUND:We aimed to provide empirical evidence of how spectrum effects can affect the sensitivity of histological assessment of Helicobacter pylori infection, which may contribute to explain the heterogeneity in prevalence estimates across populations with expectedly similar prevalence. METHODS:Cross-sectional eval...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-9-98

    authors: Lunet N,Peleteiro B,Carrilho C,Figueiredo C,Azevedo A

    更新日期:2009-12-24 00:00:00

  • Acupuncture for irritable bowel syndrome: a protocol for a pragmatic randomised controlled trial.

    abstract:BACKGROUND:There is insufficient evidence on the effectiveness of acupuncture for irritable bowel syndrome (IBS) for conclusions to be drawn. Given the current interest in acupuncture by patients, it is in the public interest to establish more rigorous evidence. Building on the positive findings from a pilot study, in ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-230X-10-63

    authors: MacPherson H,Bland M,Bloor K,Cox H,Geddes D,Kang'ombe A,Reynolds J,Stamuli E,Stuardi T,Tilbrook H,Torgerson D,Whorwell P

    更新日期:2010-06-17 00:00:00

  • Mini-Mental State Examination in patients with hepatic encephalopathy and liver cirrhosis: a prospective, quantified electroencephalography study.

    abstract:BACKGROUND:Mini-Mental State Examination (MMSE) is one of the most commonly used methods in the assessment of cognitive mental status. MMSE has been used in hepatology but its usefulness in the evaluation of hepatic encephalopathy (HE) has never been properly assessed. The aim of the study was to investigate the value ...

    journal_title:BMC gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-230X-13-107

    authors: Koziarska D,Wunsch E,Milkiewicz M,Wójcicki M,Nowacki P,Milkiewicz P

    更新日期:2013-07-02 00:00:00

  • Association between NAFLD and risk of prevalent chronic kidney disease: why there is a difference between east and west?

    abstract:BACKGROUNDS:There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this and to clarify the association between NAFLD and CKD by analyzing two population-based datasets from ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01278-z

    authors: Zhang M,Lin S,Wang MF,Huang JF,Liu SY,Wu SM,Zhang HY,Wu ZM,Liu WY,Zhang DC,Hao CM,Zhu YY,Zheng MH,Wang XZ

    更新日期:2020-05-06 00:00:00

  • The 1000IBD project: multi-omics data of 1000 inflammatory bowel disease patients; data release 1.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) is a chronic complex disease of the gastrointestinal tract. Patients with IBD can experience a wide range of symptoms, but the pathophysiological mechanisms that cause these individual differences in clinical presentation remain largely unknown. In consequence, IBD is current...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0917-5

    authors: Imhann F,Van der Velde KJ,Barbieri R,Alberts R,Voskuil MD,Vich Vila A,Collij V,Spekhorst LM,Van der Sloot KWJ,Peters V,Van Dullemen HM,Visschedijk MC,Festen EAM,Swertz MA,Dijkstra G,Weersma RK

    更新日期:2019-01-08 00:00:00

  • Chronic active EBV infection in refractory enteritis with longitudinal ulcers with a cobblestone appearance: an autopsied case report.

    abstract:BACKGROUND:Chronic active Epstein-Barr virus infection (CAEBV) is defined as Epstein-Barr virus (EBV)-positive T/NK cell-related neoplasia, and its major clinical symptom is systemic inflammation presenting as infectious mononucleocytosis, whereas enteritis and diarrhea are minor clinical symptoms. The complex mixture ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01589-1

    authors: Aihara Y,Moriya K,Shimozato N,Nagamatsu S,Kobayashi S,Uejima M,Matsuo H,Ishida E,Yagi H,Nakatani T,Yoshiji H,Kikuchi E

    更新日期:2021-01-06 00:00:00

  • Fluoroless intravascular ultrasound image-guided liver navigation in porcine models.

    abstract:BACKGROUND:An intravascular ultrasound catheter (IVUSc) was developed for intracardiac ultrasound to assess interventions with compelling results. However, intrahepatic vascular exploration was rarely tested and was always associated with X-ray techniques. The aim of this study was to demonstrate the feasibility to nav...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-021-01600-3

    authors: Urade T,Verde JM,García Vázquez A,Gunzert K,Pessaux P,Marescaux J,Giménez ME

    更新日期:2021-01-09 00:00:00