Abstract：
BACKGROUND:Portal vein thrombosis (PVT) occurs frequently in hepatocellular carcinoma (HCC) and is often diagnosed in the course of a routine patient evaluation and surveillance for liver cancer. The purpose of this study is to investigate the relationship between folate status and portal vein thrombosis. METHODS:HCC with PVT patients were 78, HCC without PVT were 60 and control subjects were 70 randomly selected. We evaluate serum and red blood cellular folate, homocysteine, alpha fetal protein cholesterol, triglycerides, prothrombin time. RESULTS:HCC patients with PVT showed lower levels of serum folate, respect HCC patients without PVT, with an average difference of 1.6 nmol/l p < 0.01 (95% CI - 2.54 to - 0.66), red cell folate 33.6 nmol/l p < 0.001 (95% CI - 43.64 to - 23.55) and albumin 0.29 g/dl p < 0.001 (95% CI - 0.42 to - 0.15); PVT patients displayed higher levels of bilirubin 0.53 mg/dl p < 0.001 (95% CI 0.23 to 0.78), INR 0.91 p < 0.001 (95% CI 0.72 to 1.09), γGT 7.9 IU/l (95% CI 4.14 to 11.65) and homocysteine 4.6 μmol/l p < 0.05 (95% CI 0.32 to 8.87) CONCLUSION: The low folate concentration and higher levels of homocysteine are associated with the loss of antithrombotic function, and with a more aggressive course of HCC and with a higher change of complications related to portal vein thrombosis.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Malaguarnera G,Catania VE,Latteri S,Borzì AM,Bertino G,Madeddu R,Drago F,Malaguarnera Mdoi
10.1186/s12876-020-01525-3subject
Has Abstractpub_date
2020-11-10 00:00:00pages
375issue
1issn
1471-230Xpii
10.1186/s12876-020-01525-3journal_volume
20pub_type
杂志文章abstract：BACKGROUND:Enteric glia cells (EGC) play an important role in the maintenance of intestinal mucosa integrity. During the course of acute Crohn's disease (CD), mucosal EGC progressively undergo apoptosis, though the mechanisms are largely unknown. We investigated the role of Glial-derived neurotrophic factor (GDNF) in t...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/1471-230X-12-6
更新日期：2012-01-17 00:00:00
abstract：BACKGROUND:Hepatic artery dissection after liver transplantation is an uncommon morbidity. The onset mechanism and management for this disorder remain unclear. The present report describes the cases of two patients with hepatic artery dissection after living-donor liver transplantation (LDLT) with simultaneous splenect...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-020-01528-0
更新日期：2020-11-12 00:00:00
abstract：BACKGROUND:This case seeks to highlight to endoscopists a rare benign disorder that may be encountered during endoscopy. Clinicians may be tempted to biopsy, which could lead to a catastrophic gastrointestinal haemorrhage. CASE PRESENTATION:A 66-year-old asymptomatic Caucasian male was referred for colonoscopy with a ...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-019-1118-6
更新日期：2019-11-27 00:00:00
abstract：BACKGROUNDS:Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in Asians. However, data on prevalence and factors associated with NAFLD in Asians are lacking. The aim of this study is to investigate the prevalence of NAFLD in Shanghai employees to assess the relationship between N...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/1471-230X-12-123
更新日期：2012-09-14 00:00:00
abstract：BACKGROUND:By means of 24 h multi-channel intraluminal impedance and pH recording (MII/pH), patients with heartburn and normal upper gastrointestinal endoscopy findings can be classified into those with non-erosive reflux disease (NERD) and those with reflux hypersensitivity (RH). Therefore, in this study, we investiga...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-017-0624-7
更新日期：2017-05-23 00:00:00
abstract：BACKGROUND:An epidermoid cyst in an intrapancreatic accessory spleen (ECIPAS) in the pancreas head is an extremely rare condition. The natural course of this condition is not well known, and it is difficult to diagnose before surgery due to the lack of specific imaging findings. CASE PRESENTATION:A tumor was found in ...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-020-01540-4
更新日期：2020-11-20 00:00:00
abstract：BACKGROUND:Patients with liver cirrhosis typically exhibit abnormal coagulation parameters in conventional coagulation tests (CCTs). Rotational thromboelastometry (ROTEM) is a holistic blood coagulation assay. This method provides an insight into the global hemostatic capabilities and has been suggested to provide a be...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-020-01413-w
更新日期：2020-08-17 00:00:00
abstract：BACKGROUND:Gastroparesis (Gp) is a poorly understood chronic gastrointestinal medical condition for which patient reported outcomes (PRO) are lacking. Previously developed symptoms scoring has been used for several decades. Using symptoms scores as a basis for documentation, 12 years of support/focus group patient feed...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-016-0523-3
更新日期：2016-08-31 00:00:00
abstract：BACKGROUND:Dysphagia and feeding intolerance are common in neurologically handicapped children. The aim is to determine the etiologies of feeding intolerance in neurologically handicapped children who are intolerant of tube feedings. METHODS:Eighteen neurologically handicapped children, followed in the Tube Feeding Cl...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/1471-230X-4-19
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abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver diseases, ranging from pure steatosis to nonalcoholic steatohepatitis (NASH), and eventually to liver cirrhosis with its complications. Identifying advanced fibrosis in patients is crucial to evaluating prognosis and possible therapeu...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/1471-230X-10-67
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abstract：BACKGROUND:Approximately 2.7 million Americans are chronically infected with hepatitis C virus (HCV). HCV patients with cirrhosis form the largest group of persons at high risk for hepatocellular carcinoma (HCC). Increased oxidative stress is regarded as a major mechanism of HCV-related liver disease progression. Defic...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-016-0432-5
更新日期：2016-02-29 00:00:00
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journal_title：BMC gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1186/1471-230X-13-12
更新日期：2013-01-16 00:00:00
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journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-020-01396-8
更新日期：2020-07-29 00:00:00
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journal_title：BMC gastroenterology
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2012-10-25 00:00:00
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journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-020-01440-7
更新日期：2020-09-11 00:00:00
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journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-015-0405-0
更新日期：2016-01-12 00:00:00
abstract：BACKGROUND:Hepatitis C virus (HCV) infection is commonly associated with a disturbance of glucose metabolism. However, there have been conflicting reports on whether the clearance of the HCV may be followed by changes of serum blood glucose and insulin resistance. The aim of the present study was to evaluate the impact...
journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-019-1003-3
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journal_title：BMC gastroenterology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1186/1471-230X-4-12
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pub_type： 杂志文章
doi：10.1186/s12876-021-01604-z
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journal_title：BMC gastroenterology
pub_type： 杂志文章
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journal_title：BMC gastroenterology
pub_type： 杂志文章,meta分析
doi：10.1186/1471-230x-2-17
更新日期：2002-07-15 00:00:00
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journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/s12876-018-0834-7
更新日期：2018-07-05 00:00:00
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journal_title：BMC gastroenterology
pub_type： 杂志文章,meta分析
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更新日期：2019-06-28 00:00:00
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journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/1471-230X-14-154
更新日期：2014-08-29 00:00:00
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pub_type： 杂志文章
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更新日期：2014-08-18 00:00:00
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journal_title：BMC gastroenterology
pub_type： 杂志文章
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journal_title：BMC gastroenterology
pub_type： 杂志文章
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更新日期：2017-08-07 00:00:00
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journal_title：BMC gastroenterology
pub_type： 杂志文章
doi：10.1186/1471-230X-12-106
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更新日期：2015-07-24 00:00:00
