Abstract:
BACKGROUND:Efforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells. In the present study, we described the first procedure of via hepatic artery transplantation of human fetal biliary tree stem cells in patients with advanced cirrhosis. METHODS:The cells were immune-sorted from human fetal biliary tree by protocols in accordance with current good manufacturing practice (cGMP) and extensively characterized. Two patients with advanced liver cirrhosis (Child-Pugh C) have been submitted to the procedure and observed through a 12 months follow-up. RESULTS:The resulting procedure was found absolutely safe. Immuno-suppressants were not required, and the patients did not display any adverse effects correlated with cell transplantation or suggestive of immunological complications. From a clinical point of view, both patients showed biochemical and clinical improvement during the 6 month follow-up and the second patient maintained a stable improvement for 12 months. CONCLUSION:This report represents proof of the concept that the human fetal biliary tree stem cells are a suitable and large source for cell therapy of liver cirrhosis. The isolation procedure can be carried out under cGMP conditions and, finally, the infusion procedure is easy and safe for the patients. This represents the basis for forthcoming controlled clinical trials.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Cardinale V,Carpino G,Gentile R,Napoletano C,Rahimi H,Franchitto A,Semeraro R,Nuti M,Onori P,Berloco PB,Rossi M,Bosco D,Brunelli R,Fraveto A,Napoli C,Torrice A,Gatto M,Venere R,Bastianelli C,Aliberti C,Salvatori Fdoi
10.1186/s12876-014-0204-zsubject
Has Abstractpub_date
2014-12-04 00:00:00pages
204issn
1471-230Xpii
s12876-014-0204-zjournal_volume
14pub_type
杂志文章abstract:BACKGROUND:Although laparoscopic surgery has been available for a long time and laparoscopic cholecystectomy has been performed universally, it is still not clear whether open appendectomy (OA) or laparoscopic appendectomy (LA) is the most appropriate surgical approach to acute appendicitis. The purpose of this work is...
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