Abstract:
BACKGROUND:Colorectal liver metastases (CLM) occur frequently and postoperative intestinal infection is a common complication. Our previous study showed that probiotics could decrease the rate of infectious complications after colectomy for colorectal cancer. To determine the effects of the perioperative administration of probiotics on serum zonulin levels which is a marker of intestinal permeability and the subsequent impact on postoperative infectious complications in patients with CLM. METHODS:150 patients with CLM were randomly divided into control group (n = 68) and probiotics group (n = 66). Probiotics and placebo were given orally for 6 days preoperatively and 10 days postoperatively to control group and probiotics group respectively. We used the local resection for metastatic tumor ,while for large tumor, the segmental hepatectomy. Postoperative outcome were recorded. Furthermore, complications in patients with normal intestinal barrier function and the relation with serum zonulin were analyzed to evaluate the impact on the liver barrier dysfunction. RESULTS:The incidence of infectious complications in the probiotics group was lower than control group. Analysis of CLM patients with normal postoperative intestinal barrier function paralleled with the serum zonulin level. And probiotics could also reduce the concentration of serum zonulin (P = 0.004) and plasma endotoxin (P < 0.001). CONCLUSION:Perioperative probiotics treatment could reduce the serum zonulin level, the rate of postoperative septicemia and maintain the liver barrier in patients undergoing CLM surgery. we propose a new model about the regulation of probiotics to liver barrier via clinical regulatory pathway. We recommend the preoperative oral intake of probiotics combined with postoperative continued probiotics treatment in patients who undergo CLM surgery. TRIAL REGISTRATION:ChiCTR-TRC- 12002841 . 2012/12/21.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Liu Z,Li C,Huang M,Tong C,Zhang X,Wang L,Peng H,Lan P,Zhang P,Huang N,Peng J,Wu X,Luo Y,Qin H,Kang L,Wang Jdoi
10.1186/s12876-015-0260-zsubject
Has Abstractpub_date
2015-03-20 00:00:00pages
34issn
1471-230Xpii
10.1186/s12876-015-0260-zjournal_volume
15pub_type
杂志文章,多中心研究,随机对照试验abstract:BACKGROUND:Symptoms suggestive of functional dyspepsia (FD) and irritable bowel syndrome (IBS) frequently overlap with those of gastroesophageal reflux disease. Despite the high prevalence of symptomatic overlap, the underlying etiology remains poorly defined. We assessed the correlation of symptomatic relief and healt...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-230X-13-145
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure stiffness, and a radio frequency (RF) vascular quantitative ultrasound technique to measure changes ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0910-z
更新日期:2018-12-05 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章
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更新日期:2013-01-16 00:00:00
abstract:BACKGROUND:To exam the biochemical, obstetric management and pregnancy outcome in women with intrahepatic cholestasis of pregnancy (ICP) and treatment with ursodeoxycholic acid (UDCA). METHODS:Pregnancy outcome in patients with ICP (N = 307) was studied and patients treated with UDCA (N = 208) vs. no UDCA were compare...
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doi:10.1186/s12876-017-0686-6
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01327-7
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abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a very common functional bowel disorder. However, the difference of depression and anxiety comorbidities among different IBS subtypes is still not well evaluated. This study aims to investigate the difference in the level and prevalence of depression and anxiety among health...
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-128
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:As anorexia and hypermetabolism are common in cirrhosis, leptin levels may be increased in this disease. In this study, we investigated the relation between the severity of disease and serum leptin levels in post-hepatitis cirrhosis and the role of body composition, gender and viral aetiology of cirrhosis in...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-4-23
更新日期:2004-09-23 00:00:00
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更新日期:2010-10-20 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-230X-8-47
更新日期:2008-10-20 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-131
更新日期:2013-08-22 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1186/s12876-020-01435-4
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-04-15 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2006-09-12 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2012-06-19 00:00:00