Changes of Treg and Th17 cells balance in the development of acute and chronic hepatitis B virus infection.


BACKGROUND:Many studies suggest that in chronic hepatitis B virus (HBV) infection regulate T (Treg) cells and interlukin-17-producing T help cells (Th17) are mutually antagonistic in the immune response. This study is aimed to reveal the cell differentiation environment and the significance of Treg and Th17 balance in the development of acute and chronic HBV infection. METHODS:Ten patients with acute HBV infection (AHB) and forty-eight patients with chronic HBV infection, including 12 asymptomatic HBV carriers (HBV carriers), 18 chronic hepatitis B patients (CHB) and 18 acute-on-chronic HBV-related liver failure (ACHBLF) were enrolled. Treg and Th17 cells differentiation related cytokine levels were detected by using ELISA. Flow cytometry was employed to count the Treg and Th17 frequency in peripheral blood. RESULTS:Compared to health controls both AHB and ACHBLF patients favoured Th17 cell differentiation, accompanied by a higher proportion of peripheral Th17 cells (P < 0.01) and high level of interleukin-17A (IL-17A) (P < 0.01). However, asymptomatic HBV carriers and CHB were conducive to Treg cell differentiation. In AHB and ACHBLF, peripheral blood IL-17A + CD4 + T cell frequency increased significantly compared with healthy controls. Changes of Treg and Th17 cell frequency were not completely consistent. Both CHB and ACHBLF had lower level of Treg/Th17 ratio than in health control (P < 0.05). Both plasm IL-17A levels (r = -0.72, p<0.001) and Th17 frequency(r = -0.49, p = 0.0003) negatively correlated with plasma HBV DNA load in patients with chronic HBV infection. In addition, both Th17 frequency and plasm IL-17A levels positively correlated with ALT (r = 0.33,p = 0.01 Vs r = 0.29, p = 0.04) and total bilirubin levels (r = 0.72,p<0.0001 Vs r = 0.53, p = 0.0001) in these chronic HBV-infected subjects. However, for AHB there were positive correlation between both Th17 frequency (r = 0.64, p = 0.04) and plasm IL-17A levels (r = 0.69, p = 0.02) with serum ALT levels, but no significant correlation between both HBV DNA level and total bilirubin level with Th17 frequency or plasm IL-17A levels were found. Furthermore, Treg/Th17 ratio was negatively correlated with total bilirubin levels (r = -0.41, p = 0.004) in chronic HBV-infected patients, especially in patients with ACHBLF (r = -0.69, p = 0.001) and positively correlated with viral load in these chronic HBV-infected subjects (r = 0.55, p<0.0001). CONCLUSIONS:Th17 cells are involved in acute and chronic HBV infection, especially in AHB and ACHBLF. CHB and ACHBLF patients manifested obvious Treg/Th17 ratio imbalance, which might be linked to disease progression and the continuous HBV infection.


BMC Gastroenterol


BMC gastroenterology


Xue-Song L,Cheng-Zhong L,Ying Z,Mo-Bin W




Has Abstract


2012-05-01 00:00:00










  • A novel collagen area fraction index to quantitatively assess bowel fibrosis in patients with Crohn's disease.

    abstract:BACKGROUND:A validated histopathological tool to precisely evaluate bowel fibrosis in patients with Crohn's disease is lacking. We attempted to establish a new index to quantify the severity of bowel fibrosis in patients with Crohn's disease-associated fibrostenosis. METHODS:We analyzed the histopathological data of 3...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Li XH,Fang ZN,Guan TM,Lin JJ,Sun CH,Huang SY,Mao R,Lu BL,Cao QH,Feng ST,Li ZP

    更新日期:2019-11-11 00:00:00

  • Evaluation of breath, plasma, and urinary markers of lactose malabsorption to diagnose lactase non-persistence following lactose or milk ingestion.

    abstract:BACKGROUND:Adult lactase non-persistence (LNP) is due to low lactase expression, resulting in lactose malabsorption (LM). LNP is a genetic trait, but is typically determined by LM markers including breath H2, blood glucose, and urinary galactose after a lactose tolerance test. Known validity of these markers using milk...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Shrestha A,Barnett MPG,Perry JK,Cameron-Smith D,Milan AM

    更新日期:2020-06-29 00:00:00

  • Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers.

    abstract:BACKGROUND AND AIM:Carbohydrate deficient transferrin (CDT) is the most specific serum biomarker of heavy alcohol consumption, defined as ≥ 350-420 g alcohol/week. Despite introduction of a standardized reference measurement technique, widespread use of CDT remains limited due to low sensitivity. The aim of this study ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Fagan KJ,Irvine KM,McWhinney BC,Fletcher LM,Horsfall LU,Johnson L,O'Rourke P,Martin J,Scott I,Pretorius CJ,Ungerer JP,Powell EE

    更新日期:2014-05-22 00:00:00

  • Pre-study protocol MagPEP: a multicentre randomized controlled trial of magnesium sulphate in the prevention of post-ERCP pancreatitis.

    abstract:BACKGROUND:Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effectively reducing the incidence of ERCP-induced pancreatitis has found its way into clinical practise. ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Fluhr G,Mayerle J,Weber E,Aghdassi A,Simon P,Gress T,Seufferlein T,Mössner J,Stallmach A,Rösch T,Müller M,Siegmund B,Büchner-Steudel P,Zuber-Jerger I,Kantowski M,Hoffmeister A,Rosendahl J,Linhart T,Maul J,Czakó L,

    更新日期:2013-01-15 00:00:00

  • Long intestinal tube splinting prevents postoperative adhesive small-bowel obstruction in sclerosing encapsulating peritonitis.

    abstract:BACKGROUND:Sclerosing encapsulating peritonitis (SEP) is a rare cause of small-bowel obstruction. The optimal treatment for this condition remains controversial. METHODS:In this study, we performed a retrospective analysis of the data of 44 patients who underwent surgery for SEP between December 2001 and 2008 at our h...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Li M,Zhu W,Li Y,Jiang J,Li J,Li N

    更新日期:2014-11-25 00:00:00

  • Intraductal papillary mucinous carcinoma of the pancreas associated with pancreas divisum: a case report and review of the literature.

    abstract:BACKGROUND:Pancreas divisum, the most common congenital anomaly of the pancreas, is caused by failure of the fusion of the ventral and dorsal pancreatic duct systems during embryological development. Although various pancreatic tumors can occur in patients with pancreas divisum, intraductal papillary mucinous neoplasm ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,评审


    authors: Nishi T,Kawabata Y,Ishikawa N,Araki A,Yano S,Maruyama R,Tajima Y

    更新日期:2015-07-08 00:00:00

  • Histological evaluation of duodenal biopsies from coeliac patients: the need for different grading criteria during follow-up.

    abstract:BACKGROUND:Coeliac disease is characterised by villous atrophy, which usually normalises after gluten withdrawal. Sometimes the revaluation of duodenal histology is required during follow-up, even if the methodology for comparing duodenal histology before and after introducing a gluten-free diet is not yet established....

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Elli L,Zini E,Tomba C,Bardella MT,Bosari S,Conte D,Runza L,Roncoroni L,Ferrero S

    更新日期:2015-10-14 00:00:00

  • A rapid, simple questionnaire to assess gastrointestinal symptoms after oral ferrous sulphate supplementation.

    abstract:BACKGROUND:Oral iron supplementation is often associated with rapid onset of gastrointestinal side-effects. The aim of this study was to develop and trial a short, simple questionnaire to capture these early side-effects and to determine which symptoms are more discriminating. METHODS:The study was a double-blind plac...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Pereira DI,Couto Irving SS,Lomer MC,Powell JJ

    更新日期:2014-06-04 00:00:00

  • Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase.

    abstract:BACKGROUND:Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated. METHODS:Wistar rats were used (6 in each group)--Groups: (1) sham, (2) ischemia...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Serracino-Inglott F,Virlos IT,Habib NA,Williamson RC,Mathie RT

    更新日期:2002-09-20 00:00:00

  • Short chain fatty acids and colon motility in a mouse model of irritable bowel syndrome.

    abstract:BACKGROUND:Irritable bowel syndrome (IBS) is defined as a multifactorial disorder associated with visceral hypersensitivity, altered gut motility and dysfunction of the brain-gut axis. Gut microbiota and its metabolites are proposed as possible etiological factors of IBS. Short chain fatty acids (SCFAs) induce both inh...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Shaidullov IF,Sorokina DM,Sitdikov FG,Hermann A,Abdulkhakov SR,Sitdikova GF

    更新日期:2021-01-26 00:00:00

  • Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I.

    abstract:BACKGROUND:Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the administration of Insulin-Like Growth Factor-I (IGF-I). The aims of this study were to explore the ev...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Castilla-Cortázar I,Pascual M,Urdaneta E,Pardo J,Puche JE,Vivas B,Díaz-Casares A,García M,Díaz-Sánchez M,Varela-Nieto I,Castilla A,González-Barón S

    更新日期:2004-06-14 00:00:00

  • A simple dummy liver assist device prolongs anhepatic survival in a porcine model of total hepatectomy by slight hypothermia.

    abstract:BACKGROUND:Advances in intensive care support such as therapeutic hypothermia or new liver assist devices have been the mainstay of treatment attempting to bridge the gap from acute liver failure to liver transplantation, but the efficacy of the available devices in reducing mortality has been questioned. To address th...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Thiel K,Schenk M,Etspüler A,Schenk T,Morgalla MH,Königsrainer A,Thiel C

    更新日期:2011-07-14 00:00:00

  • Low bone mass in microscopic colitis.

    abstract:BACKGROUND:Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis. AIMS:The aim of the present study was to evaluate bone density and metabolism in patien...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Lorinczy K,Lakatos G,Müllner K,Hritz I,Lakatos PL,Tulassay Z,Miheller P

    更新日期:2011-05-19 00:00:00

  • Endoscopic stent placement above the sphincter of Oddi for biliary strictures after living donor liver transplantation.

    abstract:BACKGROUND:Endoscopic balloon dilation and/or plastic stent placement has been a standard method for treating biliary strictures complicated post living donor liver transplantation (LDLT). The strictures may be refractory to endoscopic treatment and require long-term stent placement. However, consensus on the optimal p...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Koizumi M,Kumagi T,Kuroda T,Imamura Y,Kanemitsu K,Ogawa K,Takada Y,Hiasa Y

    更新日期:2020-04-06 00:00:00

  • Abdominal migraine in children: association between gastric motility parameters and clinical characteristics.

    abstract:BACKGROUND:Approximately 0.2-1 % of children suffers from abdominal migraine (AM). Pathophysiology of AM has not been adequately studied. This study evaluated gastric motility in children with AM. METHODS:Seventeen children (6 boys), within an age range of 4-15 years, referred to a tertiary care paediatric unit, North...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Devanarayana NM,Rajindrajith S,Benninga MA

    更新日期:2016-02-29 00:00:00

  • Macro-AST: misleading finding in an adolescent with MCAD-deficiency.

    abstract:BACKGROUND:MCAD-deficiency is the most common inborn error of fatty acid oxidation now included in many newborn screening programms using MS/MS. During prolonged catabolic episodes, patients may suffer from metabolic decompensation with dysfunction of liver, skeletal- and heart muscle as well as brain. In anabolism, ne...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Das AM,Drache S,Janzen N,Franke A

    更新日期:2012-08-30 00:00:00

  • Longitudinal fluctuations in PD1 and PD-L1 expression in association with changes in anti-viral immune response in chronic hepatitis B.

    abstract:BACKGROUND:Controversy exists regarding the role of PD1 and its ligand PD-L1 in chronic hepatitis B infection. In some studies, persistent HBV infection has been attributed to high levels of PD-1 and PD-L1 expression on HBV-specific T-cells and antigen-presenting cells (APCs) respectively. Other studies revealed that t...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Wenjin Z,Chuanhui P,Yunle W,Lateef SA,Shusen Z

    更新日期:2012-08-16 00:00:00

  • Lack of evidence of viral reactivation in HBsAg-negative HBcAb-positive and HCV patients undergoing immunosuppressive therapy for psoriasis.

    abstract:BACKGROUND:HBV and HCV reactivation have been widely reported in patients undergoing immunosuppressive therapy (IT); however, few data are available on the risk of reactivation in patients with psoriasis receiving IT. The aim of our study was to assess the prevalence of HBV and HCV infection in patients with psoriasis ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Morisco F,Guarino M,La Bella S,Di Costanzo L,Caporaso N,Ayala F,Balato N

    更新日期:2014-12-19 00:00:00

  • Sustained serological and complete responses in HBeAg-positive patients treated with Peginterferon alfa-2b: a 6-year long-term follow-up of a multicenter, randomized, controlled trial in China.

    abstract:BACKGROUND:Pegylated interferon (PEG-IFN) alfa-2b is recommended for chronic hepatitis B (CHB). We aimed to investigate the sustainability of off-treatment responses among Chinese HBeAg-positive CHB patients treated with PEG-IFN alfa-2b from a randomized trial. METHODS:Eligible Chinese patients (n = 322) were followed...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Sun J,Ding H,Chen G,Wang G,Wei L,Zhang J,Xie Q,Wan M,Tang H,Chen S,Gao Z,Wang Y,Zhang D,Huang W,Sheng J,Ning Q,Yang D,Lu J,Pan C,Yang Y,Wang J,Sun C,Wang Q,Hou J

    更新日期:2019-05-02 00:00:00

  • Alcoholic cirrhosis in Denmark - population-based incidence, prevalence, and hospitalization rates between 1988 and 2005: a descriptive cohort study.

    abstract:BACKGROUND:Denmark has one of the highest alcohol consumption rates in Northern Europe. The overall per capita alcohol consumption has been stable in recent decades, but surveys have indicated that consumption has decreased in the young and increased in the old. However, there is no recent information on the epidemiolo...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Jepsen P,Vilstrup H,Sørensen HT

    更新日期:2008-02-09 00:00:00

  • Colectomy rate in steroid-refractory colitis initially responsive to cyclosporin: a long-term retrospective cohort study.

    abstract:BACKGROUND:There is consistent evidence that 50% of patients with acute, steroid-resistant flare of ulcerative colitis (UC) may achieve remission and avoid colectomy if treated with cyclosporin (CsA). However, follow-up of the responders has shown that most of them relapse and need surgery shortly after the response. W...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Actis GC,Fadda M,David E,Sapino A

    更新日期:2007-03-27 00:00:00

  • Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation.

    abstract:BACKGROUND:Allergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal bleeding, while in some patients a multiple food allergy can occur. The aim...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Lucarelli S,Di Nardo G,Lastrucci G,D'Alfonso Y,Marcheggiano A,Federici T,Frediani S,Frediani T,Cucchiara S

    更新日期:2011-07-16 00:00:00

  • GDNF protects enteric glia from apoptosis: evidence for an autocrine loop.

    abstract:BACKGROUND:Enteric glia cells (EGC) play an important role in the maintenance of intestinal mucosa integrity. During the course of acute Crohn's disease (CD), mucosal EGC progressively undergo apoptosis, though the mechanisms are largely unknown. We investigated the role of Glial-derived neurotrophic factor (GDNF) in t...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Steinkamp M,Gundel H,Schulte N,Spaniol U,Pflueger C,Zizer E,von Boyen GB

    更新日期:2012-01-17 00:00:00

  • Medication beliefs among patients with inflammatory bowel disease who report low quality of life: a qualitative study.

    abstract:BACKGROUND:Non-adherence to drug therapy is common in Inflammatory Bowel Disease (IBD). Patients' beliefs about treatment have an important influence on adherence. An in-depth understanding of this area is, therefore, important for patient-centred care. The aim of the study was to assess patients' perspectives and beli...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Hall NJ,Rubin GP,Hungin AP,Dougall A

    更新日期:2007-06-08 00:00:00

  • How do patients with inflammatory bowel disease want their biological therapy administered?

    abstract:BACKGROUND:Infliximab is usually administered by two monthly intravenous (iv) infusions, therefore requiring visits to hospital. Adalimumab is administered by self subcutaneous (sc) injections every other week. Both of these anti-TNF drugs appear to be equally efficacious in the treatment of Crohn's Disease and therefo...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Allen PB,Lindsay H,Tham TC

    更新日期:2010-01-10 00:00:00

  • A self administered reliable questionnaire to assess lower bowel symptoms.

    abstract:BACKGROUND:Bowel symptoms are considered indicators of the presence of colorectal cancer and other bowel diseases. Self administered questionnaires that elicit information about lower bowel symptoms have not been assessed for reliability, although this has been done for upper bowel symptoms. Our aim was to develop a se...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Adelstein BA,Irwig L,Macaskill P,Katelaris PH,Jones DB,Bokey L

    更新日期:2008-03-01 00:00:00

  • Longitudinal study of gastroesophageal reflux and erosive tooth wear.

    abstract:BACKGROUND:Approximately 60% of patients presenting to dentists with erosive tooth wear have significant gastroesophageal reflux (GERD), despite minor reflux symptoms. No longitudinal studies of reflux-associated erosive tooth wear and of reflux characteristics have been reported to date. The aim of this study was to c...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Wilder-Smith CH,Materna A,Martig L,Lussi A

    更新日期:2017-10-25 00:00:00

  • Postoperative complications following colectomy for ulcerative colitis: a validation study.

    abstract:BACKGROUND:Ulcerative colitis (UC) patients failing medical management require colectomy. This study compares risk estimates for predictors of postoperative complication derived from administrative data against that of chart review and evaluates the accuracy of administrative coding for this population. METHODS:Hospit...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Ma C,Crespin M,Proulx MC,DeSilva S,Hubbard J,Prusinkiewicz M,Nguyen GC,Panaccione R,Ghosh S,Myers RP,Quan H,Kaplan GG

    更新日期:2012-04-27 00:00:00

  • Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver.

    abstract:BACKGROUND:HCC predominantly develops in the condition of chronic inflammation that has led to liver cirrhosis. A small proportion of patients with HCC is diagnosed in the non-cirrhotic liver (NCL). Data on patients with HCC in NCL in advanced stages are scarce. METHODS:A retrospective analysis was performed comparing...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Schütte K,Schulz C,Poranzke J,Antweiler K,Bornschein J,Bretschneider T,Arend J,Ricke J,Malfertheiner P

    更新日期:2014-07-03 00:00:00

  • Gastric adenocarcinoma in a patient re-infected with H. pylori after regression of MALT lymphoma with successful anti-H. pylori therapy and gastric resection: a case report.

    abstract:BACKGROUND:Helicobacter pylori (H. pylori) has been etiologically linked with primary gastric lymphoma (PGL) and gastric carcinoma (GC). There are a few reports of occurrence of both diseases in the same patients with H. pylori infection. CASE PRESENTATION:We report a patient with PGL in whom the tumor regressed after...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Ghoshal UC,Guha D,Bandyopadhyay S,Pal C,Chakraborty S,Ghoshal U,Ghosh TK,Pal BB,Banerjee PK

    更新日期:2002-01-01 00:00:00