Influence of acute pancreatitis on the in vitro responsiveness of rat mesenteric and pulmonary arteries.

Abstract:

BACKGROUND:Acute pancreatitis is an inflammatory disease characterized by local tissue injury and systemic inflammatory response leading to massive nitric oxide (NO) production and haemodynamic disturbances. Therefore, the aim of this work was to evaluate the vascular reactivity of pulmonary and mesenteric artery rings from rats submitted to experimental pancreatitis. Male Wistar rats were divided into three groups: saline (SAL); tauracholate (TAU) and phospholipase A2 (PLA2). Pancreatitis was induced by administration of TAU or PLA2 from Naja mocambique mocambique into the common bile duct of rats, and after 4 h of duct injection the animals were sacrificed. Concentration-response curves to acetylcholine (ACh), sodium nitroprusside (SNP) and phenylephrine (PHE) in isolated mesenteric and pulmonary arteries were obtained. Potency (pEC50) and maximal responses (EMAX) were determined. Blood samples were collected for biochemical analysis. RESULTS:In mesenteric rings, the potency for ACh was significantly decreased from animals treated with TAU (about 4.2-fold) or PLA2 (about 6.9-fold) compared to saline group without changes in the maximal responses. Neither pEC50 nor EMAX values for Ach were altered in pulmonary rings in any group. Similarly, the pEC50 and the EMAX values for SNP were not changed in both preparations in any group. The potency for PHE was significantly decreased in rat mesenteric and pulmonary rings from TAU group compared to SAL group (about 2.2- and 2.69-fold, for mesenteric and pulmonary rings, respectively). No changes were seen in the EMAX for PHE. The nitrite/nitrate (NOx-) levels were markedly increased in animals submitted to acute pancreatitis as compared to SAL group, approximately 76 and 68% in TAU and PLA2 protocol, respectively. CONCLUSION:Acute pancreatitis provoked deleterious effects in endothelium-dependent relaxing response for ACh in mesenteric rings that were strongly associated with high plasma NOx- levels as consequence of intense inflammatory responses. Furthermore, the subsensitivity of contractile response to PHE in both mesenteric and pulmonary rings might be due to the complications of this pathological condition in the early stage of pancreatitis.

journal_name

BMC Gastroenterol

journal_title

BMC gastroenterology

authors

Camargo EA,Delbin MA,Ferreira T,Landucci EC,Antunes E,Zanesco A

doi

10.1186/1471-230X-8-19

subject

Has Abstract

pub_date

2008-05-29 00:00:00

pages

19

issn

1471-230X

pii

1471-230X-8-19

journal_volume

8

pub_type

杂志文章
  • Fluoroless intravascular ultrasound image-guided liver navigation in porcine models.

    abstract:BACKGROUND:An intravascular ultrasound catheter (IVUSc) was developed for intracardiac ultrasound to assess interventions with compelling results. However, intrahepatic vascular exploration was rarely tested and was always associated with X-ray techniques. The aim of this study was to demonstrate the feasibility to nav...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-021-01600-3

    authors: Urade T,Verde JM,García Vázquez A,Gunzert K,Pessaux P,Marescaux J,Giménez ME

    更新日期:2021-01-09 00:00:00

  • Risk factors for hepatitis C virus infection among blood donors in southern Brazil: a case-control study.

    abstract:BACKGROUND:In Brazil, it is estimated that between 2.5 and 4.9% of the general population present anti-hepatitis C virus (HCV) antibodies, which corresponds to as many as 3.9 to 7.6 million chronic carriers. Chronic liver disease is associated with HCV infection in 20% to 58% of the Brazilian patients. The objective of...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230x-2-18

    authors: Brandão AB,Fuchs SC

    更新日期:2002-08-08 00:00:00

  • Transarterial chemoembolization plus sorafenib for the management of unresectable hepatocellular carcinoma: a systematic review and meta-analysis.

    abstract:BACKGROUND:Transarterial chemoembolization (TACE) is the recommended treatment for hepatocellular carcinoma (HCC) patients at Barcelona Clinic Liver Cancer (BCLC) B-stage, whereas sorafenib is an orally administered small molecule target drug for BCLC C-stage. This updated systemic review and meta-analysis focuses on i...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12876-018-0849-0

    authors: Li L,Zhao W,Wang M,Hu J,Wang E,Zhao Y,Liu L

    更新日期:2018-09-04 00:00:00

  • Green tea consumption and risk of esophageal cancer: a meta-analysis of epidemiologic studies.

    abstract:BACKGROUND:Green tea has shown the role of chemoprevention for cancer. Recently, several studies suggested that green tea intake may have effect on esophageal cancer risk, whereas the results were inconsistent. METHODS:We performed a meta-analysis of all English and Chinese language studies of green tea consumption an...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.1186/1471-230X-12-165

    authors: Zheng P,Zheng HM,Deng XM,Zhang YD

    更新日期:2012-11-21 00:00:00

  • Quantitative pedigree analysis and mitochondrial DNA sequence variants in adults with cyclic vomiting syndrome.

    abstract:BACKGROUND:Children with cyclic vomiting syndrome (CVS) have a high degree of maternal inheritance of functional gastrointestinal and neurological disorders. CVS in children is also associated with an increased prevalence of mitochondrial DNA single-nucleotide polymorphisms (mtDNA SNPs) 16519 T and 3010A. Preliminary d...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-181

    authors: Venkatesan T,Zaki EA,Kumar N,Sengupta J,Ali M,Malik B,Szabo A,van Tilburg MA,Boles RG

    更新日期:2014-10-21 00:00:00

  • A novel technique for repositioning a nasobiliary catheter from the mouth to nostril in endoscopic retrograde cholangiopancreatography.

    abstract:BACKGROUND:Endoscopic nasobiliary drainage (ENBD) is widely used for biliary decompression in patients with biliary disease. However, it is difficult to reposition a nasobiliary catheter from the mouth to nostril. We developed a new device, which has a curved flexible loop and bar-handle, for repositioning of ENBD cath...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-1148-0

    authors: Choi SJ,Lee JM,Choi HS,Kim ES,Keum B,Seo YS,Jeen YT,Lee HS,Chun HJ,Um SH,Kim CD,Oh CH

    更新日期:2019-12-21 00:00:00

  • A self administered reliable questionnaire to assess lower bowel symptoms.

    abstract:BACKGROUND:Bowel symptoms are considered indicators of the presence of colorectal cancer and other bowel diseases. Self administered questionnaires that elicit information about lower bowel symptoms have not been assessed for reliability, although this has been done for upper bowel symptoms. Our aim was to develop a se...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-8-8

    authors: Adelstein BA,Irwig L,Macaskill P,Katelaris PH,Jones DB,Bokey L

    更新日期:2008-03-01 00:00:00

  • Medication beliefs among patients with inflammatory bowel disease who report low quality of life: a qualitative study.

    abstract:BACKGROUND:Non-adherence to drug therapy is common in Inflammatory Bowel Disease (IBD). Patients' beliefs about treatment have an important influence on adherence. An in-depth understanding of this area is, therefore, important for patient-centred care. The aim of the study was to assess patients' perspectives and beli...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-7-20

    authors: Hall NJ,Rubin GP,Hungin AP,Dougall A

    更新日期:2007-06-08 00:00:00

  • Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn's disease.

    abstract:BACKGROUND:Glycoprotein 2 (GP2) was discovered as the major autoantigen of Crohn's disease (CD)-specific pancreatic autoantibodies (PAB). We investigated anti-GP2 IgA and IgG antibodies as novel serological parameters in CD and assessed their association with distinct disease phenotypes. METHODS:Anti-GP2 and anti-Sacc...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-102

    authors: Bogdanos DP,Roggenbuck D,Reinhold D,Wex T,Pavlidis P,von Arnim U,Malfertheiner P,Forbes A,Conrad K,Laass MW

    更新日期:2012-08-06 00:00:00

  • Acute cholecystitis with massive upper gastrointestinal bleed: a case report and review of the literature.

    abstract:BACKGROUND:Cystic artery pseudoaneurysm is a rare complication following cholecystitis. Its presentation with upper gastrointestinal hemorrhage (UGIH) is even rarer. Thirteen patients with cystic artery pseudoaneurysm have been reported in the literature but only 2 of them presented with UGIH alone. CASE PRESENTATION:...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1186/1471-230X-7-12

    authors: Saluja SS,Ray S,Gulati MS,Pal S,Sahni P,Chattopadhyay TK

    更新日期:2007-03-26 00:00:00

  • Derangements of liver tissue bioenergetics in concanavalin A-induced hepatitis.

    abstract:BACKGROUND:A novel in vitro system was employed to investigate liver tissue respiration (mitochondrial O2 consumption) in mice treated with concanavalin A (Con A). This study aimed to investigate hepatocyte bioenergetics in this well-studied hepatitis model. METHODS:C57Bl/6 and C57Bl/6 IFN-γ-/- mice were injected intr...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-13-6

    authors: Al-Shamsi M,Shahin A,Mensah-Brown EP,Souid AK

    更新日期:2013-01-12 00:00:00

  • Possible role of Escherichia coli in propagation and perpetuation of chronic inflammation in ulcerative colitis.

    abstract:BACKGROUND:This study investigated a possible role of Escherichia coli in propagation and perpetuation of the chronic inflammation in ulcerative colitis (UC). The lesions of UC are located superficially on the rectal and/or colonic mucosa. It is suggested that the commensal bacteria of the digestive tract may play a ro...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-13-61

    authors: Pilarczyk-Zurek M,Chmielarczyk A,Gosiewski T,Tomusiak A,Adamski P,Zwolinska-Wcislo M,Mach T,Heczko PB,Strus M

    更新日期:2013-04-08 00:00:00

  • Fecal carriage of multidrug-resistant Escherichia coli by community children in southern Taiwan.

    abstract:BACKGROUND:The emergence of multidrug-resistant (MDR) Escherichia coli (E. coli), particularly E. coli sequence type ST131, is becoming a global concern. Commensal bacteria, an important reservoir of antibiotic resistance genes, facilitate the spread of such genes to pathogenic bacterial strains. The objective of the s...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0807-x

    authors: Huang IF,Lee WY,Wang JL,Hung CH,Hu HH,Hung WY,Hung YJ,Chen WC,Shen YT,Cheng MF

    更新日期:2018-06-15 00:00:00

  • Efficacy and safety of infliximab induction therapy in Crohn's Disease in Central Europe--a Hungarian nationwide observational study.

    abstract:BACKGROUND:Infliximab (IFX) has proven to be an effective addition to the therapeutic arsenal for refractory, fistulizing, and steroid dependent Crohn's disease (CD), with efficacy in the induction and maintenance of clinical remission of CD. Our objective in this study is to report the nationwide, multicenter experien...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-230X-9-66

    authors: Miheller P,Lakatos PL,Horváth G,Molnár T,Szamosi T,Czeglédi Z,Salamon A,Czimmer J,Rumi G,Palatka K,Papp M,Jakab Z,Szabó A,Gelley A,Lakatos L,Barta Z,Balázs C,Rácz I,Zeher M,Döbrönte Z,Altorjay I,Hunyady B,Simo

    更新日期:2009-09-10 00:00:00

  • Simultaneous brain and lung metastases of pancreatic ductal adenocarcinoma after curative pancreatectomy: a case report and literature review.

    abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the brain; therefore, the features of brain metastasis of PDAC are still unknown. We encountered simultaneous metastases to the brain and lung in a PDAC patient after curative surgery. Case presentation A 68-year-old man with PDAC in the tail of ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01587-3

    authors: Oka Y,Takano S,Kouchi Y,Furukawa K,Takayashiki T,Kuboki S,Suzuki D,Sakai N,Kagawa S,Hosokawa I,Mishima T,Konishi T,Kishimoto T,Ohtsuka M

    更新日期:2021-01-06 00:00:00

  • Low bone mass in microscopic colitis.

    abstract:BACKGROUND:Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis. AIMS:The aim of the present study was to evaluate bone density and metabolism in patien...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-58

    authors: Lorinczy K,Lakatos G,Müllner K,Hritz I,Lakatos PL,Tulassay Z,Miheller P

    更新日期:2011-05-19 00:00:00

  • Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis.

    abstract:BACKGROUND:Animal models of non-alcoholic steatohepatitis (NASH) are important tools in preclinical research and drug discovery. Gubra-Amylin NASH (GAN) diet-induced obese (DIO) mice represent a model of fibrosing NASH. The present study directly assessed the clinical translatability of the model by head-to-head compar...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01356-2

    authors: Hansen HH,Ægidius HM,Oró D,Evers SS,Heebøll S,Eriksen PL,Thomsen KL,Bengtsson A,Veidal SS,Feigh M,Suppli MP,Knop FK,Grønbæk H,Miranda D,Trevaskis JL,Vrang N,Jelsing J,Rigbolt KTG

    更新日期:2020-07-06 00:00:00

  • Long intestinal tube splinting prevents postoperative adhesive small-bowel obstruction in sclerosing encapsulating peritonitis.

    abstract:BACKGROUND:Sclerosing encapsulating peritonitis (SEP) is a rare cause of small-bowel obstruction. The optimal treatment for this condition remains controversial. METHODS:In this study, we performed a retrospective analysis of the data of 44 patients who underwent surgery for SEP between December 2001 and 2008 at our h...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-180

    authors: Li M,Zhu W,Li Y,Jiang J,Li J,Li N

    更新日期:2014-11-25 00:00:00

  • Pre-study protocol MagPEP: a multicentre randomized controlled trial of magnesium sulphate in the prevention of post-ERCP pancreatitis.

    abstract:BACKGROUND:Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effectively reducing the incidence of ERCP-induced pancreatitis has found its way into clinical practise. ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-230X-13-11

    authors: Fluhr G,Mayerle J,Weber E,Aghdassi A,Simon P,Gress T,Seufferlein T,Mössner J,Stallmach A,Rösch T,Müller M,Siegmund B,Büchner-Steudel P,Zuber-Jerger I,Kantowski M,Hoffmeister A,Rosendahl J,Linhart T,Maul J,Czakó L,

    更新日期:2013-01-15 00:00:00

  • Effect of straining on diaphragmatic crura with identification of the straining-crural reflex. The "reflex theory" in gastroesophageal competence.

    abstract:BACKGROUND:The role of the crural diaphragm during increased intra-abdominal pressure is not exactly known. We investigated the hypothesis that the crural diaphragm undergoes reflex phasic contraction on elevation of the intra-abdominal pressure with a resulting increase of the lower esophageal pressure and prevention ...

    journal_title:BMC gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-230X-4-24

    authors: Shafik A,Shafik AA,El Sibai O,Mostafa RM

    更新日期:2004-09-30 00:00:00

  • Association of IL1B -511C/-31T haplotype and Helicobacter pylori vacA genotypes with gastric ulcer and chronic gastritis.

    abstract:BACKGROUND:The association between proinflammatory cytokine gene polymorphisms and gastric diseases related to Helicobacter pylori varies by population and geographic area.Our objective was to determine if the IL-1B -511 T>C and -31 C>T polymorphisms and H. pylori vacA genotypes are associated with risk of chronic gast...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-126

    authors: Martínez-Carrillo DN,Garza-González E,Betancourt-Linares R,Mónico-Manzano T,Antúnez-Rivera C,Román-Román A,Flores-Alfaro E,Illades-Aguiar B,Fernández-Tilapa G

    更新日期:2010-10-27 00:00:00

  • Real-world clinical effectiveness and safety of vedolizumab and anti-tumor necrosis factor alpha treatment in ulcerative colitis and Crohn's disease patients: a German retrospective chart review.

    abstract:BACKGROUND:Real-world comparisons of biologic treatment outcomes for ulcerative colitis (UC) or Crohn's disease (CD) patients are limited. We sought to evaluate the real-world effectiveness of vedolizumab (VDZ) and anti-tumor necrosis factor alpha (anti-TNFα) in UC and CD patients in Germany. METHODS:A retrospective c...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01332-w

    authors: Helwig U,Mross M,Schubert S,Hartmann H,Brandes A,Stein D,Kempf C,Knop J,Campbell-Hill S,Ehehalt R

    更新日期:2020-07-08 00:00:00

  • Comparison of clinical course and outcome of acute pancreatitis according to the two main etiologies: alcohol and gallstone.

    abstract:BACKGROUND:Studies concerning clinical course and outcome of acute pancreatitis (AP) according to etiologies were rare, especially after year 2000. This study was designed to investigate the difference between the clinical course of alcoholic and biliary AP. METHODS:Of the 153 patients diagnosed as AP with a first att...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-015-0323-1

    authors: Cho JH,Kim TN,Kim SB

    更新日期:2015-07-25 00:00:00

  • Sustained serological and complete responses in HBeAg-positive patients treated with Peginterferon alfa-2b: a 6-year long-term follow-up of a multicenter, randomized, controlled trial in China.

    abstract:BACKGROUND:Pegylated interferon (PEG-IFN) alfa-2b is recommended for chronic hepatitis B (CHB). We aimed to investigate the sustainability of off-treatment responses among Chinese HBeAg-positive CHB patients treated with PEG-IFN alfa-2b from a randomized trial. METHODS:Eligible Chinese patients (n = 322) were followed...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12876-019-0981-5

    authors: Sun J,Ding H,Chen G,Wang G,Wei L,Zhang J,Xie Q,Wan M,Tang H,Chen S,Gao Z,Wang Y,Zhang D,Huang W,Sheng J,Ning Q,Yang D,Lu J,Pan C,Yang Y,Wang J,Sun C,Wang Q,Hou J

    更新日期:2019-05-02 00:00:00

  • Overexpression of SLC38A1 is associated with poorer prognosis in Chinese patients with gastric cancer.

    abstract:BACKGROUND:Current literature has demonstrated that host glutamine depletion facilitates tumorigenesis. Likewise, the glutamine transporter SLC38A1 is putatively associated with malignant transformation and tumor progression. Taken together, this forms the premise for undertaking the current study. The twofold aim of t...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-70

    authors: Xie J,Li P,Gao HF,Qian JX,Yuan LY,Wang JJ

    更新日期:2014-04-09 00:00:00

  • Haemodynamic effects of plasma-expansion with hyperoncotic albumin in cirrhotic patients with renal failure: a prospective interventional study.

    abstract:BACKGROUND:Patients with advanced cirrhosis of the liver typically display circulatory disturbance. Haemodynamic management may be critical for avoiding and treating functional renal failure in such patients. This study investigated the effects of plasma expansion with hyperoncotic albumin solution and the role of stat...

    journal_title:BMC gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-230X-8-39

    authors: Umgelter A,Wagner K,Reindl W,Nurtsch N,Huber W,Schmid RM

    更新日期:2008-08-27 00:00:00

  • Risk of inflammatory bowel disease following a diagnosis of irritable bowel syndrome.

    abstract:BACKGROUND:Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) symptoms often overlap. In some IBS cases there are subtle inflammatory changes similar to the immune-mediated pathophysiology of IBD, and the risk of both increases after infectious gastroenteritis (IGE). METHODS:To evaluate the effect of ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-55

    authors: Porter CK,Cash BD,Pimentel M,Akinseye A,Riddle MS

    更新日期:2012-05-28 00:00:00

  • Association of gut microbiota with post-operative clinical course in Crohn's disease.

    abstract:BACKGROUND:The gut microbiome is altered in Crohn's disease. Although individual taxa have been correlated with post-operative clinical course, global trends in microbial diversity have not been described in this context. METHODS:We collected mucosal biopsies from the terminal ileum and ascending colon during surgery ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-13-131

    authors: Dey N,Soergel DA,Repo S,Brenner SE

    更新日期:2013-08-22 00:00:00

  • Endocytoscopic findings of lymphomas of the stomach.

    abstract:BACKGROUND:The gastric lesions of various lymphomas were observed at the cellular level using endocytoscopy. METHODS:Endocytoscopy and magnifying endoscopy with narrow band imaging (NBI) were performed in 17 patients with lymphomas of the stomach. The lesions consisted of 7 with low-grade mucosa-associated lymphoid ti...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-13-174

    authors: Isomoto H,Matsushima K,Hayashi T,Imaizumi Y,Shiota J,Ishii H,Minami H,Ohnita K,Takeshima F,Shikuwa S,Miyazaki Y,Nakao K

    更新日期:2013-12-26 00:00:00

  • Protocol of a multicentric prospective cohort study for the VALIDation of the IBD-disk instrument for assessing disability in inflammatory bowel diseases: the VALIDate study.

    abstract:BACKGROUND:Inflammatory Bowel Diseases (IBD) affect psychological, family, social and professional dimensions of patients' life, leading to disability which is essential to quantify as part of Patient-Reported Outcomes (PROs) newly included in the targets to reach in IBD patients. Up to now, the IBD-Disability Index (I...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01246-7

    authors: Le Berre C,Bourreille A,Flamant M,Bouguen G,Siproudhis L,Dewitte M,Dib N,Cesbron-Metivier E,Goronflot T,Hanf M,Gourraud PA,Kerdreux E,Poinas A,Trang-Poisson C

    更新日期:2020-04-16 00:00:00