Fluoroless intravascular ultrasound image-guided liver navigation in porcine models.

Abstract:

BACKGROUND:An intravascular ultrasound catheter (IVUSc) was developed for intracardiac ultrasound to assess interventions with compelling results. However, intrahepatic vascular exploration was rarely tested and was always associated with X-ray techniques. The aim of this study was to demonstrate the feasibility to navigate through the whole liver using an IVUSc, providing high-quality images and making it unnecessary to use ionizing radiation. METHODS:An ex vivo pig visceral block and an in vivo pig model were used in this study. The IVUS equipment was composed of an US system, and of an 8 French lateral firing IVUSc capable of producing 90-degree sector images in the longitudinal plane. After accessing the intravascular space with the IVUSc into the models, predetermined anatomical landmarks were visualized from the inferior vena cava and hepatic veins and corroborated. RESULTS:IVUS navigation was achieved in both models successfully. The entire navigation protocol took 87 and 48 min respectively, and 100% (21/21) and 96.15% (25/26) of the landmarks were correctly identified with the IVUSc alone in the ex vivo and in vivo models respectively. IVUS allowed to clearly visualize the vasculature beyond third-order branches of the hepatic and portal veins. CONCLUSIONS:A complete IVUS liver navigation is feasible using the IVUSc alone, making it unnecessary to use ionizing radiation. This approach provides high-definition and real-time images of the complex liver structure and offers a great potential for future clinical applications during diagnostic and therapeutic interventions.

journal_name

BMC Gastroenterol

journal_title

BMC gastroenterology

authors

Urade T,Verde JM,García Vázquez A,Gunzert K,Pessaux P,Marescaux J,Giménez ME

doi

10.1186/s12876-021-01600-3

subject

Has Abstract

pub_date

2021-01-09 00:00:00

pages

24

issue

1

issn

1471-230X

pii

10.1186/s12876-021-01600-3

journal_volume

21

pub_type

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