Real-world clinical effectiveness and safety of vedolizumab and anti-tumor necrosis factor alpha treatment in ulcerative colitis and Crohn's disease patients: a German retrospective chart review.

Abstract:

BACKGROUND:Real-world comparisons of biologic treatment outcomes for ulcerative colitis (UC) or Crohn's disease (CD) patients are limited. We sought to evaluate the real-world effectiveness of vedolizumab (VDZ) and anti-tumor necrosis factor alpha (anti-TNFα) in UC and CD patients in Germany. METHODS:A retrospective chart review (15 sites) investigated UC and CD patients who were biologic-treatment naïve (biologic-naïve) or had received no more than one prior anti-TNFα before initiating treatment with VDZ or anti-TNFα between 15 July 2014 and 20 October 2015. Kaplan-Meier analyses assessed time to first chart-documented clinical remission (CR) and symptom resolution (UC: rectal bleeding [RB], stool frequency [SF]; CD: abdominal pain [AP], liquid stools [LS]) and outcome duration. RESULTS:A total of 133 UC (76 VDZ; 57 anti-TNFα) and 174 CD (69 VDZ; 105 anti-TNFα) patients were included. By Week 26, estimated cumulative rates of patients achieving CR or symptom resolution with VDZ vs anti-TNFα treatment were for UC: CR, 53.7% vs 31.7%; RB, 66.8% vs 55.8%; and SF, 59.8% vs 50.7%, respectively; and for CD: CR, 14.4% vs 32.8%; AP, 62.5% vs 56.0%; and LS, 29.9% vs 50.3%, respectively. Outcomes were sustained similarly between treatments, except RB (VDZ vs anti-TNFα: median 38.1 vs 15.1 weeks, P = 0.03). Treatment-related adverse events occurred in 5.3% vs 7.0% (UC) and 8.7% vs 19.0% (CD) of VDZ vs anti-TNFα patients, respectively. CONCLUSIONS:Although there were differences in CR, symptom resolution, and safety profiles, real-world data support both VDZ and anti-TNFα as effective treatment options in UC and CD.

journal_name

BMC Gastroenterol

journal_title

BMC gastroenterology

authors

Helwig U,Mross M,Schubert S,Hartmann H,Brandes A,Stein D,Kempf C,Knop J,Campbell-Hill S,Ehehalt R

doi

10.1186/s12876-020-01332-w

subject

Has Abstract

pub_date

2020-07-08 00:00:00

pages

211

issue

1

issn

1471-230X

pii

10.1186/s12876-020-01332-w

journal_volume

20

pub_type

杂志文章
  • Comparability of localization data in transnasal and transoral esophagogastroduodenoscopy.

    abstract:BACKGROUND:Esophagogastroduodenoscopy is an often-used and safe diagnostic method in gastroenterology. Transnasal esophagogastroduodenoscopy is now an established addition to the endoscopic instrumentarium. Although the two examination methods can be used alongside each other, there is a lack of studies on the comparab...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-116

    authors: Aymaz S,Krakamp B,Kirschberg O,Lefering R

    更新日期:2010-10-13 00:00:00

  • Red cell distribution width and red cell distribution width to total serum calcium ratio as major predictors of severity and mortality in acute pancreatitis.

    abstract:BACKGROUND:Acute pancreatitis (AP) is associated with considerable morbidity and mortality. Current severity scores include multiple variables and some of them are only complete within 48 h of admission. Red cell distribution width (RDW) is a simple and routine parameter that seems to be related to inflammatory status....

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0834-7

    authors: Gravito-Soares M,Gravito-Soares E,Gomes D,Almeida N,Tomé L

    更新日期:2018-07-05 00:00:00

  • GDNF protects enteric glia from apoptosis: evidence for an autocrine loop.

    abstract:BACKGROUND:Enteric glia cells (EGC) play an important role in the maintenance of intestinal mucosa integrity. During the course of acute Crohn's disease (CD), mucosal EGC progressively undergo apoptosis, though the mechanisms are largely unknown. We investigated the role of Glial-derived neurotrophic factor (GDNF) in t...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-6

    authors: Steinkamp M,Gundel H,Schulte N,Spaniol U,Pflueger C,Zizer E,von Boyen GB

    更新日期:2012-01-17 00:00:00

  • Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver.

    abstract:BACKGROUND:HCC predominantly develops in the condition of chronic inflammation that has led to liver cirrhosis. A small proportion of patients with HCC is diagnosed in the non-cirrhotic liver (NCL). Data on patients with HCC in NCL in advanced stages are scarce. METHODS:A retrospective analysis was performed comparing...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-117

    authors: Schütte K,Schulz C,Poranzke J,Antweiler K,Bornschein J,Bretschneider T,Arend J,Ricke J,Malfertheiner P

    更新日期:2014-07-03 00:00:00

  • Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis.

    abstract:BACKGROUND:The natural course and treatment strategies for asymptomatic or oligosymptomatic pancreatic necrosis are still poorly defined. The aim of this retrospective study was to establish criteria for the need of intervention in patients with pancreatic necrosis. METHODS:A total of 31 consecutive patients (18 male,...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-48

    authors: Jürgensen C,Arlt A,Neser F,Fritscher-Ravens A,Stölzel U,Hampe J

    更新日期:2012-05-14 00:00:00

  • Narrow-band imaging and high-definition white-light endoscopy in patients with serrated lesions not fulfilling criteria for serrated polyposis syndrome: a randomized controlled trial with tandem colonoscopy.

    abstract:BACKGROUND:It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-light endoscopy (HD-WLE) in detecting serrated lesions in patients with prior serrated lesions > 5 mm not completely fulfilling serrated polyposis syndrome (SPS) criteria. METHODS:We conducted a randomized, cr...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12876-020-01257-4

    authors: Riu Pons F,Andreu M,Naranjo D,Álvarez-González MA,Seoane A,Dedeu JM,Barranco L,Bessa X

    更新日期:2020-04-16 00:00:00

  • The prevalence, incidence and natural history of primary sclerosing cholangitis in an ethnically diverse population.

    abstract:BACKGROUND:Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease often associated with inflammatory bowel diseases (IBD). Current epidemiological data are limited to studies of predominantly Caucasian populations. Our aim was to define the epidemiology of PSC in a large, ethnically diverse US...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-83

    authors: Toy E,Balasubramanian S,Selmi C,Li CS,Bowlus CL

    更新日期:2011-07-18 00:00:00

  • Laparoscopic versus conventional appendectomy--a meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Although laparoscopic surgery has been available for a long time and laparoscopic cholecystectomy has been performed universally, it is still not clear whether open appendectomy (OA) or laparoscopic appendectomy (LA) is the most appropriate surgical approach to acute appendicitis. The purpose of this work is...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/1471-230X-10-129

    authors: Li X,Zhang J,Sang L,Zhang W,Chu Z,Li X,Liu Y

    更新日期:2010-11-03 00:00:00

  • Gastric adenocarcinoma in a patient re-infected with H. pylori after regression of MALT lymphoma with successful anti-H. pylori therapy and gastric resection: a case report.

    abstract:BACKGROUND:Helicobacter pylori (H. pylori) has been etiologically linked with primary gastric lymphoma (PGL) and gastric carcinoma (GC). There are a few reports of occurrence of both diseases in the same patients with H. pylori infection. CASE PRESENTATION:We report a patient with PGL in whom the tumor regressed after...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230x-2-6

    authors: Ghoshal UC,Guha D,Bandyopadhyay S,Pal C,Chakraborty S,Ghoshal U,Ghosh TK,Pal BB,Banerjee PK

    更新日期:2002-01-01 00:00:00

  • Transarterial chemoembolization plus sorafenib for the management of unresectable hepatocellular carcinoma: a systematic review and meta-analysis.

    abstract:BACKGROUND:Transarterial chemoembolization (TACE) is the recommended treatment for hepatocellular carcinoma (HCC) patients at Barcelona Clinic Liver Cancer (BCLC) B-stage, whereas sorafenib is an orally administered small molecule target drug for BCLC C-stage. This updated systemic review and meta-analysis focuses on i...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12876-018-0849-0

    authors: Li L,Zhao W,Wang M,Hu J,Wang E,Zhao Y,Liu L

    更新日期:2018-09-04 00:00:00

  • Asymptomatic hepatic artery dissection early after living-donor liver transplantation with simultaneous splenectomy: two case reports.

    abstract:BACKGROUND:Hepatic artery dissection after liver transplantation is an uncommon morbidity. The onset mechanism and management for this disorder remain unclear. The present report describes the cases of two patients with hepatic artery dissection after living-donor liver transplantation (LDLT) with simultaneous splenect...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01528-0

    authors: Shimata K,Sugawara Y,Irie T,Sambommatsu Y,Kadohisa M,Ibuki S,Kawabata S,Isono K,Honda M,Yamamoto H,Hibi T

    更新日期:2020-11-12 00:00:00

  • Risk factors for second primary neoplasia of esophagus in newly diagnosed head and neck cancer patients: a case-control study.

    abstract:BACKGROUND:The prevalence of esophageal neoplasia in head and neck (H&N) cancer patients is not low; however, routine esophageal surveillance is not included in staging of newly-diagnosed H&N cancers. We aimed to investigate the risk factors for synchronous esophageal neoplasia and the impact of endoscopy on management...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-13-154

    authors: Chung CS,Liao LJ,Lo WC,Chou YH,Chang YC,Lin YC,Hsu WF,Shueng PW,Lee TH

    更新日期:2013-10-25 00:00:00

  • Endoscopic stent placement above the sphincter of Oddi for biliary strictures after living donor liver transplantation.

    abstract:BACKGROUND:Endoscopic balloon dilation and/or plastic stent placement has been a standard method for treating biliary strictures complicated post living donor liver transplantation (LDLT). The strictures may be refractory to endoscopic treatment and require long-term stent placement. However, consensus on the optimal p...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01226-x

    authors: Koizumi M,Kumagi T,Kuroda T,Imamura Y,Kanemitsu K,Ogawa K,Takada Y,Hiasa Y

    更新日期:2020-04-06 00:00:00

  • Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND:Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocarcinoma (ICC) which may be derived from small bile duct cells or liver progenitor cells (LPCs) was known to us...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01471-0

    authors: Shen Z,Xiao J,Wang J,Lu L,Wan X,Cai X

    更新日期:2020-10-02 00:00:00

  • Human cystic echinococcosis in Heilongjiang Province, China: a retrospective study.

    abstract:BACKGROUND:Cystic echinococcosis (CE) is one of emerging zoonotic parasitic diseases throughout the world, having significant medical and economic importance in developing countries. The western and northwestern China is considered as CE endemic areas. In northeastern China's Heilongjiang Province, the increasing numbe...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-015-0256-8

    authors: Zhang T,Zhao W,Yang D,Piao D,Huang S,Mi Y,Zhao X,Cao J,Shen Y,Zhang W,Liu A

    更新日期:2015-03-10 00:00:00

  • Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age.

    abstract:BACKGROUND:FibroTest (FT) is a validated biomarker of fibrosis. To assess the applicability rate and to reduce the risk of false positives/negatives (RFPN), security algorithms were developed. The aims were to estimate the prevalence of RFPN and of proven failures, and to identify factors associated with their occurren...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-39

    authors: Poynard T,Munteanu M,Deckmyn O,Ngo Y,Drane F,Messous D,Castille JM,Housset C,Ratziu V,Imbert-Bismut F

    更新日期:2011-04-14 00:00:00

  • Sensitivity is not an intrinsic property of a diagnostic test: empirical evidence from histological diagnosis of Helicobacter pylori infection.

    abstract:BACKGROUND:We aimed to provide empirical evidence of how spectrum effects can affect the sensitivity of histological assessment of Helicobacter pylori infection, which may contribute to explain the heterogeneity in prevalence estimates across populations with expectedly similar prevalence. METHODS:Cross-sectional eval...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-9-98

    authors: Lunet N,Peleteiro B,Carrilho C,Figueiredo C,Azevedo A

    更新日期:2009-12-24 00:00:00

  • Non-selective beta blocker use is associated with improved short-term survival in patients with cirrhosis referred for liver transplantation.

    abstract:BACKGROUND:Recent evidence cautions against the use of non-selective beta-blockers (NSBB) in patients with refractory ascites or spontaneous bacterial peritonitis while other data suggests a survival benefit in patients with advanced liver disease. The aim of this study was to describe the use and impact of NSBB in pat...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-1155-1

    authors: Ngwa T,Orman E,Gomez EV,Vuppalanchi R,Kubal C,Chalasani N,Ghabril M

    更新日期:2020-01-06 00:00:00

  • Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer: a study from Guangxi Zhuang.

    abstract:BACKGROUND:There are obviously ethnic differences between the UGT1A1 gene polymorphisms. Due to the difference of genetic background and environment, the treatment with colorectal cancer patients of Guangxi Zhuang should not completely follow the Euramerican or Chinese han patients. The study aimed to explore the corre...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01227-w

    authors: Chen S,Hua L,Feng C,Mo Q,Wei M,Shen Y,Lin Z,Li G,Xu J,Guo C,Huang H

    更新日期:2020-04-07 00:00:00

  • Gastric tuberculosis mimicking submucosal tumor: a case series.

    abstract:BACKGROUND:Gastric tuberculosis mimicking submucosal tumors is extremely rare and often misdiagnosed. CASE PRESENTATION:Three cases of gastric tuberculosis mimicking submucosal tumors were identified among patients admitted to local county hospitals because of upper abdominal discomfort and pain, with gastroscopy show...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-1175-x

    authors: Zhu R,Zhou Y,Wang H,Di L,Zhao K,Tuo B,Wu H

    更新日期:2020-01-30 00:00:00

  • Metabolic syndrome and biochemical changes among non-alcoholic fatty liver disease patients attending a tertiary care hospital of Nepal.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. Worldwide, 6.3 to 33% of the general populations are estimated to suffer from the disease with even higher prevalence in the group sharing metabo...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0843-6

    authors: Pardhe BD,Shakya S,Bhetwal A,Mathias J,Khanal PR,Pandit R,Shakya J,Joshi HO,Marahatta SB

    更新日期:2018-07-06 00:00:00

  • Slug down-regulation by RNA interference inhibits invasion growth in human esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice. METHODS:We utilized RNA interference to knockdown Slug gene expr...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-60

    authors: Tang P,Yu Z,Zhang K,Wang Y,Ma Z,Zhang S,Chen D,Zhou Y

    更新日期:2011-05-20 00:00:00

  • Incidental finding of diffuse cavernous rectal haemangiomatosis during bowel cancer screening.

    abstract:BACKGROUND:This case seeks to highlight to endoscopists a rare benign disorder that may be encountered during endoscopy. Clinicians may be tempted to biopsy, which could lead to a catastrophic gastrointestinal haemorrhage. CASE PRESENTATION:A 66-year-old asymptomatic Caucasian male was referred for colonoscopy with a ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-1118-6

    authors: Abeysekera KWM,Pearl DS,Burn P,Lowe A

    更新日期:2019-11-27 00:00:00

  • Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I.

    abstract:BACKGROUND:Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the administration of Insulin-Like Growth Factor-I (IGF-I). The aims of this study were to explore the ev...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-4-12

    authors: Castilla-Cortázar I,Pascual M,Urdaneta E,Pardo J,Puche JE,Vivas B,Díaz-Casares A,García M,Díaz-Sánchez M,Varela-Nieto I,Castilla A,González-Barón S

    更新日期:2004-06-14 00:00:00

  • Safety and efficacy of protease inhibitor based combination therapy in a single-center "real-life" cohort of 110 patients with chronic hepatitis C genotype 1 infection.

    abstract:BACKGROUND:The combination of boceprevir or telaprevir with peginterferon-alfa and ribavirin for the treatment of patients infected with HCV genotype 1 has led to significantly increased rates of sustained virological response (SVR) in phase III trials. There is only limited data regarding the safety and efficacy in a ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-87

    authors: Wehmeyer MH,Eißing F,Jordan S,Röder C,Hennigs A,Degen O,Hüfner A,Hertling S,Schmiedel S,Sterneck M,van Lunzen J,Lohse AW,Schulze zur Wiesch J,Lüth S

    更新日期:2014-05-05 00:00:00

  • Transient elastography for predicting esophageal/gastric varices in children with biliary atresia.

    abstract:BACKGROUND:Transient elastography (TE) is an innovative, noninvasive technique to assess liver fibrosis by measuring liver stiffness in patients with chronic liver diseases. The purpose of this study has been to explore the accuracy of TE and clinical parameters in predicting the presence of esophageal/gastric varices ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-41

    authors: Chongsrisawat V,Vejapipat P,Siripon N,Poovorawan Y

    更新日期:2011-04-18 00:00:00

  • Gall bladder wall thickening as non-invasive screening parameter for esophageal varices - a comparative endoscopic - sonographic study.

    abstract:BACKGROUND:The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening markers for the presence of EV are of interest. Here, we aim to investigate whether non-inflammatory gall...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0852-5

    authors: Tsaknakis B,Masri R,Amanzada A,Petzold G,Ellenrieder V,Neesse A,Kunsch S

    更新日期:2018-08-02 00:00:00

  • High-definition endoscopy with digital chromoendoscopy for histologic prediction of distal colorectal polyps.

    abstract:BACKGROUND:Distal diminutive colorectal polyps are common and accurate endoscopic prediction of hyperplastic or adenomatous polyp histology could reduce procedural time, costs and potential risks associated with the resection. Within this study we assessed whether digital chromoendoscopy can accurately predict the hist...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-015-0374-3

    authors: Rath T,Tontini GE,Nägel A,Vieth M,Zopf S,Günther C,Hoffman A,Neurath MF,Neumann H

    更新日期:2015-10-22 00:00:00

  • Risk of inflammatory bowel disease following a diagnosis of irritable bowel syndrome.

    abstract:BACKGROUND:Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) symptoms often overlap. In some IBS cases there are subtle inflammatory changes similar to the immune-mediated pathophysiology of IBD, and the risk of both increases after infectious gastroenteritis (IGE). METHODS:To evaluate the effect of ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-55

    authors: Porter CK,Cash BD,Pimentel M,Akinseye A,Riddle MS

    更新日期:2012-05-28 00:00:00

  • Hepatic sonic hedgehog protein expression measured by computer assisted morphometry significantly correlates with features of non-alcoholic steatohepatitis.

    abstract:BACKGROUND:Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnosis of NASH. This pilot study was designed to confirm that staining for SHH is useful in NASH diagnos...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-0951-y

    authors: Estep M,Mehta R,Bratthauer G,Alaparthi L,Monge F,Ali S,Abdelatif D,Younoszai Z,Stepanova M,Goodman ZD,Younossi ZM

    更新日期:2019-02-11 00:00:00