Abstract:
BACKGROUND:Transarterial chemoembolization (TACE) and sorafenib are the therapeutic standard for intermediate and advanced stage hepatocellular carcinoma (HCC) patients respectively. High costs with adverse events (AE) of sorafenib might limit sorafenib dosage, further affecting therapeutic response. To attain greatest benefit, we evaluated the efficacy of different doses and effect of TACE during and after sorafenib discontinuation in patients representing Child-Pugh Classification Class A with venous or extra-hepatic invasion. METHODS:A total 156 patients met the criteria and were divided into Groups I (n = 52) accepting 800 mg/day; II (n = 58) accepting 800 mg/day and reduced to 400 mg/day owing to AE; and III (n = 46) accepting 400 mg/day. TACE was performed during and after sorafenib discontinuation and therapeutic response bimonthly to four-monthly was rated thereafter. RESULTS:Median duration of sorafenib treatment and patients' survival were 4.00 ± 0.45 and 7.50 ± 1.44 months in all cases; 2.50 ± 0.90 and 5.00 ± 1.10 months in Group I; 5.50 ± 1.27 and 16.50 ± 1.86 months in Group II; 4.00 ± 0.94 and 6.50 ± 2.49 months in Group III. Group II presented the best response and survival benefit (p = 0.010 and p = 0.011 respectively). Child-Pugh Classification score 5 (Hazard Ratio = 0.492, p = 0.049), absent AE (3.423, p = 0.015), tumor numbers ≤ 3 (0.313, p = 0.009), sorafenib duration ≤ 1 cycle (3.694, p = 0.004), and absent TACE (3.197, p = 0.008) significantly correlated with patient survival. TACE benefit appeared in separate and total cases during (p = 0.002, p = 0.595, p = 0.074, p = 0.002 respectively) and after discontinuation of sorafenib administration (p = 0.001, p = 0.034, p = 0.647, p = 0.001 respectively). CONCLUSIONS:Low-dosage sorafenib not only appeared tolerable and lowered economic pressure but also provided satisfactory results. TACE benefited patient's survival during and after sorafenib discontinuation.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Hsiao WD,Peng CY,Chuang PH,Lai HC,Cheng KS,Chou JW,Chen YY,Yu CJ,Feng CL,Su WP,Chen SH,Kao JTdoi
10.1186/s12876-016-0464-xsubject
Has Abstractpub_date
2016-04-27 00:00:00pages
50issn
1471-230Xpii
10.1186/s12876-016-0464-xjournal_volume
16pub_type
杂志文章abstract:BACKGROUND:Perianal fistula surgery can damage the anal sphincters which may cause faecal incontinence. By measuring regional pressures, 3D-HRAM potentially provides better guidance for surgical strategy in patients with perianal fistulas. The aim was to measure regional anal pressures with 3D-HRAM and to compare these...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0770-6
更新日期:2018-04-04 00:00:00
abstract:BACKGROUND:Colorectal liver metastases (CLM) occur frequently and postoperative intestinal infection is a common complication. Our previous study showed that probiotics could decrease the rate of infectious complications after colectomy for colorectal cancer. To determine the effects of the perioperative administration...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12876-015-0260-z
更新日期:2015-03-20 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver diseases, ranging from pure steatosis to nonalcoholic steatohepatitis (NASH), and eventually to liver cirrhosis with its complications. Identifying advanced fibrosis in patients is crucial to evaluating prognosis and possible therapeu...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-67
更新日期:2010-06-28 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is a risk factor for colorectal neoplasms. Our goal is to explore the relationship between NAFLD and colorectal cancer (CRC) and to analyze potential indicators for screening CRC in NAFLD based on clinical big data. METHODS:Demographic information and routine clinica...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01327-7
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocarcinoma (ICC) which may be derived from small bile duct cells or liver progenitor cells (LPCs) was known to us...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01471-0
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:Colon cancer is one of the most aggressive human malignancies, with a very poor prognosis. Although it has been suggested that different isoforms of the lymphoid enhancer factor (LEF-1) have opposing biological activities, the biological outcome of aberrant LEF-1 activation in colon cancer is still unclear. ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-53
更新日期:2012-05-28 00:00:00
abstract:BACKGROUND:Cystic echinococcosis (CE) is one of emerging zoonotic parasitic diseases throughout the world, having significant medical and economic importance in developing countries. The western and northwestern China is considered as CE endemic areas. In northeastern China's Heilongjiang Province, the increasing numbe...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0256-8
更新日期:2015-03-10 00:00:00
abstract:BACKGROUND:Enteroaggregative Escherichia coli (EAEC) causes diarrhea, malnutrition and poor growth in children. Human breast milk decreases disease-causing bacteria by supplying nutrients and antimicrobial factors such as lysozyme. Goat milk with and without human lysozyme (HLZ) may improve the repair of intestinal bar...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-106
更新日期:2012-08-11 00:00:00
abstract:BACKGROUND:A gluten-free diet (GFD) is the only effective treatment for celiac patients and assessing adherence to this diet is important. Celiac disease Adherence Test (CDAT) is a valid English-language questionnaire that is used for assessing the adherence to the GFD. In the present study, we aimed to translate the C...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01396-8
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:The assessment of residual gastric volume is common practice in critical care units. However, the effects and safety of discarding or returning gastric aspirates remain uncertain. Therefore, we aimed to evaluate the role of discarding or returning gastric aspirates on the gastric residual volumes in critical...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1186/s12876-019-1028-7
更新日期:2019-06-28 00:00:00
abstract:BACKGROUND:Helicobacter pylori (H. pylori) infection and excessive salt intake are known as important risk factors for stomach cancer in humans. However, interactions of these two factors with gene expression profiles during gastric carcinogenesis remain unclear. In the present study, we investigated the global gene ex...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-122
更新日期:2013-07-30 00:00:00
abstract:BACKGROUND:Dysphagia and feeding intolerance are common in neurologically handicapped children. The aim is to determine the etiologies of feeding intolerance in neurologically handicapped children who are intolerant of tube feedings. METHODS:Eighteen neurologically handicapped children, followed in the Tube Feeding Cl...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-19
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:The use of thickeners is a standard therapy for decreasing episodes of regurgitation or vomiting in infants. However, it remains to be investigated whether thickener is effective for vomiting and/or chronic respiratory symptoms in children with cerebral palsy. METHODS:We enrolled 18 neurologically impaired ...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-230X-8-11
更新日期:2008-04-16 00:00:00
abstract:BACKGROUND:Approximately 0.2-1 % of children suffers from abdominal migraine (AM). Pathophysiology of AM has not been adequately studied. This study evaluated gastric motility in children with AM. METHODS:Seventeen children (6 boys), within an age range of 4-15 years, referred to a tertiary care paediatric unit, North...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0435-2
更新日期:2016-02-29 00:00:00
abstract:BACKGROUNDS:Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in Asians. However, data on prevalence and factors associated with NAFLD in Asians are lacking. The aim of this study is to investigate the prevalence of NAFLD in Shanghai employees to assess the relationship between N...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-123
更新日期:2012-09-14 00:00:00
abstract:BACKGROUND:The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respon...
journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-230X-12-162
更新日期:2012-11-16 00:00:00
abstract:BACKGROUND:Infection is one of the important causes of death in patients with severe acute pancreatitis (SAP), but the bacterial spectrum and antibiotic resistance are constantly changing. Making good use of antibiotics and controlling multi-drug-resistant (MDR) bacterial infections are of vital importance in improving...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01563-x
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The search for better non-invasive biomarkers for gastric cancer remains ongoing. We investigated the predictive power of serum trefoil factor (TFF) levels as biomarkers for gastric cancer in comparison with the pepsinogen (PG) test. METHODS:Patients with gastric cancer, chronic atrophic gastritis (CAG) or ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-74
更新日期:2014-04-11 00:00:00
abstract:BACKGROUND:Infliximab (IFX) has proven to be an effective addition to the therapeutic arsenal for refractory, fistulizing, and steroid dependent Crohn's disease (CD), with efficacy in the induction and maintenance of clinical remission of CD. Our objective in this study is to report the nationwide, multicenter experien...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-9-66
更新日期:2009-09-10 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is the most common cancer in Europe with a mortality rate of almost 50%. The prognosis of patients is largely determined by the clinical and pathological stage at the time of diagnosis. Population screening has been shown to reduce CRC-related mortality rate. Most screening programs w...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-73
更新日期:2012-06-19 00:00:00
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journal_title:BMC gastroenterology
pub_type: 信件
doi:10.1186/1471-230X-9-93
更新日期:2009-12-14 00:00:00
abstract:BACKGROUND:Foreign body ingestion complicated by perforation of the digestive tract is a well-known occurrence. Contrary to this, perforation by fishbones has most often been described in South East Asian populations, and has the unusual characteristic of often being paucisymptomatic until secondary complications occur...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-167
更新日期:2014-09-27 00:00:00
abstract:BACKGROUND:The majority of colonic obstructions result from colorectal cancer. However, malignancies of extra-colonic origin can also disrupt colorectal patency, and the efficacy of self-expanding metal stents (SEMS) insertion as a bridge to surgery in these patients are still in debate. The aim of this study is to eva...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01273-4
更新日期:2020-04-19 00:00:00
abstract:BACKGROUND:Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis. AIMS:The aim of the present study was to evaluate bone density and metabolism in patien...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-58
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the brain; therefore, the features of brain metastasis of PDAC are still unknown. We encountered simultaneous metastases to the brain and lung in a PDAC patient after curative surgery. Case presentation A 68-year-old man with PDAC in the tail of ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01587-3
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Biliary atresia (BA) is a progressive inflammatory disorder of the extrahepatic bile ducts leading to the obliteration of bile flow. The purpose of this study was to determine serum adiponectin in BA patients and to investigate the relationship of adiponectin with clinical parameters and liver stiffness scor...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-16
更新日期:2011-02-28 00:00:00
abstract:BACKGROUND:Tumor-to-tumor metastasis is a rare event. Rectal cancer to primary thyroid neoplasm metastasis is extremely rare. Herein, we reported a case of metastatic rectal adenocarcinoma to a papillary thyroid carcinoma. The incidence and clinicopathological characteristics of metastatic colorectal cancer to a thyroi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01286-z
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:The association between proinflammatory cytokine gene polymorphisms and gastric diseases related to Helicobacter pylori varies by population and geographic area.Our objective was to determine if the IL-1B -511 T>C and -31 C>T polymorphisms and H. pylori vacA genotypes are associated with risk of chronic gast...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-126
更新日期:2010-10-27 00:00:00
abstract:BACKGROUND:Pancreatic Stone Protein (PSP) is a protein naturally produced mainly in the pancreas and the gut. There is evidence from experimental and clinical trials that blood PSP levels rise in the presence of inflammation or infection. However, it is not known whether PSP is superior to other established blood tests...
journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/1471-230X-12-154
更新日期:2012-10-25 00:00:00
abstract:BACKGROUND:Carrageenan is a traditional ingredient that has been widely used in the food industry. In the present study, we propose a hypothesis that carrageenan is a conditional inflammatory agent. When the intestinal tract is in an "unhealthy" state such as that during bacterial infection or acute inflammation, carra...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0459-7
更新日期:2016-03-25 00:00:00