Nitric oxide-an endogenous inhibitor of gastric acid secretion in isolated human gastric glands.

Abstract:

BACKGROUND:Endothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various animal models. The present study was conducted to investigate the influence of exogenously and endogenously derived NO on histamine- and cAMP-stimulated gastric acid secretion in isolated human oxyntic glands. METHODS:Oxyntic glands were isolated from human gastric biopsies and were subsequently pre-treated with NO donors and nitric oxide synthase inhibitors and then exposed to histamine or dibutyryl-cAMP (db-cAMP). The secretory response of the glands was determined as accumulation of [14C]aminopyrine. RESULTS:The histamine- or db-cAMP-induced acid secretion was attenuated by L-arginine, a known source of endogenous NO, and also by the NO-donors sodium nitroprusside (SNP) and S-nitroso-N-acetyl-penicillamine (SNAP). Pre-treatment with either of the NOS inhibitors NG-nitro-L-arginine methyl ester (L-NAME) or NG-nitro-L-arginine (L-NNA) enhanced the secretory response. CONCLUSION:Our results show that NO inhibits gastric acid secretion in isolated human gastric glands, and that there is endogenous formation of NO within the glandular epithelium in the vicinity of the parietal cells.

journal_name

BMC Gastroenterol

journal_title

BMC gastroenterology

authors

Berg A,Redeen S,Ericson AC,Sjöstrand SE

doi

10.1186/1471-230X-4-16

keywords:

subject

Has Abstract

pub_date

2004-08-06 00:00:00

pages

16

issn

1471-230X

pii

1471-230X-4-16

journal_volume

4

pub_type

杂志文章
  • TGF beta1 and PDGF AA override collagen type I inhibition of proliferation in human liver connective tissue cells.

    abstract:BACKGROUND:A marked expansion of the connective tissue population and an abnormal deposition of extracellular matrix proteins are hallmarks of chronic and acute injuries to liver tissue. Liver connective tissue cells, also called stellate cells, derived from fibrotic liver have been thoroughly characterized and corresp...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-4-30

    authors: Geremias AT,Carvalho MA,Borojevic R,Monteiro AN

    更新日期:2004-12-03 00:00:00

  • A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome.

    abstract:BACKGROUND:Irritable Bowel Syndrome (IBS) is a common chronic gastrointestinal disorder and the evidence for efficacy of most drug therapies in the treatment of IBS is weak. A popular alternative is probiotics, which have been used in several conditions. including IBS. Probiotics are live microbial food supplements.The...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/1471-230X-9-15

    authors: Hoveyda N,Heneghan C,Mahtani KR,Perera R,Roberts N,Glasziou P

    更新日期:2009-02-16 00:00:00

  • Red cell distribution width and red cell distribution width to total serum calcium ratio as major predictors of severity and mortality in acute pancreatitis.

    abstract:BACKGROUND:Acute pancreatitis (AP) is associated with considerable morbidity and mortality. Current severity scores include multiple variables and some of them are only complete within 48 h of admission. Red cell distribution width (RDW) is a simple and routine parameter that seems to be related to inflammatory status....

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0834-7

    authors: Gravito-Soares M,Gravito-Soares E,Gomes D,Almeida N,Tomé L

    更新日期:2018-07-05 00:00:00

  • Histological improvement in chronic hepatitis B patients treated with bicyclol: real world experience.

    abstract:BACKGROUND:Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes after bicyclol treatment in these patients are scarce. Therefore, this study has been conducted to fin...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-1005-1

    authors: Chi X,Xiao H,Shi M,Cai G,Xie Y,Jiang J,Tian G,Wu S,Zhang C,Zhao P,Chen J

    更新日期:2019-06-13 00:00:00

  • Early stage signet ring cell carcinoma of the colon examined by magnifying endoscopy with narrow-band imaging: a case report.

    abstract:BACKGROUND:Signet ring cell carcinoma of the colon and rectum is rare, and most cases are detected at an advanced stage. We present a case of primary signet ring cell carcinoma detected at an early stage by magnifying endoscopy with narrow-band imaging (NBI) and crystal violet staining. CASE PRESENTATION:A 73-year-old...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-015-0317-z

    authors: Ohnita K,Isomoto H,Akashi T,Hashiguchi K,Matsushima K,Minami H,Akazawa Y,Yamaguchi N,Takeshima F,To K,Takeshita H,Yasui H,Abe K,Nakao K

    更新日期:2015-07-24 00:00:00

  • Fluoroless intravascular ultrasound image-guided liver navigation in porcine models.

    abstract:BACKGROUND:An intravascular ultrasound catheter (IVUSc) was developed for intracardiac ultrasound to assess interventions with compelling results. However, intrahepatic vascular exploration was rarely tested and was always associated with X-ray techniques. The aim of this study was to demonstrate the feasibility to nav...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-021-01600-3

    authors: Urade T,Verde JM,García Vázquez A,Gunzert K,Pessaux P,Marescaux J,Giménez ME

    更新日期:2021-01-09 00:00:00

  • Tuberous Sclerosis Complex with rare associated findings in the gastrointestinal system: a case report and review of the literature.

    abstract:BACKGROUND:Tuberous Sclerosis Complex (TSC) is a complex and heterogeneous genetic disease that has well-established clinical diagnostic criteria. These criteria do not include gastrointestinal tumors. CASE PRESENTATION:We report a 45-year-old patient with a clinical and molecular diagnosis of TSC and a family history...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01481-y

    authors: Reis LB,Konzen D,Netto CBO,Braghini PMB,Prolla G,Ashton-Prolla P

    更新日期:2020-11-23 00:00:00

  • "Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study".

    abstract:BACKGROUND:A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Jap...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-1152-4

    authors: Mardian Y,Yano Y,Ratnasari N,Choridah L,Wasityastuti W,Setyawan NH,Hayashi Y

    更新日期:2019-12-30 00:00:00

  • Medication beliefs among patients with inflammatory bowel disease who report low quality of life: a qualitative study.

    abstract:BACKGROUND:Non-adherence to drug therapy is common in Inflammatory Bowel Disease (IBD). Patients' beliefs about treatment have an important influence on adherence. An in-depth understanding of this area is, therefore, important for patient-centred care. The aim of the study was to assess patients' perspectives and beli...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-7-20

    authors: Hall NJ,Rubin GP,Hungin AP,Dougall A

    更新日期:2007-06-08 00:00:00

  • Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-beta and extracellular matrix proteins.

    abstract:BACKGROUND:Liver fibrosis is the result of continuous liver injury stemming from different etiological factors. Bile duct injury induces an altered expression of TGF-beta, which has an important role in liver fibrosis because this cytokine induces the expression of target genes such as collagens, PAI-1, TIMPs, and othe...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-9-81

    authors: del Pilar Alatorre-Carranza M,Miranda-Díaz A,Yañez-Sánchez I,Pizano-Martínez O,Hermosillo-Sandoval JM,Vázquez-Del Mercado M,Hernández-Hoyos S,Martínez-Abundis R,Fafutis-Morris M,Segura-Ortega J,Delgado-Rizo V

    更新日期:2009-10-31 00:00:00

  • The addition of a pH-sensitive gel improves microemulsion stability for the targeted removal of colonic ammonia.

    abstract:BACKGROUND:We prepared an oral W/O microemulsion for the removal of colonic ammonia (ME-RCA). The effect of this microemulsion was influenced by the digestion process in the gastrointestinal tract. In this paper, we aim to show that stability was improved by using a microemulsion-based gel for the removal of colonic am...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-50

    authors: Wang AH,Duan ZJ,Tian G,Lu D,Zhang WJ,He GH,Fang GH

    更新日期:2011-05-10 00:00:00

  • Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH.

    abstract:BACKGROUND:The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapri...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-230X-12-25

    authors: Iida H,Inamori M,Fujii T,Sekino Y,Endo H,Hosono K,Nonaka T,Koide T,Takahashi H,Yoneda M,Goto A,Abe Y,Kobayashi N,Kirikoshi H,Kubota K,Saito S,Gotoh E,Maeda S,Nakajima A

    更新日期:2012-03-26 00:00:00

  • Increasing rate of inflammatory bowel disease: a 12-year retrospective study in NingXia, China.

    abstract:BACKGROUND:In China, the incidence of Inflammatory bowel disease (IBD) has shown a significant growth trend. Analysis of the epidemiology, clinical manifestations, diagnostic means, and treatment of IBD will further improve the clinician's understanding of IBD, improve knowledge and further enable early diagnosis and s...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-015-0405-0

    authors: Zhai H,Liu A,Huang W,Liu X,Feng S,Wu J,Yao Y,Wang C,Li Q,Hao Q,Hu J,Zhang S

    更新日期:2016-01-12 00:00:00

  • Steroid-refractory ulcerative colitis treated with corticosteroids, metronidazole and vancomycin: a case report.

    abstract:BACKGROUND:Increasing evidence elucidating the pathogenic mechanisms of ulcerative colitis (UC) has accumulated and the disease is widely assumed to be the consequence of genetic susceptibility and an abnormal immune response to commensal bacteria. However evidence regarding an infectious etiology in UC remains elusive...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-5-3

    authors: Miner J,Gillan MM,Alex P,Centola M

    更新日期:2005-01-24 00:00:00

  • Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers.

    abstract:BACKGROUND AND AIM:Carbohydrate deficient transferrin (CDT) is the most specific serum biomarker of heavy alcohol consumption, defined as ≥ 350-420 g alcohol/week. Despite introduction of a standardized reference measurement technique, widespread use of CDT remains limited due to low sensitivity. The aim of this study ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-97

    authors: Fagan KJ,Irvine KM,McWhinney BC,Fletcher LM,Horsfall LU,Johnson L,O'Rourke P,Martin J,Scott I,Pretorius CJ,Ungerer JP,Powell EE

    更新日期:2014-05-22 00:00:00

  • Hypophosphataemia after ferric carboxymaltose is unrelated to symptoms, intestinal inflammation or vitamin D status.

    abstract:BACKGROUND:Intravenous iron replacement is recommended for iron-deficient patients with inflammatory bowel disease (IBD), but may be associated with hypophosphataemia, predisposing to osteomalacia and fractures. This study aimed to evaluate the incidence and risk factors for hypophosphataemia following intravenous ferr...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01298-9

    authors: Fang W,Kenny R,Rizvi QU,McMahon LP,Garg M

    更新日期:2020-06-10 00:00:00

  • Pancreatic duct guidewire placement for biliary cannulation as a risk factor for stone residue after endoscopic transpapillary stone removal.

    abstract:BACKGROUND:Recent improvements in stone extraction implements and apparatus have lessened the complexity of the endoscopic bile duct stone treatment. However, despite confirmation of complete removal, cases of residual stones have been reported, which can result in recurrent biliary symptoms, cholangitis, and pancreati...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01428-3

    authors: Fujita A,Nakahara K,Michikawa Y,Morita R,Suetani K,Sato J,Igarashi Y,Araki R,Ikeda H,Matsunaga K,Watanabe T,Itoh F

    更新日期:2020-08-24 00:00:00

  • Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous polyposis patients.

    abstract:BACKGROUND:Patients with familial adenomatous polyposis (FAP) frequently undergo colectomy to reduce the 70 to 90% lifetime risk of colorectal cancer. After risk-reducing colectomy, duodenal cancer and complications from duodenal surgeries are the main cause of morbidity. Our objective was to prospectively describe the...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0841-8

    authors: Sample DC,Samadder NJ,Pappas LM,Boucher KM,Samowitz WS,Berry T,Westover M,Nathan D,Kanth P,Byrne KR,Burt RW,Neklason DW

    更新日期:2018-07-16 00:00:00

  • HCV genotype 1a shows a better virological response to antiviral therapy than HCV genotype 1b.

    abstract:BACKGROUND:The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respon...

    journal_title:BMC gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-230X-12-162

    authors: Pellicelli AM,Romano M,Stroffolini T,Mazzoni E,Mecenate F,Monarca R,Picardi A,Bonaventura ME,Mastropietro C,Vignally P,Andreoli A,Marignani M,D'Ambrosio C,Miglioresi L,Nosotti L,Mitidieri O,Gentilucci UV,Puoti C,Barba

    更新日期:2012-11-16 00:00:00

  • Histological evaluation of duodenal biopsies from coeliac patients: the need for different grading criteria during follow-up.

    abstract:BACKGROUND:Coeliac disease is characterised by villous atrophy, which usually normalises after gluten withdrawal. Sometimes the revaluation of duodenal histology is required during follow-up, even if the methodology for comparing duodenal histology before and after introducing a gluten-free diet is not yet established....

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-015-0361-8

    authors: Elli L,Zini E,Tomba C,Bardella MT,Bosari S,Conte D,Runza L,Roncoroni L,Ferrero S

    更新日期:2015-10-14 00:00:00

  • Serum trefoil factor 3 is a promising non-invasive biomarker for gastric cancer screening: a monocentric cohort study in China.

    abstract:BACKGROUND:The search for better non-invasive biomarkers for gastric cancer remains ongoing. We investigated the predictive power of serum trefoil factor (TFF) levels as biomarkers for gastric cancer in comparison with the pepsinogen (PG) test. METHODS:Patients with gastric cancer, chronic atrophic gastritis (CAG) or ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-74

    authors: Huang Z,Zhang X,Lu H,Wu L,Wang D,Zhang Q,Ding H

    更新日期:2014-04-11 00:00:00

  • Sleep problems and functional disability in children with functional gastrointestinal disorders: an examination of the potential mediating effects of physical and emotional symptoms.

    abstract:BACKGROUND:Sleep disturbances are increasingly recognized as a common problem for children and adolescents with chronic pain conditions, but little is known about the prevalence, type, and impact of sleep problems in pediatric functional gastrointestinal disorders (FGIDs). The objectives of the current study were two-f...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-142

    authors: Schurman JV,Friesen CA,Dai H,Danda CE,Hyman PE,Cocjin JT

    更新日期:2012-10-15 00:00:00

  • Is discard better than return gastric residual aspirates: a systematic review and meta-analysis.

    abstract:BACKGROUND:The assessment of residual gastric volume is common practice in critical care units. However, the effects and safety of discarding or returning gastric aspirates remain uncertain. Therefore, we aimed to evaluate the role of discarding or returning gastric aspirates on the gastric residual volumes in critical...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12876-019-1028-7

    authors: Wen Z,Xie A,Peng M,Bian L,Wei L,Li M

    更新日期:2019-06-28 00:00:00

  • How do patients with inflammatory bowel disease want their biological therapy administered?

    abstract:BACKGROUND:Infliximab is usually administered by two monthly intravenous (iv) infusions, therefore requiring visits to hospital. Adalimumab is administered by self subcutaneous (sc) injections every other week. Both of these anti-TNF drugs appear to be equally efficacious in the treatment of Crohn's Disease and therefo...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-1

    authors: Allen PB,Lindsay H,Tham TC

    更新日期:2010-01-10 00:00:00

  • Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis.

    abstract:BACKGROUND:Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity. METHODS:Thirty-seven UC ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-29

    authors: Ishikawa D,Ando T,Watanabe O,Ishiguro K,Maeda O,Miyake N,Nakamura M,Miyahara R,Ohmiya N,Hirooka Y,El-Omar EM,Goto H

    更新日期:2011-03-31 00:00:00

  • HFD and HFD-provoked hepatic hypoxia act as reciprocal causation for NAFLD via HIF-independent signaling.

    abstract:BACKGROUND:The occurrence of non-alcoholic fatty liver disease (NAFLD) is found to be higher in patients with obstructive sleep apnea (OSA), which is characterized by intermittent hypoxia. Activation of hypoxia-inducible factors has been shown in the development and progression of NAFLD, implying a cause and effects re...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01515-5

    authors: Zhang X,Huang C,Li X,Shangguan Z,Wei W,Liu S,Yang S,Liu Y

    更新日期:2020-11-03 00:00:00

  • Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis.

    abstract:BACKGROUND:The natural course and treatment strategies for asymptomatic or oligosymptomatic pancreatic necrosis are still poorly defined. The aim of this retrospective study was to establish criteria for the need of intervention in patients with pancreatic necrosis. METHODS:A total of 31 consecutive patients (18 male,...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-48

    authors: Jürgensen C,Arlt A,Neser F,Fritscher-Ravens A,Stölzel U,Hampe J

    更新日期:2012-05-14 00:00:00

  • Chlamydia trachomatis antigens in enteroendocrine cells and macrophages of the small bowel in patients with severe irritable bowel syndrome.

    abstract:BACKGROUND:Inflammation and immune activation have repeatedly been suggested as pathogentic factors in irritable bowel syndrome (IBS). The driving force for immune activation in IBS remains unknown. The aim of our study was to find out if the obligate intracellular pathogen Chlamydia could be involved in the pathogenes...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-19

    authors: Dlugosz A,Törnblom H,Mohammadian G,Morgan G,Veress B,Edvinsson B,Sandström G,Lindberg G

    更新日期:2010-02-16 00:00:00

  • Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome.

    abstract:BACKGROUND:The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotics exert their beneficial effects are largely unknown. The aim of the study is to evaluate the role o...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-017-0605-x

    authors: Compare D,Rocco A,Coccoli P,Angrisani D,Sgamato C,Iovine B,Salvatore U,Nardone G

    更新日期:2017-04-14 00:00:00

  • Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase.

    abstract:BACKGROUND:Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated. METHODS:Wistar rats were used (6 in each group)--Groups: (1) sham, (2) ischemia...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230x-2-22

    authors: Serracino-Inglott F,Virlos IT,Habib NA,Williamson RC,Mathie RT

    更新日期:2002-09-20 00:00:00