Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis.


BACKGROUND:Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity. METHODS:Thirty-seven UC patients undergoing EG and colonoscopy were invited to enroll. EG findings were classified as normal, homogeneous, random, or hard, and colonoscopic findings as normal, mucosal edema and erosion, punched-out ulcer, and extensive mucosal abrasion. Clinical findings were evaluated using clinical activity index (CAI) scores for each patient at colonoscopy. RESULTS:On EG, 10 cases were classified as normal, 11 as homogeneous, 6 as random, and 10 as hard. EG findings showed a significant correlation those of colonoscopy (p < 0.001). Seven of 10 (70%) normal-type patients were in the remission phase, while all 6 random-type patients were in the active phase. Among active-phase patients, 4 of 7 (57%) homogeneous-type patients responded to steroid or leukocytapheresis therapy, while 3 of 6 (50%) random-type patients required treatment with cyclosporine. Three of 10 (30%) hard-type patients required colectomy. CONCLUSIONS:In this small series, EG findings reflected colonoscopic findings and correlated with disease activity among patients with UC.


BMC Gastroenterol


BMC gastroenterology


Ishikawa D,Ando T,Watanabe O,Ishiguro K,Maeda O,Miyake N,Nakamura M,Miyahara R,Ohmiya N,Hirooka Y,El-Omar EM,Goto H




Has Abstract


2011-03-31 00:00:00










  • Risk factors for hepatitis C virus infection among blood donors in southern Brazil: a case-control study.

    abstract:BACKGROUND:In Brazil, it is estimated that between 2.5 and 4.9% of the general population present anti-hepatitis C virus (HCV) antibodies, which corresponds to as many as 3.9 to 7.6 million chronic carriers. Chronic liver disease is associated with HCV infection in 20% to 58% of the Brazilian patients. The objective of...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Brandão AB,Fuchs SC

    更新日期:2002-08-08 00:00:00

  • The addition of locust bean gum but not water delayed the gastric emptying rate of a nutrient semisolid meal in healthy subjects.

    abstract:BACKGROUND:Most of the previous studies regarding the effects of gel-forming fibres have considered the gastric emptying of liquid or solid meals after the addition of pectin or guar gum. The influence of locust bean gum, on gastric emptying of nutrient semisolid meals in humans has been less well studied, despite its ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Darwiche G,Björgell O,Almér LO

    更新日期:2003-06-06 00:00:00

  • Rectal forceps biopsy procedure in cystic fibrosis: technical aspects and patients perspective for clinical trials feasibility.

    abstract:BACKGROUND:Measurements of CFTR function in rectal biopsies ex vivo have been used for diagnosis and prognosis of Cystic Fibrosis (CF) disease. Here, we aimed to evaluate this procedure regarding: i) viability of the rectal specimens obtained by biopsy forceps for ex vivo bioelectrical and biochemical laboratory analys...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Servidoni MF,Sousa M,Vinagre AM,Cardoso SR,Ribeiro MA,Meirelles LR,de Carvalho RB,Kunzelmann K,Ribeiro AF,Ribeiro JD,Amaral MD

    更新日期:2013-05-20 00:00:00

  • Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome.

    abstract:BACKGROUND:The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotics exert their beneficial effects are largely unknown. The aim of the study is to evaluate the role o...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Compare D,Rocco A,Coccoli P,Angrisani D,Sgamato C,Iovine B,Salvatore U,Nardone G

    更新日期:2017-04-14 00:00:00

  • The balance between two isoforms of LEF-1 regulates colon carcinoma growth.

    abstract:BACKGROUND:Colon cancer is one of the most aggressive human malignancies, with a very poor prognosis. Although it has been suggested that different isoforms of the lymphoid enhancer factor (LEF-1) have opposing biological activities, the biological outcome of aberrant LEF-1 activation in colon cancer is still unclear. ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Wang SH,Nan KJ,Wang YC,Wang WJ,Tian T

    更新日期:2012-05-28 00:00:00

  • Do gastrointestinal and respiratory signs and symptoms correlate with the severity of gastroesophageal reflux?

    abstract:BACKGROUND:Gastroesophageal reflux (GER) is a disorder that is common by seen in childhood and may lead to severe complications. In this study, we ascertained the incidence of GER among the children who had typical and atypical complaints of GER and whether there was a difference between two groups comparing the findin...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Uzun H,Alagoz D,Okur M,Dikici B,Kocabay K,Senses DA,Ozkan A,Kaya M

    更新日期:2012-03-21 00:00:00

  • Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial.

    abstract:BACKGROUND:Rebamipide is a gastroprotective agent with promising results against gastric damage induced by non-steroidal anti-inflammatory drugs. The present study evaluated if rebamipide protects against naproxen-induced gastric damage in healthy volunteers. Changes in gastric PGE2 tissue concentration were also evalu...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Gagliano-Jucá T,Moreno RA,Zaminelli T,Napolitano M,Magalhães AF,Carvalhaes A,Trevisan MS,Wallace JL,De Nucci G

    更新日期:2016-06-04 00:00:00

  • The role of MR imaging in detection of hepatic iron overload in patients with cirrhosis of different origins.

    abstract:BACKGROUND:There are many pathological conditions with hepatic iron overload. Classical definite diagnostic methods of these disorders are invasive and based on a direct tissue biopsy material. For the last years the role of MR imaging in liver diagnostics has been increasing. MRI shows changes of liver intensity in pa...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Szurowska E,Sikorska K,Izycka-Swieszewska E,Nowicki T,Romanowski T,Bielawski KP,Studniarek M

    更新日期:2010-01-27 00:00:00

  • Age and pain score before gastrointestinal endoscopies in children are predictors for post procedure pain.

    abstract:BACKGROUND:Gastrointestinal endoscopy may be associated with pain and anxiety. Predictors for high pain scores after endoscopies in children are not known. The aim of our study was to identify risk factors for prolonged recovery and higher pain scores after gastrointestinal endoscopy in children. METHODS:All the child...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Galai T,Yerushalmy-Feler A,Heller NP,Ben-Tov A,Weintraub Y,Amir A,Moran-Lev H,Zac L,Cohen S

    更新日期:2020-11-26 00:00:00

  • Possible etiology of improvements in both quality of life and overlapping gastroesophageal reflux disease by proton pump inhibitor treatment in a prospective randomized controlled trial.

    abstract:BACKGROUND:Symptoms suggestive of functional dyspepsia (FD) and irritable bowel syndrome (IBS) frequently overlap with those of gastroesophageal reflux disease. Despite the high prevalence of symptomatic overlap, the underlying etiology remains poorly defined. We assessed the correlation of symptomatic relief and healt...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mönnikes H,Schwan T,van Rensburg C,Straszak A,Theek C,Lühmann R,Sander P,Tholen A

    更新日期:2013-10-01 00:00:00

  • Korean colonoscopy screening pilot study (K-cospi) for screening colorectal cancer: study protocol for the multicenter, community-based clinical trial.

    abstract:BACKGROUND:The Korean National Cancer Screening Program has been providing annual fecal immunochemical test for colorectal cancer (CRC) to adults aged 50 years and older since 2004. The Korean Colonoscopy Screening Pilot Study was developed to evaluate the effectiveness of colonoscopy screening for CRC incidence and mo...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Park B,Jun JK,Kim BC,Choi KS,Suh M,Expert Advisory Committee.,Monitoring Committee.,Center for Korean Colonoscopy Screening Pilot Study.,Research Team on the Protocol Development of Pilot study.

    更新日期:2021-01-26 00:00:00

  • Vitamin K deficiency-induced hemorrhagic shock after thoracentesis: a case report.

    abstract:BACKGROUND:Vitamin K deficiency results in serious coagulation dysfunction, but hemorrhagic shock is rare. Herein, we describe a case of vitamin K deficiency and abnormality in the path of the intercostal artery, the combination of which led to hemorrhagic shock. CASE PRESENTATION:An 83-year-old woman was hospitalized...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Itagaki H,Hagino T

    更新日期:2019-04-18 00:00:00

  • Reactive lymphoid hyperplasia of the liver in a patient with colon cancer: report of two cases.

    abstract:BACKGROUND:Reactive lymphoid hyperplasia (RLH) of the liver is very rarely reported, and we encountered two cases of RLH of the liver in a patient with colon cancer. CASE PRESENTATION:In the first case, a 77-year-old woman was admitted for the surgical removal of a ascending colon cancer. A hepatic tumor in the left l...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Takahashi H,Sawai H,Matsuo Y,Funahashi H,Satoh M,Okada Y,Inagaki H,Takeyama H,Manabe T

    更新日期:2006-09-12 00:00:00

  • Hypophosphataemia after ferric carboxymaltose is unrelated to symptoms, intestinal inflammation or vitamin D status.

    abstract:BACKGROUND:Intravenous iron replacement is recommended for iron-deficient patients with inflammatory bowel disease (IBD), but may be associated with hypophosphataemia, predisposing to osteomalacia and fractures. This study aimed to evaluate the incidence and risk factors for hypophosphataemia following intravenous ferr...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Fang W,Kenny R,Rizvi QU,McMahon LP,Garg M

    更新日期:2020-06-10 00:00:00

  • Gastric tuberculosis mimicking submucosal tumor: a case series.

    abstract:BACKGROUND:Gastric tuberculosis mimicking submucosal tumors is extremely rare and often misdiagnosed. CASE PRESENTATION:Three cases of gastric tuberculosis mimicking submucosal tumors were identified among patients admitted to local county hospitals because of upper abdominal discomfort and pain, with gastroscopy show...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Zhu R,Zhou Y,Wang H,Di L,Zhao K,Tuo B,Wu H

    更新日期:2020-01-30 00:00:00

  • Non-selective beta blocker use is associated with improved short-term survival in patients with cirrhosis referred for liver transplantation.

    abstract:BACKGROUND:Recent evidence cautions against the use of non-selective beta-blockers (NSBB) in patients with refractory ascites or spontaneous bacterial peritonitis while other data suggests a survival benefit in patients with advanced liver disease. The aim of this study was to describe the use and impact of NSBB in pat...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Ngwa T,Orman E,Gomez EV,Vuppalanchi R,Kubal C,Chalasani N,Ghabril M

    更新日期:2020-01-06 00:00:00

  • Protective effect of leptin against ischemia-reperfusion injury in the rat small intestine.

    abstract:BACKGROUND:The small intestine is extremely sensitive to ischemia-reperfusion (I/R) injury and a range of microcirculatory disturbances which contribute to tissue damage. Previous studies have shown that leptin plays an important physiological role in the microvasculature. The aim of this study was to evaluate the prot...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Hacioglu A,Algin C,Pasaoglu O,Pasaoglu E,Kanbak G

    更新日期:2005-11-21 00:00:00

  • Risk of inflammatory bowel disease following a diagnosis of irritable bowel syndrome.

    abstract:BACKGROUND:Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) symptoms often overlap. In some IBS cases there are subtle inflammatory changes similar to the immune-mediated pathophysiology of IBD, and the risk of both increases after infectious gastroenteritis (IGE). METHODS:To evaluate the effect of ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Porter CK,Cash BD,Pimentel M,Akinseye A,Riddle MS

    更新日期:2012-05-28 00:00:00

  • "Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study".

    abstract:BACKGROUND:A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SMI and IMF on the survival of Indonesian HCC patients, whose characteristics differ from those of Jap...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Mardian Y,Yano Y,Ratnasari N,Choridah L,Wasityastuti W,Setyawan NH,Hayashi Y

    更新日期:2019-12-30 00:00:00

  • Health education program improves QOL in students with irritable bowel syndrome after the Wenchuan earthquake: a five-year multi-center study.

    abstract:BACKGROUND:Stress is a common contributing factor for irritable bowel syndrome (IBS). This study was to evaluate the efficacy of the centralized health education program in improving the quality of life (QOL) of middle school students with IBS who experienced the Wenchuan earthquake on May 12, 2008. METHODS:A multi-ce...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zheng SC,Gong H,Wang YP,Zhang Q,Wang LL,Liao XF,He DW,Wu J

    更新日期:2018-07-27 00:00:00

  • The level and prevalence of depression and anxiety among patients with different subtypes of irritable bowel syndrome: a network meta-analysis.

    abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a very common functional bowel disorder. However, the difference of depression and anxiety comorbidities among different IBS subtypes is still not well evaluated. This study aims to investigate the difference in the level and prevalence of depression and anxiety among health...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Hu Z,Li M,Yao L,Wang Y,Wang E,Yuan J,Wang F,Yang K,Bian Z,Zhong LLD

    更新日期:2021-01-07 00:00:00

  • Adequacy and quality of abdominal echographies requested by primary care professionals.

    abstract:BACKGROUND:The value of abdominal echography in primary care is great because it is innocuous, inexpensive, easy to perform and provides a great deal of information making this the first examination to be requested in cases of probable abdominal disease. However, too many abdominal echographies are probably requested o...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Auladell MA,Caballeria L,Pera G,Rodríguez L,Casas JD,Aznar J,Miranda D,Sánchez C,Negrete A,Castellví JM,Bernad J,Canut S,Aubà J,Aizpurua MM,Torán P

    更新日期:2010-09-06 00:00:00

  • Efficacy and safety of infliximab induction therapy in Crohn's Disease in Central Europe--a Hungarian nationwide observational study.

    abstract:BACKGROUND:Infliximab (IFX) has proven to be an effective addition to the therapeutic arsenal for refractory, fistulizing, and steroid dependent Crohn's disease (CD), with efficacy in the induction and maintenance of clinical remission of CD. Our objective in this study is to report the nationwide, multicenter experien...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Miheller P,Lakatos PL,Horváth G,Molnár T,Szamosi T,Czeglédi Z,Salamon A,Czimmer J,Rumi G,Palatka K,Papp M,Jakab Z,Szabó A,Gelley A,Lakatos L,Barta Z,Balázs C,Rácz I,Zeher M,Döbrönte Z,Altorjay I,Hunyady B,Simo

    更新日期:2009-09-10 00:00:00

  • Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn's disease.

    abstract:BACKGROUND:Glycoprotein 2 (GP2) was discovered as the major autoantigen of Crohn's disease (CD)-specific pancreatic autoantibodies (PAB). We investigated anti-GP2 IgA and IgG antibodies as novel serological parameters in CD and assessed their association with distinct disease phenotypes. METHODS:Anti-GP2 and anti-Sacc...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Bogdanos DP,Roggenbuck D,Reinhold D,Wex T,Pavlidis P,von Arnim U,Malfertheiner P,Forbes A,Conrad K,Laass MW

    更新日期:2012-08-06 00:00:00

  • Epstein-Barr virus infection is associated with a higher Child-Pugh score and may predict poor prognoses for patients with liver cirrhosis.

    abstract:BACKGROUND:Studies on Epstein-Barr virus (EBV) have focused mostly on neoplastic disease. Few studies have considered immunocompetent patients who are not severely immunocompromised. Liver cirrhosis is associated with various levels of immune dysfunction. In the current study, we determined EBV infection rates, the inf...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Hu J,Zhang X,Yu G,Cai H,Gu J,Hu M,Xiang D,Lian J,Yu L,Jia H,Zhang Y,Yang Y

    更新日期:2019-06-18 00:00:00

  • Role of vitamin D3 combined to alginates in preventing acid and oxidative injury in cultured gastric epithelial cells.

    abstract:BACKGROUND:Gastric diseases are a worldwide problem in modern society, as reported in the USA, in the range of 0.5-2 episodes/year/person and an incidence of 5-100 episodes/1000/week according to seasons and age. There is convincing evidence that oxidative stress is involved in the pathogenesis of acute gastric injury....

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Uberti F,Bardelli C,Morsanuto V,Ghirlanda S,Molinari C

    更新日期:2016-10-07 00:00:00

  • Implementation of population screening for colorectal cancer by repeated Fecal Immunochemical Test (FIT): third round.

    abstract:BACKGROUND:Colorectal cancer (CRC) is the most common cancer in Europe with a mortality rate of almost 50%. The prognosis of patients is largely determined by the clinical and pathological stage at the time of diagnosis. Population screening has been shown to reduce CRC-related mortality rate. Most screening programs w...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Stegeman I,de Wijkerslooth TR,Mallant-Hent RC,de Groot K,Stroobants AK,Fockens P,Mundt M,Bossuyt PM,Dekker E

    更新日期:2012-06-19 00:00:00

  • Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis.

    abstract:BACKGROUND:The natural course and treatment strategies for asymptomatic or oligosymptomatic pancreatic necrosis are still poorly defined. The aim of this retrospective study was to establish criteria for the need of intervention in patients with pancreatic necrosis. METHODS:A total of 31 consecutive patients (18 male,...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Jürgensen C,Arlt A,Neser F,Fritscher-Ravens A,Stölzel U,Hampe J

    更新日期:2012-05-14 00:00:00

  • Case report: an aortic aneurysm as cause of pseudoachalasia.

    abstract:BACKGROUND:Pseudoachalasia is a rare disorder which has clinical, radiographic, and manometric findings that are often indistinguishable from primary achalasia. It is usually associated with malignancy. Few reports describe vascular compression as a cause of pseudoachalasia. CASE PRESENTATION:Here we present a case of...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: Dejaeger M,Lormans M,Dejaeger E,Fagard K

    更新日期:2020-03-06 00:00:00

  • The relation between plasma tyrosine concentration and fatigue in primary biliary cirrhosis and primary sclerosing cholangitis.

    abstract:BACKGROUND:In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several non-hepatological conditions but for PBC and PSC no data are available. This study aimed to identify...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章


    authors: ter Borg PC,Fekkes D,Vrolijk JM,van Buuren HR

    更新日期:2005-03-24 00:00:00