Abstract:
BACKGROUND:The natural course and treatment strategies for asymptomatic or oligosymptomatic pancreatic necrosis are still poorly defined. The aim of this retrospective study was to establish criteria for the need of intervention in patients with pancreatic necrosis. METHODS:A total of 31 consecutive patients (18 male, median age 58 yrs.) diagnosed with pancreatic necrosis by endoscopic ultrasound, in whom a decision for initial conservative treatment was made, were followed for the need of interventions such as endoscopic or surgical intervention, or death. RESULTS:After a median follow-up of 243 days, 21 patients remained well without intervention and in 10 patients an endpoint event occurred. In a multivariate logistic regression analysis of the clinical and endosonographic parameters, liquid content was the single independent predictor for intervention (p = 0.0006). The presence of high liquid content in the pancreatic necrosis resulted in a 64% predicted endpoint risk as compared to 2% for solid necrosis. CONCLUSIONS:Pancreatic necrotic cavities with high liquid content are associated with a high risk of complications. Therefore, close clinical monitoring is needed and early elective intervention might be considered in these patients.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Jürgensen C,Arlt A,Neser F,Fritscher-Ravens A,Stölzel U,Hampe Jdoi
10.1186/1471-230X-12-48subject
Has Abstractpub_date
2012-05-14 00:00:00pages
48issn
1471-230Xpii
1471-230X-12-48journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Measurements of CFTR function in rectal biopsies ex vivo have been used for diagnosis and prognosis of Cystic Fibrosis (CF) disease. Here, we aimed to evaluate this procedure regarding: i) viability of the rectal specimens obtained by biopsy forceps for ex vivo bioelectrical and biochemical laboratory analys...
journal_title:BMC gastroenterology
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pub_type: 杂志文章,多中心研究
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