High quality health systems in the SDG era: Country-specific priorities for improving quality of care.

abstract：BACKGROUND:Although the involvement of intra-tumor genetic heterogeneity in tumor progression, treatment resistance, and metastasis is established, genetic heterogeneity is seldom examined in clinical trials or practice. Many studies of heterogeneity have had prespecified markers for tumor subpopulations, limiting thei...

journal_title：PLoS medicine

authors： Mroz EA,Tward AD,Hammon RJ,Ren Y,Rocco JW

更新日期：2015-02-10 00:00:00

abstract：BACKGROUND:We simulated tobacco control and pharmacological strategies for preventing cardiovascular deaths in India, the country that is expected to experience more cardiovascular deaths than any other over the next decade. METHODS AND FINDINGS:A microsimulation model was developed to quantify the differential effect...

journal_title：PLoS medicine

authors： Basu S,Glantz S,Bitton A,Millett C

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The cesarean section (CS) rate has risen globally during the last two decades. Effective and feasible strategies are needed to reduce it. The aim of this study was to assess the CS rate change after a two-stage intervention package that was designed to reduce the overall CS rate in Guangzhou, China. METHODS...

journal_title：PLoS medicine

authors： Xia X,Zhou Z,Shen S,Lu J,Zhang L,Huang P,Yu J,Yang L,Wang P,Lam KH,Jacobsson B,Mol BW,Xia H,Qiu X

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:Endometrial cancer is the most common gynecologic malignancy, and its incidence and associated mortality are increasing. Despite the immediate need to detect these cancers at an earlier stage, there is no effective screening methodology or protocol for endometrial cancer. The comprehensive, genomics-based an...

journal_title：PLoS medicine

authors： Nair N,Camacho-Vanegas O,Rykunov D,Dashkoff M,Camacho SC,Schumacher CA,Irish JC,Harkins TT,Freeman E,Garcia I,Pereira E,Kendall S,Belfer R,Kalir T,Sebra R,Reva B,Dottino P,Martignetti JA

更新日期：2016-12-27 00:00:00

abstract：:Martin Gerdin and colleagues argue that disaster health interventions and decision-making can benefit from an evidence-based approach Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Gerdin M,Clarke M,Allen C,Kayabu B,Summerskill W,Devane D,MacLachlan M,Spiegel P,Ghosh A,Zachariah R,Gupta S,Barbour V,Murray V,von Schreeb J

更新日期：2014-04-22 00:00:00

abstract：:David Studdert and colleagues explore how to balance public health, individual freedom, and good government when it comes to sugar-sweetened drinks. ...

journal_title：PLoS medicine

authors： Studdert DM,Flanders J,Mello MM

更新日期：2015-07-07 00:00:00

abstract：BACKGROUND:Animal studies suggest vital roles of sphingolipids, especially ceramides, in the pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell dysfunction, and inflammation, but human studies are limited. We aimed to evaluate the associations of circulating sphingolipids with inc...

journal_title：PLoS medicine

authors： Yun H,Sun L,Wu Q,Zong G,Qi Q,Li H,Zheng H,Zeng R,Liang L,Lin X

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Effective implementation strategies are needed to increase engagement in HIV services in hyperendemic settings. We conducted a pragmatic cluster-randomized trial in a high-risk, highly mobile fishing community (HIV prevalence: approximately 38%) in Rakai, Uganda, to assess the impact of a community health wo...

journal_title：PLoS medicine

authors： Chang LW,Mbabali I,Hutton H,Amico KR,Kong X,Mulamba J,Anok A,Ssekasanvu J,Long A,Thomas AG,Thomas K,Bugos E,Pollard R,van Wickle K,Kennedy CE,Nalugoda F,Serwadda D,Bollinger RC,Quinn TC,Reynolds SJ,Gray RH,Wawer

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Research needs to be reported transparently so readers can critically assess the strengths and weaknesses of the design, conduct, and analysis of studies. Reporting guidelines have been developed to inform reporting for a variety of study designs. The objective of this study was to identify whether there is ...

journal_title：PLoS medicine

authors： Bennett C,Khangura S,Brehaut JC,Graham ID,Moher D,Potter BK,Grimshaw JM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Socioeconomic disparities in infant mortality have persisted for decades in high-income countries and may have become stronger in some populations. Therefore, new understandings of the mechanisms that underlie socioeconomic differences in infant deaths are essential for creating and implementing health initi...

journal_title：PLoS medicine

authors： Yu Y,Liew Z,Wang A,Arah OA,Li J,Olsen J,Cnattingius S,Qin G,Obel C,Fu B,Li J

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:Hospitalisation for adversity-related injury (violent, drug/alcohol-related, or self-inflicted injury) has been described as a "teachable moment", when intervention may reduce risks of further harm. Which adolescents are likely to benefit most from intervention strongly depends on their long-term risks of ha...

journal_title：PLoS medicine

authors： Herbert A,Gilbert R,González-Izquierdo A,Pitman A,Li L

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:Malaysia's stable health care system is facing challenges with increasing medicine costs. To investigate these issues a survey was carried out to evaluate medicine prices, availability, affordability, and the structure of price components. METHODS AND FINDINGS:The methodology developed by the World Health O...

journal_title：PLoS medicine

authors： Babar ZU,Ibrahim MI,Singh H,Bukahri NI,Creese A

更新日期：2007-03-27 00:00:00

abstract：:Matthew Fox and Sydney Rosen discuss a cascade of HIV care adapted to WHO-recommended antiretroviral therapy irrespective of CD4 cell count. ...

journal_title：PLoS medicine

authors： Fox MP,Rosen S

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large populations treated in routine clinical practice is lacking. The objective of this study was to measure the association...

journal_title：PLoS medicine

authors： Douglas IJ,Bhaskaran K,Batterham RL,Smeeth L

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:There is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19). We investigated racial and ethnic disparities in patterns of COVI...

journal_title：PLoS medicine

authors： Rentsch CT,Kidwai-Khan F,Tate JP,Park LS,King JT Jr,Skanderson M,Hauser RG,Schultze A,Jarvis CI,Holodniy M,Lo Re V 3rd,Akgün KM,Crothers K,Taddei TH,Freiberg MS,Justice AC

更新日期：2020-09-22 00:00:00

abstract：BACKGROUND:For treating multidrug-resistant tuberculosis (MDR TB), the World Health Organization (WHO) recommends a regimen of at least four second-line drugs that are likely to be effective as well as pyrazinamide. WHO guidelines indicate only marginal benefit for regimens based directly on drug susceptibility testing...

journal_title：PLoS medicine

authors： Yuen CM,Kurbatova EV,Tupasi T,Caoili JC,Van Der Walt M,Kvasnovsky C,Yagui M,Bayona J,Contreras C,Leimane V,Ershova J,Via LE,Kim H,Akksilp S,Kazennyy BY,Volchenkov GV,Jou R,Kliiman K,Demikhova OV,Vasilyeva IA,Dalto

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:Lifetime glycemic exposure and its relationship with age at diagnosis in type 2 diabetes (T2D) are unknown. Pharmacologic glycemic management strategies for young-onset T2D (age at diagnosis <40 years) are poorly defined. We studied how age at diagnosis affects glycemic exposure, glycemic deterioration, and ...

journal_title：PLoS medicine

authors： Ke C,Stukel TA,Shah BR,Lau E,Ma RC,So WY,Kong AP,Chow E,Chan JCN,Luk A

更新日期：2020-09-18 00:00:00

abstract：:Pharmacogenomics is one of the first clinical applications of the postgenomic era. It promises personalized medicine rather than the established "one size fits all" approach to drugs and dosages. The expected reduction in trial and error should ultimately lead to more efficient and safer drug therapy. In recent years,...

journal_title：PLoS medicine

authors： Swen JJ,Huizinga TW,Gelderblom H,de Vries EG,Assendelft WJ,Kirchheiner J,Guchelaar HJ

更新日期：2007-08-01 00:00:00

abstract：:Alexander Tsai and colleagues highlight the complex relationship between poverty and HIV stigma in sub-Saharan Africa, and discuss possible ways to break the cycle. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Tsai AC,Bangsberg DR,Weiser SD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Rates of diseases and injuries and the effects of their risk factors can have substantial subnational heterogeneity, especially in middle-income countries like Mexico. Subnational analysis of the burden of diseases, injuries, and risk factors can improve characterization of the epidemiological transition and...

journal_title：PLoS medicine

authors： Stevens G,Dias RH,Thomas KJ,Rivera JA,Carvalho N,Barquera S,Hill K,Ezzati M

更新日期：2008-06-17 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002781.]. ...

journal_title：PLoS medicine

authors： Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74

更新日期：2019-07-18 00:00:00

abstract：:In an essay, Paul Bloem and Ikechukwu Ogbuanu discuss the public health implications of HPV vaccination. ...

journal_title：PLoS medicine

authors： Bloem P,Ogbuanu I

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups. ME...

journal_title：PLoS medicine

authors： Lipnicki DM,Makkar SR,Crawford JD,Thalamuthu A,Kochan NA,Lima-Costa MF,Castro-Costa E,Ferri CP,Brayne C,Stephan B,Llibre-Rodriguez JJ,Llibre-Guerra JJ,Valhuerdi-Cepero AJ,Lipton RB,Katz MJ,Derby CA,Ritchie K,Ancelin ML

更新日期：2019-07-23 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) released revised guidelines in 2015 recommending that all people living with HIV, regardless of CD4 count, initiate antiretroviral therapy (ART) upon diagnosis. However, few studies have projected the global resources needed for rapid scale-up of ART. Under the Health Poli...

journal_title：PLoS medicine

authors： Dutta A,Barker C,Kallarakal A

更新日期：2015-11-24 00:00:00

abstract：:Nina Finley and co-authors discuss public involvement in planning and reporting medical research. ...

journal_title：PLoS medicine

authors： Finley N,Swartz TH,Cao K,Tucker JD

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:While patterns of incidence of clinical influenza have been well described, much uncertainty remains over patterns of incidence of infection. The 2009 pandemic provided both the motivation and opportunity to investigate patterns of mild and asymptomatic infection using serological techniques. However, to dat...

journal_title：PLoS medicine

authors： Riley S,Kwok KO,Wu KM,Ning DY,Cowling BJ,Wu JT,Ho LM,Tsang T,Lo SV,Chu DK,Ma ES,Peiris JS

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Leber congenital amaurosis (LCA), a heterogeneous early-onset retinal dystrophy, accounts for approximately 15% of inherited congenital blindness. One cause of LCA is loss of the enzyme lecithin:retinol acyl transferase (LRAT), which is required for regeneration of the visual photopigment in the retina. MET...

journal_title：PLoS medicine

authors： Batten ML,Imanishi Y,Tu DC,Doan T,Zhu L,Pang J,Glushakova L,Moise AR,Baehr W,Van Gelder RN,Hauswirth WW,Rieke F,Palczewski K

更新日期：2005-11-01 00:00:00

abstract：:Is it ethical for scientists to conduct or to benefit from research in another country if that research would be unlawful, or not generally accepted, in their own country? ...

journal_title：PLoS medicine

authors： Skene L

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:In patients treated with cardiotoxic chemotherapies, the presence of cardiovascular risk factors and previous cardiac disease have been strongly correlated to the onset of cardiotoxicity. The influence of overweight and obesity as risk factors in the development of treatment-related cardiotoxicity in breast ...

journal_title：PLoS medicine

authors： Kaboré EG,Guenancia C,Vaz-Luis I,Di Meglio A,Pistilli B,Coutant C,Cottu P,Lesur A,Petit T,Dalenc F,Rouanet P,Arnaud A,Arsene O,Ibrahim M,Wassermann J,Boileau-Jolimoy G,Martin AL,Lemonnier J,André F,Arveux P

更新日期：2019-12-23 00:00:00

abstract：BACKGROUND:Identifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity. Recently, the intensity and the quality of the host immune response in the tumor microenvironment h...

journal_title：PLoS medicine

authors： Sanz-Pamplona R,Melas M,Maoz A,Schmit SL,Rennert H,Lejbkowicz F,Greenson JK,Sanjuan X,Lopez-Zambrano M,Alonso MH,Qu C,McDonnell KJ,Idos GE,Vignali M,Emerson R,Fields P,Guinó E,Santos C,Salazar R,Robins HS,Rennert

更新日期：2020-09-24 00:00:00