Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

abstract：BACKGROUND:Clear recognition of the damaging effects of poverty on early childhood development has fueled an interest in interventions aimed at mitigating these harmful consequences. Psychosocial interventions aimed at alleviating the negative impacts of poverty on children are frequently shown to be of benefit, but ef...

journal_title：PLoS medicine

authors： Morgan B,Kumsta R,Fearon P,Moser D,Skeen S,Cooper P,Murray L,Moran G,Tomlinson M

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:Despite repeated outbreaks, in particular the devastating 2014-2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among the drug candidates is the broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile in patients with EVD (JI...

journal_title：PLoS medicine

authors： Guedj J,Piorkowski G,Jacquot F,Madelain V,Nguyen THT,Rodallec A,Gunther S,Carbonnelle C,Mentré F,Raoul H,de Lamballerie X

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Puberty is a critical period for bone mass accrual, and late puberty in boys is associated with reduced bone mass in adult men. The role of variations in pubertal timing within the normal range for adult fracture risk in men is, however, unknown. We, therefore, assessed the association between age at peak he...

journal_title：PLoS medicine

authors： Vandenput L,Kindblom JM,Bygdell M,Nethander M,Ohlsson C

更新日期：2019-12-02 00:00:00

abstract：:In a Perspective, Lynn Morris and Nonhlanhla Mkhize discuss the prospects for broadly neutralizing antibodies to be used in preventing HIV infection. ...

journal_title：PLoS medicine

authors： Morris L,Mkhize NN

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:Suboptimal weight gain during pregnancy is a potentially modifiable risk factor. We aimed to investigate the association between suboptimal gestational weight gain and severe adverse birth outcomes by pre-pregnancy body mass index (BMI) categories, including obesity class I to III. METHODS AND FINDINGS:We c...

journal_title：PLoS medicine

authors： Ukah UV,Bayrampour H,Sabr Y,Razaz N,Chan WS,Lim KI,Lisonkova S

更新日期：2019-12-30 00:00:00

abstract：:Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due to advancements in both prevention and treatment of HIV. However, major challenges still remain. We describe basic principles of epidemic control in the context of HIV and identify a number of attainable goals in terms of control a...

journal_title：PLoS medicine

authors： Jones J,Sullivan PS,Curran JW

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:Tobacco addiction is a complex, multicomponent phenomenon stemming from nicotine's pharmacology and the user's biology, psychology, sociology, and environment. After decades of public denial, the tobacco industry now agrees with public health authorities that nicotine is addictive. In 2000, Philip Morris bec...

journal_title：PLoS medicine

authors： Elias J,Hendlin YH,Ling PM

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:The cesarean section (CS) rate has risen globally during the last two decades. Effective and feasible strategies are needed to reduce it. The aim of this study was to assess the CS rate change after a two-stage intervention package that was designed to reduce the overall CS rate in Guangzhou, China. METHODS...

journal_title：PLoS medicine

authors： Xia X,Zhou Z,Shen S,Lu J,Zhang L,Huang P,Yu J,Yang L,Wang P,Lam KH,Jacobsson B,Mol BW,Xia H,Qiu X

更新日期：2019-07-08 00:00:00

abstract：:In an Editorial, Guest Editors Nicola Low and Nathalie Broutet discuss the Collection on sexually transmitted infections in the context of research priorities in the field. ...

journal_title：PLoS medicine

authors： Low N,Broutet NJ

更新日期：2017-12-27 00:00:00

abstract：BACKGROUND:Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to laboratory-based tests in Mozambique. METHODS AND FINDINGS:We use a validated model of HIV testing, linkag...

journal_title：PLoS medicine

authors： Hyle EP,Jani IV,Lehe J,Su AE,Wood R,Quevedo J,Losina E,Bassett IV,Pei PP,Paltiel AD,Resch S,Freedberg KA,Peter T,Walensky RP

更新日期：2014-09-16 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1001895.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2016-06-10 00:00:00

abstract：:Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers...

journal_title：PLoS medicine

authors： Liberati A,Altman DG,Tetzlaff J,Mulrow C,Gøtzsche PC,Ioannidis JP,Clarke M,Devereaux PJ,Kleijnen J,Moher D

更新日期：2009-07-21 00:00:00

abstract：:This month in PLOS Medicine we launched a Special Issue on New Tools and Strategies for Tuberculosis Diagnosis, Care, and Elimination. In this issue's Editorial, the Guest Editors Claudia Denkinger, Richard Chaisson, and Mark Hatherill highlight some of the research that will publish and how these studies focusing on ...

journal_title：PLoS medicine

authors： Hatherill M,Chaisson RE,Denkinger CM

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:Plasmodium falciparum merozoite surface protein 3 is a malaria vaccine candidate that was identified, characterised, and developed based on a unique immuno-clinical approach. The vaccine construct was derived from regions fully conserved among various strains and containing B cell epitopes targeted by human ...

journal_title：PLoS medicine

authors： Druilhe P,Spertini F,Soesoe D,Corradin G,Mejia P,Singh S,Audran R,Bouzidi A,Oeuvray C,Roussilhon C

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Historically, the main focus of studies of childhood mortality has been the infant and under-five mortality rates. Neonatal mortality (deaths <28 days of age) has received limited attention, although such deaths account for about 41% of all child deaths. To better assess progress, we developed annual estimat...

journal_title：PLoS medicine

authors： Oestergaard MZ,Inoue M,Yoshida S,Mahanani WR,Gore FM,Cousens S,Lawn JE,Mathers CD,United Nations Inter-Agency Group for Child Mortality Estimation and the Child Health Epidemiology Reference Group.

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Introduction of pneumococcal conjugate vaccines (PCVs) of limited valency is justified in Africa by the high burden of pneumococcal disease. Long-term beneficial effects of PCVs may be countered by serotype replacement. We aimed to determine the impact of PCV-7 vaccination on pneumococcal carriage in rural G...

journal_title：PLoS medicine

authors： Roca A,Hill PC,Townend J,Egere U,Antonio M,Bojang A,Akisanya A,Litchfield T,Nsekpong DE,Oluwalana C,Howie SR,Greenwood B,Adegbola RA

更新日期：2011-10-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002718.]. ...

journal_title：PLoS medicine

authors： Liu Z,Kuo PL,Horvath S,Crimmins E,Ferrucci L,Levine M

更新日期：2019-02-25 00:00:00

abstract：BACKGROUND:WHO recommends prompt diagnosis and quinine plus clindamycin for treatment of uncomplicated malaria in the first trimester and artemisinin-based combination therapies in subsequent trimesters. We undertook a systematic review of women's access to and healthcare provider adherence to WHO case management polic...

journal_title：PLoS medicine

authors： Hill J,D'Mello-Guyett L,Hoyt J,van Eijk AM,ter Kuile FO,Webster J

更新日期：2014-08-05 00:00:00

abstract：BACKGROUND:Experimental and observational research has suggested the potential for increased type 2 diabetes (T2D) risk among populations taking statins for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). However, few studies have directly compared statin-associated benefits and harms or exami...

journal_title：PLoS medicine

authors： Engeda JC,Lhachimi SK,Rosamond WD,Lund JL,Keyserling TC,Safford MM,Colantonio LD,Muntner P,Avery CL

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large populations treated in routine clinical practice is lacking. The objective of this study was to measure the association...

journal_title：PLoS medicine

authors： Douglas IJ,Bhaskaran K,Batterham RL,Smeeth L

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Published research on prescribed opioid analgesic (POA) use during pregnancy and birth outcomes is limited in scope and has not adequately adjusted for potential confounding factors. To help address these gaps, we estimated associations between maternal POAs during pregnancy and two adverse birth outcomes us...

journal_title：PLoS medicine

authors： Sujan AC,Quinn PD,Rickert ME,Wiggs KK,Lichtenstein P,Larsson H,Almqvist C,Öberg AS,D'Onofrio BM

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Through major efforts to reduce costs and expand access to antiretroviral therapy worldwide, widespread delivery of effective treatment to people living with HIV/AIDS is now conceivable even in severely resource-constrained settings. However, the potential epidemiologic impact of treatment in the context of ...

journal_title：PLoS medicine

authors： Salomon JA,Hogan DR,Stover J,Stanecki KA,Walker N,Ghys PD,Schwartländer B

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:In common with many other low- and middle-income countries (LMICs), rural to urban migrants in India are at increased risk of obesity, but it is unclear whether this is due to increased energy intake, reduced energy expenditure, or both. Knowing this and the relative contribution of specific dietary and phys...

journal_title：PLoS medicine

authors： Kinra S,Mallinson PAC,Cresswell JA,Bowen LJ,Lyngdoh T,Prabhakaran D,Reddy KS,Vaz M,Kurpad AV,Davey Smith G,Ben-Shlomo Y,Ebrahim S

更新日期：2020-08-07 00:00:00

abstract：BACKGROUND:It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain. METHODS AND FINDINGS:We report a "nested" case-control comparison within a prospective study in Reykjavik...

journal_title：PLoS medicine

authors： Wheeler JG,Juzwishin KD,Eiriksdottir G,Gudnason V,Danesh J

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:National responses will need to be markedly accelerated to achieve the ambitious target of the Joint United Nations Programme on HIV/AIDS (UNAIDS). This target aims for 90% of HIV-positive individuals to be aware of their status, for 90% of those aware to receive antiretroviral therapy (ART), and for 90% of ...

journal_title：PLoS medicine

authors： Maheu-Giroux M,Vesga JF,Diabaté S,Alary M,Baral S,Diouf D,Abo K,Boily MC

更新日期：2017-06-15 00:00:00

abstract：:In a Policy Forum, Peter Hotez and colleagues discuss vaccination exemptions in US states and possible consequences for infectious disease outbreaks. ...

journal_title：PLoS medicine

authors： Olive JK,Hotez PJ,Damania A,Nolan MS

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:For more than a decade, most parts of Somalia have not been under the control of any type of government. This "failure of state" is complete in the central and southern regions and most apparent in Mogadishu, which had been for a long period in the hands of warlords deploying their private militias in a batt...

journal_title：PLoS medicine

authors： Odenwald M,Hinkel H,Schauer E,Neuner F,Schauer M,Elbert TR,Rockstroh B

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Previous epidemiological studies suggest that working-aged persons with a history of moderate-to-severe traumatic brain injury (TBI) may have an increased risk for developing neurodegenerative disease (NDD) while persons with a history of mild TBI do not. In this comprehensive nationwide study in Finland, we...

journal_title：PLoS medicine

authors： Raj R,Kaprio J,Korja M,Mikkonen ED,Jousilahti P,Siironen J

更新日期：2017-07-05 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most lethal form of brain cancer. With the available treatments, survival does not exceed 12-14 mo from the time of diagnosis. We describe a novel strategy to selectively induce the death of glioblastoma cells and other cancer cells that over-express the EGF receptor. Usi...

journal_title：PLoS medicine

authors： Shir A,Ogris M,Wagner E,Levitzki A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Cohort studies are recommended for understanding ethnic disparities in cardiovascular disease. Our objective was to review the process for identifying, including, and excluding ethnic minority populations in published cardiovascular cohort studies in Europe and North America. METHODS AND FINDINGS:We found t...

journal_title：PLoS medicine

authors： Ranganathan M,Bhopal R

更新日期：2006-03-01 00:00:00