Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

abstract：BACKGROUND:Preventive chemotherapy represents a powerful but short-term control strategy for soil-transmitted helminthiasis. Since humans are often re-infected rapidly, long-term solutions require improvements in water, sanitation, and hygiene (WASH). The purpose of this study was to quantitatively summarize the relati...

journal_title：PLoS medicine

authors： Strunz EC,Addiss DG,Stocks ME,Ogden S,Utzinger J,Freeman MC

更新日期：2014-03-25 00:00:00

abstract：BACKGROUND:Nocturnal hypoglycemia frequently occurs in patients with type 1 diabetes mellitus (T1DM). It can be fatal and is believed to promote the development of the hypoglycemia-unawareness syndrome. Whether hypoglycemia normally provokes awakening from sleep in individuals who do not have diabetes, and whether this...

journal_title：PLoS medicine

authors： Schultes B,Jauch-Chara K,Gais S,Hallschmid M,Reiprich E,Kern W,Oltmanns KM,Peters A,Fehm HL,Born J

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Rare diseases affect as many as 60 million people in the United States and Europe. However, most rare diseases lack effective therapies and are in critical need of clinical research. Our objective was to determine the frequency of noncompletion and nonpublication of trials studying rare diseases. METHODS AN...

journal_title：PLoS medicine

authors： Rees CA,Pica N,Monuteaux MC,Bourgeois FT

更新日期：2019-11-21 00:00:00

abstract：:Martin Gerdin and colleagues argue that disaster health interventions and decision-making can benefit from an evidence-based approach Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Gerdin M,Clarke M,Allen C,Kayabu B,Summerskill W,Devane D,MacLachlan M,Spiegel P,Ghosh A,Zachariah R,Gupta S,Barbour V,Murray V,von Schreeb J

更新日期：2014-04-22 00:00:00

abstract：:In a Perspective, David Peiris and Dorairaj Prabhakaran discuss implications and challenges of cardiovascular disease risk assessments in the population of India. ...

journal_title：PLoS medicine

authors： Peiris D,Prabhakaran D

更新日期：2018-06-19 00:00:00

abstract：BACKGROUND:Patients with multimorbidities have the greatest healthcare needs and generate the highest expenditure in the health system. There is an increasing focus on identifying specific disease combinations for addressing poor outcomes. Existing research has identified a small number of prevalent "clusters" in the g...

journal_title：PLoS medicine

authors： Stokes J,Guthrie B,Mercer SW,Rice N,Sutton M

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:Identifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity. Recently, the intensity and the quality of the host immune response in the tumor microenvironment h...

journal_title：PLoS medicine

authors： Sanz-Pamplona R,Melas M,Maoz A,Schmit SL,Rennert H,Lejbkowicz F,Greenson JK,Sanjuan X,Lopez-Zambrano M,Alonso MH,Qu C,McDonnell KJ,Idos GE,Vignali M,Emerson R,Fields P,Guinó E,Santos C,Salazar R,Robins HS,Rennert

更新日期：2020-09-24 00:00:00

abstract：BACKGROUND:Leber congenital amaurosis (LCA), a heterogeneous early-onset retinal dystrophy, accounts for approximately 15% of inherited congenital blindness. One cause of LCA is loss of the enzyme lecithin:retinol acyl transferase (LRAT), which is required for regeneration of the visual photopigment in the retina. MET...

journal_title：PLoS medicine

authors： Batten ML,Imanishi Y,Tu DC,Doan T,Zhu L,Pang J,Glushakova L,Moise AR,Baehr W,Van Gelder RN,Hauswirth WW,Rieke F,Palczewski K

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Although the success of HIV treatment programs depends on retention and viral suppression, routine program monitoring of these outcomes may be incomplete. We used data from the national electronic medical record (EMR) system in Zambia to enumerate a large and regionally representative cohort of patients on t...

journal_title：PLoS medicine

authors： Sikazwe I,Eshun-Wilson I,Sikombe K,Czaicki N,Somwe P,Mody A,Simbeza S,Glidden DV,Chizema E,Mulenga LB,Padian N,Duncombe CJ,Bolton-Moore C,Beres LK,Holmes CB,Geng E

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:Our objective was to examine whether gestational diabetes mellitus (GDM) or newborns' high birthweight can be prevented by lifestyle counseling in pregnant women at high risk of GDM. METHOD AND FINDINGS:We conducted a cluster-randomized trial, the NELLI study, in 14 municipalities in Finland, where 2,271 wo...

journal_title：PLoS medicine

authors： Luoto R,Kinnunen TI,Aittasalo M,Kolu P,Raitanen J,Ojala K,Mansikkamäki K,Lamberg S,Vasankari T,Komulainen T,Tulokas S

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:We simulated tobacco control and pharmacological strategies for preventing cardiovascular deaths in India, the country that is expected to experience more cardiovascular deaths than any other over the next decade. METHODS AND FINDINGS:A microsimulation model was developed to quantify the differential effect...

journal_title：PLoS medicine

authors： Basu S,Glantz S,Bitton A,Millett C

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Randomized clinical trials of oral antiretroviral pre-exposure prophylaxis (PrEP) for HIV prevention have widely divergent efficacy estimates, ranging from 0% to 75%. These discrepancies are likely due to differences in adherence. To our knowledge, no studies to date have examined the impact of improving adh...

journal_title：PLoS medicine

authors： Haberer JE,Baeten JM,Campbell J,Wangisi J,Katabira E,Ronald A,Tumwesigye E,Psaros C,Safren SA,Ware NC,Thomas KK,Donnell D,Krows M,Kidoguchi L,Celum C,Bangsberg DR

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Obesity is associated with low-grade chronic inflammation, and serum markers of inflammation are independent risk factors for cardiovascular disease (CVD). However, the molecular and cellular mechanisms that link obesity to chronic inflammation and CVD are poorly understood. METHODS AND FINDINGS:Acute-phase...

journal_title：PLoS medicine

authors： Yang RZ,Lee MJ,Hu H,Pollin TI,Ryan AS,Nicklas BJ,Snitker S,Horenstein RB,Hull K,Goldberg NH,Goldberg AP,Shuldiner AR,Fried SK,Gong DW

更新日期：2006-06-01 00:00:00

abstract：:Philippe Calain discusses the health and environmental hazards of extractive industries like mining and explores the tensions that arise when medical humanitarian organizations are called to intervene in emergencies involving the extractive sector. ...

journal_title：PLoS medicine

authors： Calain P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The association between fetal exposure to major radiodiagnostic testing in pregnancy-computed tomography (CT) and radionuclide imaging-and the risk of childhood cancer is not established. METHODS AND FINDINGS:We completed a population-based study of 1.8 million maternal-child pairs in the province of Ontari...

journal_title：PLoS medicine

authors： Ray JG,Schull MJ,Urquia ML,You JJ,Guttmann A,Vermeulen MJ

更新日期：2010-09-07 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002511.]. ...

journal_title：PLoS medicine

authors： Torrone EA,Morrison CS,Chen PL,Kwok C,Francis SC,Hayes RJ,Looker KJ,McCormack S,McGrath N,van de Wijgert JHHM,Watson-Jones D,Low N,Gottlieb SL,STIMA Working Group.

更新日期：2018-06-26 00:00:00

abstract：:The PLOS Medicine editors discuss the new extension to the PRISMA reporting guidelines, PRISMA for Equity (PRISMA-E), and why it is relevant to the journal and to health research more generally. ...

journal_title：PLoS medicine

authors： PLOS Medicine Editors.

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Tissue advanced glycation end product (AGE) accumulation has been proposed as a marker of cumulative metabolic stress that can be assessed noninvasively by measurement of skin autofluorescence (SAF). In persons on haemodialysis, SAF is an independent risk factor for cardiovascular events (CVEs) and all-cause...

journal_title：PLoS medicine

authors： Shardlow A,McIntyre NJ,Kolhe NV,Nellums LB,Fluck RJ,McIntyre CW,Taal MW

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men with clinically suspected prostate cancer (PCa), but the long acquisition times, high costs, and inter-center/reader variability of routine multiparametric prostate MRI limit its wider adoption. METHODS AND FINDI...

journal_title：PLoS medicine

authors： Jambor I,Verho J,Ettala O,Knaapila J,Taimen P,Syvänen KT,Kiviniemi A,Kähkönen E,Perez IM,Seppänen M,Rannikko A,Oksanen O,Riikonen J,Vimpeli SM,Kauko T,Merisaari H,Kallajoki M,Mirtti T,Lamminen T,Saunavaara J,Arone

更新日期：2019-06-03 00:00:00

abstract：:H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials. ...

journal_title：PLoS medicine

authors： van der Worp HB,Howells DW,Sena ES,Porritt MJ,Rewell S,O'Collins V,Macleod MR

更新日期：2010-03-30 00:00:00

abstract：BACKGROUND:Observational epidemiological studies indicate that maternal height is associated with gestational age at birth and fetal growth measures (i.e., shorter mothers deliver infants at earlier gestational ages with lower birth weight and birth length). Different mechanisms have been postulated to explain these as...

journal_title：PLoS medicine

authors： Zhang G,Bacelis J,Lengyel C,Teramo K,Hallman M,Helgeland Ø,Johansson S,Myhre R,Sengpiel V,Njølstad PR,Jacobsson B,Muglia L

更新日期：2015-08-18 00:00:00

abstract：BACKGROUND:There have been increasing concerns regarding the safety and efficacy of neuroleptics in people with dementia, but there are very few long-term trials to inform clinical practice. The aim of this study was to determine the impact of long-term treatment with neuroleptic agents upon global cognitive decline an...

journal_title：PLoS medicine

authors： Ballard C,Lana MM,Theodoulou M,Douglas S,McShane R,Jacoby R,Kossakowski K,Yu LM,Juszczak E,Investigators DART AD.

更新日期：2008-04-01 00:00:00

abstract：:Hannah Leslie and co-authors discuss priorities in individual countries for health system reform. ...

journal_title：PLoS medicine

authors： Thapa G,Jhalani M,García-Saisó S,Malata A,Roder-DeWan S,Leslie HH

更新日期：2019-10-03 00:00:00

abstract：BACKGROUND:With cesarean section rates increasing worldwide, clarity regarding negative effects is essential. This study aimed to investigate the rate of subsequent stillbirth, miscarriage, and ectopic pregnancy following primary cesarean section, controlling for confounding by indication. METHODS AND FINDINGS:We perf...

journal_title：PLoS medicine

authors： O'Neill SM,Agerbo E,Kenny LC,Henriksen TB,Kearney PM,Greene RA,Mortensen PB,Khashan AS

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Standardised packaging (SP) of tobacco products is an innovative tobacco control measure opposed by transnational tobacco companies (TTCs) whose responses to the UK government's public consultation on SP argued that evidence was inadequate to support implementing the measure. The government's initial decisio...

journal_title：PLoS medicine

authors： Ulucanlar S,Fooks GJ,Hatchard JL,Gilmore AB

更新日期：2014-03-25 00:00:00

abstract：BACKGROUND:The "fitness" of an infectious pathogen is defined as the ability of the pathogen to survive, reproduce, be transmitted, and cause disease. The fitness of multidrug-resistant tuberculosis (MDRTB) relative to drug-susceptible tuberculosis is cited as one of the most important determinants of MDRTB spread and ...

journal_title：PLoS medicine

authors： Grandjean L,Gilman RH,Martin L,Soto E,Castro B,Lopez S,Coronel J,Castillo E,Alarcon V,Lopez V,San Miguel A,Quispe N,Asencios L,Dye C,Moore DA

更新日期：2015-06-23 00:00:00

abstract：BACKGROUND:Violence against women by intimate partners remains unacceptably common worldwide. The evidence base for the assumed psychological impacts of intimate partner violence (IPV) is derived primarily from studies conducted in high-income countries. A recently published systematic review identified 13 studies link...

journal_title：PLoS medicine

authors： Tsai AC,Tomlinson M,Comulada WS,Rotheram-Borus MJ

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:trans-fatty acids (TFAs) are a well-known risk factor of ischemic heart disease (IHD). In Australia, the highest TFA intake is concentrated to the most socioeconomically disadvantaged groups. Elimination of industrial TFA (iTFA) from the Australian food supply could result in reduced IHD mortality and morbid...

journal_title：PLoS medicine

authors： Marklund M,Zheng M,Veerman JL,Wu JHY

更新日期：2020-11-02 00:00:00

abstract：BACKGROUND:Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs. There are numerous psychiatric conditions that present with psychotic symptoms, most importantly schizophrenia, bipolar affective disorder, an...

journal_title：PLoS medicine

authors： Huang JT,Leweke FM,Oxley D,Wang L,Harris N,Koethe D,Gerth CW,Nolden BM,Gross S,Schreiber D,Reed B,Bahn S

更新日期：2006-11-01 00:00:00

abstract：:Andrew Seale and colleagues discuss the development of a global strategy to counter sexually transmitted infections. ...

journal_title：PLoS medicine

authors： Seale A,Broutet N,Narasimhan M

更新日期：2017-06-27 00:00:00