Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.


:[This corrects the article DOI: 10.1371/journal.pmed.1002781.].


PLoS Med


PLoS medicine


Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74




Has Abstract


2019-07-18 00:00:00














  • Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial.

    abstract:BACKGROUND:Clear recognition of the damaging effects of poverty on early childhood development has fueled an interest in interventions aimed at mitigating these harmful consequences. Psychosocial interventions aimed at alleviating the negative impacts of poverty on children are frequently shown to be of benefit, but ef...

    journal_title:PLoS medicine

    pub_type: 杂志文章,随机对照试验


    authors: Morgan B,Kumsta R,Fearon P,Moser D,Skeen S,Cooper P,Murray L,Moran G,Tomlinson M

    更新日期:2017-02-28 00:00:00

  • Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques.

    abstract:BACKGROUND:Despite repeated outbreaks, in particular the devastating 2014-2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among the drug candidates is the broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile in patients with EVD (JI...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Guedj J,Piorkowski G,Jacquot F,Madelain V,Nguyen THT,Rodallec A,Gunther S,Carbonnelle C,Mentré F,Raoul H,de Lamballerie X

    更新日期:2018-03-27 00:00:00

  • Pubertal timing and adult fracture risk in men: A population-based cohort study.

    abstract:BACKGROUND:Puberty is a critical period for bone mass accrual, and late puberty in boys is associated with reduced bone mass in adult men. The role of variations in pubertal timing within the normal range for adult fracture risk in men is, however, unknown. We, therefore, assessed the association between age at peak he...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Vandenput L,Kindblom JM,Bygdell M,Nethander M,Ohlsson C

    更新日期:2019-12-02 00:00:00

  • Prospects for passive immunity to prevent HIV infection.

    abstract::In a Perspective, Lynn Morris and Nonhlanhla Mkhize discuss the prospects for broadly neutralizing antibodies to be used in preventing HIV infection. ...

    journal_title:PLoS medicine

    pub_type: 杂志文章,评审


    authors: Morris L,Mkhize NN

    更新日期:2017-11-14 00:00:00

  • Association between gestational weight gain and severe adverse birth outcomes in Washington State, US: A population-based retrospective cohort study, 2004-2013.

    abstract:BACKGROUND:Suboptimal weight gain during pregnancy is a potentially modifiable risk factor. We aimed to investigate the association between suboptimal gestational weight gain and severe adverse birth outcomes by pre-pregnancy body mass index (BMI) categories, including obesity class I to III. METHODS AND FINDINGS:We c...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Ukah UV,Bayrampour H,Sabr Y,Razaz N,Chan WS,Lim KI,Lisonkova S

    更新日期:2019-12-30 00:00:00

  • Progress in the HIV epidemic: Identifying goals and measuring success.

    abstract::Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due to advancements in both prevention and treatment of HIV. However, major challenges still remain. We describe basic principles of epidemic control in the context of HIV and identify a number of attainable goals in terms of control a...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Jones J,Sullivan PS,Curran JW

    更新日期:2019-01-18 00:00:00

  • Public versus internal conceptions of addiction: An analysis of internal Philip Morris documents.

    abstract:BACKGROUND:Tobacco addiction is a complex, multicomponent phenomenon stemming from nicotine's pharmacology and the user's biology, psychology, sociology, and environment. After decades of public denial, the tobacco industry now agrees with public health authorities that nicotine is addictive. In 2000, Philip Morris bec...

    journal_title:PLoS medicine

    pub_type: 历史文章,杂志文章


    authors: Elias J,Hendlin YH,Ling PM

    更新日期:2018-05-01 00:00:00

  • Effect of a two-stage intervention package on the cesarean section rate in Guangzhou, China: A before-and-after study.

    abstract:BACKGROUND:The cesarean section (CS) rate has risen globally during the last two decades. Effective and feasible strategies are needed to reduce it. The aim of this study was to assess the CS rate change after a two-stage intervention package that was designed to reduce the overall CS rate in Guangzhou, China. METHODS...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Xia X,Zhou Z,Shen S,Lu J,Zhang L,Huang P,Yu J,Yang L,Wang P,Lam KH,Jacobsson B,Mol BW,Xia H,Qiu X

    更新日期:2019-07-08 00:00:00

  • Sexually transmitted infections-Research priorities for new challenges.

    abstract::In an Editorial, Guest Editors Nicola Low and Nathalie Broutet discuss the Collection on sexually transmitted infections in the context of research priorities in the field. ...

    journal_title:PLoS medicine

    pub_type: 社论


    authors: Low N,Broutet NJ

    更新日期:2017-12-27 00:00:00

  • The clinical and economic impact of point-of-care CD4 testing in mozambique and other resource-limited settings: a cost-effectiveness analysis.

    abstract:BACKGROUND:Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to laboratory-based tests in Mozambique. METHODS AND FINDINGS:We use a validated model of HIV testing, linkag...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Hyle EP,Jani IV,Lehe J,Su AE,Wood R,Quevedo J,Losina E,Bassett IV,Pei PP,Paltiel AD,Resch S,Freedberg KA,Peter T,Walensky RP

    更新日期:2014-09-16 00:00:00

  • Correction: Using Qualitative Evidence in Decision Making for Health and Social Interventions: An Approach to Assess Confidence in Findings from Qualitative Evidence Syntheses (GRADE-CERQual).

    abstract::[This corrects the article DOI: 10.1371/journal.pmed.1001895.]. ...

    journal_title:PLoS medicine

    pub_type: 已发布勘误


    authors: PLOS Medicine Staff.

    更新日期:2016-06-10 00:00:00

  • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.

    abstract::Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers...

    journal_title:PLoS medicine

    pub_type: 共识发展会议,指南,杂志文章


    authors: Liberati A,Altman DG,Tetzlaff J,Mulrow C,Gøtzsche PC,Ioannidis JP,Clarke M,Devereaux PJ,Kleijnen J,Moher D

    更新日期:2009-07-21 00:00:00

  • Addressing critical needs in the fight to end tuberculosis with innovative tools and strategies.

    abstract::This month in PLOS Medicine we launched a Special Issue on New Tools and Strategies for Tuberculosis Diagnosis, Care, and Elimination. In this issue's Editorial, the Guest Editors Claudia Denkinger, Richard Chaisson, and Mark Hatherill highlight some of the research that will publish and how these studies focusing on ...

    journal_title:PLoS medicine

    pub_type: 社论


    authors: Hatherill M,Chaisson RE,Denkinger CM

    更新日期:2019-04-30 00:00:00

  • A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum.

    abstract:BACKGROUND:Plasmodium falciparum merozoite surface protein 3 is a malaria vaccine candidate that was identified, characterised, and developed based on a unique immuno-clinical approach. The vaccine construct was derived from regions fully conserved among various strains and containing B cell epitopes targeted by human ...

    journal_title:PLoS medicine

    pub_type: 临床试验,杂志文章


    authors: Druilhe P,Spertini F,Soesoe D,Corradin G,Mejia P,Singh S,Audran R,Bouzidi A,Oeuvray C,Roussilhon C

    更新日期:2005-11-01 00:00:00

  • Neonatal mortality levels for 193 countries in 2009 with trends since 1990: a systematic analysis of progress, projections, and priorities.

    abstract:BACKGROUND:Historically, the main focus of studies of childhood mortality has been the infant and under-five mortality rates. Neonatal mortality (deaths <28 days of age) has received limited attention, although such deaths account for about 41% of all child deaths. To better assess progress, we developed annual estimat...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Oestergaard MZ,Inoue M,Yoshida S,Mahanani WR,Gore FM,Cousens S,Lawn JE,Mathers CD,United Nations Inter-Agency Group for Child Mortality Estimation and the Child Health Epidemiology Reference Group.

    更新日期:2011-08-01 00:00:00

  • Effects of community-wide vaccination with PCV-7 on pneumococcal nasopharyngeal carriage in the Gambia: a cluster-randomized trial.

    abstract:BACKGROUND:Introduction of pneumococcal conjugate vaccines (PCVs) of limited valency is justified in Africa by the high burden of pneumococcal disease. Long-term beneficial effects of PCVs may be countered by serotype replacement. We aimed to determine the impact of PCV-7 vaccination on pneumococcal carriage in rural G...

    journal_title:PLoS medicine

    pub_type: 杂志文章,随机对照试验


    authors: Roca A,Hill PC,Townend J,Egere U,Antonio M,Bojang A,Akisanya A,Litchfield T,Nsekpong DE,Oluwalana C,Howie SR,Greenwood B,Adegbola RA

    更新日期:2011-10-01 00:00:00

  • Correction: A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study.

    abstract::[This corrects the article DOI: 10.1371/journal.pmed.1002718.]. ...

    journal_title:PLoS medicine

    pub_type: 已发布勘误


    authors: Liu Z,Kuo PL,Horvath S,Crimmins E,Ferrucci L,Levine M

    更新日期:2019-02-25 00:00:00

  • Women's access and provider practices for the case management of malaria during pregnancy: a systematic review and meta-analysis.

    abstract:BACKGROUND:WHO recommends prompt diagnosis and quinine plus clindamycin for treatment of uncomplicated malaria in the first trimester and artemisinin-based combination therapies in subsequent trimesters. We undertook a systematic review of women's access to and healthcare provider adherence to WHO case management polic...

    journal_title:PLoS medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Hill J,D'Mello-Guyett L,Hoyt J,van Eijk AM,ter Kuile FO,Webster J

    更新日期:2014-08-05 00:00:00

  • Projections of incident atherosclerotic cardiovascular disease and incident type 2 diabetes across evolving statin treatment guidelines and recommendations: A modelling study.

    abstract:BACKGROUND:Experimental and observational research has suggested the potential for increased type 2 diabetes (T2D) risk among populations taking statins for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). However, few studies have directly compared statin-associated benefits and harms or exami...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Engeda JC,Lhachimi SK,Rosamond WD,Lund JL,Keyserling TC,Safford MM,Colantonio LD,Muntner P,Avery CL

    更新日期:2020-08-26 00:00:00

  • Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.

    abstract:BACKGROUND:Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large populations treated in routine clinical practice is lacking. The objective of this study was to measure the association...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Douglas IJ,Bhaskaran K,Batterham RL,Smeeth L

    更新日期:2015-12-22 00:00:00

  • Maternal prescribed opioid analgesic use during pregnancy and associations with adverse birth outcomes: A population-based study.

    abstract:BACKGROUND:Published research on prescribed opioid analgesic (POA) use during pregnancy and birth outcomes is limited in scope and has not adequately adjusted for potential confounding factors. To help address these gaps, we estimated associations between maternal POAs during pregnancy and two adverse birth outcomes us...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Sujan AC,Quinn PD,Rickert ME,Wiggs KK,Lichtenstein P,Larsson H,Almqvist C,Öberg AS,D'Onofrio BM

    更新日期:2019-12-02 00:00:00

  • Integrating HIV prevention and treatment: from slogans to impact.

    abstract:BACKGROUND:Through major efforts to reduce costs and expand access to antiretroviral therapy worldwide, widespread delivery of effective treatment to people living with HIV/AIDS is now conceivable even in severely resource-constrained settings. However, the potential epidemiologic impact of treatment in the context of ...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Salomon JA,Hogan DR,Stover J,Stanecki KA,Walker N,Ghys PD,Schwartländer B

    更新日期:2005-01-01 00:00:00

  • Relative contribution of diet and physical activity to increased adiposity among rural to urban migrants in India: A cross-sectional study.

    abstract:BACKGROUND:In common with many other low- and middle-income countries (LMICs), rural to urban migrants in India are at increased risk of obesity, but it is unclear whether this is due to increased energy intake, reduced energy expenditure, or both. Knowing this and the relative contribution of specific dietary and phys...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Kinra S,Mallinson PAC,Cresswell JA,Bowen LJ,Lyngdoh T,Prabhakaran D,Reddy KS,Vaz M,Kurpad AV,Davey Smith G,Ben-Shlomo Y,Ebrahim S

    更新日期:2020-08-07 00:00:00

  • Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis.

    abstract:BACKGROUND:It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain. METHODS AND FINDINGS:We report a "nested" case-control comparison within a prospective study in Reykjavik...

    journal_title:PLoS medicine

    pub_type: 杂志文章,meta分析


    authors: Wheeler JG,Juzwishin KD,Eiriksdottir G,Gudnason V,Danesh J

    更新日期:2005-03-01 00:00:00

  • Population-level impact of an accelerated HIV response plan to reach the UNAIDS 90-90-90 target in Côte d'Ivoire: Insights from mathematical modeling.

    abstract:BACKGROUND:National responses will need to be markedly accelerated to achieve the ambitious target of the Joint United Nations Programme on HIV/AIDS (UNAIDS). This target aims for 90% of HIV-positive individuals to be aware of their status, for 90% of those aware to receive antiretroviral therapy (ART), and for 90% of ...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Maheu-Giroux M,Vesga JF,Diabaté S,Alary M,Baral S,Diouf D,Abo K,Boily MC

    更新日期:2017-06-15 00:00:00

  • The state of the antivaccine movement in the United States: A focused examination of nonmedical exemptions in states and counties.

    abstract::In a Policy Forum, Peter Hotez and colleagues discuss vaccination exemptions in US states and possible consequences for infectious disease outbreaks. ...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Olive JK,Hotez PJ,Damania A,Nolan MS

    更新日期:2018-06-12 00:00:00

  • The consumption of khat and other drugs in Somali combatants: a cross-sectional study.

    abstract:BACKGROUND:For more than a decade, most parts of Somalia have not been under the control of any type of government. This "failure of state" is complete in the central and southern regions and most apparent in Mogadishu, which had been for a long period in the hands of warlords deploying their private militias in a batt...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Odenwald M,Hinkel H,Schauer E,Neuner F,Schauer M,Elbert TR,Rockstroh B

    更新日期:2007-12-01 00:00:00

  • Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: A retrospective cohort study using the Finnish national health registries.

    abstract:BACKGROUND:Previous epidemiological studies suggest that working-aged persons with a history of moderate-to-severe traumatic brain injury (TBI) may have an increased risk for developing neurodegenerative disease (NDD) while persons with a history of mild TBI do not. In this comprehensive nationwide study in Finland, we...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Raj R,Kaprio J,Korja M,Mikkonen ED,Jousilahti P,Siironen J

    更新日期:2017-07-05 00:00:00

  • EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice.

    abstract:BACKGROUND:Glioblastoma multiforme (GBM) is the most lethal form of brain cancer. With the available treatments, survival does not exceed 12-14 mo from the time of diagnosis. We describe a novel strategy to selectively induce the death of glioblastoma cells and other cancer cells that over-express the EGF receptor. Usi...

    journal_title:PLoS medicine

    pub_type: 杂志文章


    authors: Shir A,Ogris M,Wagner E,Levitzki A

    更新日期:2006-01-01 00:00:00

  • Exclusion and inclusion of nonwhite ethnic minority groups in 72 North American and European cardiovascular cohort studies.

    abstract:BACKGROUND:Cohort studies are recommended for understanding ethnic disparities in cardiovascular disease. Our objective was to review the process for identifying, including, and excluding ethnic minority populations in published cardiovascular cohort studies in Europe and North America. METHODS AND FINDINGS:We found t...

    journal_title:PLoS medicine

    pub_type: 杂志文章,meta分析


    authors: Ranganathan M,Bhopal R

    更新日期:2006-03-01 00:00:00