Developing cardiovascular disease risk programs in India-Why location and wealth matter.

abstract：BACKGROUND:Type 2 diabetes (T2D) is a progressive disease whereby there is often deterioration in glucose control despite escalation in treatment. There is significant heterogeneity to this progression of glycemia after onset of diabetes, yet the factors that influence glycemic progression are not well understood. Give...

journal_title：PLoS medicine

authors： Jiang G,Luk AO,Tam CHT,Lau ES,Ozaki R,Chow EYK,Kong APS,Lim CKP,Lee KF,Siu SC,Hui G,Tsang CC,Lau KP,Leung JYY,Tsang MW,Kam G,Lau IT,Li JK,Yeung VT,Lau E,Lo S,Fung SKS,Cheng YL,Chow CC,Pearson ER,So WY,

更新日期：2020-07-28 00:00:00

abstract：:Leo Sher and colleagues discuss recent research on interventions to prevent secondary suicide and discuss the additional research that is needed. ...

journal_title：PLoS medicine

authors： Ganz D,Braquehais MD,Sher L

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Puberty is a critical period for bone mass accrual, and late puberty in boys is associated with reduced bone mass in adult men. The role of variations in pubertal timing within the normal range for adult fracture risk in men is, however, unknown. We, therefore, assessed the association between age at peak he...

journal_title：PLoS medicine

authors： Vandenput L,Kindblom JM,Bygdell M,Nethander M,Ohlsson C

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Perinatal mortality and morbidity continue to be major global health challenges strongly associated with prematurity and reduced fetal growth, an issue of further interest given the mounting evidence that fetal growth in general is linked to degrees of risk of common noncommunicable diseases in adulthood. Ag...

journal_title：PLoS medicine

authors： Kiserud T,Piaggio G,Carroli G,Widmer M,Carvalho J,Neerup Jensen L,Giordano D,Cecatti JG,Abdel Aleem H,Talegawkar SA,Benachi A,Diemert A,Tshefu Kitoto A,Thinkhamrop J,Lumbiganon P,Tabor A,Kriplani A,Gonzalez Perez R,He

更新日期：2017-01-24 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002511.]. ...

journal_title：PLoS medicine

authors： Torrone EA,Morrison CS,Chen PL,Kwok C,Francis SC,Hayes RJ,Looker KJ,McCormack S,McGrath N,van de Wijgert JHHM,Watson-Jones D,Low N,Gottlieb SL,STIMA Working Group.

更新日期：2018-06-26 00:00:00

abstract：BACKGROUND:Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by serotypes of the Enterovirus A species in the genus Enterovirus of the Picornaviridae family. The disease has had a substantial burden throughout East and Southeast Asia over the past 15 y. China reported 9 million cases of HFMD bet...

journal_title：PLoS medicine

authors： Takahashi S,Liao Q,Van Boeckel TP,Xing W,Sun J,Hsiao VY,Metcalf CJ,Chang Z,Liu F,Zhang J,Wu JT,Cowling BJ,Leung GM,Farrar JJ,van Doorn HR,Grenfell BT,Yu H

更新日期：2016-02-16 00:00:00

abstract：BACKGROUND:Ovarian cancer kills approximately 15,000 women in the United States every year, and more than 140,000 women worldwide. Most deaths from ovarian cancer are caused by tumors of the serous histological type, which are rarely diagnosed before the cancer has spread. Rational design of a potentially life-saving e...

journal_title：PLoS medicine

authors： Brown PO,Palmer C

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:At the beginning of June 2020, there were nearly 7 million reported cases of coronavirus disease 2019 (COVID-19) worldwide and over 400,000 deaths in people with COVID-19. The objective of this study was to determine associations between comorbidities listed in the Charlson comorbidity index and mortality am...

journal_title：PLoS medicine

authors： Harrison SL,Fazio-Eynullayeva E,Lane DA,Underhill P,Lip GYH

更新日期：2020-09-10 00:00:00

abstract：:Antimalarial drugs will be essential tools at all stages of malaria elimination along the path towards eradication, including the early control or "attack" phase to drive down transmission and the later stages of maintaining interruption of transmission, preventing reintroduction of malaria, and eliminating the last r...

journal_title：PLoS medicine

authors： malERA Consultative Group on Drugs.

更新日期：2011-01-25 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associ...

journal_title：PLoS medicine

authors： Musso G,Gambino R,Tabibian JH,Ekstedt M,Kechagias S,Hamaguchi M,Hultcrantz R,Hagström H,Yoon SK,Charatcharoenwitthaya P,George J,Barrera F,Hafliðadóttir S,Björnsson ES,Armstrong MJ,Hopkins LJ,Gao X,Francque S,Verrijke

更新日期：2014-07-22 00:00:00

abstract：BACKGROUND:In patients treated with cardiotoxic chemotherapies, the presence of cardiovascular risk factors and previous cardiac disease have been strongly correlated to the onset of cardiotoxicity. The influence of overweight and obesity as risk factors in the development of treatment-related cardiotoxicity in breast ...

journal_title：PLoS medicine

authors： Kaboré EG,Guenancia C,Vaz-Luis I,Di Meglio A,Pistilli B,Coutant C,Cottu P,Lesur A,Petit T,Dalenc F,Rouanet P,Arnaud A,Arsene O,Ibrahim M,Wassermann J,Boileau-Jolimoy G,Martin AL,Lemonnier J,André F,Arveux P

更新日期：2019-12-23 00:00:00

abstract：BACKGROUND:A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ultimate translation into a point-of-care ...

journal_title：PLoS medicine

authors： Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Pedometers can increase walking and moderate-to-vigorous physical activity (MVPA) levels, but their effectiveness with or without support has not been rigorously evaluated. We assessed the effectiveness of a pedometer-based walking intervention in predominantly inactive adults, delivered by post or through p...

journal_title：PLoS medicine

authors： Harris T,Kerry SM,Limb ES,Victor CR,Iliffe S,Ussher M,Whincup PH,Ekelund U,Fox-Rushby J,Furness C,Anokye N,Ibison J,DeWilde S,David L,Howard E,Dale R,Smith J,Cook DG

更新日期：2017-01-03 00:00:00

abstract：:H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials. ...

journal_title：PLoS medicine

authors： van der Worp HB,Howells DW,Sena ES,Porritt MJ,Rewell S,O'Collins V,Macleod MR

更新日期：2010-03-30 00:00:00

abstract：BACKGROUND:In common with many other low- and middle-income countries (LMICs), rural to urban migrants in India are at increased risk of obesity, but it is unclear whether this is due to increased energy intake, reduced energy expenditure, or both. Knowing this and the relative contribution of specific dietary and phys...

journal_title：PLoS medicine

authors： Kinra S,Mallinson PAC,Cresswell JA,Bowen LJ,Lyngdoh T,Prabhakaran D,Reddy KS,Vaz M,Kurpad AV,Davey Smith G,Ben-Shlomo Y,Ebrahim S

更新日期：2020-08-07 00:00:00

abstract：BACKGROUND:Unrecognized myocardial infarction (UMI) is known to constitute a substantial portion of potentially lethal coronary heart disease. However, the diagnosis of UMI is based on the appearance of incidental Q-waves on 12-lead electrocardiography. Thus, the syndrome of non-Q-wave UMI has not been investigated. De...

journal_title：PLoS medicine

authors： Kim HW,Klem I,Shah DJ,Wu E,Meyers SN,Parker MA,Crowley AL,Bonow RO,Judd RM,Kim RJ

更新日期：2009-04-21 00:00:00

abstract：BACKGROUND:The anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab improves outcomes in patients with node-positive HER2+ early breast cancer. Given trastuzumab's high cost, we aimed to estimate its cost-effectiveness by heterogeneity in age and estrogen receptor (ER) and progesterone r...

journal_title：PLoS medicine

authors： Leung W,Kvizhinadze G,Nair N,Blakely T

更新日期：2016-08-09 00:00:00

abstract：:Hannah Leslie and co-authors discuss priorities in individual countries for health system reform. ...

journal_title：PLoS medicine

authors： Thapa G,Jhalani M,García-Saisó S,Malata A,Roder-DeWan S,Leslie HH

更新日期：2019-10-03 00:00:00

abstract：:Gordon C. Smith discusses the study by Katy Kozhimannil and colleagues that examines variations in cesarean section rates in the US and argues for the need for high-quality routine data collection to better understand the reasons for these variations. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Smith GC

更新日期：2014-10-21 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV)-specific T cell responses are critical for spontaneous resolution of HCV viremia. Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection. METHODS AND FINDINGS:We measured T cell responsiveness...

journal_title：PLoS medicine

authors： Kim AY,Schulze zur Wiesch J,Kuntzen T,Timm J,Kaufmann DE,Duncan JE,Jones AM,Wurcel AG,Davis BT,Gandhi RT,Robbins GK,Allen TM,Chung RT,Lauer GM,Walker BD

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Four studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight (LBW; <2,500 g) may depend upon maternal nutritional status. We investigated this dependence further using a large, diverse study population. METHODS AND FINDINGS:We evaluated the interacti...

journal_title：PLoS medicine

authors： Cates JE,Unger HW,Briand V,Fievet N,Valea I,Tinto H,D'Alessandro U,Landis SH,Adu-Afarwuah S,Dewey KG,Ter Kuile FO,Desai M,Dellicour S,Ouma P,Gutman J,Oneko M,Slutsker L,Terlouw DJ,Kariuki S,Ayisi J,Madanitsa M,M

更新日期：2017-08-08 00:00:00

abstract：BACKGROUND:Despite repeated outbreaks, in particular the devastating 2014-2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among the drug candidates is the broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile in patients with EVD (JI...

journal_title：PLoS medicine

authors： Guedj J,Piorkowski G,Jacquot F,Madelain V,Nguyen THT,Rodallec A,Gunther S,Carbonnelle C,Mentré F,Raoul H,de Lamballerie X

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:For treating multidrug-resistant tuberculosis (MDR TB), the World Health Organization (WHO) recommends a regimen of at least four second-line drugs that are likely to be effective as well as pyrazinamide. WHO guidelines indicate only marginal benefit for regimens based directly on drug susceptibility testing...

journal_title：PLoS medicine

authors： Yuen CM,Kurbatova EV,Tupasi T,Caoili JC,Van Der Walt M,Kvasnovsky C,Yagui M,Bayona J,Contreras C,Leimane V,Ershova J,Via LE,Kim H,Akksilp S,Kazennyy BY,Volchenkov GV,Jou R,Kliiman K,Demikhova OV,Vasilyeva IA,Dalto

更新日期：2015-12-29 00:00:00

abstract：:Drawing upon interviews with experts and a review of the literature, Gavin Yamey proposes a new framework for scaling up global health interventions. ...

journal_title：PLoS medicine

authors： Yamey G

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Attrition during the period from HIV testing to antiretroviral therapy (ART) initiation is high worldwide. We assessed whether same-day HIV testing and ART initiation improves retention and virologic suppression. METHODS AND FINDINGS:We conducted an unblinded, randomized trial of standard ART initiation ver...

journal_title：PLoS medicine

authors： Koenig SP,Dorvil N,Dévieux JG,Hedt-Gauthier BL,Riviere C,Faustin M,Lavoile K,Perodin C,Apollon A,Duverger L,McNairy ML,Hennessey KA,Souroutzidis A,Cremieux PY,Severe P,Pape JW

更新日期：2017-07-25 00:00:00

abstract：:Peter Openshaw discusses the challenges in advancing respiratory syncytial virus (RSV) treatments and the implications of a study by Mejias and colleagues using a newly identified gene signature for diagnosis and prediction of RSV severity. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Openshaw PJ

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The standard approaches to diagnosing autism spectrum disorder (ASD) evaluate between 20 and 100 behaviors and take several hours to complete. This has in part contributed to long wait times for a diagnosis and subsequent delays in access to therapy. We hypothesize that the use of machine learning analysis o...

journal_title：PLoS medicine

authors： Tariq Q,Daniels J,Schwartz JN,Washington P,Kalantarian H,Wall DP

更新日期：2018-11-27 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002718.]. ...

journal_title：PLoS medicine

authors： Liu Z,Kuo PL,Horvath S,Crimmins E,Ferrucci L,Levine M

更新日期：2019-02-25 00:00:00

abstract：BACKGROUND:A number of epidemiologic studies have observed an association between secondhand smoke (SHS) exposure and pediatric invasive bacterial disease (IBD) but the evidence has not been systematically reviewed. We carried out a systematic review and meta-analysis of SHS exposure and two outcomes, IBD and pharyngea...

journal_title：PLoS medicine

authors： Lee CC,Middaugh NA,Howie SR,Ezzati M

更新日期：2010-12-07 00:00:00

abstract：:In an essay, Paul Bloem and Ikechukwu Ogbuanu discuss the public health implications of HPV vaccination. ...

journal_title：PLoS medicine

authors： Bloem P,Ogbuanu I

更新日期：2017-06-27 00:00:00