Correction: A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study.

abstract：BACKGROUND:The standard approaches to diagnosing autism spectrum disorder (ASD) evaluate between 20 and 100 behaviors and take several hours to complete. This has in part contributed to long wait times for a diagnosis and subsequent delays in access to therapy. We hypothesize that the use of machine learning analysis o...

journal_title：PLoS medicine

authors： Tariq Q,Daniels J,Schwartz JN,Washington P,Kalantarian H,Wall DP

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:Leber congenital amaurosis (LCA), a heterogeneous early-onset retinal dystrophy, accounts for approximately 15% of inherited congenital blindness. One cause of LCA is loss of the enzyme lecithin:retinol acyl transferase (LRAT), which is required for regeneration of the visual photopigment in the retina. MET...

journal_title：PLoS medicine

authors： Batten ML,Imanishi Y,Tu DC,Doan T,Zhu L,Pang J,Glushakova L,Moise AR,Baehr W,Van Gelder RN,Hauswirth WW,Rieke F,Palczewski K

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Whole genome sequencing provides better delineation of transmission clusters in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal individual transmission links within clusters is limited. Here, we used a 2-step approach based on Bayesian transmission reconstruction to (1) id...

journal_title：PLoS medicine

authors： Xu Y,Cancino-Muñoz I,Torres-Puente M,Villamayor LM,Borrás R,Borrás-Máñez M,Bosque M,Camarena JJ,Colomer-Roig E,Colomina J,Escribano I,Esparcia-Rodríguez O,Gil-Brusola A,Gimeno C,Gimeno-Gascón A,Gomila-Sard B,González-Gran

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associ...

journal_title：PLoS medicine

authors： Musso G,Gambino R,Tabibian JH,Ekstedt M,Kechagias S,Hamaguchi M,Hultcrantz R,Hagström H,Yoon SK,Charatcharoenwitthaya P,George J,Barrera F,Hafliðadóttir S,Björnsson ES,Armstrong MJ,Hopkins LJ,Gao X,Francque S,Verrijke

更新日期：2014-07-22 00:00:00

abstract：BACKGROUND:Spurred by the creation of potential modified risk tobacco products, the US Food and Drug Administration (FDA) commissioned the Institute of Medicine (IOM) to assess the science base for tobacco "harm reduction," leading to the 2001 IOM report Clearing the Smoke. The objective of this study was to determine ...

journal_title：PLoS medicine

authors： Tan CE,Kyriss T,Glantz SA

更新日期：2013-01-01 00:00:00

abstract：:H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials. ...

journal_title：PLoS medicine

authors： van der Worp HB,Howells DW,Sena ES,Porritt MJ,Rewell S,O'Collins V,Macleod MR

更新日期：2010-03-30 00:00:00

abstract：BACKGROUND:Childbirth with a skilled attendant is crucial for preventing maternal mortality and is an important opportunity for prevention of mother-to-child transmission of HIV. The Maternity in Migori and AIDS Stigma Study (MAMAS Study) is a prospective mixed-methods investigation conducted in a high HIV prevalence a...

journal_title：PLoS medicine

authors： Turan JM,Hatcher AH,Medema-Wijnveen J,Onono M,Miller S,Bukusi EA,Turan B,Cohen CR

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Four studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight (LBW; <2,500 g) may depend upon maternal nutritional status. We investigated this dependence further using a large, diverse study population. METHODS AND FINDINGS:We evaluated the interacti...

journal_title：PLoS medicine

authors： Cates JE,Unger HW,Briand V,Fievet N,Valea I,Tinto H,D'Alessandro U,Landis SH,Adu-Afarwuah S,Dewey KG,Ter Kuile FO,Desai M,Dellicour S,Ouma P,Gutman J,Oneko M,Slutsker L,Terlouw DJ,Kariuki S,Ayisi J,Madanitsa M,M

更新日期：2017-08-08 00:00:00

abstract：BACKGROUND:Clear recognition of the damaging effects of poverty on early childhood development has fueled an interest in interventions aimed at mitigating these harmful consequences. Psychosocial interventions aimed at alleviating the negative impacts of poverty on children are frequently shown to be of benefit, but ef...

journal_title：PLoS medicine

authors： Morgan B,Kumsta R,Fearon P,Moser D,Skeen S,Cooper P,Murray L,Moran G,Tomlinson M

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:Resistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is increasing in prevalence in Africa. Combination therapy can both improve treatment and provide important public health benefits if it curbs the spread of parasites harbouring resistance genes. Thus, drug combinations m...

journal_title：PLoS medicine

authors： Sutherland CJ,Ord R,Dunyo S,Jawara M,Drakeley CJ,Alexander N,Coleman R,Pinder M,Walraven G,Targett GA

更新日期：2005-04-01 00:00:00

abstract：:Is it ethical for scientists to conduct or to benefit from research in another country if that research would be unlawful, or not generally accepted, in their own country? ...

journal_title：PLoS medicine

authors： Skene L

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Published research on prescribed opioid analgesic (POA) use during pregnancy and birth outcomes is limited in scope and has not adequately adjusted for potential confounding factors. To help address these gaps, we estimated associations between maternal POAs during pregnancy and two adverse birth outcomes us...

journal_title：PLoS medicine

authors： Sujan AC,Quinn PD,Rickert ME,Wiggs KK,Lichtenstein P,Larsson H,Almqvist C,Öberg AS,D'Onofrio BM

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Childhood obstructive sleep apnea (OSA) is associated with neuropsychological deficits of memory, learning, and executive function. There is no evidence of neuronal brain injury in children with OSA. We hypothesized that childhood OSA is associated with neuropsychological performance dysfunction, and with ne...

journal_title：PLoS medicine

authors： Halbower AC,Degaonkar M,Barker PB,Earley CJ,Marcus CL,Smith PL,Prahme MC,Mahone EM

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ultimate translation into a point-of-care ...

journal_title：PLoS medicine

authors： Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Puberty is a critical period for bone mass accrual, and late puberty in boys is associated with reduced bone mass in adult men. The role of variations in pubertal timing within the normal range for adult fracture risk in men is, however, unknown. We, therefore, assessed the association between age at peak he...

journal_title：PLoS medicine

authors： Vandenput L,Kindblom JM,Bygdell M,Nethander M,Ohlsson C

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Bilharzia is one of the major parasitic infections affecting the public health and socioeconomic circumstances in (sub) tropical areas. Its causative agents are schistosomes. Since these worms remain in their host for decades, they have developed mechanisms to evade or resist the immune system. Like several ...

journal_title：PLoS medicine

authors： Sprong H,Suchanek M,van Dijk SM,van Remoortere A,Klumperman J,Avram D,van der Linden J,Leusen JH,van Hellemond JJ,Thiele C

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:The anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab improves outcomes in patients with node-positive HER2+ early breast cancer. Given trastuzumab's high cost, we aimed to estimate its cost-effectiveness by heterogeneity in age and estrogen receptor (ER) and progesterone r...

journal_title：PLoS medicine

authors： Leung W,Kvizhinadze G,Nair N,Blakely T

更新日期：2016-08-09 00:00:00

abstract：BACKGROUND:Assessing the mortality impact of the 2009 influenza A H1N1 virus (H1N1pdm09) is essential for optimizing public health responses to future pandemics. The World Health Organization reported 18,631 laboratory-confirmed pandemic deaths, but the total pandemic mortality burden was substantially higher. We estim...

journal_title：PLoS medicine

authors： Simonsen L,Spreeuwenberg P,Lustig R,Taylor RJ,Fleming DM,Kroneman M,Van Kerkhove MD,Mounts AW,Paget WJ,GLaMOR Collaborating Teams.

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:This paper examines the efforts of consultants affiliated with Philip Morris (PM), the world's leading transnational tobacco corporation, to influence scientific research and training in Thailand via the Chulabhorn Research Institute (CRI). A leading Southeast Asian institute for environmental health science...

journal_title：PLoS medicine

authors： Mackenzie R,Collin J

更新日期：2008-12-23 00:00:00

abstract：BACKGROUND:With cesarean section rates increasing worldwide, clarity regarding negative effects is essential. This study aimed to investigate the rate of subsequent stillbirth, miscarriage, and ectopic pregnancy following primary cesarean section, controlling for confounding by indication. METHODS AND FINDINGS:We perf...

journal_title：PLoS medicine

authors： O'Neill SM,Agerbo E,Kenny LC,Henriksen TB,Kearney PM,Greene RA,Mortensen PB,Khashan AS

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Polygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quantify the potential advantage of adding information on PRSs to conventional risk factors in the primary prevention of CVD. METHODS AND FINDINGS:Using data from UK Biobank on 306,654 individual...

journal_title：PLoS medicine

authors： Sun L,Pennells L,Kaptoge S,Nelson CP,Ritchie SC,Abraham G,Arnold M,Bell S,Bolton T,Burgess S,Dudbridge F,Guo Q,Sofianopoulou E,Stevens D,Thompson JR,Butterworth AS,Wood A,Danesh J,Samani NJ,Inouye M,Di Angelantoni

更新日期：2021-01-14 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1003293.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:Intimate partner violence (IPV) against women is a major global health issue, particularly in low- and middle-income countries (LMICs), that is associated with poor physical and mental health, but its association with breastfeeding practices is understudied. Both the World Health Organization (WHO) and the U...

journal_title：PLoS medicine

authors： Caleyachetty R,Uthman OA,Bekele HN,Martín-Cañavate R,Marais D,Coles J,Steele B,Uauy R,Koniz-Booher P

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Previous estimates of mortality in Iraq attributable to the 2003 invasion have been heterogeneous and controversial, and none were produced after 2006. The purpose of this research was to estimate direct and indirect deaths attributable to the war in Iraq between 2003 and 2011. METHODS AND FINDINGS:We condu...

journal_title：PLoS medicine

authors： Hagopian A,Flaxman AD,Takaro TK,Esa Al Shatari SA,Rajaratnam J,Becker S,Levin-Rector A,Galway L,Hadi Al-Yasseri BJ,Weiss WM,Murray CJ,Burnham G

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU]) developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indication that FIAU would b...

journal_title：PLoS medicine

authors： Xu D,Nishimura T,Nishimura S,Zhang H,Zheng M,Guo YY,Masek M,Michie SA,Glenn J,Peltz G

更新日期：2014-04-15 00:00:00

abstract：:Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers...

journal_title：PLoS medicine

authors： Liberati A,Altman DG,Tetzlaff J,Mulrow C,Gøtzsche PC,Ioannidis JP,Clarke M,Devereaux PJ,Kleijnen J,Moher D

更新日期：2009-07-21 00:00:00

abstract：BACKGROUND:Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate. Novel antimalarial drug targets are urgently needed to reduce global morbidity and mortality. Our prior results suggested that inhibiting erythrocyte Gs signaling blocked invas...

journal_title：PLoS medicine

authors： Murphy SC,Harrison T,Hamm HE,Lomasney JW,Mohandas N,Haldar K

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Very-low-birth-weight (VLBW, <1,500 g) infants have compromised bone mass accrual during childhood, but it is unclear whether this results in subnormal peak bone mass and increased risk of impaired skeletal health in adulthood. We hypothesized that VLBW is associated with reduced bone mineral density (BMD) i...

journal_title：PLoS medicine

authors： Hovi P,Andersson S,Järvenpää AL,Eriksson JG,Strang-Karlsson S,Kajantie E,Mäkitie O

更新日期：2009-08-01 00:00:00

abstract：:Sanjay Basu and Kristine Madsen discuss the effects of taxes on sugar-sweetened beverages in both Australia and Berkeley, USA. ...

journal_title：PLoS medicine

authors： Basu S,Madsen K

更新日期：2017-06-27 00:00:00

abstract：:In this month's editorial, the PLOS Medicine Editors discuss the role of preprints in human health research and propose a 3-part framework for ensuring benefit. ...

journal_title：PLoS medicine

authors： Peiperl L,PLOS Medicine Editors.

更新日期：2018-04-16 00:00:00