Correction: Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project).

abstract：:In this month's editorial, PLOS Medicine's Chief Editor Larry Peiperl discusses the relevance of patient care to a journal editor's work. ...

journal_title：PLoS medicine

authors： Peiperl L,PLOS Medicine Editors.

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:Evidence suggests that variations in fasting glucose and insulin amongst those without frank type 2 diabetes mellitus are important determinants of cardiovascular disease. However, the relative importance of variations in fasting insulin, glucose, and glycated haemoglobin as risk factors for cardiovascular d...

journal_title：PLoS medicine

authors： Lawlor DA,Fraser A,Ebrahim S,Smith GD

更新日期：2007-08-01 00:00:00

abstract：:In a Perspective, David Peiris and Dorairaj Prabhakaran discuss implications and challenges of cardiovascular disease risk assessments in the population of India. ...

journal_title：PLoS medicine

authors： Peiris D,Prabhakaran D

更新日期：2018-06-19 00:00:00

abstract：BACKGROUND:In South Africa, within-country migration is common. Mobility affects many of the factors in the pathway for entry to or retention in care among people living with HIV. We characterized the patterns of migration (i.e., change in residency) among peripartum women from rural South Africa and their association ...

journal_title：PLoS medicine

authors： Kim HY,Dobra A,Tanser F

更新日期：2020-03-31 00:00:00

abstract：:How do we spot the next sexually transmitted infection? Kyle Bernstein and colleagues look for lessons from past discovery. ...

journal_title：PLoS medicine

authors： Bernstein K,Bowen VB,Kim CR,Counotte MJ,Kirkcaldy RD,Kara E,Bolan G,Low N,Broutet N

更新日期：2017-12-27 00:00:00

abstract：:Hannah Leslie and co-authors discuss priorities in individual countries for health system reform. ...

journal_title：PLoS medicine

authors： Thapa G,Jhalani M,García-Saisó S,Malata A,Roder-DeWan S,Leslie HH

更新日期：2019-10-03 00:00:00

abstract：BACKGROUND:Mobile text messaging and medication monitors (medication monitor boxes) have the potential to improve adherence to tuberculosis (TB) treatment and reduce the need for directly observed treatment (DOT), but to our knowledge they have not been properly evaluated in TB patients. We assessed the effectiveness o...

journal_title：PLoS medicine

authors： Liu X,Lewis JJ,Zhang H,Lu W,Zhang S,Zheng G,Bai L,Li J,Li X,Chen H,Liu M,Chen R,Chi J,Lu J,Huan S,Cheng S,Wang L,Jiang S,Chin DP,Fielding KL

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Malaria and hypertension are major causes of maternal mortality in tropical countries, especially during first pregnancies, but evidence for a relationship between these syndromes is contradictory. METHODS AND FINDINGS:In a cross-sectional survey of Tanzanian parturients, the rate of hypertension was simila...

journal_title：PLoS medicine

authors： Muehlenbachs A,Mutabingwa TK,Edmonds S,Fried M,Duffy PE

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Endometrial cancer is the most common gynecologic malignancy, and its incidence and associated mortality are increasing. Despite the immediate need to detect these cancers at an earlier stage, there is no effective screening methodology or protocol for endometrial cancer. The comprehensive, genomics-based an...

journal_title：PLoS medicine

authors： Nair N,Camacho-Vanegas O,Rykunov D,Dashkoff M,Camacho SC,Schumacher CA,Irish JC,Harkins TT,Freeman E,Garcia I,Pereira E,Kendall S,Belfer R,Kalir T,Sebra R,Reva B,Dottino P,Martignetti JA

更新日期：2016-12-27 00:00:00

abstract：:Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due to advancements in both prevention and treatment of HIV. However, major challenges still remain. We describe basic principles of epidemic control in the context of HIV and identify a number of attainable goals in terms of control a...

journal_title：PLoS medicine

authors： Jones J,Sullivan PS,Curran JW

更新日期：2019-01-18 00:00:00

abstract：:Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by...

journal_title：PLoS medicine

authors： Rabinovich RN,Drakeley C,Djimde AA,Hall BF,Hay SI,Hemingway J,Kaslow DC,Noor A,Okumu F,Steketee R,Tanner M,Wells TNC,Whittaker MA,Winzeler EA,Wirth DF,Whitfield K,Alonso PL

更新日期：2017-11-30 00:00:00

abstract：BACKGROUND:Diarrhea remains a leading cause of mortality among young children in low- and middle-income countries. Although the evidence for individual diarrhea prevention and treatment interventions is solid, the effect a comprehensive scale-up effort would have on diarrhea mortality has not been estimated. METHODS A...

journal_title：PLoS medicine

authors： Fischer Walker CL,Friberg IK,Binkin N,Young M,Walker N,Fontaine O,Weissman E,Gupta A,Black RE

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Our objective was to examine whether gestational diabetes mellitus (GDM) or newborns' high birthweight can be prevented by lifestyle counseling in pregnant women at high risk of GDM. METHOD AND FINDINGS:We conducted a cluster-randomized trial, the NELLI study, in 14 municipalities in Finland, where 2,271 wo...

journal_title：PLoS medicine

authors： Luoto R,Kinnunen TI,Aittasalo M,Kolu P,Raitanen J,Ojala K,Mansikkamäki K,Lamberg S,Vasankari T,Komulainen T,Tulokas S

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Midwifery continuity of care is the only health system intervention shown to reduce preterm birth (PTB) and improve perinatal survival, but no trial evidence exists for women with identified risk factors for PTB. We aimed to assess feasibility, fidelity, and clinical outcomes of a model of midwifery continui...

journal_title：PLoS medicine

authors： Fernandez Turienzo C,Bick D,Briley AL,Bollard M,Coxon K,Cross P,Silverio SA,Singh C,Seed PT,Tribe RM,Shennan AH,Sandall J,POPPIE Pilot Collaborative Group.

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:Electronic medical records provide large-scale real-world clinical data for use in developing clinical decision systems. However, sophisticated methodology and analytical skills are required to handle the large-scale datasets necessary for the optimisation of prediction accuracy. Myopia is a common cause of ...

journal_title：PLoS medicine

authors： Lin H,Long E,Ding X,Diao H,Chen Z,Liu R,Huang J,Cai J,Xu S,Zhang X,Wang D,Chen K,Yu T,Wu D,Zhao X,Liu Z,Wu X,Jiang Y,Yang X,Cui D,Liu W,Zheng Y,Luo L,Wang H,Chan CC,Morgan IG,He M,Liu Y

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated. METHODS AND FINDINGS:In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of T...

journal_title：PLoS medicine

authors： Dunning J,Sahr F,Rojek A,Gannon F,Carson G,Idriss B,Massaquoi T,Gandi R,Joseph S,Osman HK,Brooks TJ,Simpson AJ,Goodfellow I,Thorne L,Arias A,Merson L,Castle L,Howell-Jones R,Pardinaz-Solis R,Hope-Gill B,Ferri M,

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Leber congenital amaurosis (LCA), a heterogeneous early-onset retinal dystrophy, accounts for approximately 15% of inherited congenital blindness. One cause of LCA is loss of the enzyme lecithin:retinol acyl transferase (LRAT), which is required for regeneration of the visual photopigment in the retina. MET...

journal_title：PLoS medicine

authors： Batten ML,Imanishi Y,Tu DC,Doan T,Zhu L,Pang J,Glushakova L,Moise AR,Baehr W,Van Gelder RN,Hauswirth WW,Rieke F,Palczewski K

更新日期：2005-11-01 00:00:00

abstract：:The PLoS Medicine Editors discuss the link between shift work, diet, and type 2 diabetes, and argue that unhealthy eating should be considered a new form of occupational hazard. ...

journal_title：PLoS medicine

authors： PLoS Medicine Editors.

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes (T2D) is a progressive disease whereby there is often deterioration in glucose control despite escalation in treatment. There is significant heterogeneity to this progression of glycemia after onset of diabetes, yet the factors that influence glycemic progression are not well understood. Give...

journal_title：PLoS medicine

authors： Jiang G,Luk AO,Tam CHT,Lau ES,Ozaki R,Chow EYK,Kong APS,Lim CKP,Lee KF,Siu SC,Hui G,Tsang CC,Lau KP,Leung JYY,Tsang MW,Kam G,Lau IT,Li JK,Yeung VT,Lau E,Lo S,Fung SKS,Cheng YL,Chow CC,Pearson ER,So WY,

更新日期：2020-07-28 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002718.]. ...

journal_title：PLoS medicine

authors： Liu Z,Kuo PL,Horvath S,Crimmins E,Ferrucci L,Levine M

更新日期：2019-02-25 00:00:00

abstract：BACKGROUND:Malaria vaccines based on the 19-kDa region of merozoite surface protein 1 (MSP-1(19)) derived from the 3D7 strain of Plasmodium falciparum are being tested in clinical trials in Africa. Knowledge of the distribution and natural dynamics of vaccine antigen polymorphisms in populations in which malaria vaccin...

journal_title：PLoS medicine

authors： Takala SL,Coulibaly D,Thera MA,Dicko A,Smith DL,Guindo AB,Kone AK,Traore K,Ouattara A,Djimde AA,Sehdev PS,Lyke KE,Diallo DA,Doumbo OK,Plowe CV

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimalarials is extremely limited. Addressing the urgent need for the develo...

journal_title：PLoS medicine

authors： Le Bihan A,de Kanter R,Angulo-Barturen I,Binkert C,Boss C,Brun R,Brunner R,Buchmann S,Burrows J,Dechering KJ,Delves M,Ewerling S,Ferrer S,Fischli C,Gamo-Benito FJ,Gnädig NF,Heidmann B,Jiménez-Díaz MB,Leroy D,Martíne

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:Spurred by the creation of potential modified risk tobacco products, the US Food and Drug Administration (FDA) commissioned the Institute of Medicine (IOM) to assess the science base for tobacco "harm reduction," leading to the 2001 IOM report Clearing the Smoke. The objective of this study was to determine ...

journal_title：PLoS medicine

authors： Tan CE,Kyriss T,Glantz SA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Undiagnosed and misdiagnosed tuberculosis (TB) drives the epidemic in India. Serological (antibody detection) TB tests are not recommended by any agency, but widely used in many countries, including the Indian private sector. The cost and impact of using serology compared with other diagnostic techniques is ...

journal_title：PLoS medicine

authors： Dowdy DW,Steingart KR,Pai M

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Observational epidemiological studies indicate that maternal height is associated with gestational age at birth and fetal growth measures (i.e., shorter mothers deliver infants at earlier gestational ages with lower birth weight and birth length). Different mechanisms have been postulated to explain these as...

journal_title：PLoS medicine

authors： Zhang G,Bacelis J,Lengyel C,Teramo K,Hallman M,Helgeland Ø,Johansson S,Myhre R,Sengpiel V,Njølstad PR,Jacobsson B,Muglia L

更新日期：2015-08-18 00:00:00

abstract：:Andrew Seale and colleagues discuss the development of a global strategy to counter sexually transmitted infections. ...

journal_title：PLoS medicine

authors： Seale A,Broutet N,Narasimhan M

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to laboratory-based tests in Mozambique. METHODS AND FINDINGS:We use a validated model of HIV testing, linkag...

journal_title：PLoS medicine

authors： Hyle EP,Jani IV,Lehe J,Su AE,Wood R,Quevedo J,Losina E,Bassett IV,Pei PP,Paltiel AD,Resch S,Freedberg KA,Peter T,Walensky RP

更新日期：2014-09-16 00:00:00

abstract：BACKGROUND:Pancreatic cancer has an extremely poor prognosis and prolonged survival is achieved only by resection with macroscopic tumor clearance. There is a strong rationale for a neoadjuvant approach, since a relevant percentage of pancreatic cancer patients present with non-metastatic but locally advanced disease a...

journal_title：PLoS medicine

authors： Gillen S,Schuster T,Meyer Zum Büschenfelde C,Friess H,Kleeff J

更新日期：2010-04-20 00:00:00

abstract：BACKGROUND:Plasmodium falciparum merozoite surface protein 3 is a malaria vaccine candidate that was identified, characterised, and developed based on a unique immuno-clinical approach. The vaccine construct was derived from regions fully conserved among various strains and containing B cell epitopes targeted by human ...

journal_title：PLoS medicine

authors： Druilhe P,Spertini F,Soesoe D,Corradin G,Mejia P,Singh S,Audran R,Bouzidi A,Oeuvray C,Roussilhon C

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the leading cause of cancer-related mortality in children. T cell ALL (T-ALL) represents about 15% of pediatric ALL cases and is considered a high-risk disease. T-ALL is often associated with resistance to treatment, includi...

journal_title：PLoS medicine

authors： Li Y,Buijs-Gladdines JG,Canté-Barrett K,Stubbs AP,Vroegindeweij EM,Smits WK,van Marion R,Dinjens WN,Horstmann M,Kuiper RP,Buijsman RC,Zaman GJ,van der Spek PJ,Pieters R,Meijerink JP

更新日期：2016-12-20 00:00:00