Undertaking research in other countries: national ethico-legal barometers and international ethical consensus statements.

abstract：BACKGROUND:Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to laboratory-based tests in Mozambique. METHODS AND FINDINGS:We use a validated model of HIV testing, linkag...

journal_title：PLoS medicine

authors： Hyle EP,Jani IV,Lehe J,Su AE,Wood R,Quevedo J,Losina E,Bassett IV,Pei PP,Paltiel AD,Resch S,Freedberg KA,Peter T,Walensky RP

更新日期：2014-09-16 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1003293.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:Women with preeclampsia (PEC) and gestational hypertension (GH) exhibit insulin resistance during pregnancy, independent of obesity and glucose intolerance. Our aim was to determine whether women with PEC or GH during pregnancy have an increased risk of developing diabetes after pregnancy, and whether the pr...

journal_title：PLoS medicine

authors： Feig DS,Shah BR,Lipscombe LL,Wu CF,Ray JG,Lowe J,Hwee J,Booth GL

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:To reduce the risk of drug-induced haemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the treatment of vivax malaria. This systematic review and individual patient meta-analysis assessed the uti...

journal_title：PLoS medicine

authors： Ley B,Winasti Satyagraha A,Rahmat H,von Fricken ME,Douglas NM,Pfeffer DA,Espino F,von Seidlein L,Henriques G,Oo NN,Menard D,Parikh S,Bancone G,Karahalios A,Price RN

更新日期：2019-12-13 00:00:00

abstract：BACKGROUND:The US Food and Drug Administration Amendments Act requires results from clinical trials of Food and Drug Administration-approved drugs to be posted at ClinicalTrials.gov within 1 y after trial completion. We compared the timing and completeness of results of drug trials posted at ClinicalTrials.gov and publ...

journal_title：PLoS medicine

authors： Riveros C,Dechartres A,Perrodeau E,Haneef R,Boutron I,Ravaud P

更新日期：2013-12-01 00:00:00

abstract：:In an Editorial, Guest Editors Nicola Low and Nathalie Broutet discuss the Collection on sexually transmitted infections in the context of research priorities in the field. ...

journal_title：PLoS medicine

authors： Low N,Broutet NJ

更新日期：2017-12-27 00:00:00

abstract：BACKGROUND:Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and cardiometabolic traits independent of childhood adiposity. METHODS AND FINDINGS:One-sample Mendelian randomisation (MR) analyses were conducted on up to ...

journal_title：PLoS medicine

authors： Bell JA,Carslake D,Wade KH,Richmond RC,Langdon RJ,Vincent EE,Holmes MV,Timpson NJ,Davey Smith G

更新日期：2018-08-28 00:00:00

abstract：:Leo Sher and colleagues discuss recent research on interventions to prevent secondary suicide and discuss the additional research that is needed. ...

journal_title：PLoS medicine

authors： Ganz D,Braquehais MD,Sher L

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The cesarean section (CS) rate has risen globally during the last two decades. Effective and feasible strategies are needed to reduce it. The aim of this study was to assess the CS rate change after a two-stage intervention package that was designed to reduce the overall CS rate in Guangzhou, China. METHODS...

journal_title：PLoS medicine

authors： Xia X,Zhou Z,Shen S,Lu J,Zhang L,Huang P,Yu J,Yang L,Wang P,Lam KH,Jacobsson B,Mol BW,Xia H,Qiu X

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:Although gastric cancer has declined dramatically in the US, the disease remains the second leading cause of cancer mortality worldwide. A better understanding of reasons for the decline can provide important insights into effective preventive strategies. We sought to estimate the contribution of risk factor...

journal_title：PLoS medicine

authors： Yeh JM,Hur C,Schrag D,Kuntz KM,Ezzati M,Stout N,Ward Z,Goldie SJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:There is increasing emphasis on using patient-reported outcomes (PROs) to complement traditional clinical outcomes in medical research, including in multiple sclerosis (MS). Research, particularly in oncology and heart failure, has shown that PROs can be prognostic of hard clinical endpoints such as survival...

journal_title：PLoS medicine

authors： Raffel J,Wallace A,Gveric D,Reynolds R,Friede T,Nicholas R

更新日期：2017-07-10 00:00:00

abstract：:David Studdert and colleagues explore how to balance public health, individual freedom, and good government when it comes to sugar-sweetened drinks. ...

journal_title：PLoS medicine

authors： Studdert DM,Flanders J,Mello MM

更新日期：2015-07-07 00:00:00

abstract：:Pharmacogenomics is one of the first clinical applications of the postgenomic era. It promises personalized medicine rather than the established "one size fits all" approach to drugs and dosages. The expected reduction in trial and error should ultimately lead to more efficient and safer drug therapy. In recent years,...

journal_title：PLoS medicine

authors： Swen JJ,Huizinga TW,Gelderblom H,de Vries EG,Assendelft WJ,Kirchheiner J,Guchelaar HJ

更新日期：2007-08-01 00:00:00

abstract：:In a Perspective, Hilary Seligman and Sanjay Basu discuss future scenarios of food assistance programs to improve population health in a changing political environment. ...

journal_title：PLoS medicine

authors： Seligman HK,Basu S

更新日期：2018-10-02 00:00:00

abstract：BACKGROUND:Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by serotypes of the Enterovirus A species in the genus Enterovirus of the Picornaviridae family. The disease has had a substantial burden throughout East and Southeast Asia over the past 15 y. China reported 9 million cases of HFMD bet...

journal_title：PLoS medicine

authors： Takahashi S,Liao Q,Van Boeckel TP,Xing W,Sun J,Hsiao VY,Metcalf CJ,Chang Z,Liu F,Zhang J,Wu JT,Cowling BJ,Leung GM,Farrar JJ,van Doorn HR,Grenfell BT,Yu H

更新日期：2016-02-16 00:00:00

abstract：BACKGROUND:Malaysia's stable health care system is facing challenges with increasing medicine costs. To investigate these issues a survey was carried out to evaluate medicine prices, availability, affordability, and the structure of price components. METHODS AND FINDINGS:The methodology developed by the World Health O...

journal_title：PLoS medicine

authors： Babar ZU,Ibrahim MI,Singh H,Bukahri NI,Creese A

更新日期：2007-03-27 00:00:00

abstract：:In an Editorial accompanying PLOS Medicine's Special Issue on Diabetes Prevention, Guest Editors Nicholas Wareham and William Herman discuss some of the challenges for researchers and policy makers in developing effective and equitable solutions to the worldwide problem of type 2 diabetes. ...

journal_title：PLoS medicine

authors： Wareham NJ,Herman WH

更新日期：2016-07-26 00:00:00

abstract：BACKGROUND:Epidemiological studies have provided compelling evidence of associations between ambient temperature and cardiovascular disease. However, evidence of effects of daily temperature variability on cardiovascular disease is scarce and mixed. We aimed to examine short-term associations between temperature variab...

journal_title：PLoS medicine

authors： Tian Y,Liu H,Si Y,Cao Y,Song J,Li M,Wu Y,Wang X,Xiang X,Juan J,Chen L,Wei C,Gao P,Hu Y

更新日期：2019-01-28 00:00:00

abstract：BACKGROUND:It is unclear whether an upper gastrointestinal bleed is an isolated gastrointestinal event or an indicator of a deterioration in a patient's overall health status. Therefore, we investigated the excess causes of death in individuals after a non-variceal bleed compared with deaths in a matched sample of the ...

journal_title：PLoS medicine

authors： Crooks CJ,Card TR,West J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Hospitalisation for adversity-related injury (violent, drug/alcohol-related, or self-inflicted injury) has been described as a "teachable moment", when intervention may reduce risks of further harm. Which adolescents are likely to benefit most from intervention strongly depends on their long-term risks of ha...

journal_title：PLoS medicine

authors： Herbert A,Gilbert R,González-Izquierdo A,Pitman A,Li L

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:Envenoming resulting from snakebites is an important public health problem in many tropical and subtropical countries. Few attempts have been made to quantify the burden, and recent estimates all suffer from the lack of an objective and reproducible methodology. In an attempt to provide an accurate, up-to-da...

journal_title：PLoS medicine

authors： Kasturiratne A,Wickremasinghe AR,de Silva N,Gunawardena NK,Pathmeswaran A,Premaratna R,Savioli L,Lalloo DG,de Silva HJ

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:Undiagnosed and misdiagnosed tuberculosis (TB) drives the epidemic in India. Serological (antibody detection) TB tests are not recommended by any agency, but widely used in many countries, including the Indian private sector. The cost and impact of using serology compared with other diagnostic techniques is ...

journal_title：PLoS medicine

authors： Dowdy DW,Steingart KR,Pai M

更新日期：2011-08-01 00:00:00

abstract：:Harald Schmidt and Anne Barnhill highlight the need to ensure equity in the proposed Sustainable Development Goals. ...

journal_title：PLoS medicine

authors： Schmidt H,Barnhill A

更新日期：2015-09-08 00:00:00

abstract：BACKGROUND:Both food insufficiency and HIV infection are major public health problems in sub-Saharan Africa, yet the impact of food insufficiency on HIV risk behavior has not been systematically investigated. We tested the hypothesis that food insufficiency is associated with HIV transmission behavior. METHODS AND FIN...

journal_title：PLoS medicine

authors： Weiser SD,Leiter K,Bangsberg DR,Butler LM,Percy-de Korte F,Hlanze Z,Phaladze N,Iacopino V,Heisler M

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:It remains unclear when standard systematic reviews and meta-analyses that rely on published aggregate data (AD) can provide robust clinical conclusions. We aimed to compare the results from a large cohort of systematic reviews and meta-analyses based on individual participant data (IPD) with meta-analyses o...

journal_title：PLoS medicine

authors： Tierney JF,Fisher DJ,Burdett S,Stewart LA,Parmar MKB

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Various risk factors have been associated with epithelial ovarian cancer risk in observational epidemiological studies. However, the causal nature of the risk factors reported, and thus their suitability as effective intervention targets, is unclear given the susceptibility of conventional observational desi...

journal_title：PLoS medicine

authors： Yarmolinsky J,Relton CL,Lophatananon A,Muir K,Menon U,Gentry-Maharaj A,Walther A,Zheng J,Fasching P,Zheng W,Yin Ling W,Park SK,Kim BG,Choi JY,Park B,Davey Smith G,Martin RM,Lewis SJ

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is estimated to affect 130-180 million people worldwide. Although its origin is unknown, patterns of viral diversity suggest that HCV genotype 1 probably originated from West Africa. Previous attempts to estimate the spatiotemporal parameters of the virus, both globally and regionally...

journal_title：PLoS medicine

authors： Magiorkinis G,Magiorkinis E,Paraskevis D,Ho SY,Shapiro B,Pybus OG,Allain JP,Hatzakis A

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Assessing the mortality impact of the 2009 influenza A H1N1 virus (H1N1pdm09) is essential for optimizing public health responses to future pandemics. The World Health Organization reported 18,631 laboratory-confirmed pandemic deaths, but the total pandemic mortality burden was substantially higher. We estim...

journal_title：PLoS medicine

authors： Simonsen L,Spreeuwenberg P,Lustig R,Taylor RJ,Fleming DM,Kroneman M,Van Kerkhove MD,Mounts AW,Paget WJ,GLaMOR Collaborating Teams.

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The National Health Service (NHS) in England introduced a population-wide programme for cardiovascular disease (CVD) prevention in 2009, known as NHS Health Checks. This research aimed to measure the cardiovascular risk management and cardiovascular risk factor outcomes of the health check programme during s...

journal_title：PLoS medicine

authors： Alageel S,Gulliford MC

更新日期：2019-07-30 00:00:00

abstract：BACKGROUND:Renal involvement is a serious manifestation of systemic lupus erythematosus (SLE); it may portend a poor prognosis as it may lead to end-stage renal disease (ESRD). The purpose of this study was to determine the factors predicting the development of renal involvement and its progression to ESRD in a multi-e...

journal_title：PLoS medicine

authors： Alarcón GS,McGwin G Jr,Petri M,Ramsey-Goldman R,Fessler BJ,Vilá LM,Edberg JC,Reveille JD,Kimberly RP,PROFILE Study Group.

更新日期：2006-10-01 00:00:00