Searching for Public Health Law's Sweet Spot: The Regulation of Sugar-Sweetened Beverages.

abstract：BACKGROUND:Pedometers can increase walking and moderate-to-vigorous physical activity (MVPA) levels, but their effectiveness with or without support has not been rigorously evaluated. We assessed the effectiveness of a pedometer-based walking intervention in predominantly inactive adults, delivered by post or through p...

journal_title：PLoS medicine

authors： Harris T,Kerry SM,Limb ES,Victor CR,Iliffe S,Ussher M,Whincup PH,Ekelund U,Fox-Rushby J,Furness C,Anokye N,Ibison J,DeWilde S,David L,Howard E,Dale R,Smith J,Cook DG

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain. METHODS AND FINDINGS:We report a "nested" case-control comparison within a prospective study in Reykjavik...

journal_title：PLoS medicine

authors： Wheeler JG,Juzwishin KD,Eiriksdottir G,Gudnason V,Danesh J

更新日期：2005-03-01 00:00:00

abstract：:Xonghong Xiao and colleagues analyze the challenge of antimicrobial resistance in China. A government strategy to promote rational use of antimicrobials in health care reduced antibiotic sales and percentage of prescriptions for antimicrobials for both hospitalized patients and outpatients, and offers insights to shap...

journal_title：PLoS medicine

authors： Xiao Y,Zhang J,Zheng B,Zhao L,Li S,Li L

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:HVTN 100 evaluated the safety and immunogenicity of an HIV subtype C pox-protein vaccine regimen, investigating a 12-month booster to extend vaccine-induced immune responses. METHODS AND FINDINGS:A phase 1-2 randomized double-blind placebo-controlled trial enrolled 252 participants (210 vaccine/42 placebo; ...

journal_title：PLoS medicine

authors： Laher F,Moodie Z,Cohen KW,Grunenberg N,Bekker LG,Allen M,Frahm N,Yates NL,Morris L,Malahleha M,Mngadi K,Daniels B,Innes C,Saunders K,Grant S,Yu C,Gilbert PB,Phogat S,DiazGranados CA,Koutsoukos M,Van Der Meeren O,

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:While many individual genes have been identified that confer protection against malaria, the overall impact of host genetics on malarial risk remains unknown. METHODS AND FINDINGS:We have used pedigree-based genetic variance component analysis to determine the relative contributions of genetic and other fac...

journal_title：PLoS medicine

authors： Mackinnon MJ,Mwangi TW,Snow RW,Marsh K,Williams TN

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Fibre is promoted as part of a healthy dietary pattern and in diabetes management. We have considered the role of high-fibre diets on mortality and increasing fibre intake on glycaemic control and other cardiometabolic risk factors of adults with prediabetes or diabetes. METHODS AND FINDINGS:We conducted a ...

journal_title：PLoS medicine

authors： Reynolds AN,Akerman AP,Mann J

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder characterized by fibroproliferation and excessive accumulation of extracellular matrix in the lung. METHODS AND FINDINGS:Using oligonucleotide arrays, we identified osteopontin as one of the genes that significantly distinguishes IPF f...

journal_title：PLoS medicine

authors： Pardo A,Gibson K,Cisneros J,Richards TJ,Yang Y,Becerril C,Yousem S,Herrera I,Ruiz V,Selman M,Kaminski N

更新日期：2005-09-01 00:00:00

abstract：:In this month's editorial, PLOS Medicine's Chief Editor Larry Peiperl discusses the relevance of patient care to a journal editor's work. ...

journal_title：PLoS medicine

authors： Peiperl L,PLOS Medicine Editors.

更新日期：2017-09-26 00:00:00

abstract：:In an Editorial, Ligia Kiss and Cathy Zimmerman discuss the need for research on the prevention of human trafficking and mitigation of its effects. ...

journal_title：PLoS medicine

authors： Kiss L,Zimmerman C

更新日期：2019-01-29 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002511.]. ...

journal_title：PLoS medicine

authors： Torrone EA,Morrison CS,Chen PL,Kwok C,Francis SC,Hayes RJ,Looker KJ,McCormack S,McGrath N,van de Wijgert JHHM,Watson-Jones D,Low N,Gottlieb SL,STIMA Working Group.

更新日期：2018-06-26 00:00:00

abstract：:Peter Openshaw discusses the challenges in advancing respiratory syncytial virus (RSV) treatments and the implications of a study by Mejias and colleagues using a newly identified gene signature for diagnosis and prediction of RSV severity. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Openshaw PJ

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:A number of epidemiologic studies have observed an association between secondhand smoke (SHS) exposure and pediatric invasive bacterial disease (IBD) but the evidence has not been systematically reviewed. We carried out a systematic review and meta-analysis of SHS exposure and two outcomes, IBD and pharyngea...

journal_title：PLoS medicine

authors： Lee CC,Middaugh NA,Howie SR,Ezzati M

更新日期：2010-12-07 00:00:00

abstract：:The PLOS Medicine editors discuss the new extension to the PRISMA reporting guidelines, PRISMA for Equity (PRISMA-E), and why it is relevant to the journal and to health research more generally. ...

journal_title：PLoS medicine

authors： PLOS Medicine Editors.

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Rates of diseases and injuries and the effects of their risk factors can have substantial subnational heterogeneity, especially in middle-income countries like Mexico. Subnational analysis of the burden of diseases, injuries, and risk factors can improve characterization of the epidemiological transition and...

journal_title：PLoS medicine

authors： Stevens G,Dias RH,Thomas KJ,Rivera JA,Carvalho N,Barquera S,Hill K,Ezzati M

更新日期：2008-06-17 00:00:00

abstract：BACKGROUND:Although the success of HIV treatment programs depends on retention and viral suppression, routine program monitoring of these outcomes may be incomplete. We used data from the national electronic medical record (EMR) system in Zambia to enumerate a large and regionally representative cohort of patients on t...

journal_title：PLoS medicine

authors： Sikazwe I,Eshun-Wilson I,Sikombe K,Czaicki N,Somwe P,Mody A,Simbeza S,Glidden DV,Chizema E,Mulenga LB,Padian N,Duncombe CJ,Bolton-Moore C,Beres LK,Holmes CB,Geng E

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:There is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19). We investigated racial and ethnic disparities in patterns of COVI...

journal_title：PLoS medicine

authors： Rentsch CT,Kidwai-Khan F,Tate JP,Park LS,King JT Jr,Skanderson M,Hauser RG,Schultze A,Jarvis CI,Holodniy M,Lo Re V 3rd,Akgün KM,Crothers K,Taddei TH,Freiberg MS,Justice AC

更新日期：2020-09-22 00:00:00

abstract：BACKGROUND:Ovarian cancer kills approximately 15,000 women in the United States every year, and more than 140,000 women worldwide. Most deaths from ovarian cancer are caused by tumors of the serous histological type, which are rarely diagnosed before the cancer has spread. Rational design of a potentially life-saving e...

journal_title：PLoS medicine

authors： Brown PO,Palmer C

更新日期：2009-07-01 00:00:00

abstract：:Community efforts and peer support programs are needed in addition to provider-initiated and opt-out HIV testing in adolescents, Sheri Weiser and colleagues discuss. ...

journal_title：PLoS medicine

authors： Lightfoot M,Dunbar M,Weiser SD

更新日期：2017-07-25 00:00:00

abstract：:Results from several observational studies of HIV-discordant couples and a randomized controlled trial (HIV Prevention Trials Network 052) show that antiretroviral therapy (ART) can greatly reduce heterosexual HIV transmission in stable HIV-discordant couples. However, such data do not prove that ART will reduce HIV i...

journal_title：PLoS medicine

authors： Smith MK,Powers KA,Muessig KE,Miller WC,Cohen MS

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Leber congenital amaurosis (LCA) is a genetically heterogeneous group of retinal diseases that cause congenital blindness in infants and children. Mutations in the GUCY2D gene that encodes retinal guanylate cyclase-1 (retGC1) were the first to be linked to this disease group (LCA type 1 [LCA1]) and account f...

journal_title：PLoS medicine

authors： Williams ML,Coleman JE,Haire SE,Aleman TS,Cideciyan AV,Sokal I,Palczewski K,Jacobson SG,Semple-Rowland SL

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Postpartum hemorrhage (PPH) is a leading cause of maternal death in sub-Saharan Africa. Although the World Health Organization recommends use of oxytocin for prevention of PPH, misoprostol use is increasingly common owing to advantages in shelf life and potential for sublingual administration. There is a lac...

journal_title：PLoS medicine

authors： Atukunda EC,Siedner MJ,Obua C,Mugyenyi GR,Twagirumukiza M,Agaba AG

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:Suboptimal weight gain during pregnancy is a potentially modifiable risk factor. We aimed to investigate the association between suboptimal gestational weight gain and severe adverse birth outcomes by pre-pregnancy body mass index (BMI) categories, including obesity class I to III. METHODS AND FINDINGS:We c...

journal_title：PLoS medicine

authors： Ukah UV,Bayrampour H,Sabr Y,Razaz N,Chan WS,Lim KI,Lisonkova S

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU]) developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indication that FIAU would b...

journal_title：PLoS medicine

authors： Xu D,Nishimura T,Nishimura S,Zhang H,Zheng M,Guo YY,Masek M,Michie SA,Glenn J,Peltz G

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:Tissue advanced glycation end product (AGE) accumulation has been proposed as a marker of cumulative metabolic stress that can be assessed noninvasively by measurement of skin autofluorescence (SAF). In persons on haemodialysis, SAF is an independent risk factor for cardiovascular events (CVEs) and all-cause...

journal_title：PLoS medicine

authors： Shardlow A,McIntyre NJ,Kolhe NV,Nellums LB,Fluck RJ,McIntyre CW,Taal MW

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Hip and knee replacement are some of the most frequently performed surgical procedures in the world. Resurfacing of the hip and unicondylar knee replacement are increasingly being used. There is relatively little evidence on their performance. To study performance of joint replacement in England, we investig...

journal_title：PLoS medicine

authors： Sibanda N,Copley LP,Lewsey JD,Borroff M,Gregg P,MacGregor AJ,Pickford M,Porter M,Tucker K,van der Meulen JH,Steering Committee of the National Joint Registry (NJR) for England and Wales.

更新日期：2008-09-30 00:00:00

abstract：:In this Perspective on the clinical trial by Rita Alloway and colleagues, Simon Ball explains the benefits to healthcare systems and individual patients of the bioequivalence established between generic and brand-name formulations of an immunosuppressive drug in transplant recipients. ...

journal_title：PLoS medicine

authors： Ball S

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:Both food insufficiency and HIV infection are major public health problems in sub-Saharan Africa, yet the impact of food insufficiency on HIV risk behavior has not been systematically investigated. We tested the hypothesis that food insufficiency is associated with HIV transmission behavior. METHODS AND FIN...

journal_title：PLoS medicine

authors： Weiser SD,Leiter K,Bangsberg DR,Butler LM,Percy-de Korte F,Hlanze Z,Phaladze N,Iacopino V,Heisler M

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate mortality for patients with the major subtypes of breast cancer as classified using five immunohistochemical markers, to investigate ...

journal_title：PLoS medicine

authors： Blows FM,Driver KE,Schmidt MK,Broeks A,van Leeuwen FE,Wesseling J,Cheang MC,Gelmon K,Nielsen TO,Blomqvist C,Heikkilä P,Heikkinen T,Nevanlinna H,Akslen LA,Bégin LR,Foulkes WD,Couch FJ,Wang X,Cafourek V,Olson JE,Bag

更新日期：2010-05-25 00:00:00

abstract：BACKGROUND:Polygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quantify the potential advantage of adding information on PRSs to conventional risk factors in the primary prevention of CVD. METHODS AND FINDINGS:Using data from UK Biobank on 306,654 individual...

journal_title：PLoS medicine

authors： Sun L,Pennells L,Kaptoge S,Nelson CP,Ritchie SC,Abraham G,Arnold M,Bell S,Bolton T,Burgess S,Dudbridge F,Guo Q,Sofianopoulou E,Stevens D,Thompson JR,Butterworth AS,Wood A,Danesh J,Samani NJ,Inouye M,Di Angelantoni

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Counties are the smallest unit for which mortality data are routinely available, allowing consistent and comparable long-term analysis of trends in health disparities. Average life expectancy has steadily increased in the United States but there is limited information on long-term mortality trends in the US ...

journal_title：PLoS medicine

authors： Ezzati M,Friedman AB,Kulkarni SC,Murray CJ

更新日期：2008-04-22 00:00:00