Bioequivalence of twice-daily oral tacrolimus in transplant recipients: More evidence for consensus?

abstract：BACKGROUND TO THE DEBATE:The tobacco control community is divided on whether or not to inform the public that using oral, smokeless tobacco (Swedish snus) is less hazardous to health than smoking tobacco. Proponents of "harm reduction" point to the Swedish experience. Snus seems to be widely used as an alternative to c...

journal_title：PLoS medicine

authors： Gartner CE,Hall WD,Chapman S,Freeman B

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Development of noninvasive molecular assays to improve disease diagnosis and patient monitoring is a critical need. In renal transplantation, acute rejection (AR) increases the risk for chronic graft injury and failure. Noninvasive diagnostic assays to improve current late and nonspecific diagnosis of reject...

journal_title：PLoS medicine

authors： Roedder S,Sigdel T,Salomonis N,Hsieh S,Dai H,Bestard O,Metes D,Zeevi A,Gritsch A,Cheeseman J,Macedo C,Peddy R,Medeiros M,Vincenti F,Asher N,Salvatierra O,Shapiro R,Kirk A,Reed EF,Sarwal MM

更新日期：2014-11-11 00:00:00

abstract：BACKGROUND:Envenoming resulting from snakebites is an important public health problem in many tropical and subtropical countries. Few attempts have been made to quantify the burden, and recent estimates all suffer from the lack of an objective and reproducible methodology. In an attempt to provide an accurate, up-to-da...

journal_title：PLoS medicine

authors： Kasturiratne A,Wickremasinghe AR,de Silva N,Gunawardena NK,Pathmeswaran A,Premaratna R,Savioli L,Lalloo DG,de Silva HJ

更新日期：2008-11-04 00:00:00

abstract：:Diarrhea morbidity and mortality remain important child health problems in low- and middle-income countries. The treatment of diarrhea and accurate measurement of treatment coverage are critical if child mortality is going to continue to decline. In this review, we examine diarrhea treatment coverage indicators collec...

journal_title：PLoS medicine

authors： Fischer Walker CL,Fontaine O,Black RE

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1003293.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large populations treated in routine clinical practice is lacking. The objective of this study was to measure the association...

journal_title：PLoS medicine

authors： Douglas IJ,Bhaskaran K,Batterham RL,Smeeth L

更新日期：2015-12-22 00:00:00

abstract：:In a Perspective, Hilary Seligman and Sanjay Basu discuss future scenarios of food assistance programs to improve population health in a changing political environment. ...

journal_title：PLoS medicine

authors： Seligman HK,Basu S

更新日期：2018-10-02 00:00:00

abstract：BACKGROUND:Outbreaks of emerging infectious diseases, especially those of a global nature, require rapid epidemiological analysis and information dissemination. The final products of those activities usually comprise internal memoranda and briefs within public health authorities and original research published in peer-...

journal_title：PLoS medicine

authors： Xing W,Hejblum G,Leung GM,Valleron AJ

更新日期：2010-05-04 00:00:00

abstract：BACKGROUND:Vital registration and cause of death reporting is incomplete in the countries in which the HIV epidemic is most severe. A reliable tool that is independent of HIV status is needed for measuring the frequency of AIDS deaths and ultimately the impact of antiretroviral therapy on mortality. METHODS AND FINDIN...

journal_title：PLoS medicine

authors： Lopman BA,Barnabas RV,Boerma JT,Chawira G,Gaitskell K,Harrop T,Mason P,Donnelly CA,Garnett GP,Nyamukapa C,Gregson S

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Leber congenital amaurosis (LCA) is a genetically heterogeneous group of retinal diseases that cause congenital blindness in infants and children. Mutations in the GUCY2D gene that encodes retinal guanylate cyclase-1 (retGC1) were the first to be linked to this disease group (LCA type 1 [LCA1]) and account f...

journal_title：PLoS medicine

authors： Williams ML,Coleman JE,Haire SE,Aleman TS,Cideciyan AV,Sokal I,Palczewski K,Jacobson SG,Semple-Rowland SL

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Bariatric and metabolic surgery is used as a treatment for patients with severe and complex obesity. However, there is a need to improve outcome selection and reporting in bariatric surgery trials. A Core Outcome Set (COS), an agreed minimum set of outcomes reported in all studies of a specific condition, ma...

journal_title：PLoS medicine

authors： Coulman KD,Hopkins J,Brookes ST,Chalmers K,Main B,Owen-Smith A,Andrews RC,Byrne J,Donovan JL,Mazza G,Reeves BC,Rogers CA,Thompson JL,Welbourn R,Wordsworth S,Blazeby JM,BARIACT working group.

更新日期：2016-11-29 00:00:00

abstract：:Considerable progress has been made in reducing maternal, newborn, and child mortality worldwide, but many more deaths could be prevented if effective interventions were available to all who could benefit from them. Timely, high-quality measurements of intervention coverage--the proportion of a population in need of a...

journal_title：PLoS medicine

authors： Bryce J,Arnold F,Blanc A,Hancioglu A,Newby H,Requejo J,Wardlaw T,CHERG Working Group on Improving Coverage Measurement.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Mobile text messaging and medication monitors (medication monitor boxes) have the potential to improve adherence to tuberculosis (TB) treatment and reduce the need for directly observed treatment (DOT), but to our knowledge they have not been properly evaluated in TB patients. We assessed the effectiveness o...

journal_title：PLoS medicine

authors： Liu X,Lewis JJ,Zhang H,Lu W,Zhang S,Zheng G,Bai L,Li J,Li X,Chen H,Liu M,Chen R,Chi J,Lu J,Huan S,Cheng S,Wang L,Jiang S,Chin DP,Fielding KL

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:The response to the next influenza pandemic will likely include extensive use of antiviral drugs (mainly oseltamivir), combined with other transmission-reducing measures. Animal and in vitro studies suggest that some strains of influenza may become resistant to oseltamivir while maintaining infectiousness (f...

journal_title：PLoS medicine

authors： Lipsitch M,Cohen T,Murray M,Levin BR

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Socioeconomic adversity in early life has been hypothesized to "program" a vulnerable phenotype with exaggerated inflammatory responses, so increasing the risk of developing type 2 diabetes in adulthood. The aim of this study is to test this hypothesis by assessing the extent to which the association between...

journal_title：PLoS medicine

authors： Stringhini S,Batty GD,Bovet P,Shipley MJ,Marmot MG,Kumari M,Tabak AG,Kivimäki M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Although the success of HIV treatment programs depends on retention and viral suppression, routine program monitoring of these outcomes may be incomplete. We used data from the national electronic medical record (EMR) system in Zambia to enumerate a large and regionally representative cohort of patients on t...

journal_title：PLoS medicine

authors： Sikazwe I,Eshun-Wilson I,Sikombe K,Czaicki N,Somwe P,Mody A,Simbeza S,Glidden DV,Chizema E,Mulenga LB,Padian N,Duncombe CJ,Bolton-Moore C,Beres LK,Holmes CB,Geng E

更新日期：2019-05-31 00:00:00

abstract：:In a Perspective, Lynn Morris and Nonhlanhla Mkhize discuss the prospects for broadly neutralizing antibodies to be used in preventing HIV infection. ...

journal_title：PLoS medicine

authors： Morris L,Mkhize NN

更新日期：2017-11-14 00:00:00

abstract：:The PLOS Medicine editors discuss the new extension to the PRISMA reporting guidelines, PRISMA for Equity (PRISMA-E), and why it is relevant to the journal and to health research more generally. ...

journal_title：PLoS medicine

authors： PLOS Medicine Editors.

更新日期：2012-10-01 00:00:00

abstract：:A major challenge in monitoring universal health coverage (UHC) is identifying an indicator that can adequately capture the multiple components underlying the UHC initiative. Effective coverage, which unites individual and intervention characteristics into a single metric, offers a direct and flexible means to measure...

journal_title：PLoS medicine

authors： Ng M,Fullman N,Dieleman JL,Flaxman AD,Murray CJ,Lim SS

更新日期：2014-09-22 00:00:00

abstract：BACKGROUND:Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and cardiometabolic traits independent of childhood adiposity. METHODS AND FINDINGS:One-sample Mendelian randomisation (MR) analyses were conducted on up to ...

journal_title：PLoS medicine

authors： Bell JA,Carslake D,Wade KH,Richmond RC,Langdon RJ,Vincent EE,Holmes MV,Timpson NJ,Davey Smith G

更新日期：2018-08-28 00:00:00

abstract：:Kwonjune Seung and colleagues describe the Eugene Bell Foundation's experience of treating MDR-TB in North Korea. ...

journal_title：PLoS medicine

authors： Seung KJ,Franke M,Linton SW

更新日期：2016-08-02 00:00:00

abstract：BACKGROUND:Stillbirth is strongly related to impaired fetal growth. However, the relationship between fetal growth and stillbirth is difficult to determine because of uncertainty in the timing of death and confounding characteristics affecting normal fetal growth. METHODS AND FINDINGS:We conducted a population-based c...

journal_title：PLoS medicine

authors： Bukowski R,Hansen NI,Willinger M,Reddy UM,Parker CB,Pinar H,Silver RM,Dudley DJ,Stoll BJ,Saade GR,Koch MA,Rowland Hogue CJ,Varner MW,Conway DL,Coustan D,Goldenberg RL,Eunice Kennedy Shriver National Institute of Child Hea

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU]) developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indication that FIAU would b...

journal_title：PLoS medicine

authors： Xu D,Nishimura T,Nishimura S,Zhang H,Zheng M,Guo YY,Masek M,Michie SA,Glenn J,Peltz G

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs. There are numerous psychiatric conditions that present with psychotic symptoms, most importantly schizophrenia, bipolar affective disorder, an...

journal_title：PLoS medicine

authors： Huang JT,Leweke FM,Oxley D,Wang L,Harris N,Koethe D,Gerth CW,Nolden BM,Gross S,Schreiber D,Reed B,Bahn S

更新日期：2006-11-01 00:00:00

abstract：:Financial risk protection is a key component of universal health coverage (UHC), which is defined as access to all needed quality health services without financial hardship. As part of the PLOS Medicine Collection on measurement of UHC, the aim of this paper is to examine and to compare and contrast existing measures ...

journal_title：PLoS medicine

authors： Saksena P,Hsu J,Evans DB

更新日期：2014-09-22 00:00:00

abstract：:Aaron Kesselheim and colleagues examine orphan-designated drugs approved between 2009 and 2015 in the United States. ...

journal_title：PLoS medicine

authors： Kesselheim AS,Treasure CL,Joffe S

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:Trachoma is the world's leading cause of infectious blindness. The World Health Organization (WHO) has endorsed the SAFE strategy in order to eliminate blindness due to trachoma by 2020 through "surgery," "antibiotics," "facial cleanliness," and "environmental improvement." While the S and A components have ...

journal_title：PLoS medicine

authors： Stocks ME,Ogden S,Haddad D,Addiss DG,McGuire C,Freeman MC

更新日期：2014-02-25 00:00:00

abstract：:How do we spot the next sexually transmitted infection? Kyle Bernstein and colleagues look for lessons from past discovery. ...

journal_title：PLoS medicine

authors： Bernstein K,Bowen VB,Kim CR,Counotte MJ,Kirkcaldy RD,Kara E,Bolan G,Low N,Broutet N

更新日期：2017-12-27 00:00:00

abstract：BACKGROUND:There is increasing emphasis on using patient-reported outcomes (PROs) to complement traditional clinical outcomes in medical research, including in multiple sclerosis (MS). Research, particularly in oncology and heart failure, has shown that PROs can be prognostic of hard clinical endpoints such as survival...

journal_title：PLoS medicine

authors： Raffel J,Wallace A,Gveric D,Reynolds R,Friede T,Nicholas R

更新日期：2017-07-10 00:00:00

abstract：BACKGROUND:Resistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is increasing in prevalence in Africa. Combination therapy can both improve treatment and provide important public health benefits if it curbs the spread of parasites harbouring resistance genes. Thus, drug combinations m...

journal_title：PLoS medicine

authors： Sutherland CJ,Ord R,Dunyo S,Jawara M,Drakeley CJ,Alexander N,Coleman R,Pinder M,Walraven G,Targett GA

更新日期：2005-04-01 00:00:00