Association of lifecourse socioeconomic status with chronic inflammation and type 2 diabetes risk: the Whitehall II prospective cohort study.

abstract：BACKGROUND:Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premature death, little is known about the combined impact on mortality outcomes, in particular among Chinese ...

journal_title：PLoS medicine

authors： Nechuta SJ,Shu XO,Li HL,Yang G,Xiang YB,Cai H,Chow WH,Ji B,Zhang X,Wen W,Gao YT,Zheng W

更新日期：2010-09-14 00:00:00

abstract：BACKGROUND:Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU]) developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indication that FIAU would b...

journal_title：PLoS medicine

authors： Xu D,Nishimura T,Nishimura S,Zhang H,Zheng M,Guo YY,Masek M,Michie SA,Glenn J,Peltz G

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:Escalation in the global rates of labour interventions, particularly cesarean section and oxytocin augmentation, has renewed interest in a better understanding of natural labour progression. Methodological advancements in statistical and computational techniques addressing the limitations of pioneer studies ...

journal_title：PLoS medicine

authors： Oladapo OT,Souza JP,Fawole B,Mugerwa K,Perdoná G,Alves D,Souza H,Reis R,Oliveira-Ciabati L,Maiorano A,Akintan A,Alu FE,Oyeneyin L,Adebayo A,Byamugisha J,Nakalembe M,Idris HA,Okike O,Althabe F,Hundley V,Donnay F,

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:Identifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity. Recently, the intensity and the quality of the host immune response in the tumor microenvironment h...

journal_title：PLoS medicine

authors： Sanz-Pamplona R,Melas M,Maoz A,Schmit SL,Rennert H,Lejbkowicz F,Greenson JK,Sanjuan X,Lopez-Zambrano M,Alonso MH,Qu C,McDonnell KJ,Idos GE,Vignali M,Emerson R,Fields P,Guinó E,Santos C,Salazar R,Robins HS,Rennert

更新日期：2020-09-24 00:00:00

abstract：:In an essay, Paul Bloem and Ikechukwu Ogbuanu discuss the public health implications of HPV vaccination. ...

journal_title：PLoS medicine

authors： Bloem P,Ogbuanu I

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Midwifery continuity of care is the only health system intervention shown to reduce preterm birth (PTB) and improve perinatal survival, but no trial evidence exists for women with identified risk factors for PTB. We aimed to assess feasibility, fidelity, and clinical outcomes of a model of midwifery continui...

journal_title：PLoS medicine

authors： Fernandez Turienzo C,Bick D,Briley AL,Bollard M,Coxon K,Cross P,Silverio SA,Singh C,Seed PT,Tribe RM,Shennan AH,Sandall J,POPPIE Pilot Collaborative Group.

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:In common with many other low- and middle-income countries (LMICs), rural to urban migrants in India are at increased risk of obesity, but it is unclear whether this is due to increased energy intake, reduced energy expenditure, or both. Knowing this and the relative contribution of specific dietary and phys...

journal_title：PLoS medicine

authors： Kinra S,Mallinson PAC,Cresswell JA,Bowen LJ,Lyngdoh T,Prabhakaran D,Reddy KS,Vaz M,Kurpad AV,Davey Smith G,Ben-Shlomo Y,Ebrahim S

更新日期：2020-08-07 00:00:00

abstract：BACKGROUND:Renal involvement is a serious manifestation of systemic lupus erythematosus (SLE); it may portend a poor prognosis as it may lead to end-stage renal disease (ESRD). The purpose of this study was to determine the factors predicting the development of renal involvement and its progression to ESRD in a multi-e...

journal_title：PLoS medicine

authors： Alarcón GS,McGwin G Jr,Petri M,Ramsey-Goldman R,Fessler BJ,Vilá LM,Edberg JC,Reveille JD,Kimberly RP,PROFILE Study Group.

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Randomized clinical trials of oral antiretroviral pre-exposure prophylaxis (PrEP) for HIV prevention have widely divergent efficacy estimates, ranging from 0% to 75%. These discrepancies are likely due to differences in adherence. To our knowledge, no studies to date have examined the impact of improving adh...

journal_title：PLoS medicine

authors： Haberer JE,Baeten JM,Campbell J,Wangisi J,Katabira E,Ronald A,Tumwesigye E,Psaros C,Safren SA,Ware NC,Thomas KK,Donnell D,Krows M,Kidoguchi L,Celum C,Bangsberg DR

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:In June 2016, the first phase of the Chilean Food Labelling and Advertising Law that mandated front-of-package warning labels and marketing restrictions for unhealthy foods and beverages was implemented. We assess foods and beverages reformulation after this initial implementation. METHODS AND FINDINGS:A da...

journal_title：PLoS medicine

authors： Reyes M,Smith Taillie L,Popkin B,Kanter R,Vandevijvere S,Corvalán C

更新日期：2020-07-28 00:00:00

abstract：:Philippe Calain discusses the health and environmental hazards of extractive industries like mining and explores the tensions that arise when medical humanitarian organizations are called to intervene in emergencies involving the extractive sector. ...

journal_title：PLoS medicine

authors： Calain P

更新日期：2012-01-01 00:00:00

abstract：:This month in PLOS Medicine we launched a Special Issue on New Tools and Strategies for Tuberculosis Diagnosis, Care, and Elimination. In this issue's Editorial, the Guest Editors Claudia Denkinger, Richard Chaisson, and Mark Hatherill highlight some of the research that will publish and how these studies focusing on ...

journal_title：PLoS medicine

authors： Hatherill M,Chaisson RE,Denkinger CM

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:Bariatric and metabolic surgery is used as a treatment for patients with severe and complex obesity. However, there is a need to improve outcome selection and reporting in bariatric surgery trials. A Core Outcome Set (COS), an agreed minimum set of outcomes reported in all studies of a specific condition, ma...

journal_title：PLoS medicine

authors： Coulman KD,Hopkins J,Brookes ST,Chalmers K,Main B,Owen-Smith A,Andrews RC,Byrne J,Donovan JL,Mazza G,Reeves BC,Rogers CA,Thompson JL,Welbourn R,Wordsworth S,Blazeby JM,BARIACT working group.

更新日期：2016-11-29 00:00:00

abstract：BACKGROUND:Violence against women by intimate partners remains unacceptably common worldwide. The evidence base for the assumed psychological impacts of intimate partner violence (IPV) is derived primarily from studies conducted in high-income countries. A recently published systematic review identified 13 studies link...

journal_title：PLoS medicine

authors： Tsai AC,Tomlinson M,Comulada WS,Rotheram-Borus MJ

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:Breast cancer is a leading malignancy affecting the female population worldwide. Most morbidity is caused by metastases that remain incurable to date. TGF-β1 has been identified as a key driving force behind metastatic breast cancer, with promising therapeutic implications. METHODS AND FINDINGS:Employing im...

journal_title：PLoS medicine

authors： Maris P,Blomme A,Palacios AP,Costanza B,Bellahcène A,Bianchi E,Gofflot S,Drion P,Trombino GE,Di Valentin E,Cusumano PG,Maweja S,Jerusalem G,Delvenne P,Lifrange E,Castronovo V,Turtoi A

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:There is very limited data on the time trend of diabetes incidence in Asia. Using population-level data, we report the secular trend of the incidence of type 1 and type 2 diabetes in Hong Kong between 2002 and 2015. METHODS AND FINDINGS:The Hong Kong Diabetes Surveillance Database hosts clinical information...

journal_title：PLoS medicine

authors： Luk AOY,Ke C,Lau ESH,Wu H,Goggins W,Ma RCW,Chow E,Kong APS,So WY,Chan JCN

更新日期：2020-02-20 00:00:00

abstract：BACKGROUND:Vital registration and cause of death reporting is incomplete in the countries in which the HIV epidemic is most severe. A reliable tool that is independent of HIV status is needed for measuring the frequency of AIDS deaths and ultimately the impact of antiretroviral therapy on mortality. METHODS AND FINDIN...

journal_title：PLoS medicine

authors： Lopman BA,Barnabas RV,Boerma JT,Chawira G,Gaitskell K,Harrop T,Mason P,Donnelly CA,Garnett GP,Nyamukapa C,Gregson S

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Through major efforts to reduce costs and expand access to antiretroviral therapy worldwide, widespread delivery of effective treatment to people living with HIV/AIDS is now conceivable even in severely resource-constrained settings. However, the potential epidemiologic impact of treatment in the context of ...

journal_title：PLoS medicine

authors： Salomon JA,Hogan DR,Stover J,Stanecki KA,Walker N,Ghys PD,Schwartländer B

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The identification and characterization of tumor suppressor genes has enhanced our understanding of the biology of cancer and enabled the development of new diagnostic and therapeutic modalities. Whereas in past decades, a handful of tumor suppressors have been slowly identified using techniques such as link...

journal_title：PLoS medicine

authors： Chan TA,Glockner S,Yi JM,Chen W,Van Neste L,Cope L,Herman JG,Velculescu V,Schuebel KE,Ahuja N,Baylin SB

更新日期：2008-05-27 00:00:00

abstract：:Community efforts and peer support programs are needed in addition to provider-initiated and opt-out HIV testing in adolescents, Sheri Weiser and colleagues discuss. ...

journal_title：PLoS medicine

authors： Lightfoot M,Dunbar M,Weiser SD

更新日期：2017-07-25 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is estimated to affect 130-180 million people worldwide. Although its origin is unknown, patterns of viral diversity suggest that HCV genotype 1 probably originated from West Africa. Previous attempts to estimate the spatiotemporal parameters of the virus, both globally and regionally...

journal_title：PLoS medicine

authors： Magiorkinis G,Magiorkinis E,Paraskevis D,Ho SY,Shapiro B,Pybus OG,Allain JP,Hatzakis A

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Opioid misuse and deaths are increasing in the United States. In 2017, Ohio had the second highest overdose rates in the US, with the city of Cincinnati experiencing a 50% rise in opioid overdoses since 2015. Understanding the temporal and geographic variation in overdose emergencies may help guide public po...

journal_title：PLoS medicine

authors： Li ZR,Xie E,Crawford FW,Warren JL,McConnell K,Copple JT,Johnson T,Gonsalves GS

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Policymakers worldwide are considering requiring warnings for sugary drinks. A growing number of experimental studies have examined sugary drink warnings' impacts, but no research to our knowledge has synthesized this literature. To inform ongoing policy debates, this study aimed to identify the effects of s...

journal_title：PLoS medicine

authors： Grummon AH,Hall MG

更新日期：2020-05-20 00:00:00

abstract：BACKGROUND:trans-fatty acids (TFAs) are a well-known risk factor of ischemic heart disease (IHD). In Australia, the highest TFA intake is concentrated to the most socioeconomically disadvantaged groups. Elimination of industrial TFA (iTFA) from the Australian food supply could result in reduced IHD mortality and morbid...

journal_title：PLoS medicine

authors： Marklund M,Zheng M,Veerman JL,Wu JHY

更新日期：2020-11-02 00:00:00

abstract：BACKGROUND:Malaria vaccines based on the 19-kDa region of merozoite surface protein 1 (MSP-1(19)) derived from the 3D7 strain of Plasmodium falciparum are being tested in clinical trials in Africa. Knowledge of the distribution and natural dynamics of vaccine antigen polymorphisms in populations in which malaria vaccin...

journal_title：PLoS medicine

authors： Takala SL,Coulibaly D,Thera MA,Dicko A,Smith DL,Guindo AB,Kone AK,Traore K,Ouattara A,Djimde AA,Sehdev PS,Lyke KE,Diallo DA,Doumbo OK,Plowe CV

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Increased adiposity is linked with higher risk for cardiometabolic diseases. We aimed to determine to what extent elevated body mass index (BMI) within the normal weight range has causal effects on the detailed systemic metabolite profile in early adulthood. METHODS AND FINDINGS:We used Mendelian randomizat...

journal_title：PLoS medicine

authors： Würtz P,Wang Q,Kangas AJ,Richmond RC,Skarp J,Tiainen M,Tynkkynen T,Soininen P,Havulinna AS,Kaakinen M,Viikari JS,Savolainen MJ,Kähönen M,Lehtimäki T,Männistö S,Blankenberg S,Zeller T,Laitinen J,Pouta A,Mäntyselkä P

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Oncolytic viruses hold much promise for clinical treatment of many cancers, but a lack of systemic delivery and insufficient tumor cell killing have limited their usefulness. We have previously demonstrated that vaccinia virus strains are capable of systemic delivery to tumors in mouse models, but infection ...

journal_title：PLoS medicine

authors： Kirn DH,Wang Y,Le Boeuf F,Bell J,Thorne SH

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Puberty is a critical period for bone mass accrual, and late puberty in boys is associated with reduced bone mass in adult men. The role of variations in pubertal timing within the normal range for adult fracture risk in men is, however, unknown. We, therefore, assessed the association between age at peak he...

journal_title：PLoS medicine

authors： Vandenput L,Kindblom JM,Bygdell M,Nethander M,Ohlsson C

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Antiretroviral-based interventions for HIV-1 prevention, including antiretroviral therapy (ART) to reduce the infectiousness of HIV-1 infected persons and pre-exposure prophylaxis (PrEP) to reduce the susceptibility of HIV-1 uninfected persons, showed high efficacy for HIV-1 protection in randomized clinical...

journal_title：PLoS medicine

authors： Baeten JM,Heffron R,Kidoguchi L,Mugo NR,Katabira E,Bukusi EA,Asiimwe S,Haberer JE,Morton J,Ngure K,Bulya N,Odoyo J,Tindimwebwa E,Hendrix C,Marzinke MA,Ware NC,Wyatt MA,Morrison S,Haugen H,Mujugira A,Donnell D,Ce

更新日期：2016-08-23 00:00:00

abstract：BACKGROUND:Envenoming resulting from snakebites is an important public health problem in many tropical and subtropical countries. Few attempts have been made to quantify the burden, and recent estimates all suffer from the lack of an objective and reproducible methodology. In an attempt to provide an accurate, up-to-da...

journal_title：PLoS medicine

authors： Kasturiratne A,Wickremasinghe AR,de Silva N,Gunawardena NK,Pathmeswaran A,Premaratna R,Savioli L,Lalloo DG,de Silva HJ

更新日期：2008-11-04 00:00:00