Effective coverage: a metric for monitoring Universal Health Coverage.

abstract：BACKGROUND:Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associ...

journal_title：PLoS medicine

authors： Musso G,Gambino R,Tabibian JH,Ekstedt M,Kechagias S,Hamaguchi M,Hultcrantz R,Hagström H,Yoon SK,Charatcharoenwitthaya P,George J,Barrera F,Hafliðadóttir S,Björnsson ES,Armstrong MJ,Hopkins LJ,Gao X,Francque S,Verrijke

更新日期：2014-07-22 00:00:00

abstract：BACKGROUND:Women with preeclampsia (PEC) and gestational hypertension (GH) exhibit insulin resistance during pregnancy, independent of obesity and glucose intolerance. Our aim was to determine whether women with PEC or GH during pregnancy have an increased risk of developing diabetes after pregnancy, and whether the pr...

journal_title：PLoS medicine

authors： Feig DS,Shah BR,Lipscombe LL,Wu CF,Ray JG,Lowe J,Hwee J,Booth GL

更新日期：2013-01-01 00:00:00

abstract：:In a Policy Forum, Irva Hertz-Picciotto and colleagues review the scientific evidence linking organophosphate pesticides to cognitive, behavioral, and neurological deficits in children and recommend actions to reduce exposures. ...

journal_title：PLoS medicine

authors： Hertz-Picciotto I,Sass JB,Engel S,Bennett DH,Bradman A,Eskenazi B,Lanphear B,Whyatt R

更新日期：2018-10-24 00:00:00

abstract：BACKGROUND:Whole genome sequencing provides better delineation of transmission clusters in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal individual transmission links within clusters is limited. Here, we used a 2-step approach based on Bayesian transmission reconstruction to (1) id...

journal_title：PLoS medicine

authors： Xu Y,Cancino-Muñoz I,Torres-Puente M,Villamayor LM,Borrás R,Borrás-Máñez M,Bosque M,Camarena JJ,Colomer-Roig E,Colomina J,Escribano I,Esparcia-Rodríguez O,Gil-Brusola A,Gimeno C,Gimeno-Gascón A,Gomila-Sard B,González-Gran

更新日期：2019-10-31 00:00:00

abstract：:Andrew Seale and colleagues discuss the development of a global strategy to counter sexually transmitted infections. ...

journal_title：PLoS medicine

authors： Seale A,Broutet N,Narasimhan M

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Postpartum hemorrhage (PPH) is a leading cause of maternal death in sub-Saharan Africa. Although the World Health Organization recommends use of oxytocin for prevention of PPH, misoprostol use is increasingly common owing to advantages in shelf life and potential for sublingual administration. There is a lac...

journal_title：PLoS medicine

authors： Atukunda EC,Siedner MJ,Obua C,Mugyenyi GR,Twagirumukiza M,Agaba AG

更新日期：2014-11-04 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002718.]. ...

journal_title：PLoS medicine

authors： Liu Z,Kuo PL,Horvath S,Crimmins E,Ferrucci L,Levine M

更新日期：2019-02-25 00:00:00

abstract：BACKGROUND:It remains unclear when standard systematic reviews and meta-analyses that rely on published aggregate data (AD) can provide robust clinical conclusions. We aimed to compare the results from a large cohort of systematic reviews and meta-analyses based on individual participant data (IPD) with meta-analyses o...

journal_title：PLoS medicine

authors： Tierney JF,Fisher DJ,Burdett S,Stewart LA,Parmar MKB

更新日期：2020-01-31 00:00:00

abstract：:Kevin Outterson and colleagues outline a model to address access, conservation, and innovation of antibiotics. ...

journal_title：PLoS medicine

authors： Outterson K,Gopinathan U,Clift C,So AD,Morel CM,Røttingen JA

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:Violence against women by intimate partners remains unacceptably common worldwide. The evidence base for the assumed psychological impacts of intimate partner violence (IPV) is derived primarily from studies conducted in high-income countries. A recently published systematic review identified 13 studies link...

journal_title：PLoS medicine

authors： Tsai AC,Tomlinson M,Comulada WS,Rotheram-Borus MJ

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:As the number of HIV-infected women initiating lifelong antiretroviral therapy (ART) during pregnancy increases globally, concerns have emerged regarding low levels of retention in HIV services and suboptimal adherence to ART during the postpartum period. We examined the impact of integrating postpartum ART ...

journal_title：PLoS medicine

authors： Myer L,Phillips TK,Zerbe A,Brittain K,Lesosky M,Hsiao NY,Remien RH,Mellins CA,McIntyre JA,Abrams EJ

更新日期：2018-03-30 00:00:00

abstract：BACKGROUND:In many European countries, medicines promotion is governed by voluntary codes of practice administered by the pharmaceutical industry under its own system of self-regulation. Involvement of industry organizations in policing promotion has been proposed to deter illicit conduct, but few detailed studies on s...

journal_title：PLoS medicine

authors： Zetterqvist AV,Merlo J,Mulinari S

更新日期：2015-02-17 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV)-specific T cell responses are critical for spontaneous resolution of HCV viremia. Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection. METHODS AND FINDINGS:We measured T cell responsiveness...

journal_title：PLoS medicine

authors： Kim AY,Schulze zur Wiesch J,Kuntzen T,Timm J,Kaufmann DE,Duncan JE,Jones AM,Wurcel AG,Davis BT,Gandhi RT,Robbins GK,Allen TM,Chung RT,Lauer GM,Walker BD

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:In Botswana, an estimated 24% of adults ages 15-49 years are infected with HIV. While alcohol use is strongly associated with HIV infection in Africa, few population-based studies have characterized the association of alcohol use with specific high-risk sexual behaviors. METHODS AND FINDINGS:We conducted a ...

journal_title：PLoS medicine

authors： Weiser SD,Leiter K,Heisler M,McFarland W,Percy-de Korte F,DeMonner SM,Tlou S,Phaladze N,Iacopino V,Bangsberg DR

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:There is an urgent need to identify tools able to provide reliable information on the cause of death in low-income regions, since current methods (verbal autopsy, clinical records, and complete autopsies) are either inaccurate, not feasible, or poorly accepted. We aimed to compare the performance of a standa...

journal_title：PLoS medicine

authors： Castillo P,Martínez MJ,Ussene E,Jordao D,Lovane L,Ismail MR,Carrilho C,Lorenzoni C,Fernandes F,Bene R,Palhares A,Ferreira L,Lacerda M,Mandomando I,Vila J,Hurtado JC,Munguambe K,Maixenchs M,Sanz A,Quintó L,Macete E

更新日期：2016-11-22 00:00:00

abstract：BACKGROUND:Average profiles of salivary progesterone in women vary significantly at the inter- and intrapopulation level as a function of age and acute energetic conditions related to energy intake, energy expenditure, or a combination of both. In addition to acute stressors, baseline progesterone levels differ among p...

journal_title：PLoS medicine

authors： Núñez-de la Mora A,Chatterton RT,Choudhury OA,Napolitano DA,Bentley GR

更新日期：2007-05-01 00:00:00

abstract：:Nathan Ford and Gottfried Hirnschall reflect on recent research by Jan Hontelez and colleagues published in this week's PLOS Medicine. The authors argue that the future HIV modeling efforts should focus on helping programs make choices about which interventions need to be prioritized in order to achieve the levels of ...

journal_title：PLoS medicine

authors： Ford N,Hirnschall G

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The "fitness" of an infectious pathogen is defined as the ability of the pathogen to survive, reproduce, be transmitted, and cause disease. The fitness of multidrug-resistant tuberculosis (MDRTB) relative to drug-susceptible tuberculosis is cited as one of the most important determinants of MDRTB spread and ...

journal_title：PLoS medicine

authors： Grandjean L,Gilman RH,Martin L,Soto E,Castro B,Lopez S,Coronel J,Castillo E,Alarcon V,Lopez V,San Miguel A,Quispe N,Asencios L,Dye C,Moore DA

更新日期：2015-06-23 00:00:00

abstract：BACKGROUND:The identification and characterization of tumor suppressor genes has enhanced our understanding of the biology of cancer and enabled the development of new diagnostic and therapeutic modalities. Whereas in past decades, a handful of tumor suppressors have been slowly identified using techniques such as link...

journal_title：PLoS medicine

authors： Chan TA,Glockner S,Yi JM,Chen W,Van Neste L,Cope L,Herman JG,Velculescu V,Schuebel KE,Ahuja N,Baylin SB

更新日期：2008-05-27 00:00:00

abstract：:Alexander Tsai and colleagues highlight the complex relationship between poverty and HIV stigma in sub-Saharan Africa, and discuss possible ways to break the cycle. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Tsai AC,Bangsberg DR,Weiser SD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab improves outcomes in patients with node-positive HER2+ early breast cancer. Given trastuzumab's high cost, we aimed to estimate its cost-effectiveness by heterogeneity in age and estrogen receptor (ER) and progesterone r...

journal_title：PLoS medicine

authors： Leung W,Kvizhinadze G,Nair N,Blakely T

更新日期：2016-08-09 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men with clinically suspected prostate cancer (PCa), but the long acquisition times, high costs, and inter-center/reader variability of routine multiparametric prostate MRI limit its wider adoption. METHODS AND FINDI...

journal_title：PLoS medicine

authors： Jambor I,Verho J,Ettala O,Knaapila J,Taimen P,Syvänen KT,Kiviniemi A,Kähkönen E,Perez IM,Seppänen M,Rannikko A,Oksanen O,Riikonen J,Vimpeli SM,Kauko T,Merisaari H,Kallajoki M,Mirtti T,Lamminen T,Saunavaara J,Arone

更新日期：2019-06-03 00:00:00

abstract：:Financial risk protection is a key component of universal health coverage (UHC), which is defined as access to all needed quality health services without financial hardship. As part of the PLOS Medicine Collection on measurement of UHC, the aim of this paper is to examine and to compare and contrast existing measures ...

journal_title：PLoS medicine

authors： Saksena P,Hsu J,Evans DB

更新日期：2014-09-22 00:00:00

abstract：BACKGROUND:Endometrial cancer is the most common gynecologic malignancy, and its incidence and associated mortality are increasing. Despite the immediate need to detect these cancers at an earlier stage, there is no effective screening methodology or protocol for endometrial cancer. The comprehensive, genomics-based an...

journal_title：PLoS medicine

authors： Nair N,Camacho-Vanegas O,Rykunov D,Dashkoff M,Camacho SC,Schumacher CA,Irish JC,Harkins TT,Freeman E,Garcia I,Pereira E,Kendall S,Belfer R,Kalir T,Sebra R,Reva B,Dottino P,Martignetti JA

更新日期：2016-12-27 00:00:00

abstract：:Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by...

journal_title：PLoS medicine

authors： Rabinovich RN,Drakeley C,Djimde AA,Hall BF,Hay SI,Hemingway J,Kaslow DC,Noor A,Okumu F,Steketee R,Tanner M,Wells TNC,Whittaker MA,Winzeler EA,Wirth DF,Whitfield K,Alonso PL

更新日期：2017-11-30 00:00:00

abstract：BACKGROUND:With cesarean section rates increasing worldwide, clarity regarding negative effects is essential. This study aimed to investigate the rate of subsequent stillbirth, miscarriage, and ectopic pregnancy following primary cesarean section, controlling for confounding by indication. METHODS AND FINDINGS:We perf...

journal_title：PLoS medicine

authors： O'Neill SM,Agerbo E,Kenny LC,Henriksen TB,Kearney PM,Greene RA,Mortensen PB,Khashan AS

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:trans-fatty acids (TFAs) are a well-known risk factor of ischemic heart disease (IHD). In Australia, the highest TFA intake is concentrated to the most socioeconomically disadvantaged groups. Elimination of industrial TFA (iTFA) from the Australian food supply could result in reduced IHD mortality and morbid...

journal_title：PLoS medicine

authors： Marklund M,Zheng M,Veerman JL,Wu JHY

更新日期：2020-11-02 00:00:00

abstract：BACKGROUND:Psoriasis is a common inflammatory skin disease that has been reported to be associated with obesity. We aimed to investigate a possible causal relationship between body mass index (BMI) and psoriasis. METHODS AND FINDINGS:Following a review of published epidemiological evidence of the association between o...

journal_title：PLoS medicine

authors： Budu-Aggrey A,Brumpton B,Tyrrell J,Watkins S,Modalsli EH,Celis-Morales C,Ferguson LD,Vie GÅ,Palmer T,Fritsche LG,Løset M,Nielsen JB,Zhou W,Tsoi LC,Wood AR,Jones SE,Beaumont R,Saunes M,Romundstad PR,Siebert S,McInn

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:Rates of diseases and injuries and the effects of their risk factors can have substantial subnational heterogeneity, especially in middle-income countries like Mexico. Subnational analysis of the burden of diseases, injuries, and risk factors can improve characterization of the epidemiological transition and...

journal_title：PLoS medicine

authors： Stevens G,Dias RH,Thomas KJ,Rivera JA,Carvalho N,Barquera S,Hill K,Ezzati M

更新日期：2008-06-17 00:00:00

abstract：BACKGROUND:Historically, the main focus of studies of childhood mortality has been the infant and under-five mortality rates. Neonatal mortality (deaths <28 days of age) has received limited attention, although such deaths account for about 41% of all child deaths. To better assess progress, we developed annual estimat...

journal_title：PLoS medicine

authors： Oestergaard MZ,Inoue M,Yoshida S,Mahanani WR,Gore FM,Cousens S,Lawn JE,Mathers CD,United Nations Inter-Agency Group for Child Mortality Estimation and the Child Health Epidemiology Reference Group.

更新日期：2011-08-01 00:00:00