Harnessing poverty alleviation to reduce the stigma of HIV in Sub-Saharan Africa.

abstract：:In a Perspective, David Peiris and Dorairaj Prabhakaran discuss implications and challenges of cardiovascular disease risk assessments in the population of India. ...

journal_title：PLoS medicine

authors： Peiris D,Prabhakaran D

更新日期：2018-06-19 00:00:00

abstract：BACKGROUND:Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU]) developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indication that FIAU would b...

journal_title：PLoS medicine

authors： Xu D,Nishimura T,Nishimura S,Zhang H,Zheng M,Guo YY,Masek M,Michie SA,Glenn J,Peltz G

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:To explore the possibility that antibody-mediated complement lysis contributes to viremia control in HIV-1 infection, we measured the activity of patient plasma in mediating complement lysis of autologous primary virus. METHODS AND FINDINGS:Sera from two groups of patients-25 with acute HIV-1 infection and ...

journal_title：PLoS medicine

authors： Huber M,Fischer M,Misselwitz B,Manrique A,Kuster H,Niederöst B,Weber R,von Wyl V,Günthard HF,Trkola A

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Many low- and middle-income countries are not on track to reach the public health targets set out in the Millennium Development Goals (MDGs). We evaluated whether differential progress towards health MDGs was associated with economic development, public health funding (both overall and as percentage of avail...

journal_title：PLoS medicine

authors： Stuckler D,Basu S,McKee M

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:A number of epidemiologic studies have observed an association between secondhand smoke (SHS) exposure and pediatric invasive bacterial disease (IBD) but the evidence has not been systematically reviewed. We carried out a systematic review and meta-analysis of SHS exposure and two outcomes, IBD and pharyngea...

journal_title：PLoS medicine

authors： Lee CC,Middaugh NA,Howie SR,Ezzati M

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:The proteases (secretases) that cleave amyloid-beta (Abeta) peptide from the amyloid precursor protein (APP) have been the focus of considerable investigation in the development of treatments for Alzheimer disease. The prediction has been that reducing Abeta production in the brain, even after the onset of c...

journal_title：PLoS medicine

authors： Jankowsky JL,Slunt HH,Gonzales V,Savonenko AV,Wen JC,Jenkins NA,Copeland NG,Younkin LH,Lester HA,Younkin SG,Borchelt DR

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Resistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is increasing in prevalence in Africa. Combination therapy can both improve treatment and provide important public health benefits if it curbs the spread of parasites harbouring resistance genes. Thus, drug combinations m...

journal_title：PLoS medicine

authors： Sutherland CJ,Ord R,Dunyo S,Jawara M,Drakeley CJ,Alexander N,Coleman R,Pinder M,Walraven G,Targett GA

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large populations treated in routine clinical practice is lacking. The objective of this study was to measure the association...

journal_title：PLoS medicine

authors： Douglas IJ,Bhaskaran K,Batterham RL,Smeeth L

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:At the beginning of June 2020, there were nearly 7 million reported cases of coronavirus disease 2019 (COVID-19) worldwide and over 400,000 deaths in people with COVID-19. The objective of this study was to determine associations between comorbidities listed in the Charlson comorbidity index and mortality am...

journal_title：PLoS medicine

authors： Harrison SL,Fazio-Eynullayeva E,Lane DA,Underhill P,Lip GYH

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:Somalia has been affected by conflict since 1991, with children aged <5 years presenting a high acute malnutrition prevalence. Cash-based interventions (CBIs) have been used in this context since 2011, despite sparse evidence of their nutritional impact. We aimed to understand whether a CBI would reduce acut...

journal_title：PLoS medicine

authors： Grijalva-Eternod CS,Jelle M,Haghparast-Bidgoli H,Colbourn T,Golden K,King S,Cox CL,Morrison J,Skordis-Worrall J,Fottrell E,Seal AJ

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:Although the success of HIV treatment programs depends on retention and viral suppression, routine program monitoring of these outcomes may be incomplete. We used data from the national electronic medical record (EMR) system in Zambia to enumerate a large and regionally representative cohort of patients on t...

journal_title：PLoS medicine

authors： Sikazwe I,Eshun-Wilson I,Sikombe K,Czaicki N,Somwe P,Mody A,Simbeza S,Glidden DV,Chizema E,Mulenga LB,Padian N,Duncombe CJ,Bolton-Moore C,Beres LK,Holmes CB,Geng E

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:The global tuberculosis epidemic results in nearly 2 million deaths and 9 million new cases of the disease a year. The vast majority of tuberculosis patients live in developing countries, where the diagnosis of tuberculosis relies on the identification of acid-fast bacilli on unprocessed sputum smears using ...

journal_title：PLoS medicine

authors： Steingart KR,Henry M,Laal S,Hopewell PC,Ramsay A,Menzies D,Cunningham J,Weldingh K,Pai M

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Although gastric cancer has declined dramatically in the US, the disease remains the second leading cause of cancer mortality worldwide. A better understanding of reasons for the decline can provide important insights into effective preventive strategies. We sought to estimate the contribution of risk factor...

journal_title：PLoS medicine

authors： Yeh JM,Hur C,Schrag D,Kuntz KM,Ezzati M,Stout N,Ward Z,Goldie SJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV)-specific T cell responses are critical for spontaneous resolution of HCV viremia. Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection. METHODS AND FINDINGS:We measured T cell responsiveness...

journal_title：PLoS medicine

authors： Kim AY,Schulze zur Wiesch J,Kuntzen T,Timm J,Kaufmann DE,Duncan JE,Jones AM,Wurcel AG,Davis BT,Gandhi RT,Robbins GK,Allen TM,Chung RT,Lauer GM,Walker BD

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups. ME...

journal_title：PLoS medicine

authors： Lipnicki DM,Makkar SR,Crawford JD,Thalamuthu A,Kochan NA,Lima-Costa MF,Castro-Costa E,Ferri CP,Brayne C,Stephan B,Llibre-Rodriguez JJ,Llibre-Guerra JJ,Valhuerdi-Cepero AJ,Lipton RB,Katz MJ,Derby CA,Ritchie K,Ancelin ML

更新日期：2019-07-23 00:00:00

abstract：:Aaron Kesselheim and colleagues examine orphan-designated drugs approved between 2009 and 2015 in the United States. ...

journal_title：PLoS medicine

authors： Kesselheim AS,Treasure CL,Joffe S

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men with clinically suspected prostate cancer (PCa), but the long acquisition times, high costs, and inter-center/reader variability of routine multiparametric prostate MRI limit its wider adoption. METHODS AND FINDI...

journal_title：PLoS medicine

authors： Jambor I,Verho J,Ettala O,Knaapila J,Taimen P,Syvänen KT,Kiviniemi A,Kähkönen E,Perez IM,Seppänen M,Rannikko A,Oksanen O,Riikonen J,Vimpeli SM,Kauko T,Merisaari H,Kallajoki M,Mirtti T,Lamminen T,Saunavaara J,Arone

更新日期：2019-06-03 00:00:00

abstract：BACKGROUND:Ovarian cancer kills approximately 15,000 women in the United States every year, and more than 140,000 women worldwide. Most deaths from ovarian cancer are caused by tumors of the serous histological type, which are rarely diagnosed before the cancer has spread. Rational design of a potentially life-saving e...

journal_title：PLoS medicine

authors： Brown PO,Palmer C

更新日期：2009-07-01 00:00:00

abstract：:The PLoS Medicine Editors discuss the link between shift work, diet, and type 2 diabetes, and argue that unhealthy eating should be considered a new form of occupational hazard. ...

journal_title：PLoS medicine

authors： PLoS Medicine Editors.

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Some 5%-15% of all women experience postpartum depression (PPD), which for many is their first psychiatric disorder. The purpose of this study was to estimate the incidence of postpartum affective disorder (AD), duration of treatment, and rate of subsequent postpartum AD and other affective episodes in a nat...

journal_title：PLoS medicine

authors： Rasmussen MH,Strøm M,Wohlfahrt J,Videbech P,Melbye M

更新日期：2017-09-26 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1001659.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:There is very limited data on the time trend of diabetes incidence in Asia. Using population-level data, we report the secular trend of the incidence of type 1 and type 2 diabetes in Hong Kong between 2002 and 2015. METHODS AND FINDINGS:The Hong Kong Diabetes Surveillance Database hosts clinical information...

journal_title：PLoS medicine

authors： Luk AOY,Ke C,Lau ESH,Wu H,Goggins W,Ma RCW,Chow E,Kong APS,So WY,Chan JCN

更新日期：2020-02-20 00:00:00

abstract：BACKGROUND:Identifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity. Recently, the intensity and the quality of the host immune response in the tumor microenvironment h...

journal_title：PLoS medicine

authors： Sanz-Pamplona R,Melas M,Maoz A,Schmit SL,Rennert H,Lejbkowicz F,Greenson JK,Sanjuan X,Lopez-Zambrano M,Alonso MH,Qu C,McDonnell KJ,Idos GE,Vignali M,Emerson R,Fields P,Guinó E,Santos C,Salazar R,Robins HS,Rennert

更新日期：2020-09-24 00:00:00

abstract：:Harald Schmidt and Anne Barnhill highlight the need to ensure equity in the proposed Sustainable Development Goals. ...

journal_title：PLoS medicine

authors： Schmidt H,Barnhill A

更新日期：2015-09-08 00:00:00

abstract：BACKGROUND:Rare diseases affect as many as 60 million people in the United States and Europe. However, most rare diseases lack effective therapies and are in critical need of clinical research. Our objective was to determine the frequency of noncompletion and nonpublication of trials studying rare diseases. METHODS AN...

journal_title：PLoS medicine

authors： Rees CA,Pica N,Monuteaux MC,Bourgeois FT

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is estimated to affect 130-180 million people worldwide. Although its origin is unknown, patterns of viral diversity suggest that HCV genotype 1 probably originated from West Africa. Previous attempts to estimate the spatiotemporal parameters of the virus, both globally and regionally...

journal_title：PLoS medicine

authors： Magiorkinis G,Magiorkinis E,Paraskevis D,Ho SY,Shapiro B,Pybus OG,Allain JP,Hatzakis A

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Historically, the main focus of studies of childhood mortality has been the infant and under-five mortality rates. Neonatal mortality (deaths <28 days of age) has received limited attention, although such deaths account for about 41% of all child deaths. To better assess progress, we developed annual estimat...

journal_title：PLoS medicine

authors： Oestergaard MZ,Inoue M,Yoshida S,Mahanani WR,Gore FM,Cousens S,Lawn JE,Mathers CD,United Nations Inter-Agency Group for Child Mortality Estimation and the Child Health Epidemiology Reference Group.

更新日期：2011-08-01 00:00:00

abstract：:Prognostic models are abundant in the medical literature yet their use in practice seems limited. In this article, the third in the PROGRESS series, the authors review how such models are developed and validated, and then address how prognostic models are assessed for their impact on practice and patient outcomes, ill...

journal_title：PLoS medicine

authors： Steyerberg EW,Moons KG,van der Windt DA,Hayden JA,Perel P,Schroter S,Riley RD,Hemingway H,Altman DG,PROGRESS Group.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain. METHODS AND FINDINGS:We report a "nested" case-control comparison within a prospective study in Reykjavik...

journal_title：PLoS medicine

authors： Wheeler JG,Juzwishin KD,Eiriksdottir G,Gudnason V,Danesh J

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Opioid misuse and deaths are increasing in the United States. In 2017, Ohio had the second highest overdose rates in the US, with the city of Cincinnati experiencing a 50% rise in opioid overdoses since 2015. Understanding the temporal and geographic variation in overdose emergencies may help guide public po...

journal_title：PLoS medicine

authors： Li ZR,Xie E,Crawford FW,Warren JL,McConnell K,Copple JT,Johnson T,Gonsalves GS

更新日期：2019-11-12 00:00:00