Prognosis Research Strategy (PROGRESS) 3: prognostic model research.

abstract：BACKGROUND:Puberty is a critical period for bone mass accrual, and late puberty in boys is associated with reduced bone mass in adult men. The role of variations in pubertal timing within the normal range for adult fracture risk in men is, however, unknown. We, therefore, assessed the association between age at peak he...

journal_title：PLoS medicine

authors： Vandenput L,Kindblom JM,Bygdell M,Nethander M,Ohlsson C

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:The global tuberculosis epidemic results in nearly 2 million deaths and 9 million new cases of the disease a year. The vast majority of tuberculosis patients live in developing countries, where the diagnosis of tuberculosis relies on the identification of acid-fast bacilli on unprocessed sputum smears using ...

journal_title：PLoS medicine

authors： Steingart KR,Henry M,Laal S,Hopewell PC,Ramsay A,Menzies D,Cunningham J,Weldingh K,Pai M

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Women with preeclampsia (PEC) and gestational hypertension (GH) exhibit insulin resistance during pregnancy, independent of obesity and glucose intolerance. Our aim was to determine whether women with PEC or GH during pregnancy have an increased risk of developing diabetes after pregnancy, and whether the pr...

journal_title：PLoS medicine

authors： Feig DS,Shah BR,Lipscombe LL,Wu CF,Ray JG,Lowe J,Hwee J,Booth GL

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The US Food and Drug Administration Amendments Act requires results from clinical trials of Food and Drug Administration-approved drugs to be posted at ClinicalTrials.gov within 1 y after trial completion. We compared the timing and completeness of results of drug trials posted at ClinicalTrials.gov and publ...

journal_title：PLoS medicine

authors： Riveros C,Dechartres A,Perrodeau E,Haneef R,Boutron I,Ravaud P

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:While patterns of incidence of clinical influenza have been well described, much uncertainty remains over patterns of incidence of infection. The 2009 pandemic provided both the motivation and opportunity to investigate patterns of mild and asymptomatic infection using serological techniques. However, to dat...

journal_title：PLoS medicine

authors： Riley S,Kwok KO,Wu KM,Ning DY,Cowling BJ,Wu JT,Ho LM,Tsang T,Lo SV,Chu DK,Ma ES,Peiris JS

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:In recent decades, increased attention has been focused on the impact of disabilities and medicinal drug use on road safety. The aim of our study was to investigate the association between prescription medicines and the risk of road traffic crashes, and estimate the attributable fraction. METHODS AND FINDIN...

journal_title：PLoS medicine

authors： Orriols L,Delorme B,Gadegbeku B,Tricotel A,Contrand B,Laumon B,Salmi LR,Lagarde E,CESIR research group.

更新日期：2010-11-16 00:00:00

abstract：BACKGROUND:Average profiles of salivary progesterone in women vary significantly at the inter- and intrapopulation level as a function of age and acute energetic conditions related to energy intake, energy expenditure, or a combination of both. In addition to acute stressors, baseline progesterone levels differ among p...

journal_title：PLoS medicine

authors： Núñez-de la Mora A,Chatterton RT,Choudhury OA,Napolitano DA,Bentley GR

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages. Either drug can induce haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, necessitating screening. The reference diagnostic method for G6PD activ...

journal_title：PLoS medicine

authors： Pfeffer DA,Ley B,Howes RE,Adu P,Alam MS,Bansil P,Boum Y 2nd,Brito M,Charoenkwan P,Clements A,Cui L,Deng Z,Egesie OJ,Espino FE,von Fricken ME,Hamid MMA,He Y,Henriques G,Khan WA,Khim N,Kim S,Lacerda M,Lon C,Me

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:HVTN 100 evaluated the safety and immunogenicity of an HIV subtype C pox-protein vaccine regimen, investigating a 12-month booster to extend vaccine-induced immune responses. METHODS AND FINDINGS:A phase 1-2 randomized double-blind placebo-controlled trial enrolled 252 participants (210 vaccine/42 placebo; ...

journal_title：PLoS medicine

authors： Laher F,Moodie Z,Cohen KW,Grunenberg N,Bekker LG,Allen M,Frahm N,Yates NL,Morris L,Malahleha M,Mngadi K,Daniels B,Innes C,Saunders K,Grant S,Yu C,Gilbert PB,Phogat S,DiazGranados CA,Koutsoukos M,Van Der Meeren O,

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-alpha and ribavirin (PegIFN/R). Viral clearance is achieved in 40%...

journal_title：PLoS medicine

authors： Suppiah V,Gaudieri S,Armstrong NJ,O'Connor KS,Berg T,Weltman M,Abate ML,Spengler U,Bassendine M,Dore GJ,Irving WL,Powell E,Hellard M,Riordan S,Matthews G,Sheridan D,Nattermann J,Smedile A,Müller T,Hammond E,Dunn D

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Tobacco addiction is a complex, multicomponent phenomenon stemming from nicotine's pharmacology and the user's biology, psychology, sociology, and environment. After decades of public denial, the tobacco industry now agrees with public health authorities that nicotine is addictive. In 2000, Philip Morris bec...

journal_title：PLoS medicine

authors： Elias J,Hendlin YH,Ling PM

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Evidence suggests that variations in fasting glucose and insulin amongst those without frank type 2 diabetes mellitus are important determinants of cardiovascular disease. However, the relative importance of variations in fasting insulin, glucose, and glycated haemoglobin as risk factors for cardiovascular d...

journal_title：PLoS medicine

authors： Lawlor DA,Fraser A,Ebrahim S,Smith GD

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes (T2D) is a progressive disease whereby there is often deterioration in glucose control despite escalation in treatment. There is significant heterogeneity to this progression of glycemia after onset of diabetes, yet the factors that influence glycemic progression are not well understood. Give...

journal_title：PLoS medicine

authors： Jiang G,Luk AO,Tam CHT,Lau ES,Ozaki R,Chow EYK,Kong APS,Lim CKP,Lee KF,Siu SC,Hui G,Tsang CC,Lau KP,Leung JYY,Tsang MW,Kam G,Lau IT,Li JK,Yeung VT,Lau E,Lo S,Fung SKS,Cheng YL,Chow CC,Pearson ER,So WY,

更新日期：2020-07-28 00:00:00

abstract：BACKGROUND:Development of noninvasive molecular assays to improve disease diagnosis and patient monitoring is a critical need. In renal transplantation, acute rejection (AR) increases the risk for chronic graft injury and failure. Noninvasive diagnostic assays to improve current late and nonspecific diagnosis of reject...

journal_title：PLoS medicine

authors： Roedder S,Sigdel T,Salomonis N,Hsieh S,Dai H,Bestard O,Metes D,Zeevi A,Gritsch A,Cheeseman J,Macedo C,Peddy R,Medeiros M,Vincenti F,Asher N,Salvatierra O,Shapiro R,Kirk A,Reed EF,Sarwal MM

更新日期：2014-11-11 00:00:00

abstract：BACKGROUND:Postpartum hemorrhage (PPH) is a leading cause of maternal death in sub-Saharan Africa. Although the World Health Organization recommends use of oxytocin for prevention of PPH, misoprostol use is increasingly common owing to advantages in shelf life and potential for sublingual administration. There is a lac...

journal_title：PLoS medicine

authors： Atukunda EC,Siedner MJ,Obua C,Mugyenyi GR,Twagirumukiza M,Agaba AG

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) are essential in host defense against pathogens by virtue of their capacity to detect microbes and initiate the immune response. TLR2 is seen as the most important receptor for gram-positive bacteria, while TLR4 is regarded as the gram-negative TLR. Melioidosis is a severe infectio...

journal_title：PLoS medicine

authors： Wiersinga WJ,Wieland CW,Dessing MC,Chantratita N,Cheng AC,Limmathurotsakul D,Chierakul W,Leendertse M,Florquin S,de Vos AF,White N,Dondorp AM,Day NP,Peacock SJ,van der Poll T

更新日期：2007-07-31 00:00:00

abstract：BACKGROUND:The risk of perinatal death and severe neonatal morbidity increases gradually after 41 weeks of pregnancy. Several randomised controlled trials (RCTs) have assessed if induction of labour (IOL) in uncomplicated pregnancies at 41 weeks will improve perinatal outcomes. We performed an individual participant da...

journal_title：PLoS medicine

authors： Alkmark M,Keulen JKJ,Kortekaas JC,Bergh C,van Dillen J,Duijnhoven RG,Hagberg H,Mol BW,Molin M,van der Post JAM,Saltvedt S,Wikström AK,Wennerholm UB,de Miranda E

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:Cohort studies are recommended for understanding ethnic disparities in cardiovascular disease. Our objective was to review the process for identifying, including, and excluding ethnic minority populations in published cardiovascular cohort studies in Europe and North America. METHODS AND FINDINGS:We found t...

journal_title：PLoS medicine

authors： Ranganathan M,Bhopal R

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Midwifery continuity of care is the only health system intervention shown to reduce preterm birth (PTB) and improve perinatal survival, but no trial evidence exists for women with identified risk factors for PTB. We aimed to assess feasibility, fidelity, and clinical outcomes of a model of midwifery continui...

journal_title：PLoS medicine

authors： Fernandez Turienzo C,Bick D,Briley AL,Bollard M,Coxon K,Cross P,Silverio SA,Singh C,Seed PT,Tribe RM,Shennan AH,Sandall J,POPPIE Pilot Collaborative Group.

更新日期：2020-10-06 00:00:00

abstract：:Voluntary medical male circumcision (VMMC) is capable of reducing the risk of sexual transmission of HIV from females to males by approximately 60%. In 2007, the WHO and the Joint United Nations Programme on HIV/AIDS (UNAIDS) recommended making VMMC part of a comprehensive HIV prevention package in countries with a ge...

journal_title：PLoS medicine

authors： Sgaier SK,Reed JB,Thomas A,Njeuhmeli E

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Annual influenza vaccination of institutional health care workers (HCWs) is advised in most Western countries, but adherence to this recommendation is generally low. Although protective effects of this intervention for nursing home patients have been demonstrated in some clinical trials, the exact relationsh...

journal_title：PLoS medicine

authors： van den Dool C,Bonten MJ,Hak E,Heijne JC,Wallinga J

更新日期：2008-10-28 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002718.]. ...

journal_title：PLoS medicine

authors： Liu Z,Kuo PL,Horvath S,Crimmins E,Ferrucci L,Levine M

更新日期：2019-02-25 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1001895.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Exposure to a nutritionally deficient environment during fetal life and early infancy may adversely alter the ontogeny of the immune system and affect an infant's ability to mount an optimal immune response to vaccination. We examined the effects of maternal nutritional supplementation during pregnancy on in...

journal_title：PLoS medicine

authors： Okala SG,Darboe MK,Sosseh F,Sonko B,Faye-Joof T,Prentice AM,Moore SE

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis. METHODS AND FINDINGS:A total of 3,274 uncircumcised men, aged 18-24 y, were randomiz...

journal_title：PLoS medicine

authors： Auvert B,Taljaard D,Lagarde E,Sobngwi-Tambekou J,Sitta R,Puren A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:The vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of preclinical research guidelines and organized recommendations according to the...

journal_title：PLoS medicine

authors： Henderson VC,Kimmelman J,Fergusson D,Grimshaw JM,Hackam DG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The relationship between population trends in delaying childbirth and rising rates of primary cesarean delivery is unclear. The aims of the present study were (1) to characterize the association between maternal age and the outcome of labor, (2) to determine the proportion of the increase in primary cesarean...

journal_title：PLoS medicine

authors： Smith GC,Cordeaux Y,White IR,Pasupathy D,Missfelder-Lobos H,Pell JP,Charnock-Jones DS,Fleming M

更新日期：2008-07-01 00:00:00

abstract：:In this month's editorial, PLOS Medicine Editorial Board member Rachel Jewkes identifies challenges that the violence prevention research community faces in substantially reducing violence against women and girls over the next 30 years. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Jewkes R

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated. METHODS AND FINDINGS:In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of T...

journal_title：PLoS medicine

authors： Dunning J,Sahr F,Rojek A,Gannon F,Carson G,Idriss B,Massaquoi T,Gandi R,Joseph S,Osman HK,Brooks TJ,Simpson AJ,Goodfellow I,Thorne L,Arias A,Merson L,Castle L,Howell-Jones R,Pardinaz-Solis R,Hope-Gill B,Ferri M,

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emerging chloroquine resistance. We undertook a systematic review and individual patient data meta-analysis to compare the efficacies of dihydroartemisinin-piperaquine (DP) and artemether-lumefan...

journal_title：PLoS medicine

authors： Commons RJ,Simpson JA,Thriemer K,Abreha T,Adam I,Anstey NM,Assefa A,Awab GR,Baird JK,Barber BE,Chu CS,Dahal P,Daher A,Davis TME,Dondorp AM,Grigg MJ,Humphreys GS,Hwang J,Karunajeewa H,Laman M,Lidia K,Moore BR,M

更新日期：2019-10-04 00:00:00