Prescription medicines and the risk of road traffic crashes: a French registry-based study.

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1001659.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2015-03-03 00:00:00

abstract：:Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due to advancements in both prevention and treatment of HIV. However, major challenges still remain. We describe basic principles of epidemic control in the context of HIV and identify a number of attainable goals in terms of control a...

journal_title：PLoS medicine

authors： Jones J,Sullivan PS,Curran JW

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:We simulated tobacco control and pharmacological strategies for preventing cardiovascular deaths in India, the country that is expected to experience more cardiovascular deaths than any other over the next decade. METHODS AND FINDINGS:A microsimulation model was developed to quantify the differential effect...

journal_title：PLoS medicine

authors： Basu S,Glantz S,Bitton A,Millett C

更新日期：2013-01-01 00:00:00

abstract：:This month in PLOS Medicine we launched a Special Issue on New Tools and Strategies for Tuberculosis Diagnosis, Care, and Elimination. In this issue's Editorial, the Guest Editors Claudia Denkinger, Richard Chaisson, and Mark Hatherill highlight some of the research that will publish and how these studies focusing on ...

journal_title：PLoS medicine

authors： Hatherill M,Chaisson RE,Denkinger CM

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate mortality for patients with the major subtypes of breast cancer as classified using five immunohistochemical markers, to investigate ...

journal_title：PLoS medicine

authors： Blows FM,Driver KE,Schmidt MK,Broeks A,van Leeuwen FE,Wesseling J,Cheang MC,Gelmon K,Nielsen TO,Blomqvist C,Heikkilä P,Heikkinen T,Nevanlinna H,Akslen LA,Bégin LR,Foulkes WD,Couch FJ,Wang X,Cafourek V,Olson JE,Bag

更新日期：2010-05-25 00:00:00

abstract：BACKGROUND:Various risk factors have been associated with epithelial ovarian cancer risk in observational epidemiological studies. However, the causal nature of the risk factors reported, and thus their suitability as effective intervention targets, is unclear given the susceptibility of conventional observational desi...

journal_title：PLoS medicine

authors： Yarmolinsky J,Relton CL,Lophatananon A,Muir K,Menon U,Gentry-Maharaj A,Walther A,Zheng J,Fasching P,Zheng W,Yin Ling W,Park SK,Kim BG,Choi JY,Park B,Davey Smith G,Martin RM,Lewis SJ

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ultimate translation into a point-of-care ...

journal_title：PLoS medicine

authors： Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Standardised packaging (SP) of tobacco products is an innovative tobacco control measure opposed by transnational tobacco companies (TTCs) whose responses to the UK government's public consultation on SP argued that evidence was inadequate to support implementing the measure. The government's initial decisio...

journal_title：PLoS medicine

authors： Ulucanlar S,Fooks GJ,Hatchard JL,Gilmore AB

更新日期：2014-03-25 00:00:00

abstract：BACKGROUND:The risk of perinatal death and severe neonatal morbidity increases gradually after 41 weeks of pregnancy. Several randomised controlled trials (RCTs) have assessed if induction of labour (IOL) in uncomplicated pregnancies at 41 weeks will improve perinatal outcomes. We performed an individual participant da...

journal_title：PLoS medicine

authors： Alkmark M,Keulen JKJ,Kortekaas JC,Bergh C,van Dillen J,Duijnhoven RG,Hagberg H,Mol BW,Molin M,van der Post JAM,Saltvedt S,Wikström AK,Wennerholm UB,de Miranda E

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:The US Food and Drug Administration Amendments Act requires results from clinical trials of Food and Drug Administration-approved drugs to be posted at ClinicalTrials.gov within 1 y after trial completion. We compared the timing and completeness of results of drug trials posted at ClinicalTrials.gov and publ...

journal_title：PLoS medicine

authors： Riveros C,Dechartres A,Perrodeau E,Haneef R,Boutron I,Ravaud P

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Care advances in the United States (US) have led to improved survival of children with neurological impairment (NI). Children with NI may account for an increasing proportion of hospital resources. However, this assumption has not been tested at a national level. METHODS AND FINDINGS:We conducted a study of...

journal_title：PLoS medicine

authors： Berry JG,Poduri A,Bonkowsky JL,Zhou J,Graham DA,Welch C,Putney H,Srivastava R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs. There are numerous psychiatric conditions that present with psychotic symptoms, most importantly schizophrenia, bipolar affective disorder, an...

journal_title：PLoS medicine

authors： Huang JT,Leweke FM,Oxley D,Wang L,Harris N,Koethe D,Gerth CW,Nolden BM,Gross S,Schreiber D,Reed B,Bahn S

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of preclinical research guidelines and organized recommendations according to the...

journal_title：PLoS medicine

authors： Henderson VC,Kimmelman J,Fergusson D,Grimshaw JM,Hackam DG

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002511.]. ...

journal_title：PLoS medicine

authors： Torrone EA,Morrison CS,Chen PL,Kwok C,Francis SC,Hayes RJ,Looker KJ,McCormack S,McGrath N,van de Wijgert JHHM,Watson-Jones D,Low N,Gottlieb SL,STIMA Working Group.

更新日期：2018-06-26 00:00:00

abstract：BACKGROUND:Perinatal mortality and morbidity continue to be major global health challenges strongly associated with prematurity and reduced fetal growth, an issue of further interest given the mounting evidence that fetal growth in general is linked to degrees of risk of common noncommunicable diseases in adulthood. Ag...

journal_title：PLoS medicine

authors： Kiserud T,Piaggio G,Carroli G,Widmer M,Carvalho J,Neerup Jensen L,Giordano D,Cecatti JG,Abdel Aleem H,Talegawkar SA,Benachi A,Diemert A,Tshefu Kitoto A,Thinkhamrop J,Lumbiganon P,Tabor A,Kriplani A,Gonzalez Perez R,He

更新日期：2017-01-24 00:00:00

abstract：BACKGROUND:CD4 cell count is a strong predictor of the subsequent risk of AIDS or death in HIV-infected patients initiating combination antiretroviral therapy (cART). It is not known whether the rate of CD4 cell decline prior to therapy is related to prognosis and should, therefore, influence the decision on when to in...

journal_title：PLoS medicine

authors： Wolbers M,Babiker A,Sabin C,Young J,Dorrucci M,Chêne G,Mussini C,Porter K,Bucher HC,CASCADE Collaboration Members.

更新日期：2010-02-23 00:00:00

abstract：:In this month's editorial, PLOS Medicine's Chief Editor Larry Peiperl discusses the relevance of patient care to a journal editor's work. ...

journal_title：PLoS medicine

authors： Peiperl L,PLOS Medicine Editors.

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate. Novel antimalarial drug targets are urgently needed to reduce global morbidity and mortality. Our prior results suggested that inhibiting erythrocyte Gs signaling blocked invas...

journal_title：PLoS medicine

authors： Murphy SC,Harrison T,Hamm HE,Lomasney JW,Mohandas N,Haldar K

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Intravenous morphine (IVM) is the most common strong analgesic used in trauma, but is associated with a clear time limitation related to the need to obtain an access route. The intranasal (IN) route provides easy administration with a fast peak action time due to high vascularization and the absence of first...

journal_title：PLoS medicine

authors： Blancher M,Maignan M,Clapé C,Quesada JL,Collomb-Muret R,Albasini F,Ageron FX,Fey S,Wuyts A,Banihachemi JJ,Bertrand B,Lehmann A,Bollart C,Debaty G,Briot R,Viglino D

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:In patients treated with cardiotoxic chemotherapies, the presence of cardiovascular risk factors and previous cardiac disease have been strongly correlated to the onset of cardiotoxicity. The influence of overweight and obesity as risk factors in the development of treatment-related cardiotoxicity in breast ...

journal_title：PLoS medicine

authors： Kaboré EG,Guenancia C,Vaz-Luis I,Di Meglio A,Pistilli B,Coutant C,Cottu P,Lesur A,Petit T,Dalenc F,Rouanet P,Arnaud A,Arsene O,Ibrahim M,Wassermann J,Boileau-Jolimoy G,Martin AL,Lemonnier J,André F,Arveux P

更新日期：2019-12-23 00:00:00

abstract：BACKGROUND:To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-alpha and ribavirin (PegIFN/R). Viral clearance is achieved in 40%...

journal_title：PLoS medicine

authors： Suppiah V,Gaudieri S,Armstrong NJ,O'Connor KS,Berg T,Weltman M,Abate ML,Spengler U,Bassendine M,Dore GJ,Irving WL,Powell E,Hellard M,Riordan S,Matthews G,Sheridan D,Nattermann J,Smedile A,Müller T,Hammond E,Dunn D

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by serotypes of the Enterovirus A species in the genus Enterovirus of the Picornaviridae family. The disease has had a substantial burden throughout East and Southeast Asia over the past 15 y. China reported 9 million cases of HFMD bet...

journal_title：PLoS medicine

authors： Takahashi S,Liao Q,Van Boeckel TP,Xing W,Sun J,Hsiao VY,Metcalf CJ,Chang Z,Liu F,Zhang J,Wu JT,Cowling BJ,Leung GM,Farrar JJ,van Doorn HR,Grenfell BT,Yu H

更新日期：2016-02-16 00:00:00

abstract：BACKGROUND:Patients with multimorbidities have the greatest healthcare needs and generate the highest expenditure in the health system. There is an increasing focus on identifying specific disease combinations for addressing poor outcomes. Existing research has identified a small number of prevalent "clusters" in the g...

journal_title：PLoS medicine

authors： Stokes J,Guthrie B,Mercer SW,Rice N,Sutton M

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:Global warming is predicted to indirectly result in more undernutrition by threatening crop production. Whether temperature rise could affect undernutrition directly is unknown. We aim to quantify the relationship between short-term heat exposure and risk of hospitalization due to undernutrition in Brazil. ...

journal_title：PLoS medicine

authors： Xu R,Zhao Q,Coelho MSZS,Saldiva PHN,Abramson MJ,Li S,Guo Y

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:Research needs to be reported transparently so readers can critically assess the strengths and weaknesses of the design, conduct, and analysis of studies. Reporting guidelines have been developed to inform reporting for a variety of study designs. The objective of this study was to identify whether there is ...

journal_title：PLoS medicine

authors： Bennett C,Khangura S,Brehaut JC,Graham ID,Moher D,Potter BK,Grimshaw JM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Antiretroviral-based interventions for HIV-1 prevention, including antiretroviral therapy (ART) to reduce the infectiousness of HIV-1 infected persons and pre-exposure prophylaxis (PrEP) to reduce the susceptibility of HIV-1 uninfected persons, showed high efficacy for HIV-1 protection in randomized clinical...

journal_title：PLoS medicine

authors： Baeten JM,Heffron R,Kidoguchi L,Mugo NR,Katabira E,Bukusi EA,Asiimwe S,Haberer JE,Morton J,Ngure K,Bulya N,Odoyo J,Tindimwebwa E,Hendrix C,Marzinke MA,Ware NC,Wyatt MA,Morrison S,Haugen H,Mujugira A,Donnell D,Ce

更新日期：2016-08-23 00:00:00

abstract：BACKGROUND:Increased adiposity is linked with higher risk for cardiometabolic diseases. We aimed to determine to what extent elevated body mass index (BMI) within the normal weight range has causal effects on the detailed systemic metabolite profile in early adulthood. METHODS AND FINDINGS:We used Mendelian randomizat...

journal_title：PLoS medicine

authors： Würtz P,Wang Q,Kangas AJ,Richmond RC,Skarp J,Tiainen M,Tynkkynen T,Soininen P,Havulinna AS,Kaakinen M,Viikari JS,Savolainen MJ,Kähönen M,Lehtimäki T,Männistö S,Blankenberg S,Zeller T,Laitinen J,Pouta A,Mäntyselkä P

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:The disease burden attributable to mental health problems and to excess or harmful alcohol use is considerable. Despite a strong relationship between these 2 important factors in population health, there are few studies quantifying the mortality risk associated with their co-occurrence in the general populat...

journal_title：PLoS medicine

authors： Degerud E,Høiseth G,Mørland J,Ariansen I,Graff-Iversen S,Ystrom E,Zuccolo L,Næss Ø

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Observational epidemiological studies indicate that maternal height is associated with gestational age at birth and fetal growth measures (i.e., shorter mothers deliver infants at earlier gestational ages with lower birth weight and birth length). Different mechanisms have been postulated to explain these as...

journal_title：PLoS medicine

authors： Zhang G,Bacelis J,Lengyel C,Teramo K,Hallman M,Helgeland Ø,Johansson S,Myhre R,Sengpiel V,Njølstad PR,Jacobsson B,Muglia L

更新日期：2015-08-18 00:00:00

abstract：BACKGROUND:Epidemiological studies have provided compelling evidence of associations between ambient temperature and cardiovascular disease. However, evidence of effects of daily temperature variability on cardiovascular disease is scarce and mixed. We aimed to examine short-term associations between temperature variab...

journal_title：PLoS medicine

authors： Tian Y,Liu H,Si Y,Cao Y,Song J,Li M,Wu Y,Wang X,Xiang X,Juan J,Chen L,Wei C,Gao P,Hu Y

更新日期：2019-01-28 00:00:00