The effects of influenza vaccination of health care workers in nursing homes: insights from a mathematical model.

abstract：BACKGROUND:Antenatal corticosteroid therapy (ACT) is used clinically to prepare the fetal lung for impending preterm birth, but animal and human studies link corticosteroids to smaller birth size. Whether ACT is associated with birth size is debated; therefore, we assessed differences in birth size in treated versus un...

journal_title：PLoS medicine

authors： Rodriguez A,Wang Y,Ali Khan A,Cartwright R,Gissler M,Järvelin MR

更新日期：2019-02-26 00:00:00

abstract：:In an Editorial, Ligia Kiss and Cathy Zimmerman discuss the need for research on the prevention of human trafficking and mitigation of its effects. ...

journal_title：PLoS medicine

authors： Kiss L,Zimmerman C

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Evidence suggests that variations in fasting glucose and insulin amongst those without frank type 2 diabetes mellitus are important determinants of cardiovascular disease. However, the relative importance of variations in fasting insulin, glucose, and glycated haemoglobin as risk factors for cardiovascular d...

journal_title：PLoS medicine

authors： Lawlor DA,Fraser A,Ebrahim S,Smith GD

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:As the number of HIV-infected women initiating lifelong antiretroviral therapy (ART) during pregnancy increases globally, concerns have emerged regarding low levels of retention in HIV services and suboptimal adherence to ART during the postpartum period. We examined the impact of integrating postpartum ART ...

journal_title：PLoS medicine

authors： Myer L,Phillips TK,Zerbe A,Brittain K,Lesosky M,Hsiao NY,Remien RH,Mellins CA,McIntyre JA,Abrams EJ

更新日期：2018-03-30 00:00:00

abstract：BACKGROUND:To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-alpha and ribavirin (PegIFN/R). Viral clearance is achieved in 40%...

journal_title：PLoS medicine

authors： Suppiah V,Gaudieri S,Armstrong NJ,O'Connor KS,Berg T,Weltman M,Abate ML,Spengler U,Bassendine M,Dore GJ,Irving WL,Powell E,Hellard M,Riordan S,Matthews G,Sheridan D,Nattermann J,Smedile A,Müller T,Hammond E,Dunn D

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Helminth and protozoan infections affect more than 1 billion children globally. Improving water quality, sanitation, handwashing, and nutrition could be more sustainable control strategies for parasite infections than mass drug administration, while providing other quality of life benefits. METHODS AND FIND...

journal_title：PLoS medicine

authors： Pickering AJ,Njenga SM,Steinbaum L,Swarthout J,Lin A,Arnold BF,Stewart CP,Dentz HN,Mureithi M,Chieng B,Wolfe M,Mahoney R,Kihara J,Byrd K,Rao G,Meerkerk T,Cheruiyot P,Papaiakovou M,Pilotte N,Williams SA,Colford JM

更新日期：2019-06-26 00:00:00

abstract：BACKGROUND:This paper examines the efforts of consultants affiliated with Philip Morris (PM), the world's leading transnational tobacco corporation, to influence scientific research and training in Thailand via the Chulabhorn Research Institute (CRI). A leading Southeast Asian institute for environmental health science...

journal_title：PLoS medicine

authors： Mackenzie R,Collin J

更新日期：2008-12-23 00:00:00

abstract：:Is it ethical for scientists to conduct or to benefit from research in another country if that research would be unlawful, or not generally accepted, in their own country? ...

journal_title：PLoS medicine

authors： Skene L

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Attrition during the period from HIV testing to antiretroviral therapy (ART) initiation is high worldwide. We assessed whether same-day HIV testing and ART initiation improves retention and virologic suppression. METHODS AND FINDINGS:We conducted an unblinded, randomized trial of standard ART initiation ver...

journal_title：PLoS medicine

authors： Koenig SP,Dorvil N,Dévieux JG,Hedt-Gauthier BL,Riviere C,Faustin M,Lavoile K,Perodin C,Apollon A,Duverger L,McNairy ML,Hennessey KA,Souroutzidis A,Cremieux PY,Severe P,Pape JW

更新日期：2017-07-25 00:00:00

abstract：:Alexander Tsai and colleagues highlight the complex relationship between poverty and HIV stigma in sub-Saharan Africa, and discuss possible ways to break the cycle. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Tsai AC,Bangsberg DR,Weiser SD

更新日期：2013-11-01 00:00:00

abstract：:Martin Gerdin and colleagues argue that disaster health interventions and decision-making can benefit from an evidence-based approach Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Gerdin M,Clarke M,Allen C,Kayabu B,Summerskill W,Devane D,MacLachlan M,Spiegel P,Ghosh A,Zachariah R,Gupta S,Barbour V,Murray V,von Schreeb J

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Temporary labor migration is an increasingly important mode of migration that generates substantial remittance flows, but raises important concerns for migrant well-being. The migration and health literature has seen a growing call for longitudinal, binational surveys that compare migrants to relevant non-mi...

journal_title：PLoS medicine

authors： Kuhn R,Barham T,Razzaque A,Turner P

更新日期：2020-03-31 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men with clinically suspected prostate cancer (PCa), but the long acquisition times, high costs, and inter-center/reader variability of routine multiparametric prostate MRI limit its wider adoption. METHODS AND FINDI...

journal_title：PLoS medicine

authors： Jambor I,Verho J,Ettala O,Knaapila J,Taimen P,Syvänen KT,Kiviniemi A,Kähkönen E,Perez IM,Seppänen M,Rannikko A,Oksanen O,Riikonen J,Vimpeli SM,Kauko T,Merisaari H,Kallajoki M,Mirtti T,Lamminen T,Saunavaara J,Arone

更新日期：2019-06-03 00:00:00

abstract：BACKGROUND:With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups. ME...

journal_title：PLoS medicine

authors： Lipnicki DM,Makkar SR,Crawford JD,Thalamuthu A,Kochan NA,Lima-Costa MF,Castro-Costa E,Ferri CP,Brayne C,Stephan B,Llibre-Rodriguez JJ,Llibre-Guerra JJ,Valhuerdi-Cepero AJ,Lipton RB,Katz MJ,Derby CA,Ritchie K,Ancelin ML

更新日期：2019-07-23 00:00:00

abstract：BACKGROUND:Vital registration and cause of death reporting is incomplete in the countries in which the HIV epidemic is most severe. A reliable tool that is independent of HIV status is needed for measuring the frequency of AIDS deaths and ultimately the impact of antiretroviral therapy on mortality. METHODS AND FINDIN...

journal_title：PLoS medicine

authors： Lopman BA,Barnabas RV,Boerma JT,Chawira G,Gaitskell K,Harrop T,Mason P,Donnelly CA,Garnett GP,Nyamukapa C,Gregson S

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Counties are the smallest unit for which mortality data are routinely available, allowing consistent and comparable long-term analysis of trends in health disparities. Average life expectancy has steadily increased in the United States but there is limited information on long-term mortality trends in the US ...

journal_title：PLoS medicine

authors： Ezzati M,Friedman AB,Kulkarni SC,Murray CJ

更新日期：2008-04-22 00:00:00

abstract：BACKGROUND:It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain. METHODS AND FINDINGS:We report a "nested" case-control comparison within a prospective study in Reykjavik...

journal_title：PLoS medicine

authors： Wheeler JG,Juzwishin KD,Eiriksdottir G,Gudnason V,Danesh J

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:With cesarean section rates increasing worldwide, clarity regarding negative effects is essential. This study aimed to investigate the rate of subsequent stillbirth, miscarriage, and ectopic pregnancy following primary cesarean section, controlling for confounding by indication. METHODS AND FINDINGS:We perf...

journal_title：PLoS medicine

authors： O'Neill SM,Agerbo E,Kenny LC,Henriksen TB,Kearney PM,Greene RA,Mortensen PB,Khashan AS

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) of houses provide effective malaria transmission control. There is conflicting evidence about whether it is more beneficial to provide both interventions in combination. A cluster randomised controlled trial was conducted to investigate wheth...

journal_title：PLoS medicine

authors： West PA,Protopopoff N,Wright A,Kivaju Z,Tigererwa R,Mosha FW,Kisinza W,Rowland M,Kleinschmidt I

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:Some 5%-15% of all women experience postpartum depression (PPD), which for many is their first psychiatric disorder. The purpose of this study was to estimate the incidence of postpartum affective disorder (AD), duration of treatment, and rate of subsequent postpartum AD and other affective episodes in a nat...

journal_title：PLoS medicine

authors： Rasmussen MH,Strøm M,Wohlfahrt J,Videbech P,Melbye M

更新日期：2017-09-26 00:00:00

abstract：:Sanjay Basu and Kristine Madsen discuss the effects of taxes on sugar-sweetened beverages in both Australia and Berkeley, USA. ...

journal_title：PLoS medicine

authors： Basu S,Madsen K

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Assessing the mortality impact of the 2009 influenza A H1N1 virus (H1N1pdm09) is essential for optimizing public health responses to future pandemics. The World Health Organization reported 18,631 laboratory-confirmed pandemic deaths, but the total pandemic mortality burden was substantially higher. We estim...

journal_title：PLoS medicine

authors： Simonsen L,Spreeuwenberg P,Lustig R,Taylor RJ,Fleming DM,Kroneman M,Van Kerkhove MD,Mounts AW,Paget WJ,GLaMOR Collaborating Teams.

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The alpha-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, the epidemiological description of the relationships between alpha-thalassaemia, malaria, and othe...

journal_title：PLoS medicine

authors： Wambua S,Mwangi TW,Kortok M,Uyoga SM,Macharia AW,Mwacharo JK,Weatherall DJ,Snow RW,Marsh K,Williams TN

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance. Yet, the efficacy of the antidepressants may also depend on the severity of initial depress...

journal_title：PLoS medicine

authors： Kirsch I,Deacon BJ,Huedo-Medina TB,Scoboria A,Moore TJ,Johnson BT

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:In patients treated with cardiotoxic chemotherapies, the presence of cardiovascular risk factors and previous cardiac disease have been strongly correlated to the onset of cardiotoxicity. The influence of overweight and obesity as risk factors in the development of treatment-related cardiotoxicity in breast ...

journal_title：PLoS medicine

authors： Kaboré EG,Guenancia C,Vaz-Luis I,Di Meglio A,Pistilli B,Coutant C,Cottu P,Lesur A,Petit T,Dalenc F,Rouanet P,Arnaud A,Arsene O,Ibrahim M,Wassermann J,Boileau-Jolimoy G,Martin AL,Lemonnier J,André F,Arveux P

更新日期：2019-12-23 00:00:00

abstract：BACKGROUND:National responses will need to be markedly accelerated to achieve the ambitious target of the Joint United Nations Programme on HIV/AIDS (UNAIDS). This target aims for 90% of HIV-positive individuals to be aware of their status, for 90% of those aware to receive antiretroviral therapy (ART), and for 90% of ...

journal_title：PLoS medicine

authors： Maheu-Giroux M,Vesga JF,Diabaté S,Alary M,Baral S,Diouf D,Abo K,Boily MC

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:CD4 cell count is a strong predictor of the subsequent risk of AIDS or death in HIV-infected patients initiating combination antiretroviral therapy (cART). It is not known whether the rate of CD4 cell decline prior to therapy is related to prognosis and should, therefore, influence the decision on when to in...

journal_title：PLoS medicine

authors： Wolbers M,Babiker A,Sabin C,Young J,Dorrucci M,Chêne G,Mussini C,Porter K,Bucher HC,CASCADE Collaboration Members.

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Whole genome sequencing provides better delineation of transmission clusters in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal individual transmission links within clusters is limited. Here, we used a 2-step approach based on Bayesian transmission reconstruction to (1) id...

journal_title：PLoS medicine

authors： Xu Y,Cancino-Muñoz I,Torres-Puente M,Villamayor LM,Borrás R,Borrás-Máñez M,Bosque M,Camarena JJ,Colomer-Roig E,Colomina J,Escribano I,Esparcia-Rodríguez O,Gil-Brusola A,Gimeno C,Gimeno-Gascón A,Gomila-Sard B,González-Gran

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:Tobacco addiction is a complex, multicomponent phenomenon stemming from nicotine's pharmacology and the user's biology, psychology, sociology, and environment. After decades of public denial, the tobacco industry now agrees with public health authorities that nicotine is addictive. In 2000, Philip Morris bec...

journal_title：PLoS medicine

authors： Elias J,Hendlin YH,Ling PM

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder characterized by fibroproliferation and excessive accumulation of extracellular matrix in the lung. METHODS AND FINDINGS:Using oligonucleotide arrays, we identified osteopontin as one of the genes that significantly distinguishes IPF f...

journal_title：PLoS medicine

authors： Pardo A,Gibson K,Cisneros J,Richards TJ,Yang Y,Becerril C,Yousem S,Herrera I,Ruiz V,Selman M,Kaminski N

更新日期：2005-09-01 00:00:00