Optimal evidence in difficult settings: improving health interventions and decision making in disasters.

abstract：BACKGROUND:Type 2 diabetes (T2D) is a progressive disease whereby there is often deterioration in glucose control despite escalation in treatment. There is significant heterogeneity to this progression of glycemia after onset of diabetes, yet the factors that influence glycemic progression are not well understood. Give...

journal_title：PLoS medicine

authors： Jiang G,Luk AO,Tam CHT,Lau ES,Ozaki R,Chow EYK,Kong APS,Lim CKP,Lee KF,Siu SC,Hui G,Tsang CC,Lau KP,Leung JYY,Tsang MW,Kam G,Lau IT,Li JK,Yeung VT,Lau E,Lo S,Fung SKS,Cheng YL,Chow CC,Pearson ER,So WY,

更新日期：2020-07-28 00:00:00

abstract：BACKGROUND:Pancreatic cancer has an extremely poor prognosis and prolonged survival is achieved only by resection with macroscopic tumor clearance. There is a strong rationale for a neoadjuvant approach, since a relevant percentage of pancreatic cancer patients present with non-metastatic but locally advanced disease a...

journal_title：PLoS medicine

authors： Gillen S,Schuster T,Meyer Zum Büschenfelde C,Friess H,Kleeff J

更新日期：2010-04-20 00:00:00

abstract：BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the leading cause of cancer-related mortality in children. T cell ALL (T-ALL) represents about 15% of pediatric ALL cases and is considered a high-risk disease. T-ALL is often associated with resistance to treatment, includi...

journal_title：PLoS medicine

authors： Li Y,Buijs-Gladdines JG,Canté-Barrett K,Stubbs AP,Vroegindeweij EM,Smits WK,van Marion R,Dinjens WN,Horstmann M,Kuiper RP,Buijsman RC,Zaman GJ,van der Spek PJ,Pieters R,Meijerink JP

更新日期：2016-12-20 00:00:00

abstract：BACKGROUND:This paper examines the efforts of consultants affiliated with Philip Morris (PM), the world's leading transnational tobacco corporation, to influence scientific research and training in Thailand via the Chulabhorn Research Institute (CRI). A leading Southeast Asian institute for environmental health science...

journal_title：PLoS medicine

authors： Mackenzie R,Collin J

更新日期：2008-12-23 00:00:00

abstract：BACKGROUND:The proteases (secretases) that cleave amyloid-beta (Abeta) peptide from the amyloid precursor protein (APP) have been the focus of considerable investigation in the development of treatments for Alzheimer disease. The prediction has been that reducing Abeta production in the brain, even after the onset of c...

journal_title：PLoS medicine

authors： Jankowsky JL,Slunt HH,Gonzales V,Savonenko AV,Wen JC,Jenkins NA,Copeland NG,Younkin LH,Lester HA,Younkin SG,Borchelt DR

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Schistosomiasis--infection with helminth parasites in the genus Schistosoma, including S. mansoni--is a widespread, devastating tropical disease affecting more than 200 million people. No vaccine is available, and praziquantel, the only drug extensively utilized, is currently administered more than 100 milli...

journal_title：PLoS medicine

authors： Kuntz AN,Davioud-Charvet E,Sayed AA,Califf LL,Dessolin J,Arnér ES,Williams DL

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Midwifery continuity of care is the only health system intervention shown to reduce preterm birth (PTB) and improve perinatal survival, but no trial evidence exists for women with identified risk factors for PTB. We aimed to assess feasibility, fidelity, and clinical outcomes of a model of midwifery continui...

journal_title：PLoS medicine

authors： Fernandez Turienzo C,Bick D,Briley AL,Bollard M,Coxon K,Cross P,Silverio SA,Singh C,Seed PT,Tribe RM,Shennan AH,Sandall J,POPPIE Pilot Collaborative Group.

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:Effective strategies are needed for the prevention of mother-to-child HIV transmission (PMTCT) in resource-limited settings. The Kisumu Breastfeeding Study was a single-arm open label trial conducted between July 2003 and February 2009. The overall aim was to investigate whether a maternal triple-antiretrovi...

journal_title：PLoS medicine

authors： Thomas TK,Masaba R,Borkowf CB,Ndivo R,Zeh C,Misore A,Otieno J,Jamieson D,Thigpen MC,Bulterys M,Slutsker L,De Cock KM,Amornkul PN,Greenberg AE,Fowler MG,KiBS Study Team.

更新日期：2011-03-01 00:00:00

abstract：:A major challenge in monitoring universal health coverage (UHC) is identifying an indicator that can adequately capture the multiple components underlying the UHC initiative. Effective coverage, which unites individual and intervention characteristics into a single metric, offers a direct and flexible means to measure...

journal_title：PLoS medicine

authors： Ng M,Fullman N,Dieleman JL,Flaxman AD,Murray CJ,Lim SS

更新日期：2014-09-22 00:00:00

abstract：BACKGROUND:Plasmodium falciparum merozoite surface protein 3 is a malaria vaccine candidate that was identified, characterised, and developed based on a unique immuno-clinical approach. The vaccine construct was derived from regions fully conserved among various strains and containing B cell epitopes targeted by human ...

journal_title：PLoS medicine

authors： Druilhe P,Spertini F,Soesoe D,Corradin G,Mejia P,Singh S,Audran R,Bouzidi A,Oeuvray C,Roussilhon C

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Rare diseases affect as many as 60 million people in the United States and Europe. However, most rare diseases lack effective therapies and are in critical need of clinical research. Our objective was to determine the frequency of noncompletion and nonpublication of trials studying rare diseases. METHODS AN...

journal_title：PLoS medicine

authors： Rees CA,Pica N,Monuteaux MC,Bourgeois FT

更新日期：2019-11-21 00:00:00

abstract：:Alexander Tsai and colleagues highlight the complex relationship between poverty and HIV stigma in sub-Saharan Africa, and discuss possible ways to break the cycle. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Tsai AC,Bangsberg DR,Weiser SD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Postpartum hemorrhage (PPH) is a leading cause of maternal death in sub-Saharan Africa. Although the World Health Organization recommends use of oxytocin for prevention of PPH, misoprostol use is increasingly common owing to advantages in shelf life and potential for sublingual administration. There is a lac...

journal_title：PLoS medicine

authors： Atukunda EC,Siedner MJ,Obua C,Mugyenyi GR,Twagirumukiza M,Agaba AG

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) of houses provide effective malaria transmission control. There is conflicting evidence about whether it is more beneficial to provide both interventions in combination. A cluster randomised controlled trial was conducted to investigate wheth...

journal_title：PLoS medicine

authors： West PA,Protopopoff N,Wright A,Kivaju Z,Tigererwa R,Mosha FW,Kisinza W,Rowland M,Kleinschmidt I

更新日期：2014-04-15 00:00:00

abstract：:In a Perspective, Lynn Morris and Nonhlanhla Mkhize discuss the prospects for broadly neutralizing antibodies to be used in preventing HIV infection. ...

journal_title：PLoS medicine

authors： Morris L,Mkhize NN

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:Experimental studies have suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors provide cardiovascular protective effects. We performed a randomized study to evaluate the effects of sitagliptin added on to the conventional therapy compared with conventional therapy alone (diet, exercise, and/or drugs, exc...

journal_title：PLoS medicine

authors： Oyama J,Murohara T,Kitakaze M,Ishizu T,Sato Y,Kitagawa K,Kamiya H,Ajioka M,Ishihara M,Dai K,Nanasato M,Sata M,Maemura K,Tomiyama H,Higashi Y,Kaku K,Yamada H,Matsuhisa M,Yamashita K,Bando YK,Kashihara N,Ueda S,

更新日期：2016-06-28 00:00:00

abstract：BACKGROUND:Although it has long been appreciated that ovarian carcinoma subtypes (serous, clear cell, endometrioid, and mucinous) are associated with different natural histories, most ovarian carcinoma biomarker studies and current treatment protocols for women with this disease are not subtype specific. With the emerg...

journal_title：PLoS medicine

authors： Köbel M,Kalloger SE,Boyd N,McKinney S,Mehl E,Palmer C,Leung S,Bowen NJ,Ionescu DN,Rajput A,Prentice LM,Miller D,Santos J,Swenerton K,Gilks CB,Huntsman D

更新日期：2008-12-02 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002511.]. ...

journal_title：PLoS medicine

authors： Torrone EA,Morrison CS,Chen PL,Kwok C,Francis SC,Hayes RJ,Looker KJ,McCormack S,McGrath N,van de Wijgert JHHM,Watson-Jones D,Low N,Gottlieb SL,STIMA Working Group.

更新日期：2018-06-26 00:00:00

abstract：BACKGROUND:The association between fetal exposure to major radiodiagnostic testing in pregnancy-computed tomography (CT) and radionuclide imaging-and the risk of childhood cancer is not established. METHODS AND FINDINGS:We completed a population-based study of 1.8 million maternal-child pairs in the province of Ontari...

journal_title：PLoS medicine

authors： Ray JG,Schull MJ,Urquia ML,You JJ,Guttmann A,Vermeulen MJ

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:Quantitative estimation of the extent to which the immune system's protective effect against one herpes simplex virus type 2 (HSV-2) infection protects against infection with additional HSV-2 strains is important for understanding the potential for HSV-2 vaccine development. Using viral genotyping, we estima...

journal_title：PLoS medicine

authors： Johnston C,Magaret A,Roychoudhury P,Greninger AL,Reeves D,Schiffer J,Jerome KR,Sather C,Diem K,Lingappa JR,Celum C,Koelle DM,Wald A

更新日期：2017-12-27 00:00:00

abstract：BACKGROUND:In recent decades, increased attention has been focused on the impact of disabilities and medicinal drug use on road safety. The aim of our study was to investigate the association between prescription medicines and the risk of road traffic crashes, and estimate the attributable fraction. METHODS AND FINDIN...

journal_title：PLoS medicine

authors： Orriols L,Delorme B,Gadegbeku B,Tricotel A,Contrand B,Laumon B,Salmi LR,Lagarde E,CESIR research group.

更新日期：2010-11-16 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002781.]. ...

journal_title：PLoS medicine

authors： Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74

更新日期：2019-07-18 00:00:00

abstract：:In this Perspective on the clinical trial by Rita Alloway and colleagues, Simon Ball explains the benefits to healthcare systems and individual patients of the bioequivalence established between generic and brand-name formulations of an immunosuppressive drug in transplant recipients. ...

journal_title：PLoS medicine

authors： Ball S

更新日期：2017-11-14 00:00:00

abstract：:Pharmacogenomics is one of the first clinical applications of the postgenomic era. It promises personalized medicine rather than the established "one size fits all" approach to drugs and dosages. The expected reduction in trial and error should ultimately lead to more efficient and safer drug therapy. In recent years,...

journal_title：PLoS medicine

authors： Swen JJ,Huizinga TW,Gelderblom H,de Vries EG,Assendelft WJ,Kirchheiner J,Guchelaar HJ

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated. METHODS AND FINDINGS:In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of T...

journal_title：PLoS medicine

authors： Dunning J,Sahr F,Rojek A,Gannon F,Carson G,Idriss B,Massaquoi T,Gandi R,Joseph S,Osman HK,Brooks TJ,Simpson AJ,Goodfellow I,Thorne L,Arias A,Merson L,Castle L,Howell-Jones R,Pardinaz-Solis R,Hope-Gill B,Ferri M,

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs. There are numerous psychiatric conditions that present with psychotic symptoms, most importantly schizophrenia, bipolar affective disorder, an...

journal_title：PLoS medicine

authors： Huang JT,Leweke FM,Oxley D,Wang L,Harris N,Koethe D,Gerth CW,Nolden BM,Gross S,Schreiber D,Reed B,Bahn S

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Increased adiposity is linked with higher risk for cardiometabolic diseases. We aimed to determine to what extent elevated body mass index (BMI) within the normal weight range has causal effects on the detailed systemic metabolite profile in early adulthood. METHODS AND FINDINGS:We used Mendelian randomizat...

journal_title：PLoS medicine

authors： Würtz P,Wang Q,Kangas AJ,Richmond RC,Skarp J,Tiainen M,Tynkkynen T,Soininen P,Havulinna AS,Kaakinen M,Viikari JS,Savolainen MJ,Kähönen M,Lehtimäki T,Männistö S,Blankenberg S,Zeller T,Laitinen J,Pouta A,Mäntyselkä P

更新日期：2014-12-09 00:00:00

abstract：:In an Editorial, Guest Editors Nicola Low and Nathalie Broutet discuss the Collection on sexually transmitted infections in the context of research priorities in the field. ...

journal_title：PLoS medicine

authors： Low N,Broutet NJ

更新日期：2017-12-27 00:00:00

abstract：BACKGROUND:Antiretroviral-based interventions for HIV-1 prevention, including antiretroviral therapy (ART) to reduce the infectiousness of HIV-1 infected persons and pre-exposure prophylaxis (PrEP) to reduce the susceptibility of HIV-1 uninfected persons, showed high efficacy for HIV-1 protection in randomized clinical...

journal_title：PLoS medicine

authors： Baeten JM,Heffron R,Kidoguchi L,Mugo NR,Katabira E,Bukusi EA,Asiimwe S,Haberer JE,Morton J,Ngure K,Bulya N,Odoyo J,Tindimwebwa E,Hendrix C,Marzinke MA,Ware NC,Wyatt MA,Morrison S,Haugen H,Mujugira A,Donnell D,Ce

更新日期：2016-08-23 00:00:00

abstract：BACKGROUND:The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages. Either drug can induce haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, necessitating screening. The reference diagnostic method for G6PD activ...

journal_title：PLoS medicine

authors： Pfeffer DA,Ley B,Howes RE,Adu P,Alam MS,Bansil P,Boum Y 2nd,Brito M,Charoenkwan P,Clements A,Cui L,Deng Z,Egesie OJ,Espino FE,von Fricken ME,Hamid MMA,He Y,Henriques G,Khan WA,Khim N,Kim S,Lacerda M,Lon C,Me

更新日期：2020-05-14 00:00:00