Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target.

abstract：BACKGROUND:In South Africa, within-country migration is common. Mobility affects many of the factors in the pathway for entry to or retention in care among people living with HIV. We characterized the patterns of migration (i.e., change in residency) among peripartum women from rural South Africa and their association ...

journal_title：PLoS medicine

authors： Kim HY,Dobra A,Tanser F

更新日期：2020-03-31 00:00:00

abstract：BACKGROUND:Development of noninvasive molecular assays to improve disease diagnosis and patient monitoring is a critical need. In renal transplantation, acute rejection (AR) increases the risk for chronic graft injury and failure. Noninvasive diagnostic assays to improve current late and nonspecific diagnosis of reject...

journal_title：PLoS medicine

authors： Roedder S,Sigdel T,Salomonis N,Hsieh S,Dai H,Bestard O,Metes D,Zeevi A,Gritsch A,Cheeseman J,Macedo C,Peddy R,Medeiros M,Vincenti F,Asher N,Salvatierra O,Shapiro R,Kirk A,Reed EF,Sarwal MM

更新日期：2014-11-11 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) are essential in host defense against pathogens by virtue of their capacity to detect microbes and initiate the immune response. TLR2 is seen as the most important receptor for gram-positive bacteria, while TLR4 is regarded as the gram-negative TLR. Melioidosis is a severe infectio...

journal_title：PLoS medicine

authors： Wiersinga WJ,Wieland CW,Dessing MC,Chantratita N,Cheng AC,Limmathurotsakul D,Chierakul W,Leendertse M,Florquin S,de Vos AF,White N,Dondorp AM,Day NP,Peacock SJ,van der Poll T

更新日期：2007-07-31 00:00:00

abstract：:Prognostic models are abundant in the medical literature yet their use in practice seems limited. In this article, the third in the PROGRESS series, the authors review how such models are developed and validated, and then address how prognostic models are assessed for their impact on practice and patient outcomes, ill...

journal_title：PLoS medicine

authors： Steyerberg EW,Moons KG,van der Windt DA,Hayden JA,Perel P,Schroter S,Riley RD,Hemingway H,Altman DG,PROGRESS Group.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes (T2D) is a progressive disease whereby there is often deterioration in glucose control despite escalation in treatment. There is significant heterogeneity to this progression of glycemia after onset of diabetes, yet the factors that influence glycemic progression are not well understood. Give...

journal_title：PLoS medicine

authors： Jiang G,Luk AO,Tam CHT,Lau ES,Ozaki R,Chow EYK,Kong APS,Lim CKP,Lee KF,Siu SC,Hui G,Tsang CC,Lau KP,Leung JYY,Tsang MW,Kam G,Lau IT,Li JK,Yeung VT,Lau E,Lo S,Fung SKS,Cheng YL,Chow CC,Pearson ER,So WY,

更新日期：2020-07-28 00:00:00

abstract：BACKGROUND:National responses will need to be markedly accelerated to achieve the ambitious target of the Joint United Nations Programme on HIV/AIDS (UNAIDS). This target aims for 90% of HIV-positive individuals to be aware of their status, for 90% of those aware to receive antiretroviral therapy (ART), and for 90% of ...

journal_title：PLoS medicine

authors： Maheu-Giroux M,Vesga JF,Diabaté S,Alary M,Baral S,Diouf D,Abo K,Boily MC

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:The proteases (secretases) that cleave amyloid-beta (Abeta) peptide from the amyloid precursor protein (APP) have been the focus of considerable investigation in the development of treatments for Alzheimer disease. The prediction has been that reducing Abeta production in the brain, even after the onset of c...

journal_title：PLoS medicine

authors： Jankowsky JL,Slunt HH,Gonzales V,Savonenko AV,Wen JC,Jenkins NA,Copeland NG,Younkin LH,Lester HA,Younkin SG,Borchelt DR

更新日期：2005-12-01 00:00:00

abstract：:Considerable progress has been made in reducing maternal, newborn, and child mortality worldwide, but many more deaths could be prevented if effective interventions were available to all who could benefit from them. Timely, high-quality measurements of intervention coverage--the proportion of a population in need of a...

journal_title：PLoS medicine

authors： Bryce J,Arnold F,Blanc A,Hancioglu A,Newby H,Requejo J,Wardlaw T,CHERG Working Group on Improving Coverage Measurement.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Evidence of the short-term effects of ambient air pollution on the risk of ischemic stroke in low- and middle-income countries is limited and inconsistent. We aimed to examine the associations between air pollution and daily hospital admissions for ischemic stroke in China. METHODS AND FINDINGS:We identifie...

journal_title：PLoS medicine

authors： Tian Y,Liu H,Zhao Z,Xiang X,Li M,Juan J,Song J,Cao Y,Wang X,Chen L,Wei C,Hu Y,Gao P

更新日期：2018-10-04 00:00:00

abstract：BACKGROUND:Cohort studies are recommended for understanding ethnic disparities in cardiovascular disease. Our objective was to review the process for identifying, including, and excluding ethnic minority populations in published cardiovascular cohort studies in Europe and North America. METHODS AND FINDINGS:We found t...

journal_title：PLoS medicine

authors： Ranganathan M,Bhopal R

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Whole genome sequencing provides better delineation of transmission clusters in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal individual transmission links within clusters is limited. Here, we used a 2-step approach based on Bayesian transmission reconstruction to (1) id...

journal_title：PLoS medicine

authors： Xu Y,Cancino-Muñoz I,Torres-Puente M,Villamayor LM,Borrás R,Borrás-Máñez M,Bosque M,Camarena JJ,Colomer-Roig E,Colomina J,Escribano I,Esparcia-Rodríguez O,Gil-Brusola A,Gimeno C,Gimeno-Gascón A,Gomila-Sard B,González-Gran

更新日期：2019-10-31 00:00:00

abstract：:Chris Beyrer and colleagues reflect on an underappreciated trend in multiple African, Asian, and Caribbean settings, in which the provision of HIV and other essential health services for sexual and gender minorities is expanding despite challenging legal and social environments. ...

journal_title：PLoS medicine

authors： Beyrer C,Makofane K,Orazulike I,Diouf D,Baral SD

更新日期：2016-10-25 00:00:00

abstract：BACKGROUND:Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to laboratory-based tests in Mozambique. METHODS AND FINDINGS:We use a validated model of HIV testing, linkag...

journal_title：PLoS medicine

authors： Hyle EP,Jani IV,Lehe J,Su AE,Wood R,Quevedo J,Losina E,Bassett IV,Pei PP,Paltiel AD,Resch S,Freedberg KA,Peter T,Walensky RP

更新日期：2014-09-16 00:00:00

abstract：:Leo Sher and colleagues discuss recent research on interventions to prevent secondary suicide and discuss the additional research that is needed. ...

journal_title：PLoS medicine

authors： Ganz D,Braquehais MD,Sher L

更新日期：2010-06-01 00:00:00

abstract：:Results from several observational studies of HIV-discordant couples and a randomized controlled trial (HIV Prevention Trials Network 052) show that antiretroviral therapy (ART) can greatly reduce heterosexual HIV transmission in stable HIV-discordant couples. However, such data do not prove that ART will reduce HIV i...

journal_title：PLoS medicine

authors： Smith MK,Powers KA,Muessig KE,Miller WC,Cohen MS

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The National Health Service (NHS) in England introduced a population-wide programme for cardiovascular disease (CVD) prevention in 2009, known as NHS Health Checks. This research aimed to measure the cardiovascular risk management and cardiovascular risk factor outcomes of the health check programme during s...

journal_title：PLoS medicine

authors： Alageel S,Gulliford MC

更新日期：2019-07-30 00:00:00

abstract：BACKGROUND:Intimate partner violence (IPV) against women is a major global health issue, particularly in low- and middle-income countries (LMICs), that is associated with poor physical and mental health, but its association with breastfeeding practices is understudied. Both the World Health Organization (WHO) and the U...

journal_title：PLoS medicine

authors： Caleyachetty R,Uthman OA,Bekele HN,Martín-Cañavate R,Marais D,Coles J,Steele B,Uauy R,Koniz-Booher P

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Rates of diseases and injuries and the effects of their risk factors can have substantial subnational heterogeneity, especially in middle-income countries like Mexico. Subnational analysis of the burden of diseases, injuries, and risk factors can improve characterization of the epidemiological transition and...

journal_title：PLoS medicine

authors： Stevens G,Dias RH,Thomas KJ,Rivera JA,Carvalho N,Barquera S,Hill K,Ezzati M

更新日期：2008-06-17 00:00:00

abstract：:Andrew Seale and colleagues discuss the development of a global strategy to counter sexually transmitted infections. ...

journal_title：PLoS medicine

authors： Seale A,Broutet N,Narasimhan M

更新日期：2017-06-27 00:00:00

abstract：:Community efforts and peer support programs are needed in addition to provider-initiated and opt-out HIV testing in adolescents, Sheri Weiser and colleagues discuss. ...

journal_title：PLoS medicine

authors： Lightfoot M,Dunbar M,Weiser SD

更新日期：2017-07-25 00:00:00

abstract：BACKGROUND:To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-alpha and ribavirin (PegIFN/R). Viral clearance is achieved in 40%...

journal_title：PLoS medicine

authors： Suppiah V,Gaudieri S,Armstrong NJ,O'Connor KS,Berg T,Weltman M,Abate ML,Spengler U,Bassendine M,Dore GJ,Irving WL,Powell E,Hellard M,Riordan S,Matthews G,Sheridan D,Nattermann J,Smedile A,Müller T,Hammond E,Dunn D

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Sales visits by pharmaceutical representatives ("drug detailing") are common, but little is known about the content of these visits or about the impact of visit characteristics on prescribing behavior. In this study, we evaluated the content and impact of detail visits for gabapentin by analyzing market rese...

journal_title：PLoS medicine

authors： Steinman MA,Harper GM,Chren MM,Landefeld CS,Bero LA

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:CD4 cell count is a strong predictor of the subsequent risk of AIDS or death in HIV-infected patients initiating combination antiretroviral therapy (cART). It is not known whether the rate of CD4 cell decline prior to therapy is related to prognosis and should, therefore, influence the decision on when to in...

journal_title：PLoS medicine

authors： Wolbers M,Babiker A,Sabin C,Young J,Dorrucci M,Chêne G,Mussini C,Porter K,Bucher HC,CASCADE Collaboration Members.

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associ...

journal_title：PLoS medicine

authors： Musso G,Gambino R,Tabibian JH,Ekstedt M,Kechagias S,Hamaguchi M,Hultcrantz R,Hagström H,Yoon SK,Charatcharoenwitthaya P,George J,Barrera F,Hafliðadóttir S,Björnsson ES,Armstrong MJ,Hopkins LJ,Gao X,Francque S,Verrijke

更新日期：2014-07-22 00:00:00

abstract：:Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers...

journal_title：PLoS medicine

authors： Liberati A,Altman DG,Tetzlaff J,Mulrow C,Gøtzsche PC,Ioannidis JP,Clarke M,Devereaux PJ,Kleijnen J,Moher D

更新日期：2009-07-21 00:00:00

abstract：BACKGROUND:At the beginning of June 2020, there were nearly 7 million reported cases of coronavirus disease 2019 (COVID-19) worldwide and over 400,000 deaths in people with COVID-19. The objective of this study was to determine associations between comorbidities listed in the Charlson comorbidity index and mortality am...

journal_title：PLoS medicine

authors： Harrison SL,Fazio-Eynullayeva E,Lane DA,Underhill P,Lip GYH

更新日期：2020-09-10 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1001659.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:Ovarian cancer kills approximately 15,000 women in the United States every year, and more than 140,000 women worldwide. Most deaths from ovarian cancer are caused by tumors of the serous histological type, which are rarely diagnosed before the cancer has spread. Rational design of a potentially life-saving e...

journal_title：PLoS medicine

authors： Brown PO,Palmer C

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Research needs to be reported transparently so readers can critically assess the strengths and weaknesses of the design, conduct, and analysis of studies. Reporting guidelines have been developed to inform reporting for a variety of study designs. The objective of this study was to identify whether there is ...

journal_title：PLoS medicine

authors： Bennett C,Khangura S,Brehaut JC,Graham ID,Moher D,Potter BK,Grimshaw JM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Vital registration and cause of death reporting is incomplete in the countries in which the HIV epidemic is most severe. A reliable tool that is independent of HIV status is needed for measuring the frequency of AIDS deaths and ultimately the impact of antiretroviral therapy on mortality. METHODS AND FINDIN...

journal_title：PLoS medicine

authors： Lopman BA,Barnabas RV,Boerma JT,Chawira G,Gaitskell K,Harrop T,Mason P,Donnelly CA,Garnett GP,Nyamukapa C,Gregson S

更新日期：2006-08-01 00:00:00