当前位置： SCI文献检索 > PLOS MEDICINE期刊下所有文献 > The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya.

The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya.

Abstract：

BACKGROUND:The alpha-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, the epidemiological description of the relationships between alpha-thalassaemia, malaria, and other common causes of child mortality remains incomplete. METHODS AND FINDINGS:We studied the alpha+-thalassaemia-specific incidence of malaria and other common childhood diseases in two cohorts of children living on the coast of Kenya. We found no associations between alpha+-thalassaemia and the prevalence of symptomless Plasmodium falciparum parasitaemia, the incidence of uncomplicated P. falciparum disease, or parasite densities during mild or severe malaria episodes. However, we found significant negative associations between alpha+-thalassaemia and the incidence rates of severe malaria and severe anaemia (haemoglobin concentration < 50 g/l). The strongest associations were for severe malaria anaemia (> 10,000 P. falciparum parasites/mul) and severe nonmalaria anaemia; the incidence rate ratios and 95% confidence intervals (CIs) for alpha+-thalassaemia heterozygotes and homozygotes combined compared to normal children were, for severe malaria anaemia, 0.33 (95% CI, 0.15,0.73; p = 0.006), and for severe nonmalaria anaemia, 0.26 (95% CI, 0.09,0.77; p = 0.015). CONCLUSIONS:Our observations suggest, first that selection for alpha+-thalassaemia might be mediated by a specific effect against severe anaemia, an observation that may lead to fresh insights into the aetiology of this important condition. Second, although alpha+-thalassaemia is strongly protective against severe and fatal malaria, its effects are not detectable at the level of any other malaria outcome; this result provides a cautionary example for studies aimed at testing malaria interventions or identifying new malaria-protective genes.

journal_name

PLoS Med

journal_title

PLoS medicine

authors

Wambua S,Mwangi TW,Kortok M,Uyoga SM,Macharia AW,Mwacharo JK,Weatherall DJ,Snow RW,Marsh K,Williams TN

doi

10.1371/journal.pmed.0030158

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

e158

issue

eissn

1549-1277

issn

1549-1676

pii

05-PLME-RA-0557R1

journal_volume

pub_type

杂志文章

在线工具

The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya.