The state of the antivaccine movement in the United States: A focused examination of nonmedical exemptions in states and counties.

abstract：BACKGROUND:Renal involvement is a serious manifestation of systemic lupus erythematosus (SLE); it may portend a poor prognosis as it may lead to end-stage renal disease (ESRD). The purpose of this study was to determine the factors predicting the development of renal involvement and its progression to ESRD in a multi-e...

journal_title：PLoS medicine

authors： Alarcón GS,McGwin G Jr,Petri M,Ramsey-Goldman R,Fessler BJ,Vilá LM,Edberg JC,Reveille JD,Kimberly RP,PROFILE Study Group.

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance. Yet, the efficacy of the antidepressants may also depend on the severity of initial depress...

journal_title：PLoS medicine

authors： Kirsch I,Deacon BJ,Huedo-Medina TB,Scoboria A,Moore TJ,Johnson BT

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Clear recognition of the damaging effects of poverty on early childhood development has fueled an interest in interventions aimed at mitigating these harmful consequences. Psychosocial interventions aimed at alleviating the negative impacts of poverty on children are frequently shown to be of benefit, but ef...

journal_title：PLoS medicine

authors： Morgan B,Kumsta R,Fearon P,Moser D,Skeen S,Cooper P,Murray L,Moran G,Tomlinson M

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:While many individual genes have been identified that confer protection against malaria, the overall impact of host genetics on malarial risk remains unknown. METHODS AND FINDINGS:We have used pedigree-based genetic variance component analysis to determine the relative contributions of genetic and other fac...

journal_title：PLoS medicine

authors： Mackinnon MJ,Mwangi TW,Snow RW,Marsh K,Williams TN

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Global warming is predicted to indirectly result in more undernutrition by threatening crop production. Whether temperature rise could affect undernutrition directly is unknown. We aim to quantify the relationship between short-term heat exposure and risk of hospitalization due to undernutrition in Brazil. ...

journal_title：PLoS medicine

authors： Xu R,Zhao Q,Coelho MSZS,Saldiva PHN,Abramson MJ,Li S,Guo Y

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated. METHODS AND FINDINGS:In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of T...

journal_title：PLoS medicine

authors： Dunning J,Sahr F,Rojek A,Gannon F,Carson G,Idriss B,Massaquoi T,Gandi R,Joseph S,Osman HK,Brooks TJ,Simpson AJ,Goodfellow I,Thorne L,Arias A,Merson L,Castle L,Howell-Jones R,Pardinaz-Solis R,Hope-Gill B,Ferri M,

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Hospitalisation for adversity-related injury (violent, drug/alcohol-related, or self-inflicted injury) has been described as a "teachable moment", when intervention may reduce risks of further harm. Which adolescents are likely to benefit most from intervention strongly depends on their long-term risks of ha...

journal_title：PLoS medicine

authors： Herbert A,Gilbert R,González-Izquierdo A,Pitman A,Li L

更新日期：2015-12-29 00:00:00

abstract：:Kevin Outterson and colleagues outline a model to address access, conservation, and innovation of antibiotics. ...

journal_title：PLoS medicine

authors： Outterson K,Gopinathan U,Clift C,So AD,Morel CM,Røttingen JA

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:Counties are the smallest unit for which mortality data are routinely available, allowing consistent and comparable long-term analysis of trends in health disparities. Average life expectancy has steadily increased in the United States but there is limited information on long-term mortality trends in the US ...

journal_title：PLoS medicine

authors： Ezzati M,Friedman AB,Kulkarni SC,Murray CJ

更新日期：2008-04-22 00:00:00

abstract：:Mirjam Kretzschmar and colleagues describe the BCoDE project, which uses a pathogen-based incidence approach to better estimate the infectious disease burden in Europe. ...

journal_title：PLoS medicine

authors： Kretzschmar M,Mangen MJ,Pinheiro P,Jahn B,Fèvre EM,Longhi S,Lai T,Havelaar AH,Stein C,Cassini A,Kramarz P,BCoDE consortium.

更新日期：2012-01-01 00:00:00

abstract：:David Studdert and colleagues explore how to balance public health, individual freedom, and good government when it comes to sugar-sweetened drinks. ...

journal_title：PLoS medicine

authors： Studdert DM,Flanders J,Mello MM

更新日期：2015-07-07 00:00:00

abstract：:Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due to advancements in both prevention and treatment of HIV. However, major challenges still remain. We describe basic principles of epidemic control in the context of HIV and identify a number of attainable goals in terms of control a...

journal_title：PLoS medicine

authors： Jones J,Sullivan PS,Curran JW

更新日期：2019-01-18 00:00:00

abstract：:Antimalarial drugs will be essential tools at all stages of malaria elimination along the path towards eradication, including the early control or "attack" phase to drive down transmission and the later stages of maintaining interruption of transmission, preventing reintroduction of malaria, and eliminating the last r...

journal_title：PLoS medicine

authors： malERA Consultative Group on Drugs.

更新日期：2011-01-25 00:00:00

abstract：:Diarrhea morbidity and mortality remain important child health problems in low- and middle-income countries. The treatment of diarrhea and accurate measurement of treatment coverage are critical if child mortality is going to continue to decline. In this review, we examine diarrhea treatment coverage indicators collec...

journal_title：PLoS medicine

authors： Fischer Walker CL,Fontaine O,Black RE

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Through major efforts to reduce costs and expand access to antiretroviral therapy worldwide, widespread delivery of effective treatment to people living with HIV/AIDS is now conceivable even in severely resource-constrained settings. However, the potential epidemiologic impact of treatment in the context of ...

journal_title：PLoS medicine

authors： Salomon JA,Hogan DR,Stover J,Stanecki KA,Walker N,Ghys PD,Schwartländer B

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Since 1998 the serious public health problem in South East Asia of counterfeit artesunate, containing no or subtherapeutic amounts of the active antimalarial ingredient, has led to deaths from untreated malaria, reduced confidence in this vital drug, large economic losses for the legitimate manufacturers, an...

journal_title：PLoS medicine

authors： Newton PN,Fernández FM,Plançon A,Mildenhall DC,Green MD,Ziyong L,Christophel EM,Phanouvong S,Howells S,McIntosh E,Laurin P,Blum N,Hampton CY,Faure K,Nyadong L,Soong CW,Santoso B,Zhiguang W,Newton J,Palmer K

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emerging chloroquine resistance. We undertook a systematic review and individual patient data meta-analysis to compare the efficacies of dihydroartemisinin-piperaquine (DP) and artemether-lumefan...

journal_title：PLoS medicine

authors： Commons RJ,Simpson JA,Thriemer K,Abreha T,Adam I,Anstey NM,Assefa A,Awab GR,Baird JK,Barber BE,Chu CS,Dahal P,Daher A,Davis TME,Dondorp AM,Grigg MJ,Humphreys GS,Hwang J,Karunajeewa H,Laman M,Lidia K,Moore BR,M

更新日期：2019-10-04 00:00:00

abstract：:In a Perspective, David Peiris and Dorairaj Prabhakaran discuss implications and challenges of cardiovascular disease risk assessments in the population of India. ...

journal_title：PLoS medicine

authors： Peiris D,Prabhakaran D

更新日期：2018-06-19 00:00:00

abstract：:Pharmacogenomics is one of the first clinical applications of the postgenomic era. It promises personalized medicine rather than the established "one size fits all" approach to drugs and dosages. The expected reduction in trial and error should ultimately lead to more efficient and safer drug therapy. In recent years,...

journal_title：PLoS medicine

authors： Swen JJ,Huizinga TW,Gelderblom H,de Vries EG,Assendelft WJ,Kirchheiner J,Guchelaar HJ

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Some 5%-15% of all women experience postpartum depression (PPD), which for many is their first psychiatric disorder. The purpose of this study was to estimate the incidence of postpartum affective disorder (AD), duration of treatment, and rate of subsequent postpartum AD and other affective episodes in a nat...

journal_title：PLoS medicine

authors： Rasmussen MH,Strøm M,Wohlfahrt J,Videbech P,Melbye M

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:Increased adiposity is linked with higher risk for cardiometabolic diseases. We aimed to determine to what extent elevated body mass index (BMI) within the normal weight range has causal effects on the detailed systemic metabolite profile in early adulthood. METHODS AND FINDINGS:We used Mendelian randomizat...

journal_title：PLoS medicine

authors： Würtz P,Wang Q,Kangas AJ,Richmond RC,Skarp J,Tiainen M,Tynkkynen T,Soininen P,Havulinna AS,Kaakinen M,Viikari JS,Savolainen MJ,Kähönen M,Lehtimäki T,Männistö S,Blankenberg S,Zeller T,Laitinen J,Pouta A,Mäntyselkä P

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:HVTN 100 evaluated the safety and immunogenicity of an HIV subtype C pox-protein vaccine regimen, investigating a 12-month booster to extend vaccine-induced immune responses. METHODS AND FINDINGS:A phase 1-2 randomized double-blind placebo-controlled trial enrolled 252 participants (210 vaccine/42 placebo; ...

journal_title：PLoS medicine

authors： Laher F,Moodie Z,Cohen KW,Grunenberg N,Bekker LG,Allen M,Frahm N,Yates NL,Morris L,Malahleha M,Mngadi K,Daniels B,Innes C,Saunders K,Grant S,Yu C,Gilbert PB,Phogat S,DiazGranados CA,Koutsoukos M,Van Der Meeren O,

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:The relationship between population trends in delaying childbirth and rising rates of primary cesarean delivery is unclear. The aims of the present study were (1) to characterize the association between maternal age and the outcome of labor, (2) to determine the proportion of the increase in primary cesarean...

journal_title：PLoS medicine

authors： Smith GC,Cordeaux Y,White IR,Pasupathy D,Missfelder-Lobos H,Pell JP,Charnock-Jones DS,Fleming M

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Leber congenital amaurosis (LCA) is a genetically heterogeneous group of retinal diseases that cause congenital blindness in infants and children. Mutations in the GUCY2D gene that encodes retinal guanylate cyclase-1 (retGC1) were the first to be linked to this disease group (LCA type 1 [LCA1]) and account f...

journal_title：PLoS medicine

authors： Williams ML,Coleman JE,Haire SE,Aleman TS,Cideciyan AV,Sokal I,Palczewski K,Jacobson SG,Semple-Rowland SL

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Annual influenza vaccination of institutional health care workers (HCWs) is advised in most Western countries, but adherence to this recommendation is generally low. Although protective effects of this intervention for nursing home patients have been demonstrated in some clinical trials, the exact relationsh...

journal_title：PLoS medicine

authors： van den Dool C,Bonten MJ,Hak E,Heijne JC,Wallinga J

更新日期：2008-10-28 00:00:00

abstract：BACKGROUND:Patients with unprovoked (i.e., without the presence of apparent transient risk factors such as recent surgery) venous thromboembolism (VTE) are at risk of recurrence if anticoagulants are stopped after 3-6 months, yet their risk remains heterogeneous. Thus, prolonging anticoagulant treatment should be consi...

journal_title：PLoS medicine

authors： Geersing GJ,Hendriksen JMT,Zuithoff NPA,Roes KC,Oudega R,Takada T,Schutgens REG,Moons KGM

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Envenoming resulting from snakebites is an important public health problem in many tropical and subtropical countries. Few attempts have been made to quantify the burden, and recent estimates all suffer from the lack of an objective and reproducible methodology. In an attempt to provide an accurate, up-to-da...

journal_title：PLoS medicine

authors： Kasturiratne A,Wickremasinghe AR,de Silva N,Gunawardena NK,Pathmeswaran A,Premaratna R,Savioli L,Lalloo DG,de Silva HJ

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:Very-low-birth-weight (VLBW, <1,500 g) infants have compromised bone mass accrual during childhood, but it is unclear whether this results in subnormal peak bone mass and increased risk of impaired skeletal health in adulthood. We hypothesized that VLBW is associated with reduced bone mineral density (BMD) i...

journal_title：PLoS medicine

authors： Hovi P,Andersson S,Järvenpää AL,Eriksson JG,Strang-Karlsson S,Kajantie E,Mäkitie O

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Oncolytic viruses hold much promise for clinical treatment of many cancers, but a lack of systemic delivery and insufficient tumor cell killing have limited their usefulness. We have previously demonstrated that vaccinia virus strains are capable of systemic delivery to tumors in mouse models, but infection ...

journal_title：PLoS medicine

authors： Kirn DH,Wang Y,Le Boeuf F,Bell J,Thorne SH

更新日期：2007-12-01 00:00:00

abstract：:Chris Beyrer and colleagues reflect on an underappreciated trend in multiple African, Asian, and Caribbean settings, in which the provision of HIV and other essential health services for sexual and gender minorities is expanding despite challenging legal and social environments. ...

journal_title：PLoS medicine

authors： Beyrer C,Makofane K,Orazulike I,Diouf D,Baral SD

更新日期：2016-10-25 00:00:00