Biomarker-Defined Subsets of Common Diseases: Policy and Economic Implications of Orphan Drug Act Coverage.

abstract：BACKGROUND:Intravenous morphine (IVM) is the most common strong analgesic used in trauma, but is associated with a clear time limitation related to the need to obtain an access route. The intranasal (IN) route provides easy administration with a fast peak action time due to high vascularization and the absence of first...

journal_title：PLoS medicine

authors： Blancher M,Maignan M,Clapé C,Quesada JL,Collomb-Muret R,Albasini F,Ageron FX,Fey S,Wuyts A,Banihachemi JJ,Bertrand B,Lehmann A,Bollart C,Debaty G,Briot R,Viglino D

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:Research needs to be reported transparently so readers can critically assess the strengths and weaknesses of the design, conduct, and analysis of studies. Reporting guidelines have been developed to inform reporting for a variety of study designs. The objective of this study was to identify whether there is ...

journal_title：PLoS medicine

authors： Bennett C,Khangura S,Brehaut JC,Graham ID,Moher D,Potter BK,Grimshaw JM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Outbreaks of emerging infectious diseases, especially those of a global nature, require rapid epidemiological analysis and information dissemination. The final products of those activities usually comprise internal memoranda and briefs within public health authorities and original research published in peer-...

journal_title：PLoS medicine

authors： Xing W,Hejblum G,Leung GM,Valleron AJ

更新日期：2010-05-04 00:00:00

abstract：:Considerable progress has been made in reducing maternal, newborn, and child mortality worldwide, but many more deaths could be prevented if effective interventions were available to all who could benefit from them. Timely, high-quality measurements of intervention coverage--the proportion of a population in need of a...

journal_title：PLoS medicine

authors： Bryce J,Arnold F,Blanc A,Hancioglu A,Newby H,Requejo J,Wardlaw T,CHERG Working Group on Improving Coverage Measurement.

更新日期：2013-01-01 00:00:00

abstract：:In an Editorial, Guest Editors Nicola Low and Nathalie Broutet discuss the Collection on sexually transmitted infections in the context of research priorities in the field. ...

journal_title：PLoS medicine

authors： Low N,Broutet NJ

更新日期：2017-12-27 00:00:00

abstract：:Voluntary medical male circumcision (VMMC) is capable of reducing the risk of sexual transmission of HIV from females to males by approximately 60%. In 2007, the WHO and the Joint United Nations Programme on HIV/AIDS (UNAIDS) recommended making VMMC part of a comprehensive HIV prevention package in countries with a ge...

journal_title：PLoS medicine

authors： Sgaier SK,Reed JB,Thomas A,Njeuhmeli E

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:The alpha-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, the epidemiological description of the relationships between alpha-thalassaemia, malaria, and othe...

journal_title：PLoS medicine

authors： Wambua S,Mwangi TW,Kortok M,Uyoga SM,Macharia AW,Mwacharo JK,Weatherall DJ,Snow RW,Marsh K,Williams TN

更新日期：2006-05-01 00:00:00

abstract：:Financial risk protection is a key component of universal health coverage (UHC), which is defined as access to all needed quality health services without financial hardship. As part of the PLOS Medicine Collection on measurement of UHC, the aim of this paper is to examine and to compare and contrast existing measures ...

journal_title：PLoS medicine

authors： Saksena P,Hsu J,Evans DB

更新日期：2014-09-22 00:00:00

abstract：:In an Editorial, Ligia Kiss and Cathy Zimmerman discuss the need for research on the prevention of human trafficking and mitigation of its effects. ...

journal_title：PLoS medicine

authors： Kiss L,Zimmerman C

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Many low- and middle-income countries are not on track to reach the public health targets set out in the Millennium Development Goals (MDGs). We evaluated whether differential progress towards health MDGs was associated with economic development, public health funding (both overall and as percentage of avail...

journal_title：PLoS medicine

authors： Stuckler D,Basu S,McKee M

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:Previous epidemiological studies suggest that working-aged persons with a history of moderate-to-severe traumatic brain injury (TBI) may have an increased risk for developing neurodegenerative disease (NDD) while persons with a history of mild TBI do not. In this comprehensive nationwide study in Finland, we...

journal_title：PLoS medicine

authors： Raj R,Kaprio J,Korja M,Mikkonen ED,Jousilahti P,Siironen J

更新日期：2017-07-05 00:00:00

abstract：:In this month's editorial, the PLOS Medicine Editors discuss the role of preprints in human health research and propose a 3-part framework for ensuring benefit. ...

journal_title：PLoS medicine

authors： Peiperl L,PLOS Medicine Editors.

更新日期：2018-04-16 00:00:00

abstract：BACKGROUND:Policymakers worldwide are considering requiring warnings for sugary drinks. A growing number of experimental studies have examined sugary drink warnings' impacts, but no research to our knowledge has synthesized this literature. To inform ongoing policy debates, this study aimed to identify the effects of s...

journal_title：PLoS medicine

authors： Grummon AH,Hall MG

更新日期：2020-05-20 00:00:00

abstract：BACKGROUND:Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large populations treated in routine clinical practice is lacking. The objective of this study was to measure the association...

journal_title：PLoS medicine

authors： Douglas IJ,Bhaskaran K,Batterham RL,Smeeth L

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Despite repeated outbreaks, in particular the devastating 2014-2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among the drug candidates is the broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile in patients with EVD (JI...

journal_title：PLoS medicine

authors： Guedj J,Piorkowski G,Jacquot F,Madelain V,Nguyen THT,Rodallec A,Gunther S,Carbonnelle C,Mentré F,Raoul H,de Lamballerie X

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:A number of epidemiologic studies have observed an association between secondhand smoke (SHS) exposure and pediatric invasive bacterial disease (IBD) but the evidence has not been systematically reviewed. We carried out a systematic review and meta-analysis of SHS exposure and two outcomes, IBD and pharyngea...

journal_title：PLoS medicine

authors： Lee CC,Middaugh NA,Howie SR,Ezzati M

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:The World Health Organization has endorsed the Xpert MTB/RIF assay for investigation of patients suspected of having tuberculosis (TB). However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral t...

journal_title：PLoS medicine

authors： Lawn SD,Brooks SV,Kranzer K,Nicol MP,Whitelaw A,Vogt M,Bekker LG,Wood R

更新日期：2011-07-01 00:00:00

abstract：:In a Perspective, David Peiris and Dorairaj Prabhakaran discuss implications and challenges of cardiovascular disease risk assessments in the population of India. ...

journal_title：PLoS medicine

authors： Peiris D,Prabhakaran D

更新日期：2018-06-19 00:00:00

abstract：:Christian Lienhardt and co-authors discuss the conclusions of the PLOS Medicine Collection on advances in clinical trial design for development of new tuberculosis treatments. ...

journal_title：PLoS medicine

authors： Lienhardt C,Nunn A,Chaisson R,Vernon AA,Zignol M,Nahid P,Delaporte E,Kasaeva T

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:Counties are the smallest unit for which mortality data are routinely available, allowing consistent and comparable long-term analysis of trends in health disparities. Average life expectancy has steadily increased in the United States but there is limited information on long-term mortality trends in the US ...

journal_title：PLoS medicine

authors： Ezzati M,Friedman AB,Kulkarni SC,Murray CJ

更新日期：2008-04-22 00:00:00

abstract：BACKGROUND:While patterns of incidence of clinical influenza have been well described, much uncertainty remains over patterns of incidence of infection. The 2009 pandemic provided both the motivation and opportunity to investigate patterns of mild and asymptomatic infection using serological techniques. However, to dat...

journal_title：PLoS medicine

authors： Riley S,Kwok KO,Wu KM,Ning DY,Cowling BJ,Wu JT,Ho LM,Tsang T,Lo SV,Chu DK,Ma ES,Peiris JS

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:With cesarean section rates increasing worldwide, clarity regarding negative effects is essential. This study aimed to investigate the rate of subsequent stillbirth, miscarriage, and ectopic pregnancy following primary cesarean section, controlling for confounding by indication. METHODS AND FINDINGS:We perf...

journal_title：PLoS medicine

authors： O'Neill SM,Agerbo E,Kenny LC,Henriksen TB,Kearney PM,Greene RA,Mortensen PB,Khashan AS

更新日期：2014-07-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1003293.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:This paper examines the efforts of consultants affiliated with Philip Morris (PM), the world's leading transnational tobacco corporation, to influence scientific research and training in Thailand via the Chulabhorn Research Institute (CRI). A leading Southeast Asian institute for environmental health science...

journal_title：PLoS medicine

authors： Mackenzie R,Collin J

更新日期：2008-12-23 00:00:00

abstract：BACKGROUND:Resistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is increasing in prevalence in Africa. Combination therapy can both improve treatment and provide important public health benefits if it curbs the spread of parasites harbouring resistance genes. Thus, drug combinations m...

journal_title：PLoS medicine

authors： Sutherland CJ,Ord R,Dunyo S,Jawara M,Drakeley CJ,Alexander N,Coleman R,Pinder M,Walraven G,Targett GA

更新日期：2005-04-01 00:00:00

abstract：:Kwonjune Seung and colleagues describe the Eugene Bell Foundation's experience of treating MDR-TB in North Korea. ...

journal_title：PLoS medicine

authors： Seung KJ,Franke M,Linton SW

更新日期：2016-08-02 00:00:00

abstract：BACKGROUND:National responses will need to be markedly accelerated to achieve the ambitious target of the Joint United Nations Programme on HIV/AIDS (UNAIDS). This target aims for 90% of HIV-positive individuals to be aware of their status, for 90% of those aware to receive antiretroviral therapy (ART), and for 90% of ...

journal_title：PLoS medicine

authors： Maheu-Giroux M,Vesga JF,Diabaté S,Alary M,Baral S,Diouf D,Abo K,Boily MC

更新日期：2017-06-15 00:00:00

abstract：:Harald Schmidt and Anne Barnhill highlight the need to ensure equity in the proposed Sustainable Development Goals. ...

journal_title：PLoS medicine

authors： Schmidt H,Barnhill A

更新日期：2015-09-08 00:00:00

abstract：BACKGROUND:Various risk factors have been associated with epithelial ovarian cancer risk in observational epidemiological studies. However, the causal nature of the risk factors reported, and thus their suitability as effective intervention targets, is unclear given the susceptibility of conventional observational desi...

journal_title：PLoS medicine

authors： Yarmolinsky J,Relton CL,Lophatananon A,Muir K,Menon U,Gentry-Maharaj A,Walther A,Zheng J,Fasching P,Zheng W,Yin Ling W,Park SK,Kim BG,Choi JY,Park B,Davey Smith G,Martin RM,Lewis SJ

更新日期：2019-08-07 00:00:00

abstract：:H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials. ...

journal_title：PLoS medicine

authors： van der Worp HB,Howells DW,Sena ES,Porritt MJ,Rewell S,O'Collins V,Macleod MR

更新日期：2010-03-30 00:00:00