Preprints in medical research: Progress and principles.

abstract：BACKGROUND:Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate mortality for patients with the major subtypes of breast cancer as classified using five immunohistochemical markers, to investigate ...

journal_title：PLoS medicine

authors： Blows FM,Driver KE,Schmidt MK,Broeks A,van Leeuwen FE,Wesseling J,Cheang MC,Gelmon K,Nielsen TO,Blomqvist C,Heikkilä P,Heikkinen T,Nevanlinna H,Akslen LA,Bégin LR,Foulkes WD,Couch FJ,Wang X,Cafourek V,Olson JE,Bag

更新日期：2010-05-25 00:00:00

abstract：BACKGROUND:Drug manufacturers have developed "evergreening" strategies to compete with generic medication after patent termination. These include marketing of slightly modified follow-on drugs. We aimed to estimate the financial impact of these drugs on overall healthcare costs and also to examine the impact of listing...

journal_title：PLoS medicine

authors： Vernaz N,Haller G,Girardin F,Huttner B,Combescure C,Dayer P,Muscionico D,Salomon JL,Bonnabry P

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple chronic diseases and premature death, little is known about the combined impact on mortality outcomes, in particular among Chinese ...

journal_title：PLoS medicine

authors： Nechuta SJ,Shu XO,Li HL,Yang G,Xiang YB,Cai H,Chow WH,Ji B,Zhang X,Wen W,Gao YT,Zheng W

更新日期：2010-09-14 00:00:00

abstract：:In an Editorial, Guest Editors Nicola Low and Nathalie Broutet discuss the Collection on sexually transmitted infections in the context of research priorities in the field. ...

journal_title：PLoS medicine

authors： Low N,Broutet NJ

更新日期：2017-12-27 00:00:00

abstract：BACKGROUND:A number of epidemiologic studies have observed an association between secondhand smoke (SHS) exposure and pediatric invasive bacterial disease (IBD) but the evidence has not been systematically reviewed. We carried out a systematic review and meta-analysis of SHS exposure and two outcomes, IBD and pharyngea...

journal_title：PLoS medicine

authors： Lee CC,Middaugh NA,Howie SR,Ezzati M

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Cohort studies are recommended for understanding ethnic disparities in cardiovascular disease. Our objective was to review the process for identifying, including, and excluding ethnic minority populations in published cardiovascular cohort studies in Europe and North America. METHODS AND FINDINGS:We found t...

journal_title：PLoS medicine

authors： Ranganathan M,Bhopal R

更新日期：2006-03-01 00:00:00

abstract：:Sanjay Basu and Kristine Madsen discuss the effects of taxes on sugar-sweetened beverages in both Australia and Berkeley, USA. ...

journal_title：PLoS medicine

authors： Basu S,Madsen K

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Pancreatic cancer has an extremely poor prognosis and prolonged survival is achieved only by resection with macroscopic tumor clearance. There is a strong rationale for a neoadjuvant approach, since a relevant percentage of pancreatic cancer patients present with non-metastatic but locally advanced disease a...

journal_title：PLoS medicine

authors： Gillen S,Schuster T,Meyer Zum Büschenfelde C,Friess H,Kleeff J

更新日期：2010-04-20 00:00:00

abstract：BACKGROUND:Through major efforts to reduce costs and expand access to antiretroviral therapy worldwide, widespread delivery of effective treatment to people living with HIV/AIDS is now conceivable even in severely resource-constrained settings. However, the potential epidemiologic impact of treatment in the context of ...

journal_title：PLoS medicine

authors： Salomon JA,Hogan DR,Stover J,Stanecki KA,Walker N,Ghys PD,Schwartländer B

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Breast cancer is a leading malignancy affecting the female population worldwide. Most morbidity is caused by metastases that remain incurable to date. TGF-β1 has been identified as a key driving force behind metastatic breast cancer, with promising therapeutic implications. METHODS AND FINDINGS:Employing im...

journal_title：PLoS medicine

authors： Maris P,Blomme A,Palacios AP,Costanza B,Bellahcène A,Bianchi E,Gofflot S,Drion P,Trombino GE,Di Valentin E,Cusumano PG,Maweja S,Jerusalem G,Delvenne P,Lifrange E,Castronovo V,Turtoi A

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:To reduce the risk of drug-induced haemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the treatment of vivax malaria. This systematic review and individual patient meta-analysis assessed the uti...

journal_title：PLoS medicine

authors： Ley B,Winasti Satyagraha A,Rahmat H,von Fricken ME,Douglas NM,Pfeffer DA,Espino F,von Seidlein L,Henriques G,Oo NN,Menard D,Parikh S,Bancone G,Karahalios A,Price RN

更新日期：2019-12-13 00:00:00

abstract：:In a Perspective, Lynn Morris and Nonhlanhla Mkhize discuss the prospects for broadly neutralizing antibodies to be used in preventing HIV infection. ...

journal_title：PLoS medicine

authors： Morris L,Mkhize NN

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:For more than a decade, most parts of Somalia have not been under the control of any type of government. This "failure of state" is complete in the central and southern regions and most apparent in Mogadishu, which had been for a long period in the hands of warlords deploying their private militias in a batt...

journal_title：PLoS medicine

authors： Odenwald M,Hinkel H,Schauer E,Neuner F,Schauer M,Elbert TR,Rockstroh B

更新日期：2007-12-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1001895.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Nutritional supplements may improve development of infants born small (preterm or small for gestational age [SGA]) but may increase the risk of later metabolic disease. We conducted a systematic review and meta-analysis to assess the effects of macronutrient supplements for infants born small on later develo...

journal_title：PLoS medicine

authors： Lin L,Amissah E,Gamble GD,Crowther CA,Harding JE

更新日期：2019-10-30 00:00:00

abstract：BACKGROUND:Bilharzia is one of the major parasitic infections affecting the public health and socioeconomic circumstances in (sub) tropical areas. Its causative agents are schistosomes. Since these worms remain in their host for decades, they have developed mechanisms to evade or resist the immune system. Like several ...

journal_title：PLoS medicine

authors： Sprong H,Suchanek M,van Dijk SM,van Remoortere A,Klumperman J,Avram D,van der Linden J,Leusen JH,van Hellemond JJ,Thiele C

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated. METHODS AND FINDINGS:In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of T...

journal_title：PLoS medicine

authors： Dunning J,Sahr F,Rojek A,Gannon F,Carson G,Idriss B,Massaquoi T,Gandi R,Joseph S,Osman HK,Brooks TJ,Simpson AJ,Goodfellow I,Thorne L,Arias A,Merson L,Castle L,Howell-Jones R,Pardinaz-Solis R,Hope-Gill B,Ferri M,

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Whole genome sequencing provides better delineation of transmission clusters in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal individual transmission links within clusters is limited. Here, we used a 2-step approach based on Bayesian transmission reconstruction to (1) id...

journal_title：PLoS medicine

authors： Xu Y,Cancino-Muñoz I,Torres-Puente M,Villamayor LM,Borrás R,Borrás-Máñez M,Bosque M,Camarena JJ,Colomer-Roig E,Colomina J,Escribano I,Esparcia-Rodríguez O,Gil-Brusola A,Gimeno C,Gimeno-Gascón A,Gomila-Sard B,González-Gran

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-alpha and ribavirin (PegIFN/R). Viral clearance is achieved in 40%...

journal_title：PLoS medicine

authors： Suppiah V,Gaudieri S,Armstrong NJ,O'Connor KS,Berg T,Weltman M,Abate ML,Spengler U,Bassendine M,Dore GJ,Irving WL,Powell E,Hellard M,Riordan S,Matthews G,Sheridan D,Nattermann J,Smedile A,Müller T,Hammond E,Dunn D

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:In recent decades, increased attention has been focused on the impact of disabilities and medicinal drug use on road safety. The aim of our study was to investigate the association between prescription medicines and the risk of road traffic crashes, and estimate the attributable fraction. METHODS AND FINDIN...

journal_title：PLoS medicine

authors： Orriols L,Delorme B,Gadegbeku B,Tricotel A,Contrand B,Laumon B,Salmi LR,Lagarde E,CESIR research group.

更新日期：2010-11-16 00:00:00

abstract：BACKGROUND:Global warming is predicted to indirectly result in more undernutrition by threatening crop production. Whether temperature rise could affect undernutrition directly is unknown. We aim to quantify the relationship between short-term heat exposure and risk of hospitalization due to undernutrition in Brazil. ...

journal_title：PLoS medicine

authors： Xu R,Zhao Q,Coelho MSZS,Saldiva PHN,Abramson MJ,Li S,Guo Y

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:Although the success of HIV treatment programs depends on retention and viral suppression, routine program monitoring of these outcomes may be incomplete. We used data from the national electronic medical record (EMR) system in Zambia to enumerate a large and regionally representative cohort of patients on t...

journal_title：PLoS medicine

authors： Sikazwe I,Eshun-Wilson I,Sikombe K,Czaicki N,Somwe P,Mody A,Simbeza S,Glidden DV,Chizema E,Mulenga LB,Padian N,Duncombe CJ,Bolton-Moore C,Beres LK,Holmes CB,Geng E

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:The risk of perinatal death and severe neonatal morbidity increases gradually after 41 weeks of pregnancy. Several randomised controlled trials (RCTs) have assessed if induction of labour (IOL) in uncomplicated pregnancies at 41 weeks will improve perinatal outcomes. We performed an individual participant da...

journal_title：PLoS medicine

authors： Alkmark M,Keulen JKJ,Kortekaas JC,Bergh C,van Dillen J,Duijnhoven RG,Hagberg H,Mol BW,Molin M,van der Post JAM,Saltvedt S,Wikström AK,Wennerholm UB,de Miranda E

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:Policymakers worldwide are considering requiring warnings for sugary drinks. A growing number of experimental studies have examined sugary drink warnings' impacts, but no research to our knowledge has synthesized this literature. To inform ongoing policy debates, this study aimed to identify the effects of s...

journal_title：PLoS medicine

authors： Grummon AH,Hall MG

更新日期：2020-05-20 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1001659.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:The "fitness" of an infectious pathogen is defined as the ability of the pathogen to survive, reproduce, be transmitted, and cause disease. The fitness of multidrug-resistant tuberculosis (MDRTB) relative to drug-susceptible tuberculosis is cited as one of the most important determinants of MDRTB spread and ...

journal_title：PLoS medicine

authors： Grandjean L,Gilman RH,Martin L,Soto E,Castro B,Lopez S,Coronel J,Castillo E,Alarcon V,Lopez V,San Miguel A,Quispe N,Asencios L,Dye C,Moore DA

更新日期：2015-06-23 00:00:00

abstract：BACKGROUND:Many low- and middle-income countries are not on track to reach the public health targets set out in the Millennium Development Goals (MDGs). We evaluated whether differential progress towards health MDGs was associated with economic development, public health funding (both overall and as percentage of avail...

journal_title：PLoS medicine

authors： Stuckler D,Basu S,McKee M

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emerging chloroquine resistance. We undertook a systematic review and individual patient data meta-analysis to compare the efficacies of dihydroartemisinin-piperaquine (DP) and artemether-lumefan...

journal_title：PLoS medicine

authors： Commons RJ,Simpson JA,Thriemer K,Abreha T,Adam I,Anstey NM,Assefa A,Awab GR,Baird JK,Barber BE,Chu CS,Dahal P,Daher A,Davis TME,Dondorp AM,Grigg MJ,Humphreys GS,Hwang J,Karunajeewa H,Laman M,Lidia K,Moore BR,M

更新日期：2019-10-04 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002781.]. ...

journal_title：PLoS medicine

authors： Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74

更新日期：2019-07-18 00:00:00

abstract：BACKGROUND:Renal involvement is a serious manifestation of systemic lupus erythematosus (SLE); it may portend a poor prognosis as it may lead to end-stage renal disease (ESRD). The purpose of this study was to determine the factors predicting the development of renal involvement and its progression to ESRD in a multi-e...

journal_title：PLoS medicine

authors： Alarcón GS,McGwin G Jr,Petri M,Ramsey-Goldman R,Fessler BJ,Vilá LM,Edberg JC,Reveille JD,Kimberly RP,PROFILE Study Group.

更新日期：2006-10-01 00:00:00