Patented drug extension strategies on healthcare spending: a cost-evaluation analysis.

abstract：BACKGROUND:The anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab improves outcomes in patients with node-positive HER2+ early breast cancer. Given trastuzumab's high cost, we aimed to estimate its cost-effectiveness by heterogeneity in age and estrogen receptor (ER) and progesterone r...

journal_title：PLoS medicine

authors： Leung W,Kvizhinadze G,Nair N,Blakely T

更新日期：2016-08-09 00:00:00

abstract：:Drawing upon interviews with experts and a review of the literature, Gavin Yamey proposes a new framework for scaling up global health interventions. ...

journal_title：PLoS medicine

authors： Yamey G

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND TO THE DEBATE:The UK Medical Research Council defines complex interventions as those comprising "a number of separate elements which seem essential to the proper functioning of the interventions although the 'active ingredient' of the intervention that is effective is difficult to specify." A typical example...

journal_title：PLoS medicine

authors： Shepperd S,Lewin S,Straus S,Clarke M,Eccles MP,Fitzpatrick R,Wong G,Sheikh A

更新日期：2009-08-01 00:00:00

abstract：:Martin Gerdin and colleagues argue that disaster health interventions and decision-making can benefit from an evidence-based approach Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Gerdin M,Clarke M,Allen C,Kayabu B,Summerskill W,Devane D,MacLachlan M,Spiegel P,Ghosh A,Zachariah R,Gupta S,Barbour V,Murray V,von Schreeb J

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Although the success of HIV treatment programs depends on retention and viral suppression, routine program monitoring of these outcomes may be incomplete. We used data from the national electronic medical record (EMR) system in Zambia to enumerate a large and regionally representative cohort of patients on t...

journal_title：PLoS medicine

authors： Sikazwe I,Eshun-Wilson I,Sikombe K,Czaicki N,Somwe P,Mody A,Simbeza S,Glidden DV,Chizema E,Mulenga LB,Padian N,Duncombe CJ,Bolton-Moore C,Beres LK,Holmes CB,Geng E

更新日期：2019-05-31 00:00:00

abstract：:The PLoS Medicine Editors discuss the link between shift work, diet, and type 2 diabetes, and argue that unhealthy eating should be considered a new form of occupational hazard. ...

journal_title：PLoS medicine

authors： PLoS Medicine Editors.

更新日期：2011-12-01 00:00:00

abstract：:Tom Boyles reflects on differing approaches taken for treating patients with Ebola virus disease in low- and high-resource settings. ...

journal_title：PLoS medicine

authors： Boyles TH

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:It is unclear whether an upper gastrointestinal bleed is an isolated gastrointestinal event or an indicator of a deterioration in a patient's overall health status. Therefore, we investigated the excess causes of death in individuals after a non-variceal bleed compared with deaths in a matched sample of the ...

journal_title：PLoS medicine

authors： Crooks CJ,Card TR,West J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load. METHODS AND FINDINGS:Using data from the Collaboration of Observational HIV E...

journal_title：PLoS medicine

authors： Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord.,Young J,Psichogiou M,Meyer L,Ayayi S,Grabar S,Raffi F,Reiss P,Gazzard B,Sharland M,Gutierrez F

更新日期：2012-01-01 00:00:00

abstract：:In an essay, Paul Bloem and Ikechukwu Ogbuanu discuss the public health implications of HPV vaccination. ...

journal_title：PLoS medicine

authors： Bloem P,Ogbuanu I

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Despite repeated outbreaks, in particular the devastating 2014-2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among the drug candidates is the broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile in patients with EVD (JI...

journal_title：PLoS medicine

authors： Guedj J,Piorkowski G,Jacquot F,Madelain V,Nguyen THT,Rodallec A,Gunther S,Carbonnelle C,Mentré F,Raoul H,de Lamballerie X

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the leading cause of cancer-related mortality in children. T cell ALL (T-ALL) represents about 15% of pediatric ALL cases and is considered a high-risk disease. T-ALL is often associated with resistance to treatment, includi...

journal_title：PLoS medicine

authors： Li Y,Buijs-Gladdines JG,Canté-Barrett K,Stubbs AP,Vroegindeweij EM,Smits WK,van Marion R,Dinjens WN,Horstmann M,Kuiper RP,Buijsman RC,Zaman GJ,van der Spek PJ,Pieters R,Meijerink JP

更新日期：2016-12-20 00:00:00

abstract：BACKGROUND:Hip and knee replacement are some of the most frequently performed surgical procedures in the world. Resurfacing of the hip and unicondylar knee replacement are increasingly being used. There is relatively little evidence on their performance. To study performance of joint replacement in England, we investig...

journal_title：PLoS medicine

authors： Sibanda N,Copley LP,Lewsey JD,Borroff M,Gregg P,MacGregor AJ,Pickford M,Porter M,Tucker K,van der Meulen JH,Steering Committee of the National Joint Registry (NJR) for England and Wales.

更新日期：2008-09-30 00:00:00

abstract：BACKGROUND:The World Health Organization has endorsed the Xpert MTB/RIF assay for investigation of patients suspected of having tuberculosis (TB). However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral t...

journal_title：PLoS medicine

authors： Lawn SD,Brooks SV,Kranzer K,Nicol MP,Whitelaw A,Vogt M,Bekker LG,Wood R

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The association between fetal exposure to major radiodiagnostic testing in pregnancy-computed tomography (CT) and radionuclide imaging-and the risk of childhood cancer is not established. METHODS AND FINDINGS:We completed a population-based study of 1.8 million maternal-child pairs in the province of Ontari...

journal_title：PLoS medicine

authors： Ray JG,Schull MJ,Urquia ML,You JJ,Guttmann A,Vermeulen MJ

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:The global tuberculosis epidemic results in nearly 2 million deaths and 9 million new cases of the disease a year. The vast majority of tuberculosis patients live in developing countries, where the diagnosis of tuberculosis relies on the identification of acid-fast bacilli on unprocessed sputum smears using ...

journal_title：PLoS medicine

authors： Steingart KR,Henry M,Laal S,Hopewell PC,Ramsay A,Menzies D,Cunningham J,Weldingh K,Pai M

更新日期：2007-06-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002511.]. ...

journal_title：PLoS medicine

authors： Torrone EA,Morrison CS,Chen PL,Kwok C,Francis SC,Hayes RJ,Looker KJ,McCormack S,McGrath N,van de Wijgert JHHM,Watson-Jones D,Low N,Gottlieb SL,STIMA Working Group.

更新日期：2018-06-26 00:00:00

abstract：:Philippe Calain discusses the health and environmental hazards of extractive industries like mining and explores the tensions that arise when medical humanitarian organizations are called to intervene in emergencies involving the extractive sector. ...

journal_title：PLoS medicine

authors： Calain P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Intimate partner violence (IPV) against women is a major global health issue, particularly in low- and middle-income countries (LMICs), that is associated with poor physical and mental health, but its association with breastfeeding practices is understudied. Both the World Health Organization (WHO) and the U...

journal_title：PLoS medicine

authors： Caleyachetty R,Uthman OA,Bekele HN,Martín-Cañavate R,Marais D,Coles J,Steele B,Uauy R,Koniz-Booher P

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Puberty is a critical period for bone mass accrual, and late puberty in boys is associated with reduced bone mass in adult men. The role of variations in pubertal timing within the normal range for adult fracture risk in men is, however, unknown. We, therefore, assessed the association between age at peak he...

journal_title：PLoS medicine

authors： Vandenput L,Kindblom JM,Bygdell M,Nethander M,Ohlsson C

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Evidence on where in the hypertension care process individuals are lost to care, and how this varies among states and population groups in a country as large as India, is essential for the design of targeted interventions and to monitor progress. Yet, to our knowledge, there has not yet been a nationally rep...

journal_title：PLoS medicine

authors： Prenissl J,Manne-Goehler J,Jaacks LM,Prabhakaran D,Awasthi A,Bischops AC,Atun R,Bärnighausen T,Davies JI,Vollmer S,Geldsetzer P

更新日期：2019-05-03 00:00:00

abstract：BACKGROUND:Although gastric cancer has declined dramatically in the US, the disease remains the second leading cause of cancer mortality worldwide. A better understanding of reasons for the decline can provide important insights into effective preventive strategies. We sought to estimate the contribution of risk factor...

journal_title：PLoS medicine

authors： Yeh JM,Hur C,Schrag D,Kuntz KM,Ezzati M,Stout N,Ward Z,Goldie SJ

更新日期：2013-01-01 00:00:00

abstract：:Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due to advancements in both prevention and treatment of HIV. However, major challenges still remain. We describe basic principles of epidemic control in the context of HIV and identify a number of attainable goals in terms of control a...

journal_title：PLoS medicine

authors： Jones J,Sullivan PS,Curran JW

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:Antenatal corticosteroid therapy (ACT) is used clinically to prepare the fetal lung for impending preterm birth, but animal and human studies link corticosteroids to smaller birth size. Whether ACT is associated with birth size is debated; therefore, we assessed differences in birth size in treated versus un...

journal_title：PLoS medicine

authors： Rodriguez A,Wang Y,Ali Khan A,Cartwright R,Gissler M,Järvelin MR

更新日期：2019-02-26 00:00:00

abstract：BACKGROUND:Growing prevalence of atrial fibrillation (AF) in the ageing population and its associated life-changing health and resource implications have led to a need to improve its early detection. Primary care is an ideal place to screen for AF; however, this is limited by shortages in general practitioner (GP) reso...

journal_title：PLoS medicine

authors： Savickas V,Stewart AJ,Rees-Roberts M,Short V,Bhamra SK,Corlett SA,Mathie A,Veale EL

更新日期：2020-07-17 00:00:00

abstract：BACKGROUND:Our objective was to examine whether gestational diabetes mellitus (GDM) or newborns' high birthweight can be prevented by lifestyle counseling in pregnant women at high risk of GDM. METHOD AND FINDINGS:We conducted a cluster-randomized trial, the NELLI study, in 14 municipalities in Finland, where 2,271 wo...

journal_title：PLoS medicine

authors： Luoto R,Kinnunen TI,Aittasalo M,Kolu P,Raitanen J,Ojala K,Mansikkamäki K,Lamberg S,Vasankari T,Komulainen T,Tulokas S

更新日期：2011-05-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1003293.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:Electronic medical records provide large-scale real-world clinical data for use in developing clinical decision systems. However, sophisticated methodology and analytical skills are required to handle the large-scale datasets necessary for the optimisation of prediction accuracy. Myopia is a common cause of ...

journal_title：PLoS medicine

authors： Lin H,Long E,Ding X,Diao H,Chen Z,Liu R,Huang J,Cai J,Xu S,Zhang X,Wang D,Chen K,Yu T,Wu D,Zhao X,Liu Z,Wu X,Jiang Y,Yang X,Cui D,Liu W,Zheng Y,Luo L,Wang H,Chan CC,Morgan IG,He M,Liu Y

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Envenoming resulting from snakebites is an important public health problem in many tropical and subtropical countries. Few attempts have been made to quantify the burden, and recent estimates all suffer from the lack of an objective and reproducible methodology. In an attempt to provide an accurate, up-to-da...

journal_title：PLoS medicine

authors： Kasturiratne A,Wickremasinghe AR,de Silva N,Gunawardena NK,Pathmeswaran A,Premaratna R,Savioli L,Lalloo DG,de Silva HJ

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups. ME...

journal_title：PLoS medicine

authors： Lipnicki DM,Makkar SR,Crawford JD,Thalamuthu A,Kochan NA,Lima-Costa MF,Castro-Costa E,Ferri CP,Brayne C,Stephan B,Llibre-Rodriguez JJ,Llibre-Guerra JJ,Valhuerdi-Cepero AJ,Lipton RB,Katz MJ,Derby CA,Ritchie K,Ancelin ML

更新日期：2019-07-23 00:00:00