Multidrug-Resistant Tuberculosis Treatment in North Korea: Is Scale-Up Possible?

abstract：BACKGROUND:Cohort studies are recommended for understanding ethnic disparities in cardiovascular disease. Our objective was to review the process for identifying, including, and excluding ethnic minority populations in published cardiovascular cohort studies in Europe and North America. METHODS AND FINDINGS:We found t...

journal_title：PLoS medicine

authors： Ranganathan M,Bhopal R

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Exposure to a nutritionally deficient environment during fetal life and early infancy may adversely alter the ontogeny of the immune system and affect an infant's ability to mount an optimal immune response to vaccination. We examined the effects of maternal nutritional supplementation during pregnancy on in...

journal_title：PLoS medicine

authors： Okala SG,Darboe MK,Sosseh F,Sonko B,Faye-Joof T,Prentice AM,Moore SE

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Previous estimates of mortality in Iraq attributable to the 2003 invasion have been heterogeneous and controversial, and none were produced after 2006. The purpose of this research was to estimate direct and indirect deaths attributable to the war in Iraq between 2003 and 2011. METHODS AND FINDINGS:We condu...

journal_title：PLoS medicine

authors： Hagopian A,Flaxman AD,Takaro TK,Esa Al Shatari SA,Rajaratnam J,Becker S,Levin-Rector A,Galway L,Hadi Al-Yasseri BJ,Weiss WM,Murray CJ,Burnham G

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Intravenous morphine (IVM) is the most common strong analgesic used in trauma, but is associated with a clear time limitation related to the need to obtain an access route. The intranasal (IN) route provides easy administration with a fast peak action time due to high vascularization and the absence of first...

journal_title：PLoS medicine

authors： Blancher M,Maignan M,Clapé C,Quesada JL,Collomb-Muret R,Albasini F,Ageron FX,Fey S,Wuyts A,Banihachemi JJ,Bertrand B,Lehmann A,Bollart C,Debaty G,Briot R,Viglino D

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:The contribution of low-penetrant susceptibility variants to cancer is not clear. With the aim of searching for genetic factors that contribute to cancer at one or more sites in the body, we have analyzed familial aggregation of cancer in extended families based on all cancer cases diagnosed in Iceland over ...

journal_title：PLoS medicine

authors： Amundadottir LT,Thorvaldsson S,Gudbjartsson DF,Sulem P,Kristjansson K,Arnason S,Gulcher JR,Bjornsson J,Kong A,Thorsteinsdottir U,Stefansson K

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Global data indicate that women with a history of hyperglycemia first detected in pregnancy (HFDP) are at up to 7 times risk of progressing to type 2 diabetes mellitus (T2DM) compared with their counterparts who have pregnancies that are not complicated by hyperglycemia. However, there are no data from the s...

journal_title：PLoS medicine

authors： Chivese T,Norris SA,Levitt NS

更新日期：2019-09-09 00:00:00

abstract：BACKGROUND:Women with preeclampsia (PEC) and gestational hypertension (GH) exhibit insulin resistance during pregnancy, independent of obesity and glucose intolerance. Our aim was to determine whether women with PEC or GH during pregnancy have an increased risk of developing diabetes after pregnancy, and whether the pr...

journal_title：PLoS medicine

authors： Feig DS,Shah BR,Lipscombe LL,Wu CF,Ray JG,Lowe J,Hwee J,Booth GL

更新日期：2013-01-01 00:00:00

abstract：:In a Policy Forum, Irva Hertz-Picciotto and colleagues review the scientific evidence linking organophosphate pesticides to cognitive, behavioral, and neurological deficits in children and recommend actions to reduce exposures. ...

journal_title：PLoS medicine

authors： Hertz-Picciotto I,Sass JB,Engel S,Bennett DH,Bradman A,Eskenazi B,Lanphear B,Whyatt R

更新日期：2018-10-24 00:00:00

abstract：BACKGROUND:The World Health Organization has endorsed the Xpert MTB/RIF assay for investigation of patients suspected of having tuberculosis (TB). However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral t...

journal_title：PLoS medicine

authors： Lawn SD,Brooks SV,Kranzer K,Nicol MP,Whitelaw A,Vogt M,Bekker LG,Wood R

更新日期：2011-07-01 00:00:00

abstract：:Leo Sher and colleagues discuss recent research on interventions to prevent secondary suicide and discuss the additional research that is needed. ...

journal_title：PLoS medicine

authors： Ganz D,Braquehais MD,Sher L

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Patients with multimorbidities have the greatest healthcare needs and generate the highest expenditure in the health system. There is an increasing focus on identifying specific disease combinations for addressing poor outcomes. Existing research has identified a small number of prevalent "clusters" in the g...

journal_title：PLoS medicine

authors： Stokes J,Guthrie B,Mercer SW,Rice N,Sutton M

更新日期：2021-01-13 00:00:00

abstract：:How do we spot the next sexually transmitted infection? Kyle Bernstein and colleagues look for lessons from past discovery. ...

journal_title：PLoS medicine

authors： Bernstein K,Bowen VB,Kim CR,Counotte MJ,Kirkcaldy RD,Kara E,Bolan G,Low N,Broutet N

更新日期：2017-12-27 00:00:00

abstract：BACKGROUND:HVTN 100 evaluated the safety and immunogenicity of an HIV subtype C pox-protein vaccine regimen, investigating a 12-month booster to extend vaccine-induced immune responses. METHODS AND FINDINGS:A phase 1-2 randomized double-blind placebo-controlled trial enrolled 252 participants (210 vaccine/42 placebo; ...

journal_title：PLoS medicine

authors： Laher F,Moodie Z,Cohen KW,Grunenberg N,Bekker LG,Allen M,Frahm N,Yates NL,Morris L,Malahleha M,Mngadi K,Daniels B,Innes C,Saunders K,Grant S,Yu C,Gilbert PB,Phogat S,DiazGranados CA,Koutsoukos M,Van Der Meeren O,

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:Violence against women by intimate partners remains unacceptably common worldwide. The evidence base for the assumed psychological impacts of intimate partner violence (IPV) is derived primarily from studies conducted in high-income countries. A recently published systematic review identified 13 studies link...

journal_title：PLoS medicine

authors： Tsai AC,Tomlinson M,Comulada WS,Rotheram-Borus MJ

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:Puberty is a critical period for bone mass accrual, and late puberty in boys is associated with reduced bone mass in adult men. The role of variations in pubertal timing within the normal range for adult fracture risk in men is, however, unknown. We, therefore, assessed the association between age at peak he...

journal_title：PLoS medicine

authors： Vandenput L,Kindblom JM,Bygdell M,Nethander M,Ohlsson C

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:The epidemiology of malaria makes surveillance-based methods of estimating its disease burden problematic. Cartographic approaches have provided alternative malaria burden estimates, but there remains widespread misunderstanding about their derivation and fidelity. The aims of this study are to present a new...

journal_title：PLoS medicine

authors： Hay SI,Okiro EA,Gething PW,Patil AP,Tatem AJ,Guerra CA,Snow RW

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-alpha and ribavirin (PegIFN/R). Viral clearance is achieved in 40%...

journal_title：PLoS medicine

authors： Suppiah V,Gaudieri S,Armstrong NJ,O'Connor KS,Berg T,Weltman M,Abate ML,Spengler U,Bassendine M,Dore GJ,Irving WL,Powell E,Hellard M,Riordan S,Matthews G,Sheridan D,Nattermann J,Smedile A,Müller T,Hammond E,Dunn D

更新日期：2011-09-01 00:00:00

abstract：:Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by...

journal_title：PLoS medicine

authors： Rabinovich RN,Drakeley C,Djimde AA,Hall BF,Hay SI,Hemingway J,Kaslow DC,Noor A,Okumu F,Steketee R,Tanner M,Wells TNC,Whittaker MA,Winzeler EA,Wirth DF,Whitfield K,Alonso PL

更新日期：2017-11-30 00:00:00

abstract：BACKGROUND:Hospitalisation for adversity-related injury (violent, drug/alcohol-related, or self-inflicted injury) has been described as a "teachable moment", when intervention may reduce risks of further harm. Which adolescents are likely to benefit most from intervention strongly depends on their long-term risks of ha...

journal_title：PLoS medicine

authors： Herbert A,Gilbert R,González-Izquierdo A,Pitman A,Li L

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:Type 2 diabetes (T2D) is a progressive disease whereby there is often deterioration in glucose control despite escalation in treatment. There is significant heterogeneity to this progression of glycemia after onset of diabetes, yet the factors that influence glycemic progression are not well understood. Give...

journal_title：PLoS medicine

authors： Jiang G,Luk AO,Tam CHT,Lau ES,Ozaki R,Chow EYK,Kong APS,Lim CKP,Lee KF,Siu SC,Hui G,Tsang CC,Lau KP,Leung JYY,Tsang MW,Kam G,Lau IT,Li JK,Yeung VT,Lau E,Lo S,Fung SKS,Cheng YL,Chow CC,Pearson ER,So WY,

更新日期：2020-07-28 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002511.]. ...

journal_title：PLoS medicine

authors： Torrone EA,Morrison CS,Chen PL,Kwok C,Francis SC,Hayes RJ,Looker KJ,McCormack S,McGrath N,van de Wijgert JHHM,Watson-Jones D,Low N,Gottlieb SL,STIMA Working Group.

更新日期：2018-06-26 00:00:00

abstract：BACKGROUND:The anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab improves outcomes in patients with node-positive HER2+ early breast cancer. Given trastuzumab's high cost, we aimed to estimate its cost-effectiveness by heterogeneity in age and estrogen receptor (ER) and progesterone r...

journal_title：PLoS medicine

authors： Leung W,Kvizhinadze G,Nair N,Blakely T

更新日期：2016-08-09 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associ...

journal_title：PLoS medicine

authors： Musso G,Gambino R,Tabibian JH,Ekstedt M,Kechagias S,Hamaguchi M,Hultcrantz R,Hagström H,Yoon SK,Charatcharoenwitthaya P,George J,Barrera F,Hafliðadóttir S,Björnsson ES,Armstrong MJ,Hopkins LJ,Gao X,Francque S,Verrijke

更新日期：2014-07-22 00:00:00

abstract：:Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due to advancements in both prevention and treatment of HIV. However, major challenges still remain. We describe basic principles of epidemic control in the context of HIV and identify a number of attainable goals in terms of control a...

journal_title：PLoS medicine

authors： Jones J,Sullivan PS,Curran JW

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:Epidemiological studies have provided compelling evidence of associations between ambient temperature and cardiovascular disease. However, evidence of effects of daily temperature variability on cardiovascular disease is scarce and mixed. We aimed to examine short-term associations between temperature variab...

journal_title：PLoS medicine

authors： Tian Y,Liu H,Si Y,Cao Y,Song J,Li M,Wu Y,Wang X,Xiang X,Juan J,Chen L,Wei C,Gao P,Hu Y

更新日期：2019-01-28 00:00:00

abstract：BACKGROUND:Leber congenital amaurosis (LCA) is a genetically heterogeneous group of retinal diseases that cause congenital blindness in infants and children. Mutations in the GUCY2D gene that encodes retinal guanylate cyclase-1 (retGC1) were the first to be linked to this disease group (LCA type 1 [LCA1]) and account f...

journal_title：PLoS medicine

authors： Williams ML,Coleman JE,Haire SE,Aleman TS,Cideciyan AV,Sokal I,Palczewski K,Jacobson SG,Semple-Rowland SL

更新日期：2006-06-01 00:00:00

abstract：:Christian Lienhardt and co-authors discuss the conclusions of the PLOS Medicine Collection on advances in clinical trial design for development of new tuberculosis treatments. ...

journal_title：PLoS medicine

authors： Lienhardt C,Nunn A,Chaisson R,Vernon AA,Zignol M,Nahid P,Delaporte E,Kasaeva T

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:Electronic medical records provide large-scale real-world clinical data for use in developing clinical decision systems. However, sophisticated methodology and analytical skills are required to handle the large-scale datasets necessary for the optimisation of prediction accuracy. Myopia is a common cause of ...

journal_title：PLoS medicine

authors： Lin H,Long E,Ding X,Diao H,Chen Z,Liu R,Huang J,Cai J,Xu S,Zhang X,Wang D,Chen K,Yu T,Wu D,Zhao X,Liu Z,Wu X,Jiang Y,Yang X,Cui D,Liu W,Zheng Y,Luo L,Wang H,Chan CC,Morgan IG,He M,Liu Y

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Tobacco addiction is a complex, multicomponent phenomenon stemming from nicotine's pharmacology and the user's biology, psychology, sociology, and environment. After decades of public denial, the tobacco industry now agrees with public health authorities that nicotine is addictive. In 2000, Philip Morris bec...

journal_title：PLoS medicine

authors： Elias J,Hendlin YH,Ling PM

更新日期：2018-05-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1001895.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2016-06-10 00:00:00