Re-emerging and newly recognized sexually transmitted infections: Can prior experiences shed light on future identification and control?

abstract：:Nathan Ford and Gottfried Hirnschall reflect on recent research by Jan Hontelez and colleagues published in this week's PLOS Medicine. The authors argue that the future HIV modeling efforts should focus on helping programs make choices about which interventions need to be prioritized in order to achieve the levels of ...

journal_title：PLoS medicine

authors： Ford N,Hirnschall G

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Although the involvement of intra-tumor genetic heterogeneity in tumor progression, treatment resistance, and metastasis is established, genetic heterogeneity is seldom examined in clinical trials or practice. Many studies of heterogeneity have had prespecified markers for tumor subpopulations, limiting thei...

journal_title：PLoS medicine

authors： Mroz EA,Tward AD,Hammon RJ,Ren Y,Rocco JW

更新日期：2015-02-10 00:00:00

abstract：BACKGROUND:Renal involvement is a serious manifestation of systemic lupus erythematosus (SLE); it may portend a poor prognosis as it may lead to end-stage renal disease (ESRD). The purpose of this study was to determine the factors predicting the development of renal involvement and its progression to ESRD in a multi-e...

journal_title：PLoS medicine

authors： Alarcón GS,McGwin G Jr,Petri M,Ramsey-Goldman R,Fessler BJ,Vilá LM,Edberg JC,Reveille JD,Kimberly RP,PROFILE Study Group.

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Hospitalisation for adversity-related injury (violent, drug/alcohol-related, or self-inflicted injury) has been described as a "teachable moment", when intervention may reduce risks of further harm. Which adolescents are likely to benefit most from intervention strongly depends on their long-term risks of ha...

journal_title：PLoS medicine

authors： Herbert A,Gilbert R,González-Izquierdo A,Pitman A,Li L

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:The proteases (secretases) that cleave amyloid-beta (Abeta) peptide from the amyloid precursor protein (APP) have been the focus of considerable investigation in the development of treatments for Alzheimer disease. The prediction has been that reducing Abeta production in the brain, even after the onset of c...

journal_title：PLoS medicine

authors： Jankowsky JL,Slunt HH,Gonzales V,Savonenko AV,Wen JC,Jenkins NA,Copeland NG,Younkin LH,Lester HA,Younkin SG,Borchelt DR

更新日期：2005-12-01 00:00:00

abstract：:Results from several observational studies of HIV-discordant couples and a randomized controlled trial (HIV Prevention Trials Network 052) show that antiretroviral therapy (ART) can greatly reduce heterosexual HIV transmission in stable HIV-discordant couples. However, such data do not prove that ART will reduce HIV i...

journal_title：PLoS medicine

authors： Smith MK,Powers KA,Muessig KE,Miller WC,Cohen MS

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Vital registration and cause of death reporting is incomplete in the countries in which the HIV epidemic is most severe. A reliable tool that is independent of HIV status is needed for measuring the frequency of AIDS deaths and ultimately the impact of antiretroviral therapy on mortality. METHODS AND FINDIN...

journal_title：PLoS medicine

authors： Lopman BA,Barnabas RV,Boerma JT,Chawira G,Gaitskell K,Harrop T,Mason P,Donnelly CA,Garnett GP,Nyamukapa C,Gregson S

更新日期：2006-08-01 00:00:00

abstract：:Drawing upon interviews with experts and a review of the literature, Gavin Yamey proposes a new framework for scaling up global health interventions. ...

journal_title：PLoS medicine

authors： Yamey G

更新日期：2011-06-01 00:00:00

abstract：:Thomas Platts-Mills and Matthew Perzanowski provide their expert Perspective on a translational study from Custovic and colleagues that identifies pairings of IgE that show value in estimating risk of concurrent asthma. ...

journal_title：PLoS medicine

authors： Platts-Mills TAE,Perzanowski M

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Bariatric and metabolic surgery is used as a treatment for patients with severe and complex obesity. However, there is a need to improve outcome selection and reporting in bariatric surgery trials. A Core Outcome Set (COS), an agreed minimum set of outcomes reported in all studies of a specific condition, ma...

journal_title：PLoS medicine

authors： Coulman KD,Hopkins J,Brookes ST,Chalmers K,Main B,Owen-Smith A,Andrews RC,Byrne J,Donovan JL,Mazza G,Reeves BC,Rogers CA,Thompson JL,Welbourn R,Wordsworth S,Blazeby JM,BARIACT working group.

更新日期：2016-11-29 00:00:00

abstract：BACKGROUND:The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages. Either drug can induce haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, necessitating screening. The reference diagnostic method for G6PD activ...

journal_title：PLoS medicine

authors： Pfeffer DA,Ley B,Howes RE,Adu P,Alam MS,Bansil P,Boum Y 2nd,Brito M,Charoenkwan P,Clements A,Cui L,Deng Z,Egesie OJ,Espino FE,von Fricken ME,Hamid MMA,He Y,Henriques G,Khan WA,Khim N,Kim S,Lacerda M,Lon C,Me

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:Effective implementation strategies are needed to increase engagement in HIV services in hyperendemic settings. We conducted a pragmatic cluster-randomized trial in a high-risk, highly mobile fishing community (HIV prevalence: approximately 38%) in Rakai, Uganda, to assess the impact of a community health wo...

journal_title：PLoS medicine

authors： Chang LW,Mbabali I,Hutton H,Amico KR,Kong X,Mulamba J,Anok A,Ssekasanvu J,Long A,Thomas AG,Thomas K,Bugos E,Pollard R,van Wickle K,Kennedy CE,Nalugoda F,Serwadda D,Bollinger RC,Quinn TC,Reynolds SJ,Gray RH,Wawer

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:A number of epidemiologic studies have observed an association between secondhand smoke (SHS) exposure and pediatric invasive bacterial disease (IBD) but the evidence has not been systematically reviewed. We carried out a systematic review and meta-analysis of SHS exposure and two outcomes, IBD and pharyngea...

journal_title：PLoS medicine

authors： Lee CC,Middaugh NA,Howie SR,Ezzati M

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Epidemiological studies have provided compelling evidence of associations between ambient temperature and cardiovascular disease. However, evidence of effects of daily temperature variability on cardiovascular disease is scarce and mixed. We aimed to examine short-term associations between temperature variab...

journal_title：PLoS medicine

authors： Tian Y,Liu H,Si Y,Cao Y,Song J,Li M,Wu Y,Wang X,Xiang X,Juan J,Chen L,Wei C,Gao P,Hu Y

更新日期：2019-01-28 00:00:00

abstract：BACKGROUND:Oncolytic viruses hold much promise for clinical treatment of many cancers, but a lack of systemic delivery and insufficient tumor cell killing have limited their usefulness. We have previously demonstrated that vaccinia virus strains are capable of systemic delivery to tumors in mouse models, but infection ...

journal_title：PLoS medicine

authors： Kirn DH,Wang Y,Le Boeuf F,Bell J,Thorne SH

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:The response to the next influenza pandemic will likely include extensive use of antiviral drugs (mainly oseltamivir), combined with other transmission-reducing measures. Animal and in vitro studies suggest that some strains of influenza may become resistant to oseltamivir while maintaining infectiousness (f...

journal_title：PLoS medicine

authors： Lipsitch M,Cohen T,Murray M,Levin BR

更新日期：2007-01-01 00:00:00

abstract：:Pharmacogenomics is one of the first clinical applications of the postgenomic era. It promises personalized medicine rather than the established "one size fits all" approach to drugs and dosages. The expected reduction in trial and error should ultimately lead to more efficient and safer drug therapy. In recent years,...

journal_title：PLoS medicine

authors： Swen JJ,Huizinga TW,Gelderblom H,de Vries EG,Assendelft WJ,Kirchheiner J,Guchelaar HJ

更新日期：2007-08-01 00:00:00

abstract：:A major challenge in monitoring universal health coverage (UHC) is identifying an indicator that can adequately capture the multiple components underlying the UHC initiative. Effective coverage, which unites individual and intervention characteristics into a single metric, offers a direct and flexible means to measure...

journal_title：PLoS medicine

authors： Ng M,Fullman N,Dieleman JL,Flaxman AD,Murray CJ,Lim SS

更新日期：2014-09-22 00:00:00

abstract：BACKGROUND:Despite repeated outbreaks, in particular the devastating 2014-2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among the drug candidates is the broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile in patients with EVD (JI...

journal_title：PLoS medicine

authors： Guedj J,Piorkowski G,Jacquot F,Madelain V,Nguyen THT,Rodallec A,Gunther S,Carbonnelle C,Mentré F,Raoul H,de Lamballerie X

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Antiretroviral-based interventions for HIV-1 prevention, including antiretroviral therapy (ART) to reduce the infectiousness of HIV-1 infected persons and pre-exposure prophylaxis (PrEP) to reduce the susceptibility of HIV-1 uninfected persons, showed high efficacy for HIV-1 protection in randomized clinical...

journal_title：PLoS medicine

authors： Baeten JM,Heffron R,Kidoguchi L,Mugo NR,Katabira E,Bukusi EA,Asiimwe S,Haberer JE,Morton J,Ngure K,Bulya N,Odoyo J,Tindimwebwa E,Hendrix C,Marzinke MA,Ware NC,Wyatt MA,Morrison S,Haugen H,Mujugira A,Donnell D,Ce

更新日期：2016-08-23 00:00:00

abstract：BACKGROUND:As the number of HIV-infected women initiating lifelong antiretroviral therapy (ART) during pregnancy increases globally, concerns have emerged regarding low levels of retention in HIV services and suboptimal adherence to ART during the postpartum period. We examined the impact of integrating postpartum ART ...

journal_title：PLoS medicine

authors： Myer L,Phillips TK,Zerbe A,Brittain K,Lesosky M,Hsiao NY,Remien RH,Mellins CA,McIntyre JA,Abrams EJ

更新日期：2018-03-30 00:00:00

abstract：BACKGROUND:Evidence suggests that variations in fasting glucose and insulin amongst those without frank type 2 diabetes mellitus are important determinants of cardiovascular disease. However, the relative importance of variations in fasting insulin, glucose, and glycated haemoglobin as risk factors for cardiovascular d...

journal_title：PLoS medicine

authors： Lawlor DA,Fraser A,Ebrahim S,Smith GD

更新日期：2007-08-01 00:00:00

abstract：:Aaron Kesselheim and colleagues examine orphan-designated drugs approved between 2009 and 2015 in the United States. ...

journal_title：PLoS medicine

authors： Kesselheim AS,Treasure CL,Joffe S

更新日期：2017-01-03 00:00:00

abstract：:In a Perspective, David Peiris and Dorairaj Prabhakaran discuss implications and challenges of cardiovascular disease risk assessments in the population of India. ...

journal_title：PLoS medicine

authors： Peiris D,Prabhakaran D

更新日期：2018-06-19 00:00:00

abstract：BACKGROUND:The optimal regimen for perioperative antimicrobial prophylaxis is controversial. Use of combination prophylaxis with a beta-lactam plus vancomycin is increasing; however, the relative risks and benefits associated with this strategy are unknown. Thus, we sought to compare postoperative outcomes following ad...

journal_title：PLoS medicine

authors： Branch-Elliman W,Ripollone JE,O'Brien WJ,Itani KMF,Schweizer ML,Perencevich E,Strymish J,Gupta K

更新日期：2017-07-10 00:00:00

abstract：BACKGROUND:Some 5%-15% of all women experience postpartum depression (PPD), which for many is their first psychiatric disorder. The purpose of this study was to estimate the incidence of postpartum affective disorder (AD), duration of treatment, and rate of subsequent postpartum AD and other affective episodes in a nat...

journal_title：PLoS medicine

authors： Rasmussen MH,Strøm M,Wohlfahrt J,Videbech P,Melbye M

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:Experimental studies have suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors provide cardiovascular protective effects. We performed a randomized study to evaluate the effects of sitagliptin added on to the conventional therapy compared with conventional therapy alone (diet, exercise, and/or drugs, exc...

journal_title：PLoS medicine

authors： Oyama J,Murohara T,Kitakaze M,Ishizu T,Sato Y,Kitagawa K,Kamiya H,Ajioka M,Ishihara M,Dai K,Nanasato M,Sata M,Maemura K,Tomiyama H,Higashi Y,Kaku K,Yamada H,Matsuhisa M,Yamashita K,Bando YK,Kashihara N,Ueda S,

更新日期：2016-06-28 00:00:00

abstract：BACKGROUND:Rare diseases affect as many as 60 million people in the United States and Europe. However, most rare diseases lack effective therapies and are in critical need of clinical research. Our objective was to determine the frequency of noncompletion and nonpublication of trials studying rare diseases. METHODS AN...

journal_title：PLoS medicine

authors： Rees CA,Pica N,Monuteaux MC,Bourgeois FT

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:At the beginning of June 2020, there were nearly 7 million reported cases of coronavirus disease 2019 (COVID-19) worldwide and over 400,000 deaths in people with COVID-19. The objective of this study was to determine associations between comorbidities listed in the Charlson comorbidity index and mortality am...

journal_title：PLoS medicine

authors： Harrison SL,Fazio-Eynullayeva E,Lane DA,Underhill P,Lip GYH

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:Identifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity. Recently, the intensity and the quality of the host immune response in the tumor microenvironment h...

journal_title：PLoS medicine

authors： Sanz-Pamplona R,Melas M,Maoz A,Schmit SL,Rennert H,Lejbkowicz F,Greenson JK,Sanjuan X,Lopez-Zambrano M,Alonso MH,Qu C,McDonnell KJ,Idos GE,Vignali M,Emerson R,Fields P,Guinó E,Santos C,Salazar R,Robins HS,Rennert

更新日期：2020-09-24 00:00:00