Abstract:
BACKGROUND:Tissue advanced glycation end product (AGE) accumulation has been proposed as a marker of cumulative metabolic stress that can be assessed noninvasively by measurement of skin autofluorescence (SAF). In persons on haemodialysis, SAF is an independent risk factor for cardiovascular events (CVEs) and all-cause mortality (ACM), but data at earlier stages of chronic kidney disease (CKD) are inconclusive. We investigated SAF as a risk factor for CVEs and ACM in a prospective study of persons with CKD stage 3. METHODS AND FINDINGS:Participants with estimated glomerular filtration rate (eGFR) 59 to 30 mL/min/1.73 m2 on two consecutive previous blood tests were recruited from 32 primary care practices across Derbyshire, United Kingdom between 2008 and 2010. SAF was measured in participants with CKD stage 3 at baseline, 1, and 5 years using an AGE reader (DiagnOptics). Data on hospital admissions with CVEs (based on international classification of diseases [ICD]-10 coding) and deaths were obtained from NHS Digital. Cox proportional hazards models were used to investigate baseline variables associated with CVEs and ACM. A total of 1,707 of 1,741 participants with SAF readings at baseline were included in this analysis: The mean (± SD) age was 72.9 ± 9.0 years; 1,036 (60.7%) were female, 1,681 (98.5%) were of white ethnicity, and mean (±SD) eGFR was 53.5 ± 11.9 mL/min/1.73 m2. We observed 319 deaths and 590 CVEs during a mean of 6.0 ± 1.5 and 5.1 ± 2.2 years of observation, respectively. Higher baseline SAF was an independent risk factor for CVEs (hazard ratio [HR] 1.12 per SD, 95% CI 1.03-1.22, p = 0.01) and ACM (HR 1.16, 95% CI 1.03-1.30, p = 0.01). Additionally, increase in SAF over 1 year was independently associated with subsequent CVEs (HR 1.11 per SD, 95% CI 1.00-1.22; p = 0.04) and ACM (HR 1.24, 95% CI 1.09-1.41, p = 0.001). We relied on ICD-10 codes to identify hospital admissions with CVEs, and there may therefore have been some misclassification. CONCLUSIONS:We have identified SAF as an independent risk factor for CVE and ACM in persons with early CKD. These findings suggest that interventions to reduce AGE accumulation, such as dietary AGE restriction, may reduce cardiovascular risk in CKD, but this requires testing in prospective randomised trials. Our findings may not be applicable to more ethnically diverse or younger populations.
journal_name
PLoS Medjournal_title
PLoS medicineauthors
Shardlow A,McIntyre NJ,Kolhe NV,Nellums LB,Fluck RJ,McIntyre CW,Taal MWdoi
10.1371/journal.pmed.1003163subject
Has Abstractpub_date
2020-07-13 00:00:00pages
e1003163issue
7eissn
1549-1277issn
1549-1676pii
PMEDICINE-D-20-00405journal_volume
17pub_type
杂志文章相关文献
PLOS MEDICINE文献大全abstract:BACKGROUND:Drug manufacturers have developed "evergreening" strategies to compete with generic medication after patent termination. These include marketing of slightly modified follow-on drugs. We aimed to estimate the financial impact of these drugs on overall healthcare costs and also to examine the impact of listing...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1001460
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Endometrial cancer is the most common gynecologic malignancy, and its incidence and associated mortality are increasing. Despite the immediate need to detect these cancers at an earlier stage, there is no effective screening methodology or protocol for endometrial cancer. The comprehensive, genomics-based an...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002206
更新日期:2016-12-27 00:00:00
abstract::David Studdert and colleagues explore how to balance public health, individual freedom, and good government when it comes to sugar-sweetened drinks. ...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1001848
更新日期:2015-07-07 00:00:00
abstract:BACKGROUND:Care advances in the United States (US) have led to improved survival of children with neurological impairment (NI). Children with NI may account for an increasing proportion of hospital resources. However, this assumption has not been tested at a national level. METHODS AND FINDINGS:We conducted a study of...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1001158
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Malaysia's stable health care system is facing challenges with increasing medicine costs. To investigate these issues a survey was carried out to evaluate medicine prices, availability, affordability, and the structure of price components. METHODS AND FINDINGS:The methodology developed by the World Health O...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.0040082
更新日期:2007-03-27 00:00:00
abstract::Financial risk protection is a key component of universal health coverage (UHC), which is defined as access to all needed quality health services without financial hardship. As part of the PLOS Medicine Collection on measurement of UHC, the aim of this paper is to examine and to compare and contrast existing measures ...
journal_title:PLoS medicine
pub_type: 杂志文章,评审
doi:10.1371/journal.pmed.1001701
更新日期:2014-09-22 00:00:00
abstract:BACKGROUND:The global tuberculosis epidemic results in nearly 2 million deaths and 9 million new cases of the disease a year. The vast majority of tuberculosis patients live in developing countries, where the diagnosis of tuberculosis relies on the identification of acid-fast bacilli on unprocessed sputum smears using ...
journal_title:PLoS medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1371/journal.pmed.0040202
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:In South Africa, within-country migration is common. Mobility affects many of the factors in the pathway for entry to or retention in care among people living with HIV. We characterized the patterns of migration (i.e., change in residency) among peripartum women from rural South Africa and their association ...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1003085
更新日期:2020-03-31 00:00:00
abstract:BACKGROUND:In patients treated with cardiotoxic chemotherapies, the presence of cardiovascular risk factors and previous cardiac disease have been strongly correlated to the onset of cardiotoxicity. The influence of overweight and obesity as risk factors in the development of treatment-related cardiotoxicity in breast ...
journal_title:PLoS medicine
pub_type: 临床试验,杂志文章
doi:10.1371/journal.pmed.1002989
更新日期:2019-12-23 00:00:00
abstract:BACKGROUND:For treating multidrug-resistant tuberculosis (MDR TB), the World Health Organization (WHO) recommends a regimen of at least four second-line drugs that are likely to be effective as well as pyrazinamide. WHO guidelines indicate only marginal benefit for regimens based directly on drug susceptibility testing...
journal_title:PLoS medicine
pub_type: 杂志文章,多中心研究
doi:10.1371/journal.pmed.1001932
更新日期:2015-12-29 00:00:00
abstract:BACKGROUND:The standard approaches to diagnosing autism spectrum disorder (ASD) evaluate between 20 and 100 behaviors and take several hours to complete. This has in part contributed to long wait times for a diagnosis and subsequent delays in access to therapy. We hypothesize that the use of machine learning analysis o...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002705
更新日期:2018-11-27 00:00:00
abstract:BACKGROUND:Trachoma is the world's leading cause of infectious blindness. The World Health Organization (WHO) has endorsed the SAFE strategy in order to eliminate blindness due to trachoma by 2020 through "surgery," "antibiotics," "facial cleanliness," and "environmental improvement." While the S and A components have ...
journal_title:PLoS medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1371/journal.pmed.1001605
更新日期:2014-02-25 00:00:00
abstract:BACKGROUND:For more than a decade, most parts of Somalia have not been under the control of any type of government. This "failure of state" is complete in the central and southern regions and most apparent in Mogadishu, which had been for a long period in the hands of warlords deploying their private militias in a batt...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.0040341
更新日期:2007-12-01 00:00:00
abstract::As participant-led health research increases, Effy Vayena and and John Tasioulas examine what ethical questions are raised, and what types of standards need to be developed for appropriate ethical oversight for participant-led research projects. ...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1001402
更新日期:2013-01-01 00:00:00
abstract::Nina Finley and co-authors discuss public involvement in planning and reporting medical research. ...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1003246
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU]) developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indication that FIAU would b...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1001628
更新日期:2014-04-15 00:00:00
abstract:BACKGROUND:WHO recommends prompt diagnosis and quinine plus clindamycin for treatment of uncomplicated malaria in the first trimester and artemisinin-based combination therapies in subsequent trimesters. We undertook a systematic review of women's access to and healthcare provider adherence to WHO case management polic...
journal_title:PLoS medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1371/journal.pmed.1001688
更新日期:2014-08-05 00:00:00
abstract:BACKGROUND:Pedometers can increase walking and moderate-to-vigorous physical activity (MVPA) levels, but their effectiveness with or without support has not been rigorously evaluated. We assessed the effectiveness of a pedometer-based walking intervention in predominantly inactive adults, delivered by post or through p...
journal_title:PLoS medicine
pub_type: 杂志文章,随机对照试验
doi:10.1371/journal.pmed.1002210
更新日期:2017-01-03 00:00:00
abstract:BACKGROUND:Polygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quantify the potential advantage of adding information on PRSs to conventional risk factors in the primary prevention of CVD. METHODS AND FINDINGS:Using data from UK Biobank on 306,654 individual...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1003498
更新日期:2021-01-14 00:00:00
abstract::Xonghong Xiao and colleagues analyze the challenge of antimicrobial resistance in China. A government strategy to promote rational use of antimicrobials in health care reduced antibiotic sales and percentage of prescriptions for antimicrobials for both hospitalized patients and outpatients, and offers insights to shap...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1001556
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Childbirth with a skilled attendant is crucial for preventing maternal mortality and is an important opportunity for prevention of mother-to-child transmission of HIV. The Maternity in Migori and AIDS Stigma Study (MAMAS Study) is a prospective mixed-methods investigation conducted in a high HIV prevalence a...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1001295
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis. METHODS AND FINDINGS:A total of 3,274 uncircumcised men, aged 18-24 y, were randomiz...
journal_title:PLoS medicine
pub_type: 杂志文章,随机对照试验
doi:10.1371/journal.pmed.0020298
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) of houses provide effective malaria transmission control. There is conflicting evidence about whether it is more beneficial to provide both interventions in combination. A cluster randomised controlled trial was conducted to investigate wheth...
journal_title:PLoS medicine
pub_type: 杂志文章,随机对照试验
doi:10.1371/journal.pmed.1001630
更新日期:2014-04-15 00:00:00
abstract::Diarrhea morbidity and mortality remain important child health problems in low- and middle-income countries. The treatment of diarrhea and accurate measurement of treatment coverage are critical if child mortality is going to continue to decline. In this review, we examine diarrhea treatment coverage indicators collec...
journal_title:PLoS medicine
pub_type: 杂志文章,评审
doi:10.1371/journal.pmed.1001385
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Our objective was to examine whether gestational diabetes mellitus (GDM) or newborns' high birthweight can be prevented by lifestyle counseling in pregnant women at high risk of GDM. METHOD AND FINDINGS:We conducted a cluster-randomized trial, the NELLI study, in 14 municipalities in Finland, where 2,271 wo...
journal_title:PLoS medicine
pub_type: 杂志文章,随机对照试验
doi:10.1371/journal.pmed.1001036
更新日期:2011-05-01 00:00:00
abstract::Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by...
journal_title:PLoS medicine
pub_type: 杂志文章,评审
doi:10.1371/journal.pmed.1002456
更新日期:2017-11-30 00:00:00
abstract:BACKGROUND:Hip and knee replacement are some of the most frequently performed surgical procedures in the world. Resurfacing of the hip and unicondylar knee replacement are increasingly being used. There is relatively little evidence on their performance. To study performance of joint replacement in England, we investig...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.0050179
更新日期:2008-09-30 00:00:00
abstract:BACKGROUND:In common with many other low- and middle-income countries (LMICs), rural to urban migrants in India are at increased risk of obesity, but it is unclear whether this is due to increased energy intake, reduced energy expenditure, or both. Knowing this and the relative contribution of specific dietary and phys...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1003234
更新日期:2020-08-07 00:00:00
abstract::Sanjay Basu and Kristine Madsen discuss the effects of taxes on sugar-sweetened beverages in both Australia and Berkeley, USA. ...
journal_title:PLoS medicine
pub_type: 评论,杂志文章
doi:10.1371/journal.pmed.1002327
更新日期:2017-06-27 00:00:00
abstract:BACKGROUND:Previous estimates of mortality in Iraq attributable to the 2003 invasion have been heterogeneous and controversial, and none were produced after 2006. The purpose of this research was to estimate direct and indirect deaths attributable to the war in Iraq between 2003 and 2011. METHODS AND FINDINGS:We condu...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1001533
更新日期:2013-10-01 00:00:00