How to make your research jump off the page: Co-creation to broaden public engagement in medical research.

abstract：BACKGROUND:CD4 cell count is a strong predictor of the subsequent risk of AIDS or death in HIV-infected patients initiating combination antiretroviral therapy (cART). It is not known whether the rate of CD4 cell decline prior to therapy is related to prognosis and should, therefore, influence the decision on when to in...

journal_title：PLoS medicine

authors： Wolbers M,Babiker A,Sabin C,Young J,Dorrucci M,Chêne G,Mussini C,Porter K,Bucher HC,CASCADE Collaboration Members.

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emerging chloroquine resistance. We undertook a systematic review and individual patient data meta-analysis to compare the efficacies of dihydroartemisinin-piperaquine (DP) and artemether-lumefan...

journal_title：PLoS medicine

authors： Commons RJ,Simpson JA,Thriemer K,Abreha T,Adam I,Anstey NM,Assefa A,Awab GR,Baird JK,Barber BE,Chu CS,Dahal P,Daher A,Davis TME,Dondorp AM,Grigg MJ,Humphreys GS,Hwang J,Karunajeewa H,Laman M,Lidia K,Moore BR,M

更新日期：2019-10-04 00:00:00

abstract：BACKGROUND:It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain. METHODS AND FINDINGS:We report a "nested" case-control comparison within a prospective study in Reykjavik...

journal_title：PLoS medicine

authors： Wheeler JG,Juzwishin KD,Eiriksdottir G,Gudnason V,Danesh J

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Perinatal mortality and morbidity continue to be major global health challenges strongly associated with prematurity and reduced fetal growth, an issue of further interest given the mounting evidence that fetal growth in general is linked to degrees of risk of common noncommunicable diseases in adulthood. Ag...

journal_title：PLoS medicine

authors： Kiserud T,Piaggio G,Carroli G,Widmer M,Carvalho J,Neerup Jensen L,Giordano D,Cecatti JG,Abdel Aleem H,Talegawkar SA,Benachi A,Diemert A,Tshefu Kitoto A,Thinkhamrop J,Lumbiganon P,Tabor A,Kriplani A,Gonzalez Perez R,He

更新日期：2017-01-24 00:00:00

abstract：:David Studdert and colleagues explore how to balance public health, individual freedom, and good government when it comes to sugar-sweetened drinks. ...

journal_title：PLoS medicine

authors： Studdert DM,Flanders J,Mello MM

更新日期：2015-07-07 00:00:00

abstract：BACKGROUND:HIV self-testing (HIVST) may play a role in addressing gaps in HIV testing coverage and as an entry point for HIV prevention services. We conducted a cluster randomized trial of 2 HIVST distribution mechanisms compared to the standard of care among female sex workers (FSWs) in Zambia. METHODS AND FINDINGS:T...

journal_title：PLoS medicine

authors： Chanda MM,Ortblad KF,Mwale M,Chongo S,Kanchele C,Kamungoma N,Fullem A,Dunn C,Barresi LG,Harling G,Bärnighausen T,Oldenburg CE

更新日期：2017-11-21 00:00:00

abstract：BACKGROUND:Antenatal corticosteroid therapy (ACT) is used clinically to prepare the fetal lung for impending preterm birth, but animal and human studies link corticosteroids to smaller birth size. Whether ACT is associated with birth size is debated; therefore, we assessed differences in birth size in treated versus un...

journal_title：PLoS medicine

authors： Rodriguez A,Wang Y,Ali Khan A,Cartwright R,Gissler M,Järvelin MR

更新日期：2019-02-26 00:00:00

abstract：BACKGROUND:While many individual genes have been identified that confer protection against malaria, the overall impact of host genetics on malarial risk remains unknown. METHODS AND FINDINGS:We have used pedigree-based genetic variance component analysis to determine the relative contributions of genetic and other fac...

journal_title：PLoS medicine

authors： Mackinnon MJ,Mwangi TW,Snow RW,Marsh K,Williams TN

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:National responses will need to be markedly accelerated to achieve the ambitious target of the Joint United Nations Programme on HIV/AIDS (UNAIDS). This target aims for 90% of HIV-positive individuals to be aware of their status, for 90% of those aware to receive antiretroviral therapy (ART), and for 90% of ...

journal_title：PLoS medicine

authors： Maheu-Giroux M,Vesga JF,Diabaté S,Alary M,Baral S,Diouf D,Abo K,Boily MC

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:Previous estimates of mortality in Iraq attributable to the 2003 invasion have been heterogeneous and controversial, and none were produced after 2006. The purpose of this research was to estimate direct and indirect deaths attributable to the war in Iraq between 2003 and 2011. METHODS AND FINDINGS:We condu...

journal_title：PLoS medicine

authors： Hagopian A,Flaxman AD,Takaro TK,Esa Al Shatari SA,Rajaratnam J,Becker S,Levin-Rector A,Galway L,Hadi Al-Yasseri BJ,Weiss WM,Murray CJ,Burnham G

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Mobile text messaging and medication monitors (medication monitor boxes) have the potential to improve adherence to tuberculosis (TB) treatment and reduce the need for directly observed treatment (DOT), but to our knowledge they have not been properly evaluated in TB patients. We assessed the effectiveness o...

journal_title：PLoS medicine

authors： Liu X,Lewis JJ,Zhang H,Lu W,Zhang S,Zheng G,Bai L,Li J,Li X,Chen H,Liu M,Chen R,Chi J,Lu J,Huan S,Cheng S,Wang L,Jiang S,Chin DP,Fielding KL

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis. METHODS AND FINDINGS:A total of 3,274 uncircumcised men, aged 18-24 y, were randomiz...

journal_title：PLoS medicine

authors： Auvert B,Taljaard D,Lagarde E,Sobngwi-Tambekou J,Sitta R,Puren A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load. METHODS AND FINDINGS:Using data from the Collaboration of Observational HIV E...

journal_title：PLoS medicine

authors： Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord.,Young J,Psichogiou M,Meyer L,Ayayi S,Grabar S,Raffi F,Reiss P,Gazzard B,Sharland M,Gutierrez F

更新日期：2012-01-01 00:00:00

abstract：:In an Editorial, Guest Editors Nicola Low and Nathalie Broutet discuss the Collection on sexually transmitted infections in the context of research priorities in the field. ...

journal_title：PLoS medicine

authors： Low N,Broutet NJ

更新日期：2017-12-27 00:00:00

abstract：:Matthew Fox and Sydney Rosen discuss a cascade of HIV care adapted to WHO-recommended antiretroviral therapy irrespective of CD4 cell count. ...

journal_title：PLoS medicine

authors： Fox MP,Rosen S

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:The World Health Organization has endorsed the Xpert MTB/RIF assay for investigation of patients suspected of having tuberculosis (TB). However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral t...

journal_title：PLoS medicine

authors： Lawn SD,Brooks SV,Kranzer K,Nicol MP,Whitelaw A,Vogt M,Bekker LG,Wood R

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men with clinically suspected prostate cancer (PCa), but the long acquisition times, high costs, and inter-center/reader variability of routine multiparametric prostate MRI limit its wider adoption. METHODS AND FINDI...

journal_title：PLoS medicine

authors： Jambor I,Verho J,Ettala O,Knaapila J,Taimen P,Syvänen KT,Kiviniemi A,Kähkönen E,Perez IM,Seppänen M,Rannikko A,Oksanen O,Riikonen J,Vimpeli SM,Kauko T,Merisaari H,Kallajoki M,Mirtti T,Lamminen T,Saunavaara J,Arone

更新日期：2019-06-03 00:00:00

abstract：BACKGROUND:Socioeconomic adversity in early life has been hypothesized to "program" a vulnerable phenotype with exaggerated inflammatory responses, so increasing the risk of developing type 2 diabetes in adulthood. The aim of this study is to test this hypothesis by assessing the extent to which the association between...

journal_title：PLoS medicine

authors： Stringhini S,Batty GD,Bovet P,Shipley MJ,Marmot MG,Kumari M,Tabak AG,Kivimäki M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Although gastric cancer has declined dramatically in the US, the disease remains the second leading cause of cancer mortality worldwide. A better understanding of reasons for the decline can provide important insights into effective preventive strategies. We sought to estimate the contribution of risk factor...

journal_title：PLoS medicine

authors： Yeh JM,Hur C,Schrag D,Kuntz KM,Ezzati M,Stout N,Ward Z,Goldie SJ

更新日期：2013-01-01 00:00:00

abstract：:Peter Openshaw discusses the challenges in advancing respiratory syncytial virus (RSV) treatments and the implications of a study by Mejias and colleagues using a newly identified gene signature for diagnosis and prediction of RSV severity. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Openshaw PJ

更新日期：2013-11-01 00:00:00

abstract：:Alexander Tsai and colleagues highlight the complex relationship between poverty and HIV stigma in sub-Saharan Africa, and discuss possible ways to break the cycle. Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Tsai AC,Bangsberg DR,Weiser SD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Effective implementation strategies are needed to increase engagement in HIV services in hyperendemic settings. We conducted a pragmatic cluster-randomized trial in a high-risk, highly mobile fishing community (HIV prevalence: approximately 38%) in Rakai, Uganda, to assess the impact of a community health wo...

journal_title：PLoS medicine

authors： Chang LW,Mbabali I,Hutton H,Amico KR,Kong X,Mulamba J,Anok A,Ssekasanvu J,Long A,Thomas AG,Thomas K,Bugos E,Pollard R,van Wickle K,Kennedy CE,Nalugoda F,Serwadda D,Bollinger RC,Quinn TC,Reynolds SJ,Gray RH,Wawer

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Animal studies suggest vital roles of sphingolipids, especially ceramides, in the pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell dysfunction, and inflammation, but human studies are limited. We aimed to evaluate the associations of circulating sphingolipids with inc...

journal_title：PLoS medicine

authors： Yun H,Sun L,Wu Q,Zong G,Qi Q,Li H,Zheng H,Zeng R,Liang L,Lin X

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Experimental and observational research has suggested the potential for increased type 2 diabetes (T2D) risk among populations taking statins for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). However, few studies have directly compared statin-associated benefits and harms or exami...

journal_title：PLoS medicine

authors： Engeda JC,Lhachimi SK,Rosamond WD,Lund JL,Keyserling TC,Safford MM,Colantonio LD,Muntner P,Avery CL

更新日期：2020-08-26 00:00:00

abstract：:On the 30th anniversary of the Chernobyl disaster, Amina Aitsi-Selmi and Virginia Murray reflect on the importance of disaster preparedness. ...

journal_title：PLoS medicine

authors： Aitsi-Selmi A,Murray V

更新日期：2016-04-25 00:00:00

abstract：BACKGROUND:To explore the possibility that antibody-mediated complement lysis contributes to viremia control in HIV-1 infection, we measured the activity of patient plasma in mediating complement lysis of autologous primary virus. METHODS AND FINDINGS:Sera from two groups of patients-25 with acute HIV-1 infection and ...

journal_title：PLoS medicine

authors： Huber M,Fischer M,Misselwitz B,Manrique A,Kuster H,Niederöst B,Weber R,von Wyl V,Günthard HF,Trkola A

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Since 1998 the serious public health problem in South East Asia of counterfeit artesunate, containing no or subtherapeutic amounts of the active antimalarial ingredient, has led to deaths from untreated malaria, reduced confidence in this vital drug, large economic losses for the legitimate manufacturers, an...

journal_title：PLoS medicine

authors： Newton PN,Fernández FM,Plançon A,Mildenhall DC,Green MD,Ziyong L,Christophel EM,Phanouvong S,Howells S,McIntosh E,Laurin P,Blum N,Hampton CY,Faure K,Nyadong L,Soong CW,Santoso B,Zhiguang W,Newton J,Palmer K

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Trachoma is the world's leading cause of infectious blindness. The World Health Organization (WHO) has endorsed the SAFE strategy in order to eliminate blindness due to trachoma by 2020 through "surgery," "antibiotics," "facial cleanliness," and "environmental improvement." While the S and A components have ...

journal_title：PLoS medicine

authors： Stocks ME,Ogden S,Haddad D,Addiss DG,McGuire C,Freeman MC

更新日期：2014-02-25 00:00:00

abstract：BACKGROUND:Nutritional supplements may improve development of infants born small (preterm or small for gestational age [SGA]) but may increase the risk of later metabolic disease. We conducted a systematic review and meta-analysis to assess the effects of macronutrient supplements for infants born small on later develo...

journal_title：PLoS medicine

authors： Lin L,Amissah E,Gamble GD,Crowther CA,Harding JE

更新日期：2019-10-30 00:00:00

abstract：:H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials. ...

journal_title：PLoS medicine

authors： van der Worp HB,Howells DW,Sena ES,Porritt MJ,Rewell S,O'Collins V,Macleod MR

更新日期：2010-03-30 00:00:00