A gene expression signature for RSV: clinical implications and limitations.

abstract：:Voluntary medical male circumcision (VMMC) is capable of reducing the risk of sexual transmission of HIV from females to males by approximately 60%. In 2007, the WHO and the Joint United Nations Programme on HIV/AIDS (UNAIDS) recommended making VMMC part of a comprehensive HIV prevention package in countries with a ge...

journal_title：PLoS medicine

authors： Sgaier SK,Reed JB,Thomas A,Njeuhmeli E

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Introduction of pneumococcal conjugate vaccines (PCVs) of limited valency is justified in Africa by the high burden of pneumococcal disease. Long-term beneficial effects of PCVs may be countered by serotype replacement. We aimed to determine the impact of PCV-7 vaccination on pneumococcal carriage in rural G...

journal_title：PLoS medicine

authors： Roca A,Hill PC,Townend J,Egere U,Antonio M,Bojang A,Akisanya A,Litchfield T,Nsekpong DE,Oluwalana C,Howie SR,Greenwood B,Adegbola RA

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Hospitalisation for adversity-related injury (violent, drug/alcohol-related, or self-inflicted injury) has been described as a "teachable moment", when intervention may reduce risks of further harm. Which adolescents are likely to benefit most from intervention strongly depends on their long-term risks of ha...

journal_title：PLoS medicine

authors： Herbert A,Gilbert R,González-Izquierdo A,Pitman A,Li L

更新日期：2015-12-29 00:00:00

abstract：BACKGROUND:Animal studies suggest vital roles of sphingolipids, especially ceramides, in the pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell dysfunction, and inflammation, but human studies are limited. We aimed to evaluate the associations of circulating sphingolipids with inc...

journal_title：PLoS medicine

authors： Yun H,Sun L,Wu Q,Zong G,Qi Q,Li H,Zheng H,Zeng R,Liang L,Lin X

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Many low- and middle-income countries are not on track to reach the public health targets set out in the Millennium Development Goals (MDGs). We evaluated whether differential progress towards health MDGs was associated with economic development, public health funding (both overall and as percentage of avail...

journal_title：PLoS medicine

authors： Stuckler D,Basu S,McKee M

更新日期：2010-03-02 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1003293.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:The risk of perinatal death and severe neonatal morbidity increases gradually after 41 weeks of pregnancy. Several randomised controlled trials (RCTs) have assessed if induction of labour (IOL) in uncomplicated pregnancies at 41 weeks will improve perinatal outcomes. We performed an individual participant da...

journal_title：PLoS medicine

authors： Alkmark M,Keulen JKJ,Kortekaas JC,Bergh C,van Dillen J,Duijnhoven RG,Hagberg H,Mol BW,Molin M,van der Post JAM,Saltvedt S,Wikström AK,Wennerholm UB,de Miranda E

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:Antiretroviral-based interventions for HIV-1 prevention, including antiretroviral therapy (ART) to reduce the infectiousness of HIV-1 infected persons and pre-exposure prophylaxis (PrEP) to reduce the susceptibility of HIV-1 uninfected persons, showed high efficacy for HIV-1 protection in randomized clinical...

journal_title：PLoS medicine

authors： Baeten JM,Heffron R,Kidoguchi L,Mugo NR,Katabira E,Bukusi EA,Asiimwe S,Haberer JE,Morton J,Ngure K,Bulya N,Odoyo J,Tindimwebwa E,Hendrix C,Marzinke MA,Ware NC,Wyatt MA,Morrison S,Haugen H,Mujugira A,Donnell D,Ce

更新日期：2016-08-23 00:00:00

abstract：BACKGROUND:Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate. Novel antimalarial drug targets are urgently needed to reduce global morbidity and mortality. Our prior results suggested that inhibiting erythrocyte Gs signaling blocked invas...

journal_title：PLoS medicine

authors： Murphy SC,Harrison T,Hamm HE,Lomasney JW,Mohandas N,Haldar K

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:In recent decades, increased attention has been focused on the impact of disabilities and medicinal drug use on road safety. The aim of our study was to investigate the association between prescription medicines and the risk of road traffic crashes, and estimate the attributable fraction. METHODS AND FINDIN...

journal_title：PLoS medicine

authors： Orriols L,Delorme B,Gadegbeku B,Tricotel A,Contrand B,Laumon B,Salmi LR,Lagarde E,CESIR research group.

更新日期：2010-11-16 00:00:00

abstract：BACKGROUND:trans-fatty acids (TFAs) are a well-known risk factor of ischemic heart disease (IHD). In Australia, the highest TFA intake is concentrated to the most socioeconomically disadvantaged groups. Elimination of industrial TFA (iTFA) from the Australian food supply could result in reduced IHD mortality and morbid...

journal_title：PLoS medicine

authors： Marklund M,Zheng M,Veerman JL,Wu JHY

更新日期：2020-11-02 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1001895.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-alpha and ribavirin (PegIFN/R). Viral clearance is achieved in 40%...

journal_title：PLoS medicine

authors： Suppiah V,Gaudieri S,Armstrong NJ,O'Connor KS,Berg T,Weltman M,Abate ML,Spengler U,Bassendine M,Dore GJ,Irving WL,Powell E,Hellard M,Riordan S,Matthews G,Sheridan D,Nattermann J,Smedile A,Müller T,Hammond E,Dunn D

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Effective implementation strategies are needed to increase engagement in HIV services in hyperendemic settings. We conducted a pragmatic cluster-randomized trial in a high-risk, highly mobile fishing community (HIV prevalence: approximately 38%) in Rakai, Uganda, to assess the impact of a community health wo...

journal_title：PLoS medicine

authors： Chang LW,Mbabali I,Hutton H,Amico KR,Kong X,Mulamba J,Anok A,Ssekasanvu J,Long A,Thomas AG,Thomas K,Bugos E,Pollard R,van Wickle K,Kennedy CE,Nalugoda F,Serwadda D,Bollinger RC,Quinn TC,Reynolds SJ,Gray RH,Wawer

更新日期：2021-01-06 00:00:00

abstract：:Thomas Platts-Mills and Matthew Perzanowski provide their expert Perspective on a translational study from Custovic and colleagues that identifies pairings of IgE that show value in estimating risk of concurrent asthma. ...

journal_title：PLoS medicine

authors： Platts-Mills TAE,Perzanowski M

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:HVTN 100 evaluated the safety and immunogenicity of an HIV subtype C pox-protein vaccine regimen, investigating a 12-month booster to extend vaccine-induced immune responses. METHODS AND FINDINGS:A phase 1-2 randomized double-blind placebo-controlled trial enrolled 252 participants (210 vaccine/42 placebo; ...

journal_title：PLoS medicine

authors： Laher F,Moodie Z,Cohen KW,Grunenberg N,Bekker LG,Allen M,Frahm N,Yates NL,Morris L,Malahleha M,Mngadi K,Daniels B,Innes C,Saunders K,Grant S,Yu C,Gilbert PB,Phogat S,DiazGranados CA,Koutsoukos M,Van Der Meeren O,

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:We simulated tobacco control and pharmacological strategies for preventing cardiovascular deaths in India, the country that is expected to experience more cardiovascular deaths than any other over the next decade. METHODS AND FINDINGS:A microsimulation model was developed to quantify the differential effect...

journal_title：PLoS medicine

authors： Basu S,Glantz S,Bitton A,Millett C

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Opioid misuse and deaths are increasing in the United States. In 2017, Ohio had the second highest overdose rates in the US, with the city of Cincinnati experiencing a 50% rise in opioid overdoses since 2015. Understanding the temporal and geographic variation in overdose emergencies may help guide public po...

journal_title：PLoS medicine

authors： Li ZR,Xie E,Crawford FW,Warren JL,McConnell K,Copple JT,Johnson T,Gonsalves GS

更新日期：2019-11-12 00:00:00

abstract：:Nina Finley and co-authors discuss public involvement in planning and reporting medical research. ...

journal_title：PLoS medicine

authors： Finley N,Swartz TH,Cao K,Tucker JD

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:CD4 cell count is a strong predictor of the subsequent risk of AIDS or death in HIV-infected patients initiating combination antiretroviral therapy (cART). It is not known whether the rate of CD4 cell decline prior to therapy is related to prognosis and should, therefore, influence the decision on when to in...

journal_title：PLoS medicine

authors： Wolbers M,Babiker A,Sabin C,Young J,Dorrucci M,Chêne G,Mussini C,Porter K,Bucher HC,CASCADE Collaboration Members.

更新日期：2010-02-23 00:00:00

abstract：:In a Perspective, Hilary Seligman and Sanjay Basu discuss future scenarios of food assistance programs to improve population health in a changing political environment. ...

journal_title：PLoS medicine

authors： Seligman HK,Basu S

更新日期：2018-10-02 00:00:00

abstract：BACKGROUND:Global warming is predicted to indirectly result in more undernutrition by threatening crop production. Whether temperature rise could affect undernutrition directly is unknown. We aim to quantify the relationship between short-term heat exposure and risk of hospitalization due to undernutrition in Brazil. ...

journal_title：PLoS medicine

authors： Xu R,Zhao Q,Coelho MSZS,Saldiva PHN,Abramson MJ,Li S,Guo Y

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:National responses will need to be markedly accelerated to achieve the ambitious target of the Joint United Nations Programme on HIV/AIDS (UNAIDS). This target aims for 90% of HIV-positive individuals to be aware of their status, for 90% of those aware to receive antiretroviral therapy (ART), and for 90% of ...

journal_title：PLoS medicine

authors： Maheu-Giroux M,Vesga JF,Diabaté S,Alary M,Baral S,Diouf D,Abo K,Boily MC

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:Exposure to a nutritionally deficient environment during fetal life and early infancy may adversely alter the ontogeny of the immune system and affect an infant's ability to mount an optimal immune response to vaccination. We examined the effects of maternal nutritional supplementation during pregnancy on in...

journal_title：PLoS medicine

authors： Okala SG,Darboe MK,Sosseh F,Sonko B,Faye-Joof T,Prentice AM,Moore SE

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Bilharzia is one of the major parasitic infections affecting the public health and socioeconomic circumstances in (sub) tropical areas. Its causative agents are schistosomes. Since these worms remain in their host for decades, they have developed mechanisms to evade or resist the immune system. Like several ...

journal_title：PLoS medicine

authors： Sprong H,Suchanek M,van Dijk SM,van Remoortere A,Klumperman J,Avram D,van der Linden J,Leusen JH,van Hellemond JJ,Thiele C

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups. ME...

journal_title：PLoS medicine

authors： Lipnicki DM,Makkar SR,Crawford JD,Thalamuthu A,Kochan NA,Lima-Costa MF,Castro-Costa E,Ferri CP,Brayne C,Stephan B,Llibre-Rodriguez JJ,Llibre-Guerra JJ,Valhuerdi-Cepero AJ,Lipton RB,Katz MJ,Derby CA,Ritchie K,Ancelin ML

更新日期：2019-07-23 00:00:00

abstract：BACKGROUND:Mobile text messaging and medication monitors (medication monitor boxes) have the potential to improve adherence to tuberculosis (TB) treatment and reduce the need for directly observed treatment (DOT), but to our knowledge they have not been properly evaluated in TB patients. We assessed the effectiveness o...

journal_title：PLoS medicine

authors： Liu X,Lewis JJ,Zhang H,Lu W,Zhang S,Zheng G,Bai L,Li J,Li X,Chen H,Liu M,Chen R,Chi J,Lu J,Huan S,Cheng S,Wang L,Jiang S,Chin DP,Fielding KL

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain. METHODS AND FINDINGS:We report a "nested" case-control comparison within a prospective study in Reykjavik...

journal_title：PLoS medicine

authors： Wheeler JG,Juzwishin KD,Eiriksdottir G,Gudnason V,Danesh J

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Childhood obstructive sleep apnea (OSA) is associated with neuropsychological deficits of memory, learning, and executive function. There is no evidence of neuronal brain injury in children with OSA. We hypothesized that childhood OSA is associated with neuropsychological performance dysfunction, and with ne...

journal_title：PLoS medicine

authors： Halbower AC,Degaonkar M,Barker PB,Earley CJ,Marcus CL,Smith PL,Prahme MC,Mahone EM

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load. METHODS AND FINDINGS:Using data from the Collaboration of Observational HIV E...

journal_title：PLoS medicine

authors： Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord.,Young J,Psichogiou M,Meyer L,Ayayi S,Grabar S,Raffi F,Reiss P,Gazzard B,Sharland M,Gutierrez F

更新日期：2012-01-01 00:00:00