A new cascade of HIV care for the era of "treat all".

abstract：:Thomas Platts-Mills and Matthew Perzanowski provide their expert Perspective on a translational study from Custovic and colleagues that identifies pairings of IgE that show value in estimating risk of concurrent asthma. ...

journal_title：PLoS medicine

authors： Platts-Mills TAE,Perzanowski M

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages. Either drug can induce haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, necessitating screening. The reference diagnostic method for G6PD activ...

journal_title：PLoS medicine

authors： Pfeffer DA,Ley B,Howes RE,Adu P,Alam MS,Bansil P,Boum Y 2nd,Brito M,Charoenkwan P,Clements A,Cui L,Deng Z,Egesie OJ,Espino FE,von Fricken ME,Hamid MMA,He Y,Henriques G,Khan WA,Khim N,Kim S,Lacerda M,Lon C,Me

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups. ME...

journal_title：PLoS medicine

authors： Lipnicki DM,Makkar SR,Crawford JD,Thalamuthu A,Kochan NA,Lima-Costa MF,Castro-Costa E,Ferri CP,Brayne C,Stephan B,Llibre-Rodriguez JJ,Llibre-Guerra JJ,Valhuerdi-Cepero AJ,Lipton RB,Katz MJ,Derby CA,Ritchie K,Ancelin ML

更新日期：2019-07-23 00:00:00

abstract：BACKGROUND:This paper examines the efforts of consultants affiliated with Philip Morris (PM), the world's leading transnational tobacco corporation, to influence scientific research and training in Thailand via the Chulabhorn Research Institute (CRI). A leading Southeast Asian institute for environmental health science...

journal_title：PLoS medicine

authors： Mackenzie R,Collin J

更新日期：2008-12-23 00:00:00

abstract：BACKGROUND:Effective implementation strategies are needed to increase engagement in HIV services in hyperendemic settings. We conducted a pragmatic cluster-randomized trial in a high-risk, highly mobile fishing community (HIV prevalence: approximately 38%) in Rakai, Uganda, to assess the impact of a community health wo...

journal_title：PLoS medicine

authors： Chang LW,Mbabali I,Hutton H,Amico KR,Kong X,Mulamba J,Anok A,Ssekasanvu J,Long A,Thomas AG,Thomas K,Bugos E,Pollard R,van Wickle K,Kennedy CE,Nalugoda F,Serwadda D,Bollinger RC,Quinn TC,Reynolds SJ,Gray RH,Wawer

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Outbreaks of emerging infectious diseases, especially those of a global nature, require rapid epidemiological analysis and information dissemination. The final products of those activities usually comprise internal memoranda and briefs within public health authorities and original research published in peer-...

journal_title：PLoS medicine

authors： Xing W,Hejblum G,Leung GM,Valleron AJ

更新日期：2010-05-04 00:00:00

abstract：:On the 30th anniversary of the Chernobyl disaster, Amina Aitsi-Selmi and Virginia Murray reflect on the importance of disaster preparedness. ...

journal_title：PLoS medicine

authors： Aitsi-Selmi A,Murray V

更新日期：2016-04-25 00:00:00

abstract：BACKGROUND:Some 5%-15% of all women experience postpartum depression (PPD), which for many is their first psychiatric disorder. The purpose of this study was to estimate the incidence of postpartum affective disorder (AD), duration of treatment, and rate of subsequent postpartum AD and other affective episodes in a nat...

journal_title：PLoS medicine

authors： Rasmussen MH,Strøm M,Wohlfahrt J,Videbech P,Melbye M

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:The disease burden attributable to mental health problems and to excess or harmful alcohol use is considerable. Despite a strong relationship between these 2 important factors in population health, there are few studies quantifying the mortality risk associated with their co-occurrence in the general populat...

journal_title：PLoS medicine

authors： Degerud E,Høiseth G,Mørland J,Ariansen I,Graff-Iversen S,Ystrom E,Zuccolo L,Næss Ø

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associ...

journal_title：PLoS medicine

authors： Musso G,Gambino R,Tabibian JH,Ekstedt M,Kechagias S,Hamaguchi M,Hultcrantz R,Hagström H,Yoon SK,Charatcharoenwitthaya P,George J,Barrera F,Hafliðadóttir S,Björnsson ES,Armstrong MJ,Hopkins LJ,Gao X,Francque S,Verrijke

更新日期：2014-07-22 00:00:00

abstract：BACKGROUND:Clear recognition of the damaging effects of poverty on early childhood development has fueled an interest in interventions aimed at mitigating these harmful consequences. Psychosocial interventions aimed at alleviating the negative impacts of poverty on children are frequently shown to be of benefit, but ef...

journal_title：PLoS medicine

authors： Morgan B,Kumsta R,Fearon P,Moser D,Skeen S,Cooper P,Murray L,Moran G,Tomlinson M

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:Mobile text messaging and medication monitors (medication monitor boxes) have the potential to improve adherence to tuberculosis (TB) treatment and reduce the need for directly observed treatment (DOT), but to our knowledge they have not been properly evaluated in TB patients. We assessed the effectiveness o...

journal_title：PLoS medicine

authors： Liu X,Lewis JJ,Zhang H,Lu W,Zhang S,Zheng G,Bai L,Li J,Li X,Chen H,Liu M,Chen R,Chi J,Lu J,Huan S,Cheng S,Wang L,Jiang S,Chin DP,Fielding KL

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:In patients treated with cardiotoxic chemotherapies, the presence of cardiovascular risk factors and previous cardiac disease have been strongly correlated to the onset of cardiotoxicity. The influence of overweight and obesity as risk factors in the development of treatment-related cardiotoxicity in breast ...

journal_title：PLoS medicine

authors： Kaboré EG,Guenancia C,Vaz-Luis I,Di Meglio A,Pistilli B,Coutant C,Cottu P,Lesur A,Petit T,Dalenc F,Rouanet P,Arnaud A,Arsene O,Ibrahim M,Wassermann J,Boileau-Jolimoy G,Martin AL,Lemonnier J,André F,Arveux P

更新日期：2019-12-23 00:00:00

abstract：BACKGROUND:Ovarian cancer kills approximately 15,000 women in the United States every year, and more than 140,000 women worldwide. Most deaths from ovarian cancer are caused by tumors of the serous histological type, which are rarely diagnosed before the cancer has spread. Rational design of a potentially life-saving e...

journal_title：PLoS medicine

authors： Brown PO,Palmer C

更新日期：2009-07-01 00:00:00

abstract：:Results from several observational studies of HIV-discordant couples and a randomized controlled trial (HIV Prevention Trials Network 052) show that antiretroviral therapy (ART) can greatly reduce heterosexual HIV transmission in stable HIV-discordant couples. However, such data do not prove that ART will reduce HIV i...

journal_title：PLoS medicine

authors： Smith MK,Powers KA,Muessig KE,Miller WC,Cohen MS

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Care advances in the United States (US) have led to improved survival of children with neurological impairment (NI). Children with NI may account for an increasing proportion of hospital resources. However, this assumption has not been tested at a national level. METHODS AND FINDINGS:We conducted a study of...

journal_title：PLoS medicine

authors： Berry JG,Poduri A,Bonkowsky JL,Zhou J,Graham DA,Welch C,Putney H,Srivastava R

更新日期：2012-01-01 00:00:00

abstract：:Diarrhea morbidity and mortality remain important child health problems in low- and middle-income countries. The treatment of diarrhea and accurate measurement of treatment coverage are critical if child mortality is going to continue to decline. In this review, we examine diarrhea treatment coverage indicators collec...

journal_title：PLoS medicine

authors： Fischer Walker CL,Fontaine O,Black RE

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Since 1998 the serious public health problem in South East Asia of counterfeit artesunate, containing no or subtherapeutic amounts of the active antimalarial ingredient, has led to deaths from untreated malaria, reduced confidence in this vital drug, large economic losses for the legitimate manufacturers, an...

journal_title：PLoS medicine

authors： Newton PN,Fernández FM,Plançon A,Mildenhall DC,Green MD,Ziyong L,Christophel EM,Phanouvong S,Howells S,McIntosh E,Laurin P,Blum N,Hampton CY,Faure K,Nyadong L,Soong CW,Santoso B,Zhiguang W,Newton J,Palmer K

更新日期：2008-02-01 00:00:00

abstract：:Martin Gerdin and colleagues argue that disaster health interventions and decision-making can benefit from an evidence-based approach Please see later in the article for the Editors' Summary. ...

journal_title：PLoS medicine

authors： Gerdin M,Clarke M,Allen C,Kayabu B,Summerskill W,Devane D,MacLachlan M,Spiegel P,Ghosh A,Zachariah R,Gupta S,Barbour V,Murray V,von Schreeb J

更新日期：2014-04-22 00:00:00

abstract：:Philippe Calain discusses the health and environmental hazards of extractive industries like mining and explores the tensions that arise when medical humanitarian organizations are called to intervene in emergencies involving the extractive sector. ...

journal_title：PLoS medicine

authors： Calain P

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ultimate translation into a point-of-care ...

journal_title：PLoS medicine

authors： Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Midwifery continuity of care is the only health system intervention shown to reduce preterm birth (PTB) and improve perinatal survival, but no trial evidence exists for women with identified risk factors for PTB. We aimed to assess feasibility, fidelity, and clinical outcomes of a model of midwifery continui...

journal_title：PLoS medicine

authors： Fernandez Turienzo C,Bick D,Briley AL,Bollard M,Coxon K,Cross P,Silverio SA,Singh C,Seed PT,Tribe RM,Shennan AH,Sandall J,POPPIE Pilot Collaborative Group.

更新日期：2020-10-06 00:00:00

abstract：:In an Editorial, Ligia Kiss and Cathy Zimmerman discuss the need for research on the prevention of human trafficking and mitigation of its effects. ...

journal_title：PLoS medicine

authors： Kiss L,Zimmerman C

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate mortality for patients with the major subtypes of breast cancer as classified using five immunohistochemical markers, to investigate ...

journal_title：PLoS medicine

authors： Blows FM,Driver KE,Schmidt MK,Broeks A,van Leeuwen FE,Wesseling J,Cheang MC,Gelmon K,Nielsen TO,Blomqvist C,Heikkilä P,Heikkinen T,Nevanlinna H,Akslen LA,Bégin LR,Foulkes WD,Couch FJ,Wang X,Cafourek V,Olson JE,Bag

更新日期：2010-05-25 00:00:00

abstract：BACKGROUND:Antiretroviral-based interventions for HIV-1 prevention, including antiretroviral therapy (ART) to reduce the infectiousness of HIV-1 infected persons and pre-exposure prophylaxis (PrEP) to reduce the susceptibility of HIV-1 uninfected persons, showed high efficacy for HIV-1 protection in randomized clinical...

journal_title：PLoS medicine

authors： Baeten JM,Heffron R,Kidoguchi L,Mugo NR,Katabira E,Bukusi EA,Asiimwe S,Haberer JE,Morton J,Ngure K,Bulya N,Odoyo J,Tindimwebwa E,Hendrix C,Marzinke MA,Ware NC,Wyatt MA,Morrison S,Haugen H,Mujugira A,Donnell D,Ce

更新日期：2016-08-23 00:00:00

abstract：BACKGROUND:Opioid misuse and deaths are increasing in the United States. In 2017, Ohio had the second highest overdose rates in the US, with the city of Cincinnati experiencing a 50% rise in opioid overdoses since 2015. Understanding the temporal and geographic variation in overdose emergencies may help guide public po...

journal_title：PLoS medicine

authors： Li ZR,Xie E,Crawford FW,Warren JL,McConnell K,Copple JT,Johnson T,Gonsalves GS

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Resistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is increasing in prevalence in Africa. Combination therapy can both improve treatment and provide important public health benefits if it curbs the spread of parasites harbouring resistance genes. Thus, drug combinations m...

journal_title：PLoS medicine

authors： Sutherland CJ,Ord R,Dunyo S,Jawara M,Drakeley CJ,Alexander N,Coleman R,Pinder M,Walraven G,Targett GA

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The association between fetal exposure to major radiodiagnostic testing in pregnancy-computed tomography (CT) and radionuclide imaging-and the risk of childhood cancer is not established. METHODS AND FINDINGS:We completed a population-based study of 1.8 million maternal-child pairs in the province of Ontari...

journal_title：PLoS medicine

authors： Ray JG,Schull MJ,Urquia ML,You JJ,Guttmann A,Vermeulen MJ

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:In recent decades, increased attention has been focused on the impact of disabilities and medicinal drug use on road safety. The aim of our study was to investigate the association between prescription medicines and the risk of road traffic crashes, and estimate the attributable fraction. METHODS AND FINDIN...

journal_title：PLoS medicine

authors： Orriols L,Delorme B,Gadegbeku B,Tricotel A,Contrand B,Laumon B,Salmi LR,Lagarde E,CESIR research group.

更新日期：2010-11-16 00:00:00

abstract：BACKGROUND:WHO recommends prompt diagnosis and quinine plus clindamycin for treatment of uncomplicated malaria in the first trimester and artemisinin-based combination therapies in subsequent trimesters. We undertook a systematic review of women's access to and healthcare provider adherence to WHO case management polic...

journal_title：PLoS medicine

authors： Hill J,D'Mello-Guyett L,Hoyt J,van Eijk AM,ter Kuile FO,Webster J

更新日期：2014-08-05 00:00:00