Abstract：
:As the human ovarian follicle enlarges in the course of a regular cycle or following controlled ovarian stimulation, the changes in its structure reveal the oocyte environment composed of cumulus oophorus cells and the follicular fluid (FF).In contrast to the dynamic nature of cells, the fluid compartment appears as a reservoir rich in biomolecules. In some aspects, it is similar to the plasma, but it also exhibits differences that likely relate to its specific localization around the oocyte. The chemical composition indicates that the follicular fluid is able to detect and buffer excessive amounts of reactive oxygen species, employing a variety of antioxidants, some of them components of the intracellular milieu.An important part is played by albumin through specific cysteine residues. But the fluid contains other molecules whose cysteine residues may be involved in sensing and buffering the local oxidative conditions. How these molecules are recruited and regulated to intervene such process is unknown but it is a critical issue in reproduction.In fact, important proteins in the FF, that regulate follicle growth and oocyte quality, exhibit cysteine residues at specific points, whose untoward oxidation would result in functional loss. Therefore, preservation of controlled oxidative conditions in the FF is a requirement for the fine-tuned oocyte maturation process. In contrast, its disturbance enhances the susceptibility to the establishment of reproductive disorders that would require the intervention of reproductive medicine technology.
journal_name
J Ovarian Resjournal_title
Journal of ovarian researchauthors
Freitas C,Neto AC,Matos L,Silva E,Ribeiro Â,Silva-Carvalho JL,Almeida Hdoi
10.1186/s13048-017-0342-3subject
Has Abstractpub_date
2017-07-12 00:00:00pages
44issue
1issn
1757-2215pii
10.1186/s13048-017-0342-3journal_volume
10pub_type
杂志文章,评审abstract：BACKGROUND:Our recent study on a panel of human ovarian cancer cells revealed that SKOV-3 cells barely express the Sprouty isoform 1 (Spry1) while 1A9 cells maintain it at a level similar to normal ovarian cells. Here we investigated the functional outcomes of induced alterations in the expression of Spry1 in the two c...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-61
更新日期：2014-06-08 00:00:00
abstract：BACKGROUND:Epithelial ovarian cancer has the highest fatality rate of all gynecologic malignancies. Although the majority of patients achieve complete clinical response after initial cytoreductive surgery and platinum-based chemotherapy, most recur and almost all will eventually acquire platinum-resistance for which tr...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0506-4
更新日期：2019-04-25 00:00:00
abstract：BACKGROUND:The prevalence of obesity is increasing worldwide and significantly affects fertility and reproduction in both men and women. Our recent study has shown that excess body fat accelerates ovarian follicle development and follicle loss in rats. The aim of the present study is to explore the effect of SIRT1 acti...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-014-0097-z
更新日期：2014-10-21 00:00:00
abstract：:We have earlier reported the presence of very small embryonic-like stem cells (VSELs) in adult mouse uterus along with slightly bigger progenitors termed endometrial stem cells (EnSCs) and their regulation by ovarian hormones thus demonstrating a crucial role played by them during proliferation, differentiation and re...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0324-5
更新日期：2017-04-24 00:00:00
abstract：UNLABELLED: BACKGROUND:Women with polycystic ovary syndrome (PCOS) have higher risk for cardiovascular disease (CVD). Heart type fatty acid binding protein (HFABP) has been found to be predictive for myocardial ischemia.Wet ested whether HFABP is the predictor for CVD in PCOS patients, who have an increased risk of ca...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-5-45
更新日期：2012-12-18 00:00:00
abstract：:The Publisher and Editor regretfully retract this article ( Hou W, Guan J, Lu H, Dong Q, Han Y, Zhang R. The effects of dexamethasone on the proliferation and apoptosis of human ovarian cancer cells induced by paclitaxel. J Ovarian Res. 2014;7:89) because the peer-review process was inappropriately influenced and comp...
journal_title：Journal of ovarian research
pub_type： 撤回出版物
doi：10.1186/s13048-015-0144-4
更新日期：2015-03-26 00:00:00
abstract：OBJECTIVES:Endometrioid carcinoma of the ovary is one of the most types of epithelial ovarian cancer associated to endometrioisis. Endometrioid tumors as well as endometriotic implants are characterized by the presence of epithelial cells, stromal cells, or a combination of booth, that resemble the endometrial cells, s...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-3-3
更新日期：2010-01-28 00:00:00
abstract：BACKGROUND:Survivin is an inhibitor of apoptosis and a regulator of mitotic progression. TP53 protein is a negative transcriptional regulator of survivin. The aim of our study was to evaluate the clinical significance of survivin expression in advanced stages ovarian cancer with respect to the TP53 status. METHODS:Sur...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-4-20
更新日期：2011-11-10 00:00:00
abstract：BACKGROUND:The imbalance of expression of microRNA-802 may have a significant place in tumor progression. However, the bio-function of epithelial ovarian cancer cells remains unclear. Therefore, we setup this study to explore the pathogenesis of epithelial ovarian cancer based on microRNA-802. METHODS:RT-qPCR analysis...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0576-3
更新日期：2019-10-22 00:00:00
abstract：BACKGROUND:Because higher survival of follicles during the freezing/thawing procedure improves the quality of cryopreserved tissue reimplanted after oncological therapies, defining an optimal method for human ovarian tissue cryopreservation remains a major issue in this field. One option to improve the cryopreservation...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0268-1
更新日期：2016-09-26 00:00:00
abstract：BACKGROUND:In recent years the question of the lack of transparency in clinical research has been debated by clinicians, researchers, citizens and their representatives, authors and publishers. This is particularly important for infrequent cancers such as ovarian cancer, where treatment still gives disappointing result...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0404-1
更新日期：2018-04-10 00:00:00
abstract：:RNA methylation can reverse the methylation modification at the RNA level, which is an extremely important epigenetic modification. The function and mechanism of YTHDF2, as a reader of m6A modification, in epithelial ovarian cancer (EOC) have not been elucidated so far. This study aimed to investigate how YTHDF2 and m...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-020-00717-5
更新日期：2020-09-18 00:00:00
abstract：BACKGROUND:Experience on sentinel node mapping in ovarian tumors is very limited. We evaluated the sentinel node concept in ovarian tumors using intra-operativeTc-99m-Phytate injection and lymphoscintigraphy imaging. METHODS:Thirty-five patients with a pelvic mass due to an ovarian pathology were included in the study...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0265-4
更新日期：2016-09-07 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via the original article. ...
journal_title：Journal of ovarian research
pub_type： 已发布勘误
doi：10.1186/s13048-020-00733-5
更新日期：2020-11-12 00:00:00
abstract：:High-Grade Serous Ovarian Carcinoma (HGSOC) is the predominant histotype of epithelial ovarian cancer (EOC), characterized by advanced stage at diagnosis, frequent TP53 mutation, rapid progression, and high responsiveness to platinum-based-chemotherapy. To date, standard first-line-chemotherapy in advanced EOC include...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0238-7
更新日期：2016-05-21 00:00:00
abstract：BACKGROUND:The polycystic ovary syndrome (PCOS) affects approximately 6-10% of women of reproductive age and is characterized by chronic anovulation and hyperandrogenism. However, a comprehensive understanding of the mechanisms that dictate androgen overproduction is lacking, which may account for inconsistencies betwe...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-5-15
更新日期：2012-05-18 00:00:00
abstract：BACKGROUND:This study was aimed to explore the role of long noncoding RNA C17orf91 and its potential mechanisms in ovarian cancer development. RESULTS:To assess its role in ovarian cancer, microarray datasets (GSE14407, GSE30587, and GSE17260) in Gene Expression Omnibus (GEO) were utilized to assess the expression and...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0258-3
更新日期：2016-08-17 00:00:00
abstract：BACKGROUND:Ovarian cancer (OVC) is the deadliest of all gynecologic cancers, primarily as a consequence of asymptomatic progression. The complex nature of OVC creates challenges for early detection, and there is a lack of specific and sensitive biomarkers suitable for screening and detecting early stage OVC. METHODS:P...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0228-9
更新日期：2016-03-31 00:00:00
abstract：BACKGROUND:Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgical resectability. As a new three-dimensional postprocessing tool for CT images, cinematic rendering (...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0461-5
更新日期：2018-09-26 00:00:00
abstract：BACKGROUND:The mechanisms regulating the function and regression of the corpus luteum (CL) have not yet been elucidated in detail. The regressed CL of cows was previously reported to be filled with unusual vessels like arteriovenous anastomosis (AVA); however how these vessels are being established during luteolysis re...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-016-0277-0
更新日期：2016-10-19 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the concentrations of IgG antibodies against Hsp60 and Hsp65 in sera of patients with ovarian cancer at various stages of clinical progress and for different histopathological types of disease. METHODS:Serum samples from 149 patients with ovarian carcinoma and 80 health...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-7-30
更新日期：2014-03-11 00:00:00
abstract：RATIONALE AND OBJECTIVES:To evaluate the impact of metabolic parameters in the peritoneal cavity on the likelihood of achieving complete tumor debulking in patients with ovarian and peritoneal cancers. MATERIALS AND METHODS:Forty-nine patients with ovarian and peritoneal cancers were included, who underwent pre-operat...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-020-00662-3
更新日期：2020-05-20 00:00:00
abstract：OBJECTIVE:To explore the risk factors for the recurrence of endometrioma and the risk factors for the recurrence of endometriosis-related pain after long-term follow-up. METHODS:This study retrospectively analyzed 358 women with endometriomas who had a minimum of 5-years follow up after laparoscopic endometrioma excis...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0552-y
更新日期：2019-08-30 00:00:00
abstract：PURPOSE:The conversion of androgens into estrogens by aromatase is called aromatization and is inhibited by aromatase inhibitors (AIs). The aim of this article is to evaluate the use of aromatase inhibitors in gynecological diseases such as endometriosis, leiomyoma, estrogen- dependent gynecologic neoplasia and inferti...
journal_title：Journal of ovarian research
pub_type： 杂志文章,评审
doi：10.1186/s13048-015-0131-9
更新日期：2015-02-25 00:00:00
abstract：BACKGROUND:The ST6Gal-I glycosyltransferase, which adds α2-6-linked sialic acids to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian cancer. Prior studies have shown that ST6Gal-I-mediated sialylation of select surface receptors remodels intracellular signaling to impart cancer s...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-019-0574-5
更新日期：2019-10-14 00:00:00
abstract：BACKGROUNDS:Long non-coding RNA is a novel group of non-protein coding transcripts over 200 nt in length. Recent studies have found that they are widely involved in many pathological and physiological processes. In our previous study, we found that lnc-GULP1-2:1 was significantly down-regulated in the ovarian cortical ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-021-00769-1
更新日期：2021-01-20 00:00:00
abstract：BACKGROUND:Whether there is a mechanistic link between FOLR1 and response to cisplatin has not been extensively examined. In this study, we determine the expression of FOLR1 in ovarian cancer and examine if FOLR1 levels influence response to cisplatin. RESULTS:(1) FOLR1 protein expression was lowest in normal ovarian ...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-018-0387-y
更新日期：2018-02-13 00:00:00
abstract：BACKGROUND:This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. METHODS:The present study reviewed the medical records of patients who received initial treatment and a postoperative pathologi...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-017-0361-0
更新日期：2017-09-18 00:00:00
abstract：OBJECTIVE:To review utilisation of elective embryo cryopreservation in the expectant management of patients at risk for developing ovarian hyperstimulation syndrome (OHSS), and report on reproductive outcome following transfer of thawed embryos. MATERIALS AND METHODS:Medical records were reviewed for patients undergoi...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/1757-2215-1-7
更新日期：2008-11-06 00:00:00
abstract：BACKGROUND:We aimed to examine the expression of miR-1307 in chemosensitive and chemoresistant epithelial ovarian cancer tissues and cell lines and to analyze the clinicopathological significance of miR-1307 in ovarian cancer. METHODS:MicroRNA microarray was used to screen differentially expressed microRNAs between th...
journal_title：Journal of ovarian research
pub_type： 杂志文章
doi：10.1186/s13048-015-0143-5
更新日期：2015-04-09 00:00:00
