当前位置： SCI文献检索 > Journal of Ovarian Research期刊下所有文献 > Transparency in ovarian cancer clinical trial results: ClinicalTrials.gov versus PubMed, Embase and Google scholar.

Transparency in ovarian cancer clinical trial results: ClinicalTrials.gov versus PubMed, Embase and Google scholar.

Abstract：

BACKGROUND:In recent years the question of the lack of transparency in clinical research has been debated by clinicians, researchers, citizens and their representatives, authors and publishers. This is particularly important for infrequent cancers such as ovarian cancer, where treatment still gives disappointing results in the majority of cases. Our aim was to assess the availability to the public of results in ClinicalTrials.gov, and the frequency of non-publication of results in ClinicalTrials.gov and in PubMed, Embase and Google Scholar. We collected all trials on ovarian cancer identified as "completed status" in the ClinicalTrials.gov registry on 17 January 2017. We checked the availability of the results in ClinicalTrials.gov and systematically identified published manuscripts on results. RESULTS:Out of 2725 trials on ovarian cancer identified, 752 were classified as "completed status". In those closed between 2008 and 2015, excluding phase I, the frequency of results in ClinicalTrials.gov was 35%. Of the 752 completed studies the frequency of published results in PubMed, Embase or Google Scholar ranged from 57.9% to 69.7% in the last years. CONCLUSIONS:These findings show a lack of transparency and credibility of research. Citizens or patients' representatives, with the medical community, should continuously support initiatives to improve the publication and dissemination of clinical study results.

journal_name

J Ovarian Res

journal_title

Journal of ovarian research

authors

Roberto A,Radrezza S,Mosconi P

doi

10.1186/s13048-018-0404-1

subject

Has Abstract

pub_date

2018-04-10 00:00:00

pages

28

issue

1

issn

1757-2215

pii

10.1186/s13048-018-0404-1

journal_volume

11

pub_type

杂志文章

相关文献

Journal of Ovarian Research文献大全
  • Heart type fatty acid binding protein response and subsequent development of atherosclerosis in insulin resistant polycystic ovary syndrome patients.

    abstract：UNLABELLED: BACKGROUND:Women with polycystic ovary syndrome (PCOS) have higher risk for cardiovascular disease (CVD). Heart type fatty acid binding protein (HFABP) has been found to be predictive for myocardial ischemia.Wet ested whether HFABP is the predictor for CVD in PCOS patients, who have an increased risk of ca...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-5-45

    authors： Cakir E,Ozbek M,Sahin M,Cakal E,Gungunes A,Ginis Z,Demirci T,Delibasi T

    更新日期：2012-12-18 00:00:00

  • Diagnostic extended usefulness of RMI: comparison of four risk of malignancy index in preoperative differentiation of borderline ovarian tumors and benign ovarian tumors.

    abstract：BACKGROUND:This study aimed to examine the performance of the four risk of malignancy index (RMI) in discriminating borderline ovarian tumors (BOTs) and benign ovarian masses in daily clinical practice. METHODS:A total of 162 women with BOTs and 379 women with benign ovarian tumors diagnosed at the Second Affiliated H...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-019-0568-3

    authors： Zhang S,Yu S,Hou W,Li X,Ning C,Wu Y,Zhang F,Jiao YF,Lee LTO,Sun L

    更新日期：2019-09-16 00:00:00

  • Evaluation of the effects of hyaluronic acid-carboxymethyl cellulose barrier on ovarian tumor progression.

    abstract：BACKGROUND:Hyaluronic acid is a prognostic factor in ovarian cancers. It is also a component of Hyaluronic Acid-Carboxymethyl Cellulose (HA-CMC) barrier, an anti-adhesion membrane widely used during abdominal surgeries in particular for ovarian carcinosis. 70% of patients who undergo ovarian surgery will relapse due to...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-7-40

    authors： Picaud L,Thibault B,Mery E,Ouali M,Martinez A,Delord JP,Couderc B,Ferron G

    更新日期：2014-04-16 00:00:00

  • Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients.

    abstract：BACKGROUND:Survivin is an inhibitor of apoptosis and a regulator of mitotic progression. TP53 protein is a negative transcriptional regulator of survivin. The aim of our study was to evaluate the clinical significance of survivin expression in advanced stages ovarian cancer with respect to the TP53 status. METHODS:Sur...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-4-20

    authors： Felisiak-Golabek A,Rembiszewska A,Rzepecka IK,Szafron L,Madry R,Murawska M,Napiorkowski T,Sobiczewski P,Osuch B,Kupryjanczyk J,Polish Ovarian Cancer Study Group (POCSG).

    更新日期：2011-11-10 00:00:00

  • The aberrant upstream pathway regulations of CDK1 protein were implicated in the proliferation and apoptosis of ovarian cancer cells.

    abstract：BACKGROUND:Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely related with the cell cycle G2/M phase regulation. The present study aimed to analyze the relationship bet...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-017-0356-x

    authors： Zhang R,Shi H,Ren F,Zhang M,Ji P,Wang W,Liu C

    更新日期：2017-09-12 00:00:00

  • Evaluation of primary adnexal masses by 3T MRI: categorization with conventional MR imaging and diffusion-weighted imaging.

    abstract：UNLABELLED: BACKGROUND:To investigate the 3.0-Tesla (3 T) magnetic resonance imaging (MRI) characteristics of primary adnexal lesions for discriminating benign from malignant lesions. METHODS:One hundred thirty-nine patients with pathologically proven primary adnexal masses referred for 3 T MRI assessment preoperativ...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-5-33

    authors： Zhang H,Zhang GF,He ZY,Li ZY,Zhu M,Zhang GX

    更新日期：2012-11-14 00:00:00

  • The expression of the Sprouty 1 protein inversely correlates with growth, proliferation, migration and invasion of ovarian cancer cells.

    abstract：BACKGROUND:Our recent study on a panel of human ovarian cancer cells revealed that SKOV-3 cells barely express the Sprouty isoform 1 (Spry1) while 1A9 cells maintain it at a level similar to normal ovarian cells. Here we investigated the functional outcomes of induced alterations in the expression of Spry1 in the two c...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-7-61

    authors： Masoumi-Moghaddam S,Amini A,Ehteda A,Wei AQ,Morris DL

    更新日期：2014-06-08 00:00:00

  • Very small embryonic-like stem cells (VSELs) in adult mouse uterine perimetrium and myometrium.

    abstract：:We have earlier reported the presence of very small embryonic-like stem cells (VSELs) in adult mouse uterus along with slightly bigger progenitors termed endometrial stem cells (EnSCs) and their regulation by ovarian hormones thus demonstrating a crucial role played by them during proliferation, differentiation and re...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-017-0324-5

    authors： Bhartiya D,James K

    更新日期：2017-04-24 00:00:00

  • Ovarian mucinous cystic tumor of borderline malignancy with a mural nodule of anaplastic spindle cell carcinoma: a case report.

    abstract：:Ovarian cystic tumors with a mural nodule are a rare entity. We report a case of a mural nodule of anaplastic spindle cell carcinoma in an ovarian mucinous cystic tumor of borderline malignancy. The patient was a 45-years-old Japanese woman who presented with an ovarian cyst. She suffered from mature cystic teratoma o...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-6-86

    authors： Yamazaki H,Matsuzawa A,Shoda T,Iguchi H,Kyushima N

    更新日期：2013-12-05 00:00:00

  • Effect of exercise intensity on weight changes and sexual hormones (androstenedione and free testosterone) in female rats with estradiol valerate-induced PCOS.

    abstract：INTRODUCTION:Weight gain and fat accumulation are predisposing factors of PCOS. Life-style modification, including increasing physical activity, is the first line approach in managing PCOS. The objective of this study is to assess the effect of exercise intensity on weight changes, androstenedione and free testosterone...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-7-37

    authors： Miri M,Karimi Jashni H,Alipour F

    更新日期：2014-04-08 00:00:00

  • MicroRNA-186 induces sensitivity of ovarian cancer cells to paclitaxel and cisplatin by targeting ABCB1.

    abstract：BACKGROUND:Recent studies have shown that microRNAs may regulate the ABCB1 gene (ATP-binding cassette, sub-family B [MDR/TAP], member 1). Computational programs have predicted that the 3'-untranslated region (3'-UTR) of ABCB1 contains a potential miRNA-binding site for miR-186. Here, we investigated the role of miR-186...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-015-0207-6

    authors： Sun KX,Jiao JW,Chen S,Liu BL,Zhao Y

    更新日期：2015-12-02 00:00:00

  • SNAP23 promotes the malignant process of ovarian cancer.

    abstract：BACKGROUND:Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. METHODS:We determined the expression of SNAP23 in OC tissues and explored the clinical signifi...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-016-0289-9

    authors： Sun Q,Huang X,Zhang Q,Qu J,Shen Y,Wang X,Sun H,Wang J,Xu L,Chen X,Ren B

    更新日期：2016-11-17 00:00:00

  • Characterization of the tumor marker muc16 (ca125) expressed by murine ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies.

    abstract：OBJECTIVES:The ovarian tumor marker CA125 is expressed on human MUC16, a cell surface bound mucin that is also shed by proteolytic cleavage. Human MUC16 is overexpressed by ovarian cancer cells. MUC16 facilitates the binding of ovarian tumor cells to mesothelial cells lining the peritoneal cavity. Additionally, MUC16 a...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-2-8

    authors： Goodell CA,Belisle JA,Gubbels JA,Migneault M,Rancourt C,Connor J,Kunnimalaiyaan M,Kravitz R,Tucker W,Zwick M,Patankar MS

    更新日期：2009-06-18 00:00:00

  • Use of aromatase inhibitors in practice of gynecology.

    abstract：PURPOSE:The conversion of androgens into estrogens by aromatase is called aromatization and is inhibited by aromatase inhibitors (AIs). The aim of this article is to evaluate the use of aromatase inhibitors in gynecological diseases such as endometriosis, leiomyoma, estrogen- dependent gynecologic neoplasia and inferti...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章,评审

    doi：10.1186/s13048-015-0131-9

    authors： Usluogullari B,Duvan C,Usluogullari C

    更新日期：2015-02-25 00:00:00

  • Lymphatic mapping and sentinel node biopsy in ovarian tumors: a study using intra-operative Tc-99m-Phytate and lymphoscintigraphy imaging.

    abstract：BACKGROUND:Experience on sentinel node mapping in ovarian tumors is very limited. We evaluated the sentinel node concept in ovarian tumors using intra-operativeTc-99m-Phytate injection and lymphoscintigraphy imaging. METHODS:Thirty-five patients with a pelvic mass due to an ovarian pathology were included in the study...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-016-0265-4

    authors： Hassanzadeh M,Hosseini Farahabadi E,Yousefi Z,Kadkhodayan S,Zarifmahmoudi L,Sadeghi R

    更新日期：2016-09-07 00:00:00

  • Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients.

    abstract：:High-Grade Serous Ovarian Carcinoma (HGSOC) is the predominant histotype of epithelial ovarian cancer (EOC), characterized by advanced stage at diagnosis, frequent TP53 mutation, rapid progression, and high responsiveness to platinum-based-chemotherapy. To date, standard first-line-chemotherapy in advanced EOC include...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-016-0238-7

    authors： Mignogna C,Staropoli N,Botta C,De Marco C,Rizzuto A,Morelli M,Di Cello A,Franco R,Camastra C,Presta I,Malara N,Salvino A,Tassone P,Tagliaferri P,Barni T,Donato G,Di Vito A

    更新日期：2016-05-21 00:00:00

  • Retraction note: The effects of dexamethasone on the proliferation and apoptosis of human ovarian cancer cells induced by paclitaxel.

    abstract：:The Publisher and Editor regretfully retract this article ( Hou W, Guan J, Lu H, Dong Q, Han Y, Zhang R. The effects of dexamethasone on the proliferation and apoptosis of human ovarian cancer cells induced by paclitaxel. J Ovarian Res. 2014;7:89) because the peer-review process was inappropriately influenced and comp...

    journal_title：Journal of ovarian research

    pub_type： 撤回出版物

    doi：10.1186/s13048-015-0144-4

    authors：

    更新日期：2015-03-26 00:00:00

  • Development of a multi-gene-based immune prognostic signature in ovarian Cancer.

    abstract：BACKGROUND:Various components of the immune system play a critical role in the prognosis and treatment response in ovarian cancer (OC). Immunotherapy has been recognized as a hallmark of cancer but the effect is contradictional. Reliable immune gene-based prognostic biomarkers or regulatory factors are necessary to be ...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-021-00766-4

    authors： Cao T,Shen H

    更新日期：2021-01-28 00:00:00

  • CT of ovarian cancer: 3D cinematic rendering for preoperative evaluation.

    abstract：BACKGROUND:Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgical resectability. As a new three-dimensional postprocessing tool for CT images, cinematic rendering (...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-018-0461-5

    authors： Jin YR,Yang XL,Li QQ,Yan ZL,Yang HY,Liao C

    更新日期：2018-09-26 00:00:00

  • Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model.

    abstract：BACKGROUND:The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine condition characterized by hyperandrogenism, hyperinsulinemia, insulin resistance and chronic anovulation. Regulation and interaction of a multitude of genes required for follicular development are found to be altered in PCOS. Micr...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-6-36

    authors： Hossain MM,Cao M,Wang Q,Kim JY,Schellander K,Tesfaye D,Tsang BK

    更新日期：2013-05-15 00:00:00

  • The clinicopathological significance of miR-1307 in chemotherapy resistant epithelial ovarian cancer.

    abstract：BACKGROUND:We aimed to examine the expression of miR-1307 in chemosensitive and chemoresistant epithelial ovarian cancer tissues and cell lines and to analyze the clinicopathological significance of miR-1307 in ovarian cancer. METHODS:MicroRNA microarray was used to screen differentially expressed microRNAs between th...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-015-0143-5

    authors： Zhou Y,Wang M,Wu J,Jie Z,Chang S,Shuang T

    更新日期：2015-04-09 00:00:00

  • Antibodies against Hsp60 and Hsp65 in the sera of women with ovarian cancer.

    abstract：BACKGROUND:The aim of this study was to evaluate the concentrations of IgG antibodies against Hsp60 and Hsp65 in sera of patients with ovarian cancer at various stages of clinical progress and for different histopathological types of disease. METHODS:Serum samples from 149 patients with ovarian carcinoma and 80 health...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-7-30

    authors： Bodzek P,Partyka R,Damasiewicz-Bodzek A

    更新日期：2014-03-11 00:00:00

  • Rate of rebound in follicle growth after cessation of ovarian stimulation in initial non-responders: a prospective cohort study.

    abstract：:Previously anecdotally observed rebounds in follicle growth after interruption of exogenous gonadotropins in absolute non-responders were the impetus for here reported study. In a prospective cohort study, we investigated 49 consecutive patients, absolutely unresponsive to maximal exogenous gonadotropin stimulation, f...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-021-00765-5

    authors： Gleicher N,Weghofer A,Darmon SK,Barad DH

    更新日期：2021-01-09 00:00:00

  • MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1.

    abstract：BACKGROUND:Epithelial ovarian cancer (EOC) is still a major gynecologic problem with poor 5 year survival rate due to distance metastases, despite routine surgery and chemotherapy. The precise underlying molecular mechanisms that trigger EOC migration and invasion are unclear. Recent studies suggest that the expression...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-6-84

    authors： Zhang H,Wang Q,Zhao Q,Di W

    更新日期：2013-11-26 00:00:00

  • Investigating the clinical potential for 14-3-3 zeta protein to serve as a biomarker for epithelial ovarian cancer.

    abstract：OBJECTIVE:Recently, 14-3-3 zeta protein was identified as a potential serum biomarker of epithelial ovarian cancer (EOC). The goal of this study was to investigate the clinical potential of 14-3-3 zeta protein for monitoring EOC progression compared with CA-125 and HE4. DESIGN:Prospective follow-up study. SETTING:Uni...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-6-79

    authors： Hatzipetros I,Gocze P,Koszegi T,Jaray A,Szereday L,Polgar B,Farkas N,Farkas B

    更新日期：2013-11-15 00:00:00

  • BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases.

    abstract：BACKGROUND:It is estimated that more than 20% of ovarian cancer cases are associated with a genetic predisposition that is only partially explained by germline mutations in the BRCA1 and BRCA2 genes. Recently, several pieces of evidence showed that mutations in three genes involved in the homologous recombination DNA r...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章,meta分析

    doi：10.1186/s13048-020-00654-3

    authors： Suszynska M,Ratajska M,Kozlowski P

    更新日期：2020-05-02 00:00:00

  • Correction to: Kallistatin inhibits tumour progression and platinum resistance in high-grade serous ovarian cancer.

    abstract：:The original article [1] contains errors in Fig. 3C, Results and Discussion. ...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章,已发布勘误

    doi：10.1186/s13048-020-00628-5

    authors： Wu H,Li R,Zhang Z,Jiang H,Ma H,Yuan C,Sun C,Li Y,Kong B

    更新日期：2020-03-13 00:00:00

  • Use of a multi-drug regimen gemcitabine, 5-fluorouracil, irinotecan, cisplatin, bevacizumab, docetaxel, and cyclophosphamide (GFIP/BDC) for heavily pretreated relapsed epithelial ovarian, fallopian tube and primary peritoneal cancer.

    abstract：BACKGROUND:Epithelial ovarian cancer has the highest fatality rate of all gynecologic malignancies. Although the majority of patients achieve complete clinical response after initial cytoreductive surgery and platinum-based chemotherapy, most recur and almost all will eventually acquire platinum-resistance for which tr...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-019-0506-4

    authors： Cohen S,Schwartz M,Dottino P,Beddoe AM

    更新日期：2019-04-25 00:00:00

  • Combined score of pretreatment platelet count and CA125 level (PLT-CA125) stratified prognosis in patients with FIGO stage IV epithelial ovarian cancer.

    abstract：BACKGROUND:The majority of death-related ovarian cancer is epithelial ovarian cancer (EOC). Regarding the Federation of Gynecology and Obstetrics (FIGO) stage IV EOC, the 5-year overall survival (OS) has not changed in last decades. Platelet (PLT) count and CA125 level are both prognostic markers that related to inflam...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/s13048-019-0544-y

    authors： Chen JP,Huang QD,Wan T,Tu H,Gu HF,Cao JY,Liu JH

    更新日期：2019-07-31 00:00:00

  • Locally existing endothelial cells and pericytes in ovarian stroma, but not bone marrow-derived vascular progenitor cells, play a central role in neovascularization during follicular development in mice.

    abstract：BACKGROUND:Neovascularization is necessary for follicular growth. Vascularization is first observed in preantral follicles, and thereafter the vasculature markedly increases in follicles undergoing development. Neovascularization includes angiogenesis and vasculogenesis. Vasculogenesis is the formation of new blood ves...

    journal_title：Journal of ovarian research

    pub_type： 杂志文章

    doi：10.1186/1757-2215-7-10

    authors： Kizuka-Shibuya F,Tokuda N,Takagi K,Adachi Y,Lee L,Tamura I,Maekawa R,Tamura H,Suzuki T,Owada Y,Sugino N

    更新日期：2014-01-21 00:00:00